|
US7138486B2
(en)
|
1986-05-05 |
2006-11-21 |
The General Hospital Corporation |
Insulinotropic hormone derivatives and uses thereof
|
|
US6849708B1
(en)
|
1986-05-05 |
2005-02-01 |
The General Hospital Corporation |
Insulinotropic hormone and uses thereof
|
|
US5614492A
(en)
*
|
1986-05-05 |
1997-03-25 |
The General Hospital Corporation |
Insulinotropic hormone GLP-1 (7-36) and uses thereof
|
|
FR2686899B1
(fr)
|
1992-01-31 |
1995-09-01 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
|
|
US6284727B1
(en)
|
1993-04-07 |
2001-09-04 |
Scios, Inc. |
Prolonged delivery of peptides
|
|
US5705483A
(en)
*
|
1993-12-09 |
1998-01-06 |
Eli Lilly And Company |
Glucagon-like insulinotropic peptides, compositions and methods
|
|
US20020006899A1
(en)
*
|
1998-10-06 |
2002-01-17 |
Pospisilik Andrew J. |
Use of dipeptidyl peptidase IV effectors for lowering blood pressure in mammals
|
|
WO1998005351A1
(en)
*
|
1996-08-08 |
1998-02-12 |
Amylin Pharmaceuticals, Inc. |
Methods for regulating gastrointestinal motility
|
|
CA2277112C
(en)
*
|
1997-01-07 |
2008-08-26 |
Amylin Pharmaceuticals, Inc. |
Use of exendins and agonists thereof for the reduction of food intake
|
|
WO1998043658A1
(en)
*
|
1997-03-31 |
1998-10-08 |
Eli Lilly And Company |
Glucagon-like peptide-1 analogs
|
|
JP2002510193A
(ja)
*
|
1997-03-31 |
2002-04-02 |
イーライ・リリー・アンド・カンパニー |
グルカゴン様ペプチド−1類似体
|
|
US7157555B1
(en)
*
|
1997-08-08 |
2007-01-02 |
Amylin Pharmaceuticals, Inc. |
Exendin agonist compounds
|
|
WO1999025727A2
(en)
|
1997-11-14 |
1999-05-27 |
Amylin Pharmaceuticals, Inc. |
Novel exendin agonist compounds
|
|
US7220721B1
(en)
*
|
1997-11-14 |
2007-05-22 |
Amylin Pharmaceuticals, Inc. |
Exendin agonist peptides
|
|
WO1999029336A1
(en)
*
|
1997-12-05 |
1999-06-17 |
Eli Lilly And Company |
Glp-1 formulations
|
|
US6380357B2
(en)
*
|
1997-12-16 |
2002-04-30 |
Eli Lilly And Company |
Glucagon-like peptide-1 crystals
|
|
FR2777283B1
(fr)
*
|
1998-04-10 |
2000-11-24 |
Adir |
Nouveaux composes peptidiques analogues du glucagon-peptide- 1 (7-37), leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
DE19823831A1
(de)
*
|
1998-05-28 |
1999-12-02 |
Probiodrug Ges Fuer Arzneim |
Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen
|
|
DE19828113A1
(de)
*
|
1998-06-24 |
2000-01-05 |
Probiodrug Ges Fuer Arzneim |
Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV
|
|
EP1306091A3
(en)
*
|
1998-07-31 |
2003-05-21 |
Novo Nordisk A/S |
Stimulation of beta cell proliferation
|
|
US6720407B1
(en)
*
|
1998-08-28 |
2004-04-13 |
Eli Lilly And Company |
Method for administering insulinotropic peptides
|
|
EP1666054A1
(en)
|
1998-08-28 |
2006-06-07 |
Eli Lilly & Company |
Method for administering insulinotropic peptides
|
|
CA2343268A1
(en)
|
1998-09-17 |
2000-03-23 |
Eli Lilly And Company |
Protein formulations
|
|
US20030176357A1
(en)
*
|
1998-10-06 |
2003-09-18 |
Pospisilik Andrew J. |
Dipeptidyl peptidase IV inhibitors and their uses for lowering blood pressure levels
|
|
US6284725B1
(en)
*
|
1998-10-08 |
2001-09-04 |
Bionebraska, Inc. |
Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue
|
|
US7259136B2
(en)
*
|
1999-04-30 |
2007-08-21 |
Amylin Pharmaceuticals, Inc. |
Compositions and methods for treating peripheral vascular disease
|
|
CN100540566C
(zh)
*
|
1998-12-07 |
2009-09-16 |
研究及应用科学协会股份有限公司 |
胰高血糖素样肽-1的类似物
|
