HUP9900071A3 - Tribenzimidazoles useful as topoisomerase i inhibitors, pharmaceutical compositions containing them and their use - Google Patents

Tribenzimidazoles useful as topoisomerase i inhibitors, pharmaceutical compositions containing them and their use

Info

Publication number
HUP9900071A3
HUP9900071A3 HU9900071A HUP9900071A HUP9900071A3 HU P9900071 A3 HUP9900071 A3 HU P9900071A3 HU 9900071 A HU9900071 A HU 9900071A HU P9900071 A HUP9900071 A HU P9900071A HU P9900071 A3 HUP9900071 A3 HU P9900071A3
Authority
HU
Hungary
Prior art keywords
tribenzimidazoles
topoisomerase
inhibitors
useful
pharmaceutical compositions
Prior art date
Application number
HU9900071A
Other languages
Hungarian (hu)
Original Assignee
Univ Rutgers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/442,657 external-priority patent/US5807874A/en
Priority claimed from US08/618,988 external-priority patent/US5767142A/en
Application filed by Univ Rutgers filed Critical Univ Rutgers
Publication of HUP9900071A2 publication Critical patent/HUP9900071A2/en
Publication of HUP9900071A3 publication Critical patent/HUP9900071A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
HU9900071A 1995-05-17 1996-05-14 Tribenzimidazoles useful as topoisomerase i inhibitors, pharmaceutical compositions containing them and their use HUP9900071A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/442,657 US5807874A (en) 1995-05-17 1995-05-17 Trisbenzimidazoles useful as topoisomerase I inhibitors
US08/618,988 US5767142A (en) 1996-03-20 1996-03-20 Trisbenzimidazoles useful as topoisomerase I inhibitors
PCT/US1996/006853 WO1996036612A1 (en) 1995-05-17 1996-05-14 Tribenzimidazoles useful as topoisomerase i inhibitors

Publications (2)

Publication Number Publication Date
HUP9900071A2 HUP9900071A2 (en) 2000-03-28
HUP9900071A3 true HUP9900071A3 (en) 2002-01-28

Family

ID=27033238

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900071A HUP9900071A3 (en) 1995-05-17 1996-05-14 Tribenzimidazoles useful as topoisomerase i inhibitors, pharmaceutical compositions containing them and their use

Country Status (10)

Country Link
EP (1) EP0839140A1 (en)
JP (1) JPH11508229A (en)
AU (1) AU713317B2 (en)
BR (1) BR9608476A (en)
CA (1) CA2221248A1 (en)
CZ (1) CZ363197A3 (en)
HU (1) HUP9900071A3 (en)
NZ (1) NZ307959A (en)
PL (1) PL324034A1 (en)
WO (1) WO1996036612A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770617A (en) * 1996-03-20 1998-06-23 Rutgers, The State University Of New Jersey Terbenzimidazoles useful as antifungal agents
EP1044199B1 (en) 1997-12-31 2008-07-23 Rutgers, The State University Of New Jersey Heterocyclic topoisomerase poisons
IL137351A0 (en) * 1998-02-12 2001-07-24 Univ Rutgers Heterocyclic topoisomerase poisons
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6740650B2 (en) 1999-10-29 2004-05-25 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
ES2311639T3 (en) 2001-11-14 2009-02-16 Rutgers, The State University CYTOTOXIC AGENTS.
EP1453507B1 (en) 2001-11-14 2009-03-04 Rutgers, The State University Solubilized topoisomerase poison agents
MXPA04004606A (en) 2001-11-14 2004-09-10 Univ Rutgers Solubilized topoisomerase poisons.
EP1453506B1 (en) 2001-11-14 2008-04-02 Rutgers, The State University Topoisomerase poison agents
AU2003268075A1 (en) 2002-08-09 2004-02-25 Edmond J. Lavoie Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents
US6992088B2 (en) 2002-08-09 2006-01-31 Rutgers, The State University Of New Jersey Nitro and amino substituted heterocycles as topoisomerase I targeting agents
US6989387B2 (en) 2002-08-09 2006-01-24 Rutgers, The State University Of New Jersey Nitro and amino substituted topoisomerase agents
AU2003290818A1 (en) 2002-11-12 2004-06-03 Edmond J. Lavoie Topoisomerase-targeting agents
WO2010102219A1 (en) 2009-03-06 2010-09-10 Rutgers, The State University Of New Jersey Methylenedioxybenzo [i] phenanthridine derivatives used to treat cancer
WO2010127363A1 (en) 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
CN109219610A (en) 2016-04-04 2019-01-15 新泽西州立拉特格斯大学 topoisomerase poisons

