DE69110150T2 - Mikrokapseln mit verzögerter Wirkstoffabgabe. - Google Patents
Mikrokapseln mit verzögerter Wirkstoffabgabe.Info
- Publication number
- DE69110150T2 DE69110150T2 DE69110150T DE69110150T DE69110150T2 DE 69110150 T2 DE69110150 T2 DE 69110150T2 DE 69110150 T DE69110150 T DE 69110150T DE 69110150 T DE69110150 T DE 69110150T DE 69110150 T2 DE69110150 T2 DE 69110150T2
- Authority
- DE
- Germany
- Prior art keywords
- water
- oil
- analogue
- aqueous phase
- microcapsules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 229920001519 homopolymer Polymers 0.000 claims abstract description 14
- 229920001577 copolymer Polymers 0.000 claims abstract description 12
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
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- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
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- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
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- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 2
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- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
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- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
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- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
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- 102000009151 Luteinizing Hormone Human genes 0.000 description 1
- 108010073521 Luteinizing Hormone Proteins 0.000 description 1
- 229940124041 Luteinizing hormone releasing hormone (LHRH) antagonist Drugs 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
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- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
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- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- BCKXLBQYZLBQEK-KVVVOXFISA-M Sodium oleate Chemical compound [Na+].CCCCCCCC\C=C/CCCCCCCC([O-])=O BCKXLBQYZLBQEK-KVVVOXFISA-M 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
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- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
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- 235000010445 lecithin Nutrition 0.000 description 1
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- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
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- 229940079827 sodium hydrogen sulfite Drugs 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
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- 239000003381 stabilizer Substances 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 238000013269 sustained drug release Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/066—TRH, thyroliberin, thyrotropin releasing hormone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
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- Bioinformatics & Cheminformatics (AREA)
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- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Reproductive Health (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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JP3313390 | 1990-02-13 | ||
JP889691 | 1991-01-29 | ||
JP3032302A JP2653255B2 (ja) | 1990-02-13 | 1991-01-31 | 長期徐放型マイクロカプセル |
CN91101017A CN1055618C (zh) | 1990-02-13 | 1991-02-12 | 缓释微胶囊的制备方法 |
Publications (2)
Publication Number | Publication Date |
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DE69110150D1 DE69110150D1 (de) | 1995-07-13 |
DE69110150T2 true DE69110150T2 (de) | 1996-01-25 |
Family
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Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69110150T Expired - Lifetime DE69110150T2 (de) | 1990-02-13 | 1991-02-11 | Mikrokapseln mit verzögerter Wirkstoffabgabe. |
Country Status (22)
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EP (1) | EP0442671B1 (es) |
JP (1) | JP2653255B2 (es) |
CN (1) | CN1055618C (es) |