|
BR9916027A
(pt)
*
|
1998-12-07 |
2001-08-28 |
Sod Conseils Rech Applic |
Análogos de glp-1
|
|
DE69928006T2
(de)
*
|
1998-12-22 |
2006-07-13 |
Eli Lilly And Co., Indianapolis |
Lagerstabile flüssige zusammensetzungen von glucagon-ähnlichem peptid-1
|
|
EP1600162A1
(en)
*
|
1998-12-22 |
2005-11-30 |
Eli Lilly & Company |
Shelf-stable formulation of glucagon-like peptide-1
|
|
US20050272652A1
(en)
|
1999-03-29 |
2005-12-08 |
Gault Victor A |
Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity
|
|
US6605648B1
(en)
*
|
1999-04-06 |
2003-08-12 |
Phillips Plastics Corporation |
Sinterable structures and method
|
|
CA2363712C
(en)
|
1999-05-17 |
2011-05-10 |
Conjuchem Inc. |
Long lasting insulinotropic peptides
|
|
US20090175821A1
(en)
*
|
1999-05-17 |
2009-07-09 |
Bridon Dominique P |
Modified therapeutic peptides with extended half-lives in vivo
|
|
US6514500B1
(en)
*
|
1999-10-15 |
2003-02-04 |
Conjuchem, Inc. |
Long lasting synthetic glucagon like peptide {GLP-!}
|
|
PT1133312E
(pt)
*
|
1999-06-21 |
2007-11-30 |
Lilly Co Eli |
Uso sinergístico de tiazolidinodionas com péptido 1 semelhante ao glucagon e os seus agonistas para tratar diabetes não insulino-dependente
|
|
US6864234B1
(en)
*
|
1999-06-25 |
2005-03-08 |
Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. |
Somatostatin agonists
|
|
US9006175B2
(en)
*
|
1999-06-29 |
2015-04-14 |
Mannkind Corporation |
Potentiation of glucose elimination
|
|
CA2377204C
(en)
|
1999-06-29 |
2015-01-20 |
Pharmaceutical Discovery Corporation |
Purification and stabilization of peptide and protein pharmaceutical agents
|
|
DE19940130A1
(de)
*
|
1999-08-24 |
2001-03-01 |
Probiodrug Ges Fuer Arzneim |
Neue Effektoren der Dipeptidyl Peptidase IV zur topischen Anwendung
|
|
WO2001052825A2
(en)
|
2000-01-21 |
2001-07-26 |
Novartis Ag |
Combinations comprising dipeptidylpeptidase-iv inhibitors and antidiabetic agents
|
|
US6448045B1
(en)
*
|
2000-03-10 |
2002-09-10 |
The Regents Of The University Of California |
Inducing insulin gene expression in pancreas cells expressing recombinant PDX-1
|
|
ATE419036T1
(de)
*
|
2000-03-31 |
2009-01-15 |
Prosidion Ltd |
Verbesserung der aktivität der inselzellen bei diabetes mellitus und dessen prävention
|
|
EP1983055A1
(en)
|
2000-04-12 |
2008-10-22 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
ES2275685T3
(es)
*
|
2000-06-16 |
2007-06-16 |
Eli Lilly And Company |
Analogos del peptido similar a glucagon 1.
|
|
KR100407792B1
(ko)
*
|
2000-08-02 |
2003-12-01 |
한국생명공학연구원 |
인간 글루카곤 유사펩타이드를 융합파트너로 이용한재조합 단백질의 제조방법
|
|
AR033390A1
(es)
|
2000-08-22 |
2003-12-17 |
Novartis Ag |
Una composicion farmaceutica que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina, el uso de dicha composicion para la fabricacion de un medicamento y un kit de partes
|
|
JP2004510716A
(ja)
*
|
2000-10-02 |
2004-04-08 |
ユーエスヴイ リミテッド |
メトフォルミン含有持続性放出薬理組成物とその製造方法
|
|
EP1328271B1
(en)
*
|
2000-10-27 |
2008-06-25 |
Probiodrug AG |
Treatment of neurological and neuropsychological disorders
|
|
CA2430934C
(en)
|
2000-12-01 |
2011-06-21 |
Takeda Chemical Industries, Ltd. |
A method of producing sustained-release preparations of a bioactive substance using high-pressure gas
|
|
MXPA03005135A
(es)
|
2000-12-13 |
2003-12-04 |
Lilly Co Eli |
Regimen de tratamiento cronico usando peptidos insulinotropicos similares al glucagon.
