DK1384707T3 - 4-Nitroxybutylester af naproxen - Google Patents

4-Nitroxybutylester af naproxen

Info

Publication number
DK1384707T3
DK1384707T3 DK03102132T DK03102132T DK1384707T3 DK 1384707 T3 DK1384707 T3 DK 1384707T3 DK 03102132 T DK03102132 T DK 03102132T DK 03102132 T DK03102132 T DK 03102132T DK 1384707 T3 DK1384707 T3 DK 1384707T3
Authority
DK
Denmark
Prior art keywords
naproxen
nitroxybutyl ester
nitroxybutyl
ester
naphthyl
Prior art date
Application number
DK03102132T
Other languages
Danish (da)
English (en)
Inventor
Francesca Benedini
Erminio Oldani
Graziano Castaldi
Antonio Tarquini
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Application granted granted Critical
Publication of DK1384707T3 publication Critical patent/DK1384707T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/02—Preparation of esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK03102132T 1999-08-04 2000-07-27 4-Nitroxybutylester af naproxen DK1384707T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999MI001753A IT1313596B1 (it) 1999-08-04 1999-08-04 Processo per la preparazione di nitrossialchil esteri del naproxene

Publications (1)

Publication Number Publication Date
DK1384707T3 true DK1384707T3 (da) 2005-08-15

Family

ID=11383500

Family Applications (2)

Application Number Title Priority Date Filing Date
DK00951456T DK1200386T3 (da) 1999-08-04 2000-07-27 Fremgangsmåde til fremstilling af nitroxyalkylestere af naproxen
DK03102132T DK1384707T3 (da) 1999-08-04 2000-07-27 4-Nitroxybutylester af naproxen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK00951456T DK1200386T3 (da) 1999-08-04 2000-07-27 Fremgangsmåde til fremstilling af nitroxyalkylestere af naproxen

Country Status (23)

Country Link
US (2) US6700011B1 (pt)
EP (2) EP1200386B1 (pt)
JP (2) JP4667691B2 (pt)
KR (1) KR100687820B1 (pt)
CN (1) CN1198786C (pt)
AT (2) ATE251109T1 (pt)
AU (1) AU778694B2 (pt)
BR (1) BRPI0012915B1 (pt)
CA (1) CA2380116C (pt)
DE (2) DE60005682T2 (pt)
DK (2) DK1200386T3 (pt)
ES (2) ES2243859T3 (pt)
HU (1) HU227109B1 (pt)
IL (1) IL147639A0 (pt)
IT (1) IT1313596B1 (pt)
MX (1) MXPA02001256A (pt)
NO (1) NO327669B1 (pt)
PL (1) PL200165B1 (pt)
PT (2) PT1200386E (pt)
RU (1) RU2248348C2 (pt)
TR (1) TR200200290T2 (pt)
WO (1) WO2001010814A1 (pt)
ZA (2) ZA200200478B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000025776A1 (en) 1998-10-30 2000-05-11 Nitromed, Inc. Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
JP4092203B2 (ja) 2000-12-21 2008-05-28 ニトロメッド，インク． 新規のシクロオキシゲナーゼ２選択的阻害剤としての置換アリール化合物、組成物、および使用方法
WO2003045896A1 (en) * 2001-11-27 2003-06-05 Astrazeneca Ab New process
EP1539134A4 (en) 2002-06-11 2007-04-11 Nitromed Inc SELECTIVE INHIBITORS OF CYCLOOXIGENASE-2 NITROSIS AND / OR NITROSYLES, COMPOSITIONS AND METHODS OF USE
CA2491127A1 (en) 2002-07-03 2004-01-15 Nitromed, Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
CA2493156A1 (en) 2002-07-29 2004-02-05 Nitromed, Inc. Cyclooxygenase-2 selective inhibitors, compositions and methods of use
ITMI20021861A1 (it) * 2002-08-29 2004-02-29 Nicox Sa Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
ITMI20022409A1 (it) * 2002-11-14 2004-05-15 Dinamite Dipharma S P A Procedimento per la purificazione di 1, 4-butandiolo mononitrato.
KR20080097989A (ko) * 2006-02-03 2008-11-06 니콕스 에스. 에이. 근위축증 치료를 위한 의약의 니트록시 유도체의 용도
CN100427475C (zh) * 2006-11-30 2008-10-22 华南理工大学 萘普生-2-芳基吗啉乙酯及其制备方法与应用
CN101730676A (zh) * 2007-06-28 2010-06-09 尼科克斯公司 1,4-丁二醇单硝酸酯的制备方法
WO2009149053A2 (en) * 2008-06-02 2009-12-10 Dr. Reddy's Laboratories Ltd. Naproxcinod process and solid dispersion
ITRM20080325A1 (it) * 2008-06-20 2009-12-21 Nicox Sa Metodo per purificare 4-(nitroosi)butil(2s)-2-(6-metossi-2-naftil) propanoato
TW201139337A (en) 2010-03-31 2011-11-16 Lonza Ag Process for the production of esters of nitric acid
TWI417276B (zh) 2011-03-01 2013-12-01 Everlight Chem Ind Corp ２-（ｓ）-（６-甲氧基-２-萘基）-丙酸之酸酐衍生物、其製法暨及其用途
CA2897571C (en) 2013-01-21 2018-12-18 Apparao Satyam Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group
CN115666549A (zh) 2020-02-10 2023-01-31 尼科斯股份有限公司 用于治疗与镰状细胞病相关的血管闭塞危象的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57145841A (en) * 1981-03-05 1982-09-09 Nissan Chem Ind Ltd L-menthyl naphthylpropionate and its preparation
IT1243367B (it) 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
DE69412109T2 (de) * 1993-10-06 1999-01-21 Nicox Sa Salzetersaüreester mit entzündungshemmender und/oder schmerzlindernder wirkung und verfahren zu deren herstellung
JP4043046B2 (ja) * 1994-05-10 2008-02-06 ニコックス エス エイ 消炎、鎮痛および抗血栓活性を有するニトロ化合物およびそれらの組成物
US5703073A (en) * 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
CN1144092A (zh) * 1995-08-25 1997-03-05 蔡雄 可释放一氧化氮的新型非类固醇类抗炎药、它们的制备方法和用途
AU6835696A (en) * 1995-10-09 1997-04-30 Russinsky Limited Esters of cyclooxygenase inhibitors and terpene derivatives as pharmaceutical products
IT1276071B1 (it) * 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria
FR2757159B1 (fr) 1996-12-12 1999-12-17 Hoechst Marion Roussel Inc Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments

Also Published As

Publication number Publication date
CA2380116A1 (en) 2001-02-15
AU778694B2 (en) 2004-12-16
IL147639A0 (en) 2002-08-14
BR0012915A (pt) 2002-06-04
PL200165B1 (pl) 2008-12-31
US6700011B1 (en) 2004-03-02
CN1367773A (zh) 2002-09-04
PL353092A1 (en) 2003-10-06
JP2011042690A (ja) 2011-03-03
IT1313596B1 (it) 2002-09-09
JP2003506425A (ja) 2003-02-18
ATE251109T1 (de) 2003-10-15
HUP0202435A3 (en) 2004-03-01
DE60020753D1 (de) 2005-07-14
HUP0202435A2 (hu) 2002-11-28
BRPI0012915B1 (pt) 2015-09-01
EP1200386B1 (en) 2003-10-01
RU2248348C2 (ru) 2005-03-20
PT1384707E (pt) 2005-08-31
ES2208390T3 (es) 2004-06-16
MXPA02001256A (es) 2005-06-06
PT1200386E (pt) 2004-02-27
CA2380116C (en) 2011-07-05
EP1200386A1 (en) 2002-05-02
NO20020515D0 (no) 2002-02-01
KR20020013974A (ko) 2002-02-21
ZA200304525B (en) 2004-04-28
ZA200200478B (en) 2003-10-29
HU227109B1 (en) 2010-07-28
US20050119339A1 (en) 2005-06-02
ITMI991753A0 (it) 1999-08-04
JP4667691B2 (ja) 2011-04-13
DE60020753T2 (de) 2006-03-16
ATE297372T1 (de) 2005-06-15
TR200200290T2 (tr) 2002-05-21
NO20020515L (no) 2002-02-01
ES2243859T3 (es) 2005-12-01
AU6438500A (en) 2001-03-05
DK1200386T3 (da) 2003-12-22
CN1198786C (zh) 2005-04-27
EP1384707B1 (en) 2005-06-08
DE60005682D1 (de) 2003-11-06
ITMI991753A1 (it) 2001-02-04
EP1384707A1 (en) 2004-01-28
NO327669B1 (no) 2009-09-07
US7238829B2 (en) 2007-07-03
KR100687820B1 (ko) 2007-02-28
DE60005682T2 (de) 2004-09-16
WO2001010814A1 (en) 2001-02-15

Similar Documents

Publication Publication Date Title
DK1384707T3 (da) 4-Nitroxybutylester af naproxen
ATE257837T1 (de) Neuartige ester abgeleitet von substituierten phenyl-zyklohexyl-verbindungen
ID22095A (id) Asam aril-akrilat ester
DE69813540T2 (de) Kosmetische zusammensetzung enthaltend ferulasäureester
DE69516678D1 (de) Laser-markieren von fluorpolymer-zusammensetzungen
ID24626A (id) Turunan-turunan asam hidroksamat sebagai penghambat metaloprotease matriks (mmp)
DK1135998T3 (da) Anvendelse af syntetiske triglycerider på basis af konjugeret linolsyre som antioxidant i levnedsmidler
ID15886A (id) Pembuatan alkil ester secara kontiniu dari asam met-akrilik
ID16433A (id) Penyediaan kontinyu alkil ester dari asam (met)akrilat
ID22013A (id) Senyawa-senyawa ester
ID15885A (id) Pembuatan alkil ester secara kontiniu dari asam met-akrilik
DE50113582D1 (de) Verwendung einer Pulver-Zusammensetzung zur Hydrophobierung von Baustoffmassen
ATE240299T1 (de) Diester prodrugs von decahydroischinoline-3- carbonsäure
ID28810A (id) Senyawa-senyawa amida-omega asam n-arilsulfonilamino
NO992500L (no) 2-imidazolinylaminobenzoksazolforbindelser anvendelige som <alfa>-2 adrenoceptoragonister
DE59810578D1 (de) Mischungen von langkettigen Phosphorsäurealkylestern
DK0888280T3 (da) Fremgangsmåde til fremstilling af 2-(2-methylphenyl)-3-methoxyacrylsyremethylester
DE3687393D1 (de) Methacrylsaeureesterharzzusammensetzung fuer optische scheiben.
EA199900888A1 (ru) Противоревматические средства
DE69707251D1 (de) Maleimidobenzosäure Ester
DK1449828T3 (da) Mellemprodukter til fremstilling af guanidinomethylcyclohexancarboxylsyreesterderivater
ES2159665T3 (es) Preparacion y utilizacion de enantiomeros puros de los acidos 8-halogeno-6-hidroxioctanoicos, sus esteres alquilicos y sus sales con los enantiomeros puros de alfa-metilbencilamina.
DE60015353D1 (de) 3-oxo-1-propansulfonsäure und -sulfonate
DE69809692D1 (de) Herstellung von Carbonsäureestern
PT1098871E (pt) Derivados de ester fenilico de alfa-aminoacidos