DK2750699T3 - Farmaceutisk kombination til anvendelse til glykæmisk kontrol hos diabetes-type 2-patienter - Google Patents
Farmaceutisk kombination til anvendelse til glykæmisk kontrol hos diabetes-type 2-patienter Download PDFInfo
- Publication number
- DK2750699T3 DK2750699T3 DK12756417.7T DK12756417T DK2750699T3 DK 2750699 T3 DK2750699 T3 DK 2750699T3 DK 12756417 T DK12756417 T DK 12756417T DK 2750699 T3 DK2750699 T3 DK 2750699T3
- Authority
- DK
- Denmark
- Prior art keywords
- patients
- patient
- pharmaceutical combination
- lixisenatide
- treatment
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Claims (16)
1. Farmaceutisk kombination til anvendelse til glykæmisk kontrol hos diabetes-type 2-patienter, hvilken kombination omfatter (a) desPro36Exendin-4 (1-39)-Lys6-NH2 og/eller et farmaceutisk acceptabelt salt deraf og (b) en glitazon og/eller et farmaceutisk acceptabelt salt deraf.
2. Farmaceutisk kombination til anvendelse ifølge krav 1, der yderligere omfatter (c) metformin og/eller et farmaceutisk acceptabelt salt deraf.
3. Farmaceutisk kombination til anvendelse ifølge krav 2, hvor metformin og/eller et farmaceutisk acceptabelt salt deraf er fremstillet til oral administration.
4. Farmaceutisk kombination til anvendelse ifølge et hvilket som helst af ovennævnte krav, hvor diabetes-type 2-patienten er adipøs.
5. Farmaceutisk kombination til anvendelse ifølge et hvilket som helst af ovennævnte krav, hvor diabetes-type 2-patienten har et BMI (body mass index) på mindst 30 kg/m2.
6. Farmaceutisk kombination til anvendelse ifølge et hvilket som helst af ovennævnte krav, hvor diabetes-type 2-patienten er en voksen patient.
7. Farmaceutisk kombination til anvendelse ifølge et hvilket som helst af ovennævnte krav, hvor diabetes-type 2-patienten ikke modtager en antidiabetisk behandling.
8. Farmaceutisk kombination til anvendelse ifølge et hvilket som helst af ovennævnte krav, hvor diabetes mellitus-type 2 hos diabetes-type 2-patienten er blevet diagnosticeret mindst 1 år eller mindst 2 år før behandlingsstart.
9. Farmaceutisk kombination til anvendelse ifølge et hvilket som helst af ovennævnte krav, hvor diabetes-type 2-patienten har en HbAic-værdi på ca. 7 % to ca. 10 %.
10. Farmaceutisk kombination til anvendelse ifølge et hvilket som helst af ovennævnte krav, hvor diabetes-type 2-patienten har en fastende plasmaglucosekoncentration på mindst 8 mmol/L.
11. Farmaceutisk kombination til anvendelse ifølge et hvilket som helst af ovennævnte krav, hvor diabetes-type 2-patienten har en plasmaglucosekoncentration 2 timer postprandialt på mindst 10 mmol/L, mindst 12 mmol/L eller mindst 14 mmol/L.
12. Farmaceutisk kombination til anvendelse ifølge et hvilket som helst af ovennævnte krav, hvor diabetes-type 2-patienten har et glucoseudsving på mindst 2 mmol/L, mindst 3 mmol/L, mindst 4 mmol/L eller mindst 5 mmol/L, hvor glucoseudsvinget er forskellen mellem plasmaglucosekoncentrationen 2 timer postprandialt og plasmaglucosekoncentrationen 30 minutter før en måltidstest.
13. Farmaceutisk kombination til anvendelse ifølge et hvilket som helst af ovennævnte krav, hvor desPro36Exendin-4(1-39) -Lys6~NH2 og/eller det farmaceutisk acceptable salt deraf er fremstillet til parenteral administration.
14. Farmaceutisk kombination til anvendelse ifølge et hvilket som helst af ovennævnte krav, hvor desPro36Exendin-4(1-39)-Lys6_NH2 og/eller det farmaceutisk acceptable salt deraf er fremstillet til administration i en daglig dosis, der er udvalgt fra intervallet fra 10 yg til 20 yg.