|
|
AU2002228608A1
(en)
*
|
2000-12-13 |
2002-06-24 |
Eli Lilly And Company |
Amidated glucagon-like peptide-1
|
|
CA2439063A1
(en)
*
|
2001-03-12 |
2002-09-19 |
Novartis Ag |
Combination of nateglinide or repaglinide with at least one further antidiabetic compound
|
|
US6573237B2
(en)
|
2001-03-16 |
2003-06-03 |
Eli Lilly And Company |
Protein formulations
|
|
US7368421B2
(en)
*
|
2001-06-27 |
2008-05-06 |
Probiodrug Ag |
Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis
|
|
US20030130199A1
(en)
*
|
2001-06-27 |
2003-07-10 |
Von Hoersten Stephan |
Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents
|
|
DE60224284T2
(de)
*
|
2001-06-28 |
2008-12-18 |
Novo Nordisk A/S |
Stabile formulierung von modifiziertem glp-1
|
|
UA74912C2
(en)
*
|
2001-07-06 |
2006-02-15 |
Merck & Co Inc |
Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
|
|
US6642003B2
(en)
|
2001-08-02 |
2003-11-04 |
Cedars-Sinai Medical Center |
Human glucose-dependent insulin-secreting cell line
|
|
JP2005504766A
(ja)
*
|
2001-08-16 |
2005-02-17 |
プロバイオドラッグ アーゲー |
プロリンエンドペプチダーゼ阻害剤の、細胞内シグナルカスケード依存性イノシトール(1,4,5)トリホスフェート濃度調節への使用。
|
|
US7238663B2
(en)
*
|
2001-08-28 |
2007-07-03 |
Eli Lilly And Company |
Pre-mixes of GLP-1 and basal insulin
|
|
US6844316B2
(en)
*
|
2001-09-06 |
2005-01-18 |
Probiodrug Ag |
Inhibitors of dipeptidyl peptidase I
|
|
US6911324B2
(en)
*
|
2001-10-18 |
2005-06-28 |
The Regents Of The University Of California |
Induction of beta cell differentiation in human cells
|
|
EP1448222A4
(en)
*
|
2001-10-19 |
2006-05-17 |
Lilly Co Eli |
BIPHASIC MIXTURES OF GLP-1 AND INSULIN
|
|
US7332819B2
(en)
*
|
2002-01-09 |
2008-02-19 |
Micron Technology, Inc. |
Stacked die in die BGA package
|
|
EP2261250B1
(en)
|
2001-12-21 |
2015-07-01 |
Human Genome Sciences, Inc. |
GCSF-Albumin fusion proteins
|
|
AU2002364587A1
(en)
*
|
2001-12-21 |
2003-07-30 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
WO2005003296A2
(en)
|
2003-01-22 |
2005-01-13 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
US7105489B2
(en)
*
|
2002-01-22 |
2006-09-12 |
Amylin Pharmaceuticals, Inc. |
Methods and compositions for treating polycystic ovary syndrome
|
|
JP4417113B2
(ja)
*
|
2002-02-20 |
2010-02-17 |
エミスフェアー・テクノロジーズ・インク |
Glp−1分子の投与方法
|
|
US7141240B2
(en)
*
|
2002-03-12 |
2006-11-28 |
Cedars-Sinai Medical Center |
Glucose-dependent insulin-secreting cells transfected with a nucleotide sequence encoding GLP-1
|
|
WO2003080149A2
(en)
|
2002-03-20 |
2003-10-02 |
Mannkind Corporation |
Inhalation apparatus
|
|
US20030232761A1
(en)
*
|
2002-03-28 |
2003-12-18 |
Hinke Simon A. |
Novel analogues of glucose-dependent insulinotropic polypeptide
|
|
US20030191056A1
(en)
|
2002-04-04 |
2003-10-09 |
Kenneth Walker |
Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
|
|
ES2327328T3
(es)
|
2002-07-04 |
2009-10-28 |
Zealand Pharma A/S |
Glp-1 y procedimientos para el tratamiento de la diabetes.
|
|
US20080260838A1
(en)
*
|
2003-08-01 |
2008-10-23 |
Mannkind Corporation |
Glucagon-like peptide 1 (glp-1) pharmaceutical formulations
|
|
US20040058876A1
(en)
*
|
2002-09-18 |
2004-03-25 |
Torsten Hoffmann |
Secondary binding site of dipeptidyl peptidase IV (DP IV)
|
|
US20050176622A1
(en)
*
|
2002-09-18 |
2005-08-11 |
Kerstin Kuhn-Wache |
Secondary binding site of dipeptidyl peptidase IV (DPIV)
|
|
EP1543030A2
(en)
|
2002-09-25 |
2005-06-22 |
Theratechnologies Inc. |
Modified glp-1 peptides with increased biological potency
|
|
US7544657B2
(en)
|
2002-10-02 |
2009-06-09 |
Zealand Pharma A/S |
Stabilized Exendin-4 compounds
|
|
BR0315523A
(pt)
*
|
2002-10-22 |
2005-08-30 |
Waratah Pharmaceuticals Inc |
Tratamento de diabetes
|
|
US20040209803A1
(en)
*
|
2002-12-19 |
2004-10-21 |
Alain Baron |
Compositions for the treatment and prevention of nephropathy
|
|
US7790681B2
(en)
*
|
2002-12-17 |
2010-09-07 |
Amylin Pharmaceuticals, Inc. |
Treatment of cardiac arrhythmias with GLP-1 receptor ligands
|
|
RU2234703C1
(ru)
*
|
2002-12-18 |
2004-08-20 |
Мищенко Борис Петрович |
Способ количественного определения гликогемоглобина
|
|
KR20050086948A
(ko)
*
|
2002-12-27 |
2005-08-30 |
디오벡스, 인코포레이티드 |
인슐린으로 인한 저혈당증을 예방하고 조절하기 위한조성물 및 방법
|
|
US7655618B2
(en)
*
|
2002-12-27 |
2010-02-02 |
Diobex, Inc. |