Also Published As

Publication number Publication date
WO1996036612A1 (en) 1996-11-21
NZ307959A (en) 1998-08-26
JPH11508229A (en) 1999-07-21
BR9608476A (en) 1999-08-17
CZ363197A3 (en) 1998-05-13
HUP9900071A2 (en) 2000-03-28
AU5746696A (en) 1996-11-29
EP0839140A1 (en) 1998-05-06
MX9708822A (en) 1998-06-30
AU713317B2 (en) 1999-11-25
CA2221248A1 (en) 1996-11-21
PL324034A1 (en) 1998-05-11

Similar Documents

Publication Publication Date Title
IL138028A0 (en) Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical use
HU228234B1 (en) Rapamycin derivatives, pharmaceutical compositions containing them and their use
HUP9901086A3 (en) Arylsulfonylaminobenzene derivatives, pharmaceutical compositions containing them and their use for producing pharmaceutical compositions
HUP9901159A3 (en) Substituted benzylaminopiperidine derivatives and use thereof, pharmaceutical compositions containing these compounds
HUP0200355A2 (en) 4-aminopyrrolopyrimidines as kinase inhibitors, pharmaceutical compositions containing them and their use
HUT74464A (en) 1n-alkyl-n-arylpyrimidinamines and derivatives thereof, and pharmaceutical compositions containing them
IL119466A (en) Thrombin inhibitors, their preparation and pharmaceutical compositions containing them
IL116851A (en) 3-arylidene-2-oxindole derivatives and pharmaceutical compositions containing them
HUP9900974A3 (en) Heterocycle-condensed morphinoid derivatives, process for the preparation thereof, their use and pharmaceutical compositions containing them
HUP0103884A3 (en) Arylsulfonanilide urea-derivatives, pharmaceutical compositions containing them and their use
HUP0001508A3 (en) 4-arylmethylene-2-imino-2,3-dihydrothiazole derivatives, their use, process for the preparation thereof and pharmaceutical compositions containing them
HUP0000167A3 (en) Pyrroles as spla2 inhibitors, and pharmaceutical compositions containing them
HUP9904694A3 (en) Spiropyrrolidine derivatives, their use and pharmaceutical compositions containing them
HUP9802937A3 (en) Benzo[g]quuinoline derivatives, pharmaceutical compositions containing them and their use
HUP9601240A1 (en) Pyridin and pyrimidin derivatives, suitable as beta-adrenerg agonists, pharmaceutical compositions containing the same and their intermediates
HUP9900071A3 (en) Tribenzimidazoles useful as topoisomerase i inhibitors, pharmaceutical compositions containing them and their use
HUP9904682A3 (en) Phenyloxazole and -thiazole derivatives, their use and pharmaceutical compositions containing them
IL108703A0 (en) Substituted azolone derivatives, their preparation and pharmaceutical compositions containing them
HUP0105075A3 (en) 3,3-biarylpiperidine and 2,2-biarylmorpholine derivatives, their use and pharmaceutical compositions containing them
HUP9802132A3 (en) Biphenyl-sulfonyl-cyanamides, their use and pharmaceutical compositions containing them
HUP9901984A3 (en) Naphthyl acetamides as spla2 inhibitors, use thereof and pharmaceutical compositions containing these compounds
HUP9901485A2 (en) Heterocyclylcarboxamide derivatives, pharmaceutical compositions containing the same, process for their preparation and their use
HUP9801386A3 (en) Indazolecarboxamide derivatives, preparation thereof and pharmaceutical compositions containing them
HUP0003577A3 (en) Tetrahydro gamma-carbolines, process for their preparation, their use and pharmaceutical compositions containing them
HUP0104852A3 (en) Oktahydro-pyrido-pyrazine derivatives and pharmaceutical compositions containing the same and their use