15. Farmaceutisk kombination til anvendelse ifølge et hvilket som helst af ovennævnte krav, hvor glitazon og/eller det farmaceutisk acceptable salt deraf er fremstillet til oral administration.
16. Farmaceutisk kombination til anvendelse ifølge et hvilket som helst af ovennævnte krav, hvor glitazon er pioglitazon.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11179149 | 2011-08-29 | ||
| PCT/EP2012/066617 WO2013030160A1 (en) | 2011-08-29 | 2012-08-27 | Pharmaceutical combination for use in glycemic control in diabetes type 2 patients |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2750699T3 true DK2750699T3 (da) | 2015-10-26 |
Family
ID=46826464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12756417.7T DK2750699T3 (da) | 2011-08-29 | 2012-08-27 | Farmaceutisk kombination til anvendelse til glykæmisk kontrol hos diabetes-type 2-patienter |
Country Status (22)
| Country | Link |
|---|---|
| US (5) | US9408893B2 (da) |
| EP (1) | EP2750699B1 (da) |
| JP (1) | JP6367115B2 (da) |
| KR (1) | KR101983982B1 (da) |
| CN (2) | CN103917241A (da) |
| AR (1) | AR087693A1 (da) |
| AU (1) | AU2012300978B2 (da) |
| BR (1) | BR112014004726A2 (da) |
| CA (1) | CA2846413C (da) |
| CY (1) | CY1116803T1 (da) |
| DK (1) | DK2750699T3 (da) |
| ES (1) | ES2550357T3 (da) |
| HK (1) | HK1196267A1 (da) |
| HR (1) | HRP20151068T1 (da) |
| HU (1) | HUE027989T2 (da) |
| MX (1) | MX370264B (da) |
| PL (1) | PL2750699T3 (da) |
| PT (1) | PT2750699E (da) |
| RU (1) | RU2650616C2 (da) |
| SI (1) | SI2750699T1 (da) |
| TW (1) | TWI608847B (da) |
| WO (1) | WO2013030160A1 (da) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX344293B (es) | 2008-10-17 | 2016-12-13 | Sanofi Aventis Deutschland | Combinacion de una insulina y un agonista de glp-1. |
| KR101772372B1 (ko) | 2009-11-13 | 2017-08-29 | 사노피-아벤티스 도이칠란트 게엠베하 | Ｇｌｐ-1 효능제 및 메티오닌을 포함하는 약제학적 조성물 |
| AU2010317995B2 (en) | 2009-11-13 | 2014-04-17 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition comprising a GLP-1 agonist, an insulin, and methionine |
| CN103179978A (zh) | 2010-08-30 | 2013-06-26 | 赛诺菲-安万特德国有限公司 | Ave0010用于制造供治疗2型糖尿病用的药物的用途 |
| JP6381914B2 (ja) * | 2011-02-02 | 2018-08-29 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | ２型糖尿病患者における低血糖の予防 |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| AU2012300978B2 (en) | 2011-08-29 | 2017-04-27 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for use in glycemic control in diabetes type 2 patients |
| TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
| TWI641381B (zh) | 2013-02-04 | 2018-11-21 | 法商賽諾菲公司 | 胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物 |
| MX2016008977A (es) | 2014-01-09 | 2016-10-04 | Sanofi Sa | Formulaciones farmaceuticas de insulina aspart estabilizadas. |
| AU2015205624A1 (en) | 2014-01-09 | 2016-07-14 | Sanofi | Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives |
| CA2932875A1 (en) | 2014-01-09 | 2015-07-16 | Sanofi | Stabilized glycerol free pharmaceutical formulations of insulin analogues and/or insulin derivatives |
| TN2017000235A1 (en) | 2014-12-12 | 2018-10-19 | Sanofi Aventis Deutschland | Insulin glargine/lixisenatide fixed ratio formulation |
| AR103415A1 (es) * | 2015-01-16 | 2017-05-10 | Sanofi Aventis Deutschland | Tratamiento de pacientes pediátricos con diabetes mellitus de tipo 2 |
| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患之治療 |
| US10251852B2 (en) * | 2016-04-13 | 2019-04-09 | Children's Hospital Medical Center | Composition and methods for treatment of lung disorders characterized by cholesterol dysregulation |
| KR102508255B1 (ko) | 2021-02-15 | 2023-03-09 | 연세대학교 산학협력단 | 비정형 pkc 활성화제를 함유하는 당 조절용 조성물 |
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