Compositions and methods for the prevention and control of insulin-induced hypoglycemia
|
|
EP1594529B1
(en)
*
|
2003-02-19 |
2010-01-20 |
Ipsen Pharma |
Analogues of glp-1
|
|
US7557183B2
(en)
*
|
2003-03-19 |
2009-07-07 |
Eli Lilly And Company |
Polyethylene glycol linked GLP-1 compounds
|
|
ATE395101T1
(de)
*
|
2003-04-15 |
2008-05-15 |
Opperbas Holding Bv |
Pharmazeutische zusammensetzung, enthaltend proteine und/oder polypeptide sowie kolloidpartikel
|
|
US7371871B2
(en)
*
|
2003-05-05 |
2008-05-13 |
Probiodrug Ag |
Inhibitors of glutaminyl cyclase
|
|
DE602004026712D1
(de)
*
|
2003-05-05 |
2010-06-02 |
Probiodrug Ag |
Medizinische verwendung von hemmern von glutaminyl und glutamatcyclasen
|
|
US8008255B2
(en)
|
2003-05-30 |
2011-08-30 |
Amylin Pharmaceuticals, Inc. |
Methods and compositions for enhanced transmucosal delivery of peptides and proteins
|
|
JP2007524592A
(ja)
*
|
2003-06-03 |
2007-08-30 |
ノボ・ノルデイスク・エー/エス |
安定化された薬学的ペプチド組成物
|
|
ATE529126T1
(de)
*
|
2003-06-03 |
2011-11-15 |
Novo Nordisk As |
Stabilisierte pharmazeutische peptid zusammensetzungen
|
|
JP4936884B2
(ja)
*
|
2003-06-03 |
2012-05-23 |
ノボ・ノルデイスク・エー/エス |
安定化された薬学的ペプチド組成物
|
|
EP1675578B9
(en)
*
|
2003-10-15 |
2014-06-25 |
Probiodrug AG |
Inhibitors of glutaminyl and glutamate cyclases for the treatment of the neurodegenerative diseases fbd and fdd
|
|
CN1882356B
(zh)
*
|
2003-11-20 |
2015-02-25 |
诺沃挪第克公司 |
对于生产和用于注射装置中是最佳的含有丙二醇的肽制剂
|
|
EP1694278A4
(en)
*
|
2003-12-16 |
2009-08-12 |
Ipsen Pharma |
GLP-1 PHARMACEUTICAL COMPOSITIONS
|
|
EP2210900A3
(en)
|
2003-12-16 |
2010-08-11 |
Ipsen Pharma |
Analogues of GLP-1
|
|
US20060286129A1
(en)
*
|
2003-12-19 |
2006-12-21 |
Emisphere Technologies, Inc. |
Oral GLP-1 formulations
|
|
BRPI0507189A
(pt)
*
|
2004-01-30 |
2007-06-26 |
Waratah Pharmaceuticals Inc |
uso combinado de um agonista de glp-1 e compostos de gastrina
|
|
EP1713780B1
(en)
|
2004-02-05 |
2012-01-18 |
Probiodrug AG |
Novel inhibitors of glutaminyl cyclase
|
|
AU2005211725B2
(en)
*
|
2004-02-09 |
2010-07-15 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
CA2564031A1
(en)
|
2004-04-23 |
2005-11-03 |
Conjuchem Biotechnologies Inc. |
Method for the purification of albumin conjugates
|
|
US20090069226A1
(en)
*
|
2004-05-28 |
2009-03-12 |
Amylin Pharmaceuticals, Inc. |
Transmucosal delivery of peptides and proteins
|
|
EP1786784B1
(en)
|
2004-08-20 |
2010-10-27 |
MannKind Corporation |
Catalysis of diketopiperazine synthesis
|
|
CN104436170B
(zh)
|
2004-08-23 |
2018-02-23 |
曼金德公司 |
用于药物输送的二酮哌嗪盐
|
|
JP4965446B2
(ja)
*
|
2004-08-31 |
2012-07-04 |
ノヴォ ノルディスク アー/エス |
ペプチド、ポリペプチド及びタンパク質の安定化のためのトリス(ヒドロキシメチル)アミノメタンの使用
|
|
DE102004043153B4
(de)
*
|
2004-09-03 |
2013-11-21 |
Philipps-Universität Marburg |
Erfindung betreffend GLP-1 und Exendin
|
|
WO2006051110A2
(en)
*
|
2004-11-12 |
2006-05-18 |
Novo Nordisk A/S |
Stable formulations of insulinoptropic peptides
|
|
WO2006069697A1
(en)
*
|
2004-12-30 |
2006-07-06 |
F. Hoffmann-La Roche Ag |
Colorimetrically assessing peptide characteristics
|
|
WO2006069779A1
(en)
*
|
2004-12-30 |
2006-07-06 |
F. Hoffmann-La Roche Ag |
Preparing of peptides with excellent solubility
|
|
US8263545B2
(en)
|
2005-02-11 |
2012-09-11 |
Amylin Pharmaceuticals, Inc. |
GIP analog and hybrid polypeptides with selectable properties
|
|
EP1853627A2
(en)
|
2005-02-11 |
2007-11-14 |
Amylin Pharmaceuticals, Inc. |
Gip analog and hybrid polypeptides with selectable properties
|
|
WO2006097535A2
(en)
*
|
2005-03-18 |
2006-09-21 |
Novo Nordisk A/S |
Peptide agonists of the glucagon family with secretin like activity
|
|
SG156683A1
(en)
|
2005-06-07 |
2009-11-26 |
Univ Rockefeller |
STIMULATION OF PANCREATIC β CELL PROLIFERATION
|
|
AU2006265814B2
(en)
*
|
2005-06-30 |
2012-05-10 |
Ipsen Pharma S.A.S. |
GLP-1 pharmaceutical compositions
|
|
US20070004616A1
(en)
*
|
2005-06-30 |
2007-01-04 |
Roland Cherif-Cheikh |
GLP-1 pharmaceutical compositions
|
|
GT200600381A
(es)
|
2005-08-25 |
2007-03-28 |
|
Compuestos organicos
|
|
IN2014DN09128A
(enExample)
|
2005-09-14 |
2015-07-10 |
Mannkind Corp |
|
|
ES2336575T3
(es)
|
2005-09-22 |
2010-04-14 |
Biocompatibles Uk Limited |
Polipeptidos de fusion glp-1 (peptido-1 similar al glucagon) con resistencia aumentada a la peptidasa.