AT (1) | ATE123413T1 (es) |
AU (1) | AU645108B2 (es) |
BR (1) | BR9103553A (es) |
CA (1) | CA2036089C (es) |
DE (1) | DE69110150T2 (es) |
DK (1) | DK0442671T3 (es) |
ES (1) | ES2073117T3 (es) |
FI (1) | FI96278C (es) |
HK (1) | HK188095A (es) |
HU (2) | HU206986B (es) |
IE (1) | IE68436B1 (es) |
LT (1) | LT3278B (es) |
LV (1) | LV10041B (es) |
MX (1) | MX9100721A (es) |
NO (1) | NO301405B1 (es) |
NZ (1) | NZ239381A (es) |
PT (1) | PT96727B (es) |
RU (2) | RU2018306C1 (es) |
UY (1) | UY23276A1 (es) |
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WO2020183718A1 (ja) | 2019-03-14 | 2020-09-17 | エム・テクニック株式会社 | Plga微粒子、その徐放性製剤及びその製造方法 |
CN115551485A (zh) | 2020-05-08 | 2022-12-30 | M技术株式会社 | 均匀分散有生理活性物质的微球及含有其的缓释制剂 |
EP4147720A4 (en) | 2020-05-08 | 2023-04-26 | M. Technique Co., Ltd. | MICROPHONES WITH A UNIFORMLY DISPERSED BIOACTIVE SUBSTANCE AND PREPARATION WITH DELAYED RELEASE CONTAINING THEM |
CN116327735A (zh) | 2020-05-08 | 2023-06-27 | M技术株式会社 | 主剂均匀分散的微球和含有其的缓释制剂 |
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JPS528375B2 (es) | 1973-07-02 | 1977-03-09 | ||
FR2238700B1 (es) | 1973-07-24 | 1977-10-14 | Takeda Chemical Industries Ltd | |
CS180644B2 (en) | 1973-09-29 | 1978-01-31 | Takeda Chemical Industries Ltd | Process for preparing nonapeptides |
JPS5726506B2 (es) | 1974-03-08 | 1982-06-04 | ||
CH583404A5 (es) | 1975-03-18 | 1976-12-31 | Patelhold Patentverwertung | |
JPS5257177A (en) | 1975-10-29 | 1977-05-11 | Parke Davis & Co | Production of novel nonapeptide |
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JPS5692846A (en) | 1979-12-27 | 1981-07-27 | Takeda Chem Ind Ltd | Tetrapeptide derivative and its preparation |
JPS5772950A (en) | 1980-10-24 | 1982-05-07 | Takeda Chem Ind Ltd | Tetrapeptide derivative, its preparation and analgesic agent |
PH19942A (en) | 1980-11-18 | 1986-08-14 | Sintex Inc | Microencapsulation of water soluble polypeptides |
JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
DE3678308D1 (de) * | 1985-02-07 | 1991-05-02 | Takeda Chemical Industries Ltd | Verfahren zur herstellung von mikrokapseln. |
JP2551756B2 (ja) * | 1985-05-07 | 1996-11-06 | 武田薬品工業株式会社 | ポリオキシカルボン酸エステルおよびその製造法 |
JPS6228799A (ja) | 1985-07-31 | 1987-02-06 | 富士通株式会社 | 音声分析装置 |
JP2526589B2 (ja) * | 1986-08-08 | 1996-08-21 | 武田薬品工業株式会社 | ペプチド含有マイクロカプセルおよびその製造法 |
JPS6341416A (ja) * | 1986-08-08 | 1988-02-22 | Takeda Chem Ind Ltd | 鎮痛性ペプチド含有マイクロカプセルの製造法 |
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JP2827287B2 (ja) * | 1988-07-05 | 1998-11-25 | 武田薬品工業株式会社 | 水溶性薬物含有徐放型マイクロカプセル |
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1991
- 1991-01-31 JP JP3032302A patent/JP2653255B2/ja not_active Expired - Lifetime
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- 1991-02-11 PT PT96727A patent/PT96727B/pt not_active IP Right Cessation
- 1991-02-11 DE DE69110150T patent/DE69110150T2/de not_active Expired - Lifetime
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- 1991-02-12 IE IE47491A patent/IE68436B1/en not_active IP Right Cessation
- 1991-02-12 RU SU4894792/14A patent/RU2018306C1/ru active
- 1991-02-12 FI FI910674A patent/FI96278C/fi active
- 1991-02-13 HU HU91475A patent/HU206986B/hu unknown
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- 1991-08-16 UY UY23276A patent/UY23276A1/es not_active IP Right Cessation
- 1991-08-19 BR BR919103553A patent/BR9103553A/pt not_active Application Discontinuation
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1992
- 1992-12-30 LV LVP-92-582A patent/LV10041B/lv unknown
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1993
- 1993-03-19 LT LTIP441A patent/LT3278B/lt not_active IP Right Cessation
- 1993-06-29 RU RU93034781/14A patent/RU2098121C1/ru active
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1995
- 1995-06-27 HU HU95P/P00464P patent/HU211586A9/hu unknown
- 1995-12-14 HK HK188095A patent/HK188095A/xx not_active IP Right Cessation
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Owner name: TAKEDA PHARMACEUTICAL CO. LTD., OSAKA, JP |