BR9608476A - Compound process to inhibit the growth of a mammalian tumor cell and therapeutic composition - Google Patents

Compound process to inhibit the growth of a mammalian tumor cell and therapeutic composition

Info

Publication number
BR9608476A
BR9608476A BR9608476A BR9608476A BR9608476A BR 9608476 A BR9608476 A BR 9608476A BR 9608476 A BR9608476 A BR 9608476A BR 9608476 A BR9608476 A BR 9608476A BR 9608476 A BR9608476 A BR 9608476A
Authority
BR
Brazil
Prior art keywords
inhibit
growth
tumor cell
therapeutic composition
mammalian tumor
Prior art date
Application number
BR9608476A
Other languages
Portuguese (pt)
Inventor
Edmund J Lavoie
Leroy Fong Liu
Qun Sun
Original Assignee
Univ Rutgers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/442,657 external-priority patent/US5807874A/en
Priority claimed from US08/618,988 external-priority patent/US5767142A/en
Application filed by Univ Rutgers filed Critical Univ Rutgers
Publication of BR9608476A publication Critical patent/BR9608476A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BR9608476A 1995-05-17 1996-05-14 Compound process to inhibit the growth of a mammalian tumor cell and therapeutic composition BR9608476A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/442,657 US5807874A (en) 1995-05-17 1995-05-17 Trisbenzimidazoles useful as topoisomerase I inhibitors
US08/618,988 US5767142A (en) 1996-03-20 1996-03-20 Trisbenzimidazoles useful as topoisomerase I inhibitors
PCT/US1996/006853 WO1996036612A1 (en) 1995-05-17 1996-05-14 Tribenzimidazoles useful as topoisomerase i inhibitors

Publications (1)

Publication Number Publication Date
BR9608476A true BR9608476A (en) 1999-08-17

Family

ID=27033238

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9608476A BR9608476A (en) 1995-05-17 1996-05-14 Compound process to inhibit the growth of a mammalian tumor cell and therapeutic composition

Country Status (10)

Country Link
EP (1) EP0839140A1 (en)
JP (1) JPH11508229A (en)
AU (1) AU713317B2 (en)
BR (1) BR9608476A (en)
CA (1) CA2221248A1 (en)
CZ (1) CZ363197A3 (en)
HU (1) HUP9900071A3 (en)
NZ (1) NZ307959A (en)
PL (1) PL324034A1 (en)
WO (1) WO1996036612A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770617A (en) * 1996-03-20 1998-06-23 Rutgers, The State University Of New Jersey Terbenzimidazoles useful as antifungal agents
PL341539A1 (en) * 1997-12-31 2001-04-23 Rutgers Heterocyclic toxins of topoisomerases
IL137351A0 (en) * 1998-02-12 2001-07-24 Univ Rutgers Heterocyclic topoisomerase poisons
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6740650B2 (en) 1999-10-29 2004-05-25 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
EP1453507B1 (en) 2001-11-14 2009-03-04 Rutgers, The State University Solubilized topoisomerase poison agents
ES2340473T3 (en) 2001-11-14 2010-06-04 Rutgers, The State University POISON OF SOLUBILIZED TOPOISOMERASES.
DE60225943T2 (en) 2001-11-14 2009-01-29 Rutgers, The State University Topoisomerase GIFT FUNDS
AU2002352708A1 (en) 2001-11-14 2003-05-26 Edmond J. Lavoie Cytotoxic agents
AU2003265405A1 (en) 2002-08-09 2004-02-25 Edmond J. Lavoie Nitro and amino substituted heterocycles as topoisomerase i targeting agents
AU2003268075A1 (en) 2002-08-09 2004-02-25 Edmond J. Lavoie Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents
AU2003265406A1 (en) 2002-08-09 2004-02-25 Edmond J. Lavoie Nitro and amino substituted topoisomerase agents
JP4774212B2 (en) 2002-11-12 2011-09-14 ラトガーズ、ザ・ステイト・ユニバーシテイ・オブ・ニユー・ジヤージー Topoisomerase-targeting agent
EP2403856B1 (en) 2009-03-06 2012-12-19 Rutgers, The State University of New Jersey Methylenedioxybenzo [i]phenanthridine derivatives used to treat cancer
WO2010127363A1 (en) 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
JP2019515025A (en) 2016-04-04 2019-06-06 ラトガース ザ ステイト ユニバーシティー オブ ニュージャージー Topoisomerase poison

Also Published As

Publication number Publication date
NZ307959A (en) 1998-08-26
CZ363197A3 (en) 1998-05-13
AU5746696A (en) 1996-11-29
PL324034A1 (en) 1998-05-11
AU713317B2 (en) 1999-11-25
JPH11508229A (en) 1999-07-21
HUP9900071A2 (en) 2000-03-28
CA2221248A1 (en) 1996-11-21
MX9708822A (en) 1998-06-30
WO1996036612A1 (en) 1996-11-21
HUP9900071A3 (en) 2002-01-28
EP0839140A1 (en) 1998-05-06

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Legal Events

Date Code Title Description
FB36 Technical and formal requirements: requirement - article 36 of industrial property law
FA8 Dismissal: dismissal - article 36, par. 1 of industrial property law