|
|
EP1943275B1
(en)
*
|
2005-11-01 |
2010-06-16 |
Activotec SPP Limited |
Insulinotropic compounds and uses thereof
|
|
GB0522295D0
(en)
*
|
2005-11-01 |
2005-12-07 |
Activotec Spp Ltd |
Peptides and uses thereof
|
|
WO2007053946A1
(en)
*
|
2005-11-09 |
2007-05-18 |
Conjuchem Biotechnologies Inc. |
Method of treating diabetes and/or obesity with reduced nausea side effects using an insulinotropic peptide conjugated to albumin
|
|
CN100374462C
(zh)
*
|
2005-11-21 |
2008-03-12 |
大连帝恩生物工程有限公司 |
截短胰高血糖素样肽1(sGLP-1)、制法及其应用
|
|
US8334257B2
(en)
|
2005-12-20 |
2012-12-18 |
Duke University |
Methods and compositions for delivering active agents with enhanced pharmacological properties
|
|
US20130172274A1
(en)
|
2005-12-20 |
2013-07-04 |
Duke University |
Methods and compositions for delivering active agents with enhanced pharmacological properties
|
|
US8178495B2
(en)
|
2008-06-27 |
2012-05-15 |
Duke University |
Therapeutic agents comprising a GLP-1 receptor agonist and elastin-like peptide
|
|
US8841255B2
(en)
|
2005-12-20 |
2014-09-23 |
Duke University |
Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
|
|
US20070269863A1
(en)
*
|
2005-12-22 |
2007-11-22 |
Bridon Dominique P |
Process for the production of preformed conjugates of albumin and a therapeutic agent
|
|
CN101389348A
(zh)
|
2006-02-22 |
2009-03-18 |
曼金德公司 |
用于改善包含二酮哌嗪和活性剂的微粒的药物性质的方法
|
|
CA2648936C
(en)
*
|
2006-04-20 |
2013-07-09 |
Amgen Inc. |
Glp-1 compounds
|
|
SI2035451T1
(sl)
*
|
2006-06-23 |
2010-06-30 |
Hoffmann La Roche |
Sinteza insulinotropnega peptida
|
|
JP2010500868A
(ja)
|
2006-07-18 |
2010-01-14 |
セントカー・インコーポレーテツド |
ヒトglp−1ミメティボディ、組成物、方法および用途
|
|
US8497240B2
(en)
|
2006-08-17 |
2013-07-30 |
Amylin Pharmaceuticals, Llc |
DPP-IV resistant GIP hybrid polypeptides with selectable properties
|
|
UY30820A1
(es)
*
|
2006-12-21 |
2008-07-03 |
Centocor Inc |
Uso de agonistas del receptor de glp-1 de accion prolongada para mejorar la sensibilidad a la insulina y los perfiles lipidicos
|
|
JP2008169195A
(ja)
|
2007-01-05 |
2008-07-24 |
Hanmi Pharmaceutical Co Ltd |
キャリア物質を用いたインスリン分泌ペプチド薬物結合体
|
|
GB2448895A
(en)
*
|
2007-05-01 |
2008-11-05 |
Activotec Spp Ltd |
GLP-1 like compounds and uses thereof
|
|
CN101842386A
(zh)
|
2007-09-05 |
2010-09-22 |
诺沃-诺迪斯克有限公司 |
截短的glp-1衍生物和它们的治疗用途
|
|
WO2009030738A1
(en)
*
|
2007-09-05 |
2009-03-12 |
Novo Nordisk A/S |
Glucagon-like peptide-1 derivatives and their pharmaceutical use
|
|
AU2008316636B2
(en)
|
2007-10-24 |
2014-02-06 |
Mannkind Corporation |
Delivery of active agents
|
|
US8785396B2
(en)
|
2007-10-24 |
2014-07-22 |
Mannkind Corporation |
Method and composition for treating migraines
|
|
HUE025485T2
(en)
*
|
2007-10-24 |
2016-02-29 |
Mannkind Corp |
Respiratory dry powder formulation containing GLP-1 for use in the treatment of hyperglycemia and diabetes by pulmonary administration
|
|
CA2703113A1
(en)
*
|
2007-10-27 |
2009-04-30 |
F. Hoffmann-La Roche Ag |
Insulinotropic peptide synthesis using solid and solution phase combination techniques
|
|
US20090181037A1
(en)
*
|
2007-11-02 |
2009-07-16 |
George Heavner |
Semi-Synthetic GLP-1 Peptide-FC Fusion Constructs, Methods and Uses
|
|
JP2011506442A
(ja)
*
|
2007-12-11 |
2011-03-03 |
コンジュケム バイオテクノロジーズ インコーポレイテッド |
インスリン分泌性ペプチド結合体の製剤
|
|
US20100317057A1
(en)
|
2007-12-28 |
2010-12-16 |
Novo Nordisk A/S |
Semi-recombinant preparation of glp-1 analogues
|
|
US9358352B2
(en)
|
2008-06-13 |
2016-06-07 |
Mannkind Corporation |
Dry powder drug delivery system and methods
|
|
CN109568740B
(zh)
|
2008-06-13 |
2022-05-27 |
曼金德公司 |
干粉吸入器和用于药物输送的系统
|
|
US8485180B2
(en)
|
2008-06-13 |
2013-07-16 |
Mannkind Corporation |
Dry powder drug delivery system
|
|
BR122020002400B1
(pt)
|
2008-06-20 |
2021-12-07 |
Mannkind Corporation |
