EA199900888A1 - Противоревматические средства - Google Patents

Противоревматические средства

Info

Publication number
EA199900888A1
EA199900888A1 EA199900888A EA199900888A EA199900888A1 EA 199900888 A1 EA199900888 A1 EA 199900888A1 EA 199900888 A EA199900888 A EA 199900888A EA 199900888 A EA199900888 A EA 199900888A EA 199900888 A1 EA199900888 A1 EA 199900888A1
Authority
EA
Eurasian Patent Office
Prior art keywords
related means
cyclopenten
dihydroxy
chem
salt
Prior art date
Application number
EA199900888A
Other languages
English (en)
Other versions
EA001798B1 (ru
Inventor
Нобуто Кояма
Хуа-Канг Ву
Таканари Томинага
Эйдзи Нисияма
Митио Хагия
Тацудзи Еноки
Хирому Охноги
Икуносин Като
Original Assignee
Такара Сузо Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Такара Сузо Ко., Лтд. filed Critical Такара Сузо Ко., Лтд.
Publication of EA199900888A1 publication Critical patent/EA199900888A1/ru
Publication of EA001798B1 publication Critical patent/EA001798B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/60—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/707—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups a keto group being part of a three- to five-membered ring
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

Противоревматическое средство, которое отличается тем, что оно содержит, по меньшей мере, одно соединение, выбранное из группы, состоящей из 4,5-дигидрокси-2-циклопентен-1-она, представленного нижеследующей формулой [I], и оптически активного вещества и соли его в качестве эффективного компонента.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900888A 1997-04-01 1998-03-18 Противоревматические средства EA001798B1 (ru)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP9639997 1997-04-01
JP16347397 1997-06-06
JP24168097 1997-08-25
JP28320497 1997-10-01
JP36227397 1997-12-12
PCT/JP1998/001149 WO1998043623A1 (fr) 1997-04-01 1998-03-18 Agents anti-rhumatismaux

Publications (2)

Publication Number Publication Date
EA199900888A1 true EA199900888A1 (ru) 2000-08-28
EA001798B1 EA001798B1 (ru) 2001-08-27

Family

ID=27525788

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900888A EA001798B1 (ru) 1997-04-01 1998-03-18 Противоревматические средства

Country Status (13)

Country Link
US (1) US6284801B1 (ru)
EP (1) EP0978277B1 (ru)
JP (1) JP3664736B2 (ru)
KR (1) KR100537871B1 (ru)
CN (1) CN1127950C (ru)
AT (1) ATE274905T1 (ru)
AU (1) AU740079C (ru)
CA (1) CA2285215A1 (ru)
DE (1) DE69825980T2 (ru)
EA (1) EA001798B1 (ru)
ES (1) ES2226106T3 (ru)
TW (1) TW529948B (ru)
WO (1) WO1998043623A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050020687A1 (en) * 1996-01-14 2005-01-27 Consiglio Nazionale Ricerche Methods of treating inflammatory and viral disorders by administering cyclopentenone compounds
WO1998041196A1 (fr) 1997-03-17 1998-09-24 Takara Shuzo Co., Ltd. Agents antiviraux
ES2227811T3 (es) 1997-03-28 2005-04-01 Takara Bio Inc. 4,5-dihidroxi-2-ciclopenten-1-ona para el tratamiento de diabetes melltus.
US6284801B1 (en) 1997-04-01 2001-09-04 Takara Shuzo Co., Ltd. Antirheumatic agents
WO1999001119A1 (fr) * 1997-07-02 1999-01-14 Takara Shuzo Co., Ltd. Agents anti-allergiques
AU1890399A (en) 1998-01-19 1999-08-02 Takara Shuzo Co., Ltd. Substances capable of inducing apoptosis
AU3665700A (en) * 1999-03-22 2000-10-09 Charterhouse Therapeutics Ltd. Chemical compounds and their uses
GB9929702D0 (en) * 1999-12-16 2000-02-09 Charterhouse Therapeutics Ltd Chemical compounds and their uses

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2608089B2 (ja) 1988-03-09 1997-05-07 帝人株式会社 ４−ヒドロキシ−２−シクロペンテノン類およびそれを含有する薬剤組成物
JP2571950B2 (ja) * 1988-03-11 1997-01-16 財団法人野口研究所 シクロペンテノン誘導体及びその製造法
JPH0768163B2 (ja) * 1989-03-17 1995-07-26 財団法人野口研究所 シクロペンテノン誘導体の製法
AU727370B2 (en) 1996-09-27 2000-12-14 Takara Bio Inc. Cyclopentenones and manufacturing methods and uses thereof
WO1998041196A1 (fr) 1997-03-17 1998-09-24 Takara Shuzo Co., Ltd. Agents antiviraux
ES2227811T3 (es) 1997-03-28 2005-04-01 Takara Bio Inc. 4,5-dihidroxi-2-ciclopenten-1-ona para el tratamiento de diabetes melltus.
US6284801B1 (en) 1997-04-01 2001-09-04 Takara Shuzo Co., Ltd. Antirheumatic agents
WO1999001119A1 (fr) 1997-07-02 1999-01-14 Takara Shuzo Co., Ltd. Agents anti-allergiques

Also Published As

Publication number Publication date
EP0978277A1 (en) 2000-02-09
CN1127950C (zh) 2003-11-19
EP0978277A4 (en) 2002-08-28
KR100537871B1 (ko) 2005-12-21
ES2226106T3 (es) 2005-03-16
DE69825980D1 (de) 2004-10-07
AU740079B2 (en) 2001-10-25
CA2285215A1 (en) 1998-10-08
KR20000076147A (ko) 2000-12-26
TW529948B (en) 2003-05-01
AU6418698A (en) 1998-10-22
DE69825980T2 (de) 2005-09-08
CN1251522A (zh) 2000-04-26
US6284801B1 (en) 2001-09-04
WO1998043623A1 (fr) 1998-10-08
AU740079C (en) 2002-05-02
EA001798B1 (ru) 2001-08-27
JP3664736B2 (ja) 2005-06-29
EP0978277B1 (en) 2004-09-01
ATE274905T1 (de) 2004-09-15

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

PC4A Registration of transfer of a eurasian patent by assignment
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU