DK1015445T3 - Antimikrobielle quinoloner, deres sammensætninger og anvendelser - Google Patents

Antimikrobielle quinoloner, deres sammensætninger og anvendelser

Info

Publication number
DK1015445T3
DK1015445T3 DK98948208T DK98948208T DK1015445T3 DK 1015445 T3 DK1015445 T3 DK 1015445T3 DK 98948208 T DK98948208 T DK 98948208T DK 98948208 T DK98948208 T DK 98948208T DK 1015445 T3 DK1015445 T3 DK 1015445T3
Authority
DK
Denmark
Prior art keywords
compositions
antimicrobial quinolones
quinolones
antimicrobial
Prior art date
Application number
DK98948208T
Other languages
Danish (da)
English (en)
Inventor
Benoit Ledoussal
Ji-In Kim Almstead
Jeffrey Lyle Gray
Xiufeng Eric Hu
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Application granted granted Critical
Publication of DK1015445T3 publication Critical patent/DK1015445T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
DK98948208T 1997-09-15 1998-09-15 Antimikrobielle quinoloner, deres sammensætninger og anvendelser DK1015445T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5889197P 1997-09-15 1997-09-15
US13985998A 1998-08-25 1998-08-25
PCT/US1998/019138 WO1999014214A1 (en) 1997-09-15 1998-09-15 Antimicrobial quinolones, their compositions and uses

Publications (1)

Publication Number Publication Date
DK1015445T3 true DK1015445T3 (da) 2009-05-11

Family

ID=26738133

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98948208T DK1015445T3 (da) 1997-09-15 1998-09-15 Antimikrobielle quinoloner, deres sammensætninger og anvendelser

Country Status (30)

Country Link
US (3) US6329391B1 (cs)
EP (1) EP1015445B1 (cs)
JP (1) JP4669607B2 (cs)
KR (1) KR100423778B1 (cs)
CN (1) CN1264837C (cs)
AR (1) AR013493A1 (cs)
AT (1) ATE423776T1 (cs)
AU (1) AU735186B2 (cs)
BR (1) BR9812644B1 (cs)
CA (1) CA2303389C (cs)
CO (1) CO4970702A1 (cs)
CY (1) CY1110255T1 (cs)
CZ (1) CZ299554B6 (cs)
DE (1) DE69840599D1 (cs)
DK (1) DK1015445T3 (cs)
ES (1) ES2321042T3 (cs)
HU (1) HUP0100051A3 (cs)
ID (1) ID24703A (cs)
IL (2) IL135036A0 (cs)
MY (1) MY138335A (cs)
NO (1) NO323563B1 (cs)
NZ (1) NZ503740A (cs)
PE (1) PE128799A1 (cs)
PL (1) PL339408A1 (cs)
PT (1) PT1015445E (cs)
RU (1) RU2193558C2 (cs)
SA (1) SA99191136B1 (cs)
SK (1) SK286420B6 (cs)
TR (2) TR200001435T2 (cs)
WO (1) WO1999014214A1 (cs)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6387928B1 (en) 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
DK1015445T3 (da) * 1997-09-15 2009-05-11 Procter & Gamble Antimikrobielle quinoloner, deres sammensætninger og anvendelser
EP1134219B1 (en) * 1998-11-24 2005-06-15 Daiichi Pharmaceutical Co., Ltd. Cycloalkyl-substituted aminomethylpyrrolidine derivatives
US6750224B1 (en) 1999-05-07 2004-06-15 Wockhardt Limited Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment
DE60040979D1 (de) * 1999-05-07 2009-01-15 Wockhardt Ltd (s)-benzochinolizincarbonsäuren und ihre verwendung als antibakterielle mittel
US6514986B2 (en) 2000-11-22 2003-02-04 Wockhardt Limited Chiral fluoroquinolone arginine salt forms
US6608078B2 (en) 2000-05-08 2003-08-19 Wockhardt Limited Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment
US7098219B2 (en) 2000-08-01 2006-08-29 Wockhart Limited Inhibitors of cellular efflux pumps of microbes
RU2298006C2 (ru) * 2000-11-20 2007-04-27 Дайити Фармасьютикал Ко., Лтд. Дегалогенированные соединения, антибактериальное средство и терапевтическое средство на их основе, способ получения антибактериального или лекарственного средства, применение дегалогенированных соединений для получения антибактериального или лекарственного средства
EP1336611B1 (en) * 2000-11-20 2007-09-05 Daiichi Pharmaceutical Co., Ltd. Dehalogeno compounds
CA2429951A1 (en) * 2000-12-14 2002-06-20 The Procter & Gamble Company Antimicrobial quinolones
DE10114364A1 (de) * 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Verfahren zur Herstellung von antibiotischen Kompositen
US6964966B2 (en) 2001-04-25 2005-11-15 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6878713B2 (en) 2001-04-25 2005-04-12 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6664267B1 (en) 2002-05-28 2003-12-16 Wockhardt Limited Crystalline fluoroquinolone arginine salt form
US6900224B2 (en) * 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
CN101353321A (zh) 2002-11-21 2009-01-28 辉瑞产品公司 3-氨基-哌啶衍生物及其制备方法
WO2004047778A1 (en) 2002-11-26 2004-06-10 Uc Tech Materials and methods for preventing and treating microbe-mediated epithelial disorders
RU2260002C2 (ru) * 2003-08-08 2005-09-10 ООО "Исследовательский институт химического разнообразия" Замещенные 6-сульфо-2-оксо-1,2-дигидрохинолин 4-карбоновые кислоты и их производные (варианты) и фокусированная библиотека
JP4675234B2 (ja) * 2003-06-06 2011-04-20 第一三共株式会社 光学活性なキノロンカルボン酸誘導体の製造中間体およびその製造法
DK1660495T3 (da) 2003-09-04 2007-11-05 Wockhardt Ltd Benzoquinolizin-2-carboxylsyreargininsalt,tetrahydrat
DE10341534A1 (de) * 2003-09-09 2005-03-31 Bayer Chemicals Ag Difluoralkylaromaten
BRPI0413964B8 (pt) 2003-09-10 2021-05-25 Kyorin Seiyaku Kk ácido derivado do ácido carboxílico quinolona, sua composição e agente antibacterial
ES2321722T3 (es) * 2003-09-22 2009-06-10 Janssen Pharmaceutica Nv Naftiridonas y quinolonas 7-amino alquilidenil-heterociclicas.
SE0400235D0 (sv) * 2004-02-06 2004-02-06 Active Biotech Ab New composition containing quinoline compounds
CN1980670A (zh) * 2004-07-02 2007-06-13 第一制药株式会社 含有喹诺酮的医药组合物
US20090156577A1 (en) * 2004-09-09 2009-06-18 Benjamin Davis 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
US7732612B2 (en) * 2004-09-09 2010-06-08 Janssen Pharmaceutica, N.V. 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
DE102006005861A1 (de) * 2006-02-09 2007-08-23 Aicuris Gmbh & Co. Kg Substituierte Chinolone III
DE102006010643A1 (de) * 2006-03-08 2007-09-13 Bayer Healthcare Aktiengesellschaft Arzneimittel enthaltend Fluorchinolone
TWI391378B (zh) * 2006-03-16 2013-04-01 Astellas Pharma Inc 喹啉酮衍生物或其製藥學上可被容許之鹽
BRPI0709220A2 (pt) 2006-03-28 2011-07-12 Procter & Gamble processo de acoplamento para preparo de intermediários de quinolona
JP5097967B2 (ja) * 2006-03-28 2012-12-12 タイゲン バイオテクノロジー カンパニー，リミテッド リンゴ酸塩類、及び（３ｓ，５ｓ）−７−［３−アミノ−５−メチルーピペリジニル］−１−シクロプロピル−１，４−ジヒドロ−８−メトキシ−４−オキソ−３−キノリンカルボン酸の多形体類
WO2007110836A1 (en) 2006-03-28 2007-10-04 The Procter & Gamble Company A hydride reduction process for preparing quinolone intermediates
CN101045725B (zh) * 2006-03-28 2012-12-05 太景生物科技股份有限公司 某些喹诺酮化合物的苹果酸盐和多晶型物
TW200811153A (en) 2006-06-23 2008-03-01 Japan Tobacco Inc 6-(heterocyclyl-substituted benzyl)-4-oxoquinoline compound and use thereof as HIV integrase inhibitor
EP2149571A4 (en) * 2007-05-24 2010-09-01 Kyorin Seiyaku Kk MUTILINE DERIVATIVE WITH A RINGED, HETEROCYCLIC AND AROMATIC CARBOXYLIC ACID STRUCTURE IN A SUBSTITUTE AT POSITION 14
US7902227B2 (en) 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
CN101361739B (zh) * 2007-08-09 2012-03-14 太景生物科技股份有限公司 抗菌剂的肠胃外制剂
US8658183B2 (en) * 2007-08-09 2014-02-25 Taigen Biotechnology Company, Ltd. Antimicrobial parenteral formulation
US8211909B2 (en) * 2008-07-01 2012-07-03 Taigen Biotechnology Co., Ltd. Treatment of antibiotic-resistant bacteria infection
CN101618039B (zh) * 2008-07-02 2012-04-11 太景生物科技股份有限公司 肺炎的治疗药物
WO2010009014A2 (en) * 2008-07-15 2010-01-21 Taigen Biotechnology Co., Ltd. Antibiotic drug
FR2936798B1 (fr) * 2008-10-03 2012-09-28 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.
FR2936951B1 (fr) * 2008-10-10 2010-12-03 Novexel Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments
FR2937034B1 (fr) * 2008-10-10 2012-11-23 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens
CA2743700C (en) * 2008-12-15 2016-07-12 Taigen Biotechnology Co., Ltd. Stereoselective synthesis of piperidine derivatives
AU2010310612A1 (en) * 2009-10-23 2012-06-14 Vertex Pharmaceuticals Incorporated Process for preparing modulators of cystic fibrosis transmembrane conductance regulator
WO2011143145A1 (en) * 2010-05-11 2011-11-17 Sanofi Substituted n-alkyl and n-acyl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof
CN102746223B (zh) * 2012-07-30 2013-10-23 浙江新东港药业股份有限公司 一种氟哌酸与氯哌酸的分离方法
CN103819401B (zh) * 2012-11-19 2016-04-13 浙江中欣氟材股份有限公司 1-环丙基-4-氧代-7-氟-8-甲氧基-1,4-二氢喹啉-3-羧酸的合成方法
EP3088399A4 (en) 2013-12-26 2017-10-25 Kinki University Alkoxycarbonyl hemiacetal-type ester prodrug of pyridone carboxylic acid antibacterial drug
RU2636751C1 (ru) 2016-11-02 2017-12-01 федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) Антибактериальные средства на основе производных ципрофлоксацина
PH12022550774A1 (en) * 2019-10-23 2023-05-03 Taigen Biotechnology Co Ltd Quinolone carboxylic acid derivatives
AU2021231765A1 (en) * 2020-03-03 2022-10-06 Redona Therapeutics, Inc. Compounds targeting RNA-binding proteins or RNA-modifying proteins

Family Cites Families (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4017622A (en) 1972-12-18 1977-04-12 Dainippon Pharmaceutical Co., Ltd. Piperazine derivatives
JPS5186476A (en) 1975-01-17 1976-07-29 Yoshitomi Pharmaceutical Shinkina kinoronkarubonsanjudotaino seiho
JPS5845426B2 (ja) 1978-09-29 1983-10-08 杏林製薬株式会社 置換キノリンカルボン酸誘導体
JPS604820B2 (ja) 1979-02-26 1985-02-06 大塚製薬株式会社 キノリンカルボン酸誘導体
JPS5649382A (en) 1979-09-28 1981-05-02 Dainippon Pharmaceut Co Ltd 6-fluoro-7-cyclic amino-1,8-naphthylidine derivative and its salt
US4665079A (en) 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
IE55898B1 (en) 1982-09-09 1991-02-14 Warner Lambert Co Antibacterial agents
US5281612A (en) 1982-09-09 1994-01-25 Warner-Lambert Company Naphthyridine antibacterial agents
DE3248506A1 (de) 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
FR2548664B1 (fr) * 1983-07-06 1986-03-21 Provesan Sa Derives 7-(pyrrol-l-yl) des acides l-ethyl-1,4-dihydro-4-oxoquinoleine-3-carboxyliques et l-ethyl-1,4-dihydro-4-oxo-(1,8-naphtyridine)-3-carboxyliques substitues, leur preparation et leur application en tant que medicaments
NZ208470A (en) * 1983-07-18 1988-06-30 Abbott Lab 6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives and antibacterial compositions containing such
US4994599A (en) 1987-11-20 1991-02-19 Abbott Laboratories Intermediates for producing quinolone-3-carboxylic acids
JPS60221484A (ja) * 1984-04-17 1985-11-06 Fuji Photo Film Co Ltd 放射線像変換方法およびその方法に用いられる放射線像変換パネル
US4822801A (en) 1984-07-20 1989-04-18 Warner-Lambert Company 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents
US4771054A (en) 1985-01-23 1988-09-13 Warner-Lambert Company Antibacterial agents
JPS61225181A (ja) * 1986-02-04 1986-10-06 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体及びその製造方法
JPS61205258A (ja) * 1985-03-08 1986-09-11 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体及びその製造方法
AU5427286A (en) 1985-03-08 1986-09-11 Kyorin Pharmaceutical Co. Ltd. 7-(1-pyrrolidinyl)-3-quinolinecarboxylic acid derivatives
EP0207420B1 (en) 1985-06-26 1992-05-06 Daiichi Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivatives
JPS6236377A (ja) * 1985-07-03 1987-02-17 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
DE3524411A1 (de) * 1985-07-09 1987-01-15 Kernforschungsz Karlsruhe Verfahren zum herstellen von spinnduesenplatten
JPS6256673A (ja) 1985-09-03 1987-03-12 Kayaba Ind Co Ltd カウンタ−バランス弁の制御装置
JPH089597B2 (ja) * 1986-01-21 1996-01-31 杏林製薬株式会社 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法
DE3705621C2 (de) 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
JPS62205060A (ja) * 1986-03-04 1987-09-09 Kyorin Pharmaceut Co Ltd ８位置換キノロンカルボン酸誘導体
JPS62215572A (ja) * 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
JPS63198664A (ja) 1986-03-31 1988-08-17 Sankyo Co Ltd キノロンカルボン酸誘導体
EP0242789A3 (en) * 1986-04-25 1990-09-05 Dainippon Pharmaceutical Co., Ltd. Novel quinoline derivates and processes for preparation thereof
JPH0717608B2 (ja) 1986-04-25 1995-03-01 杏林製薬株式会社 ６−アルコキシキノロンカルボン酸誘導体
DE3704907A1 (de) 1987-02-17 1988-08-25 Bayer Ag Topisch anwendbare zubereitungen von gyrase-inhibitoren in kombination mit kortikosteroiden
JPS6416767A (en) 1987-07-09 1989-01-20 Dainippon Pharmaceutical Co 8-halogenoquinoline derivative, its ester and salt
JPS6416767U (cs) 1987-07-20 1989-01-27
JP2608413B2 (ja) 1987-07-26 1997-05-07 本多電子株式会社 超音波駆動装置
US4780468A (en) 1987-08-07 1988-10-25 Warner-Lambert Company 8-trifluoromethyl quinolones as antibacterial agents
US4921857A (en) 1987-09-18 1990-05-01 Merck & Co., Inc. 4-Oxo-4h-quinolizine-3-carboxylic acids and derivatives thereof
FR2625200A1 (en) * 1987-12-29 1989-06-30 Esteve Labor Dr 7-(1-Azetidinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their application as medicaments
US4920120A (en) 1988-01-25 1990-04-24 Warner-Lambert Company Antibacterial agents
DE3816119A1 (de) * 1988-05-11 1989-11-23 Bayer Ag 7-substituierte chinolon- und naphthyridoncarbonsaeure-derivate
JPH0395177A (ja) * 1988-05-19 1991-04-19 Chugai Pharmaceut Co Ltd 新規キノロンカルボン酸誘導体
JP2844079B2 (ja) 1988-05-23 1999-01-06 塩野義製薬株式会社 ピリドンカルボン酸系抗菌剤
DE3906365A1 (de) 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
AU618823B2 (en) 1988-07-20 1992-01-09 Sankyo Company Limited 4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their use
US5286723A (en) 1988-08-31 1994-02-15 Daiichi Seiyaku Co., Ltd. Spiro compound
CA2001203C (en) 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Novel antimicrobial dithiocarbamoyl quinolones
US5328908A (en) 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
EP0997466A1 (en) 1988-10-24 2000-05-03 PROCTER & GAMBLE PHARMACEUTICALS, INC. Novel antimicrobial lactam-quinolones
US5164402A (en) 1989-08-16 1992-11-17 Pfizer Inc Azabicyclo quinolone and naphthyridinone carboxylic acids
IE66202B1 (en) 1989-08-16 1995-12-13 Pfizer Azabicyclo quinolone carboxylic acids
JPH03115277A (ja) 1989-09-28 1991-05-16 Banyu Pharmaceut Co Ltd ピリドンカルボン酸誘導体
EP0443498A1 (en) * 1990-02-19 1991-08-28 Kyorin Pharmaceutical Co., Ltd. Isoindoline derivatives
JPH03244733A (ja) 1990-02-21 1991-10-31 Shimizu Corp 外壁の接続構造
US5116834A (en) 1990-04-12 1992-05-26 Warner-Lambert Company Quinolinecarboxylic acid antibacterial agents
CA2081891C (en) 1990-05-02 1999-03-16 Daniel T. Chu Quinolizinone type compounds
US5580872A (en) 1990-05-02 1996-12-03 Abbott Laboratories Quinolizinone type compounds
US5726182A (en) 1990-05-02 1998-03-10 Abbott Laboratories Quinolizinone type compounds
CS567590A3 (en) * 1990-11-16 1992-06-17 Vyzk Ustav Farm Biochem Sp Fluoroquinolone derivatives having in the position 7 4-piperidone radical or modifications thereof
US5072001A (en) 1990-11-30 1991-12-10 Warner-Lambert Company Certain optically active substituted 3-pyrraidine acetic acid derivatives useful as intermediates
US5258528A (en) 1990-11-30 1993-11-02 Warner-Lambert Company Individual stereoisomers of pyrrolidine methanamines substituted on the ring nitrogen by a 1-phenylethyl group
US5364861A (en) 1990-11-30 1994-11-15 Warner-Lambert Company Optical isomers of 7-[3-(1,1-dialkylmethyl-1-amino-1-pyrrolidinyl]-quinolones and naphthyridones as antibacterial agents
JPH04265511A (ja) 1991-02-19 1992-09-21 Sony Corp 磁気記録媒体
DE4120646A1 (de) 1991-06-22 1992-12-24 Bayer Ag 7-isoindolinyl-chinolon- und naphthyridoncarbonsaeure-derivate
DE4123918A1 (de) 1991-07-19 1993-01-21 Bayer Ag 8-vinyl- und 8-ethinyl-chinoloncarbonsaeuren
WO1993013091A1 (fr) 1991-12-27 1993-07-08 Wakunaga Seiyaku Kabushiki Kaisha Nouveau derive de quinolone ou sel de ce derive et agent antibacterien contenant ce derive
EP0550016A1 (en) * 1991-12-31 1993-07-07 Korea Research Institute Of Chemical Technology Novel quinolone carboxylic acid derivatives and processes for preparing same
JPH05112554A (ja) 1992-02-19 1993-05-07 Chugai Pharmaceut Co Ltd 新規なキノロンカルボン酸誘導体
JPH05345777A (ja) 1992-04-16 1993-12-27 Hokuriku Seiyaku Co Ltd ７−（４，４−ジアルキル−３−アミノ置換ピロリジニル）キノロン−３−カルボン酸誘導体
NO304832B1 (no) 1992-05-27 1999-02-22 Ube Industries Aminokinolonderivater samt middel mot HIV
DE4230804A1 (de) 1992-09-15 1994-03-17 Bayer Ag 7-Isoindolinyl-chinolon- und -naphthyridon-Derivate
DE4234078A1 (de) 1992-10-09 1994-04-14 Bayer Ag Chinoloncarbonsäuren
KR0148277B1 (ko) 1993-01-18 1998-11-02 채영복 신규한 플루오르퀴놀론계 유도체 및 그의 제조방법
DE4301246A1 (de) * 1993-01-19 1994-07-21 Bayer Ag Chinolon- und Naphthyridoncarbonsäurederivate
DE4301245A1 (de) 1993-01-19 1994-07-21 Bayer Ag Fluor-trifluormethylbenzoesäure-Derivate
CA2152828A1 (en) 1993-03-16 1994-07-07 Shin-Ichi Uesato 8-methoxy-quinolonecarboxylic acid derivatives
TW252107B (cs) * 1993-08-27 1995-07-21 Hokuriku Pharmacetical Co Ltd
AU689809B2 (en) 1993-10-14 1998-04-09 Abbott Laboratories Quinolizinone type compounds
JPH0780847B2 (ja) 1994-03-24 1995-08-30 大日本製薬株式会社 ビシクロアミン誘導体
EP0775702B1 (en) 1994-08-12 2003-07-23 Toyama Chemical Co., Ltd. Novel quinolone- or naphthyridonecarboxylic acid derivative or salt thereof
DE69627985T2 (de) 1995-02-02 2004-02-19 Daiichi Pharmaceutical Co., Ltd. Heterozyklische verbindungen
CA2212226A1 (en) 1995-02-02 1995-08-10 Katsumi Chiba Bicyclic amino group-substituted pyridonecarboxylic acid derivatives, esters thereof and salts thereof, and bicyclic amines useful as intermediates thereof
JP3745433B2 (ja) 1995-02-02 2006-02-15 第一製薬株式会社 複素環式化合物
DE19512484A1 (de) 1995-04-04 1996-10-17 Bayer Ag Kohlenhydratmodifizierte Cytostatika
IL122296A0 (en) 1995-06-06 1998-04-05 Abbott Lab Quinolizinone type compounds
JPH092953A (ja) 1995-06-16 1997-01-07 Chugai Pharmaceut Co Ltd バルフロキサシン製剤
IT1279532B1 (it) 1995-07-24 1997-12-16 Mediolanum Farmaceutici Spa Derivati chinolonici non fluorurati e loro impiego come agenti antibatterici
JPH0952893A (ja) 1995-08-10 1997-02-25 Yoshitomi Pharmaceut Ind Ltd キノロンカルボン酸誘導体の工業的な製造法およびその合成中間体
JP3833738B2 (ja) 1995-11-15 2006-10-18 第一製薬株式会社 置換アミノメチルピロリジン誘導体
ES2258780T3 (es) 1995-11-22 2006-09-01 Daiichi Pharmaceutical Co., Ltd. Derivados de aminocicloalquilpirrolidina sustituidos.
JP2697720B2 (ja) 1995-12-27 1998-01-14 日本電気株式会社 ポラリメトリ合成開口レーダ装置
CN100395244C (zh) 1996-02-09 2008-06-18 富山化学工业株式会社 喹诺酮羧酸衍生物或它们的盐类
JPH09240318A (ja) 1996-03-07 1997-09-16 Mitsubishi Motors Corp インストルメントパネル取付け構造
JPH09287669A (ja) 1996-04-23 1997-11-04 Toshiba Corp 弁装置
CN1103769C (zh) 1996-10-25 2003-03-26 第一制药株式会社 三环胺衍生物
US6274592B1 (en) 1997-02-04 2001-08-14 Senju Pharmaceutical Co., Ltd. Method for stabilizing arylcarboxylic acid, stabilizer thereof and aqueous solution containing stabilized arylcarboxylic acid
CA2289605A1 (en) 1997-05-21 1998-11-26 Daiichi Pharmaceutical Co., Ltd. Cis-substituted substituted aminocycloalkylpyrrolidine derivatives
MY119816A (en) 1997-05-30 2005-07-29 Daiichi Seiyaku Co Substituted cyclobutylamine derivatives
KR100241673B1 (ko) 1997-08-09 2000-03-02 김충섭 퀴놀리진 카르복실산 유도체
DK1015445T3 (da) 1997-09-15 2009-05-11 Procter & Gamble Antimikrobielle quinoloner, deres sammensætninger og anvendelser
US6387928B1 (en) * 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
GB9822440D0 (en) 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
GB9914486D0 (en) 1999-06-21 1999-08-18 Smithkline Beecham Plc Medicaments
SK10572002A3 (sk) 2000-01-24 2003-10-07 Warner-Lambert Company 3-Aminochinazolín-2,4-diónové antibakteriálne činidlá
CA2429951A1 (en) * 2000-12-14 2002-06-20 The Procter & Gamble Company Antimicrobial quinolones
US6900224B2 (en) * 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses

Also Published As

Publication number Publication date
RU2193558C2 (ru) 2002-11-27
PE128799A1 (es) 2000-02-17
BR9812644A (pt) 2001-12-18
US6329391B1 (en) 2001-12-11
JP2001516756A (ja) 2001-10-02
DE69840599D1 (de) 2009-04-09
IL135036A0 (en) 2001-05-20
EP1015445B1 (en) 2009-02-25
NO323563B1 (no) 2007-06-11
US20060100436A1 (en) 2006-05-11
ES2321042T3 (es) 2009-06-01
HK1030415A1 (en) 2001-05-04
AR013493A1 (es) 2000-12-27
KR20010024007A (ko) 2001-03-26
ATE423776T1 (de) 2009-03-15
US20090111851A1 (en) 2009-04-30
TR200505120T2 (tr) 2006-08-21
CO4970702A1 (es) 2000-11-07
IL135036A (en) 2007-12-03
CA2303389C (en) 2007-07-17
US7482454B2 (en) 2009-01-27
CZ2000931A3 (cs) 2000-08-16
PL339408A1 (en) 2000-12-18
SK3812000A3 (en) 2000-09-12
SK286420B6 (sk) 2008-09-05
BR9812644B1 (pt) 2010-07-13
NO20001340D0 (no) 2000-03-15
AU9482998A (en) 1999-04-05
US7868021B2 (en) 2011-01-11
CZ299554B6 (cs) 2008-09-03
TR200001435T2 (tr) 2000-08-21
HUP0100051A2 (hu) 2001-10-28
KR100423778B1 (ko) 2004-03-24
CN1264837C (zh) 2006-07-19
CY1110255T1 (el) 2015-01-14
EP1015445A1 (en) 2000-07-05
SA99191136B1 (ar) 2006-07-30
NZ503740A (en) 2002-09-27
AU735186B2 (en) 2001-07-05
JP4669607B2 (ja) 2011-04-13
WO1999014214A1 (en) 1999-03-25
NO20001340L (no) 2000-05-15
CA2303389A1 (en) 1999-03-25
MY138335A (en) 2009-05-29
ID24703A (id) 2000-08-03
CN1278813A (zh) 2001-01-03
PT1015445E (pt) 2009-05-14
HUP0100051A3 (en) 2002-08-28

Similar Documents

Publication Publication Date Title
DK1015445T3 (da) Antimikrobielle quinoloner, deres sammensætninger og anvendelser
NO20021449L (no) Substituerte 2-tio-3,5-dicyano-4-aryl-6-aminopyridiner og deres anvendelse
FR12C0010I2 (fr) Composition herbicide
DK1128729T3 (da) Herbicid sammensætning
DE60020342D1 (de) Tiefeindringende antimikrobielle zusammensetzungen
NO20011956L (no) Substituerte fenylderivater, deres fremstilling og anvendelse
NO20015156L (no) 5-pyridyl-1,3-azolforbindelser, deres fremstilling og anvendelse
DE60014105D1 (de) Verbesserte herbizidzusammensetzunen
IT1292088B1 (it) Composizioni erbicide
DE69904699D1 (de) Pestizide Zusammensetzungen
NO20014603L (no) Tienopyrimidinforbindelser, deres fremstilling og anvendelse
DK1073672T3 (da) Antipicornavirale forbindelser, deres fremstilling og anvendelse
DK1019358T3 (da) 3,3-diarylpropylaminer, deres anvendelse og fremstilling
PT1139761E (pt) Composicoes herbicidas e concentrados tensioactivos
DE69837482D1 (de) Entschäumende zusammensetzungen
ID23096A (id) Komposisi-komposisi pestisida
ID25463A (id) Komposisi-komposisi pestisida
NO20013085D0 (no) Fosfororganiske forbindelser og deres anvendelse
NO20006479D0 (no) Tienopyridinforbindelser, deres fremstilling og anvendelse
NO20014988L (no) Pseudomycin antifungale sammensetninger og fremgangsmåter for deres anvendelser
TR199801835A3 (tr) Antimikrobiyal kompozisyonlar.
NO996156L (no) Substituerte cykloheptener, deres fremstilling og anvendelse
ID30224A (id) Komposi-komposisi fungisida
NO20011859L (no) Imidazoisokinolinforbindelser, deres sammensetninger og anvendelse
NO20022844D0 (no) N-(1-fenyletyl)-5-fenyl-imidazol-2-aminforbindelser, deres sammensetninger og anvendelser