Sistema de detecção de inalação de pó seco e sistema de monitoramento acoplável para um inalador de pó seco
|
|
TWI614024B
(zh)
|
2008-08-11 |
2018-02-11 |
曼凱公司 |
超快起作用胰島素之用途
|
|
RS59913B1
(sr)
|
2008-10-17 |
2020-03-31 |
Sanofi Aventis Deutschland |
Kombinacija insulina i glp-1-agonista
|
|
US8759539B2
(en)
*
|
2008-11-17 |
2014-06-24 |
Merck Sharp & Dohme Corp. |
Substituted bicyclic amines for the treatment of diabetes
|
|
US8314106B2
(en)
|
2008-12-29 |
2012-11-20 |
Mannkind Corporation |
Substituted diketopiperazine analogs for use as drug delivery agents
|
|
PL2405963T3
(pl)
|
2009-03-11 |
2014-04-30 |
Mannkind Corp |
Urządzenie, układ i sposób pomiaru oporu inhalatora
|
|
BRPI1012852A2
(pt)
|
2009-05-15 |
2018-06-19 |
Novartis Ag |
derivados de benzoxazolona como inibidores da sintase de aldoesterona
|
|
CA2761859A1
(en)
|
2009-05-15 |
2010-11-18 |
Novartis Ag |
Aryl pyridine as aldosterone synthase inhibitors
|
|
ES2602826T3
(es)
|
2009-05-28 |
2017-02-22 |
Novartis Ag |
Derivados aminobutíricos sustituidos como inhibidores de neprilisina
|
|
CN102448928B
(zh)
|
2009-05-28 |
2014-10-01 |
诺华股份有限公司 |
作为中性溶酶(neprilysin)抑制剂的取代的氨基丁酸衍生物
|
|
CA2764505C
(en)
|
2009-06-12 |
2018-09-25 |
Mannkind Corporation |
Diketopiperazine microparticles with defined specific surface areas
|
|
MX366935B
(es)
*
|
2009-08-14 |
2019-07-31 |
Phasebio Pharmaceuticals Inc |
Peptidos intestinales vasoactivos modificados.
|
|
EP2496295A1
(en)
|
2009-11-03 |
2012-09-12 |
MannKind Corporation |
An apparatus and method for simulating inhalation efforts
|
|
ES2534191T3
(es)
|
2009-11-13 |
2015-04-20 |
Sanofi-Aventis Deutschland Gmbh |
Composición farmacéutica que comprende un agonista de GLP-1, una insulina y metionina
|
|
CA2780043C
(en)
|
2009-11-13 |
2019-01-29 |
Sanofi-Aventis Deutschland Gmbh |
Pharmaceutical composition comprising a glp-1 agonist and methionine
|
|
EP2501678B1
(en)
|
2009-11-17 |
2015-09-23 |
Novartis AG |
Aryl-pyridine derivatives as aldosterone synthase inhibitors
|
|
JO2967B1
(en)
|
2009-11-20 |
2016-03-15 |
نوفارتس ايه جي |
Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
|
|
ES2472446T3
(es)
|
2009-11-30 |
2014-07-01 |
Novartis Ag |
Derivados de imidazol como inhibidores de aldosterona sintasa
|
|
WO2011123943A1
(en)
|
2010-04-09 |
2011-10-13 |
Mount Sinai Hospital |
Methods for treating disorders of the gastrointestinal tract using a glp-1 agonist
|
|
NZ603169A
(en)
|
2010-04-27 |
2015-02-27 |
Zealand Pharma As |
Peptide conjugates of glp-1 receptor agonists and gastrin and their use
|
|
CN103124739B
(zh)
|
2010-05-17 |
2015-11-25 |
贝达药业股份有限公司 |
一种新胰高血糖素样肽类似物、组合物及其用途
|
|
SG187904A1
(en)
|
2010-08-30 |
2013-04-30 |
Sanofi Aventis Deutschland |
Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
|
|
US8673974B2
(en)
|
2010-11-16 |
2014-03-18 |
Novartis Ag |
Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
|
|
US8877815B2
(en)
|
2010-11-16 |
2014-11-04 |
Novartis Ag |
Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
|
|
PT2651398T
(pt)
|
2010-12-16 |
2018-03-09 |
Novo Nordisk As |
Composições sólidas compreendendo um agonista de glp-1 e um sal de ácido n-(8-(2-hidroxibenzoil)amino) caprílico
|
|
JP2014502985A
(ja)
*
|
2011-01-19 |
2014-02-06 |
ノヴォ ノルディスク アー/エス |
Glp−1粒子および組成物
|
|
JP6133270B2
(ja)
|
2011-04-01 |
2017-05-24 |
マンカインド コーポレイション |
薬剤カートリッジのためのブリスター包装
|
|
MY161450A
(en)
|
2011-04-12 |
2017-04-14 |
Novo Nordisk As |
Double-acylated glp-1 derivatives
|
|
US9821032B2
(en)
|
2011-05-13 |
2017-11-21 |
Sanofi-Aventis Deutschland Gmbh |
Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
|
|
EP2717902B1
(en)
|
2011-06-06 |
2018-01-24 |
Phasebio Pharmaceuticals, Inc. |
Use of modified vasoactive intestinal peptides in the treatment of hypertension
|
|
WO2012174472A1
(en)
|
2011-06-17 |
2012-12-20 |
Mannkind Corporation |
High capacity diketopiperazine microparticles
|
|
RU2650616C2
(ru)
|
2011-08-29 |
2018-04-16 |
Санофи-Авентис Дойчланд Гмбх |
Фармацевтическая комбинация для применения при гликемическом контроле у пациентов с сахарным диабетом 2 типа
|
|
AR087744A1
(es)
|
2011-09-01 |
2014-04-16 |
Sanofi Aventis Deutschland |
Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
|
|
HK1201475A1
(en)
|
2011-10-24 |
2015-09-04 |
Mannkind Corporation |
Methods and compositions for treating pain
|
|
CA2853884A1
(en)
|
2011-11-03 |
2013-05-10 |
Zealand Pharma A/S |
Glp-1 receptor agonist peptide gastrin conjugates
|
|
RU2643515C2
(ru)
|
2011-12-29 |
2018-02-02 |
Ново Нордиск А/С |
Дипептид, содержащий непротеиногенную аминокислоту
|
|
DK2827845T3
(en)
|
2012-03-22 |
2019-04-01 |
Novo Nordisk As |
COMPOSITIONS INCLUDING A PROCEDURE AND PREPARING THEREOF
|
|
EP4324475A1
(en)
|
2012-03-22 |
2024-02-21 |
Novo Nordisk A/S |
Compositions of glp-1 peptides and preparation thereof
|
|
CN104487056A
(zh)
|
2012-06-20 |
2015-04-01 |
诺和诺德A/S(股份有限公司) |
包含肽和递送剂的片剂制剂
|
|
US20150157619A1
(en)
|
2012-07-10 |
2015-06-11 |
Takeda Pharmaceutical Company Limited |
Pharmaceutical preparation for injection
|
|
CA2878457C
(en)
|
2012-07-12 |
2021-01-19 |
Mannkind Corporation |
Dry powder drug delivery systems and methods
|
|
ES2620111T3
(es)
|
2012-07-23 |
2017-06-27 |
Zealand Pharma A/S |
Análogos de glucagón
|
|
TWI608013B
(zh)
|
2012-09-17 |
2017-12-11 |
西蘭製藥公司 |
升糖素類似物
|
|
EP2911690A1
(en)
|
2012-10-26 |
2015-09-02 |
MannKind Corporation |
Inhalable influenza vaccine compositions and methods
|
|
UY35144A
(es)
|
2012-11-20 |
2014-06-30 |
Novartis Ag |
Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
|
|
TWI780236B
(zh)
|
2013-02-04 |
2022-10-11 |
法商賽諾菲公司 |
胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物
|
|
SG11201506018PA
(en)
|
2013-02-14 |
2015-08-28 |
Novartis Ag |
Substituted bisphenyl butanoic phosphonic acid derivatives as nep (neutral endopeptidase) inhibitors
|
|
MX392016B
(es)
|
2013-03-15 |
2025-03-21 |
Mannkind Corp |
Composiciones de dicetopiperazina microcristalina y métodos.
|
|
PL2991671T3
(pl)
|
2013-05-02 |
2019-01-31 |
Novo Nordisk As |
Doustne dawkowanie związków glp-1
|
|
EP3021834A1
(en)
|
2013-07-18 |
2016-05-25 |
MannKind Corporation |
Heat-stable dry powder pharmaceutical compositions and methods
|
|
TW201536814A
(zh)
|
2013-07-25 |
2015-10-01 |
Novartis Ag |
用於治療心臟衰竭之合成環狀多肽
|
|
TW201518323A
(zh)
|
2013-07-25 |
2015-05-16 |
Novartis Ag |
合成apelin多肽之生物結合物
|
|
JP2016530930A
(ja)
|
2013-08-05 |
2016-10-06 |
マンカインド コーポレイション |
通気装置及び方法
|
|
US9988429B2
(en)
|
2013-10-17 |
2018-06-05 |
Zealand Pharma A/S |
Glucagon analogues
|
|
US9896495B2
(en)
|
2013-10-17 |
2018-02-20 |
Zealand Pharma A/S |
Acylated glucagon analogues
|
|
AU2014345569B2
(en)
|
2013-11-06 |
2020-08-13 |
Zealand Pharma A/S |
GIP-GLP-1 dual agonist compounds and methods
|
|
CA2929107C
(en)
|
2013-11-06 |
2023-09-26 |
Zealand Pharma A/S |
Glucagon-glp-1-gip triple agonist compounds
|
|
KR20160104724A
(ko)
|
2014-01-09 |
2016-09-05 |
사노피 |
인슐린 유사체 및/또는 인슐린 유도체의 안정화된 약제학적 제형
|
|
CN105899190B
(zh)
|
2014-01-09 |
2022-06-14 |
赛诺菲 |
门冬胰岛素的稳定化药物制剂
|
|
CN105899191B
(zh)
|
2014-01-09 |
2020-06-16 |
赛诺菲 |
胰岛素类似物和/或胰岛素衍生物的稳定化不含甘油的药物制剂
|
|
US10307464B2
(en)
|
2014-03-28 |
2019-06-04 |
Mannkind Corporation |
Use of ultrarapid acting insulin
|
|
WO2015172046A1
(en)
|
2014-05-08 |
2015-11-12 |
Phasebio Pharmaceuticals, Inc. |
Methods and compositions for treating cystic fibrosis
|
|
US10561806B2
(en)
|
2014-10-02 |
2020-02-18 |
Mannkind Corporation |
Mouthpiece cover for an inhaler
|
|
MX381640B
(es)
|
2014-10-29 |
2025-03-04 |
Zealand Pharma As |
Metodos y compuestos agonistas de gip.
|
|
SI3229828T1
(sl)
|
2014-12-12 |
2023-06-30 |
Sanofi-Aventis Deutschland Gmbh |
Formulacija s fiksnim razmerjem inzulin glargin/liksisenatid
|
|
CN105820233B
(zh)
*
|
2015-01-04 |
2021-06-15 |
甘李药业股份有限公司 |
一种胰岛素衍生物的制备方法
|
|
CA2972871A1
(en)
|
2015-01-23 |
2016-07-28 |
Novartis Ag |
Synthetic apelin fatty acid conjugates with improved half-life
|
|
CN107427556B
(zh)
|
2015-02-09 |
2022-02-25 |
费斯生物制药公司 |
用于治疗肌肉疾病和病症的方法和组合物
|
|
TWI748945B
(zh)
|
2015-03-13 |
2021-12-11 |
德商賽諾菲阿凡提斯德意志有限公司 |
第2型糖尿病病患治療
|
|
TW201705975A
(zh)
|
2015-03-18 |
2017-02-16 |
賽諾菲阿凡提斯德意志有限公司 |
第2型糖尿病病患之治療
|
|
ES2763329T3
(es)
|
2015-04-16 |
2020-05-28 |
Zealand Pharma As |
Análogo de glucagón acilado
|
|
JOP20190086A1
(ar)
|
2016-10-21 |
2019-04-18 |
Novartis Ag |
مشتقات نافثيريدينون جديدة واستخدامها في معالجة عدم انتظام ضربات القلب
|
|
DK3551651T3
(da)
|
2016-12-09 |
2024-05-13 |
Zealand Pharma As |
Acylerede glp-1/glp-2-dobbeltagonister
|
|
TWI847306B
(zh)
|
2017-08-24 |
2024-07-01 |
丹麥商諾佛 儂迪克股份有限公司 |
Glp-1組成物及其用途
|
|
JP6898518B2
(ja)
|
2018-02-02 |
2021-07-07 |
ノヴォ ノルディスク アー/エス |
Glp−1アゴニスト、n−(8−(2−ヒドロキシベンゾイル)アミノ)カプリル酸の塩及び滑沢剤を含む固形組成物
|
|
UY38072A
(es)
|
2018-02-07 |
2019-10-01 |
Novartis Ag |
Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos
|
|
JP7657151B2
(ja)
|
2018-11-27 |
2025-04-04 |
ノバルティス アーゲー |
代謝性障害の処置のためのプロタンパク質コンバターゼスブチリシン/ケキシン9型(pcsk9)阻害剤としての環状ペプチド
|
|
UY38485A
(es)
|
2018-11-27 |
2020-06-30 |
Novartis Ag |
Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9), método de tratamiento, uso y su preparación
|
|
WO2020110008A1
(en)
|
2018-11-27 |
2020-06-04 |
Novartis Ag |
Cyclic pentamer compounds as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorder
|
|
GB201917723D0
(en)
*
|
2019-12-04 |
2020-01-15 |
Nv Rose Llc |
Stable liquid formulations of glucagon-like peptide 1 or analogues thereof
|
|
PE20230819A1
(es)
|
2020-02-18 |
2023-05-19 |
Novo Nordisk As |
Composiciones y usos de glp-1
|
|
WO2023084449A1
(en)
|
2021-11-12 |
2023-05-19 |
Novartis Ag |
Diaminocyclopentylpyridine derivatives for the treatment of a disease or disorder
|
|
AR127698A1
(es)
|
2021-11-23 |
2024-02-21 |
Novartis Ag |
Derivados de naftiridinona para el tratamiento de una enfermedad o un trastorno
|
|
WO2024123812A1
(en)
|
2022-12-05 |
2024-06-13 |
Shattuck Labs, Inc. |
Fusion proteins for the treatment of cardiometabolic diseases
|
|
WO2024241229A1
(en)
|
2023-05-24 |
2024-11-28 |
Novartis Ag |
Naphthyridinone derivatives for the treatment of a disease or disorder
|