LTIP441A - Microcapsules and process for preparing thereof - Google Patents

Microcapsules and process for preparing thereof

Info

Publication number
LTIP441A
LTIP441A LTIP441A LTIP441A LTIP441A LT IP441 A LTIP441 A LT IP441A LT IP441 A LTIP441 A LT IP441A LT IP441 A LTIP441 A LT IP441A LT IP441 A LTIP441 A LT IP441A
Authority
LT
Lithuania
Prior art keywords
preparing
layer containing
water
oil emulsion
oil
Prior art date
Application number
LTIP441A
Inventor
Hiroaki Okada
Yayoi Inoue
Yasuaki Ogawa
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of LTIP441A publication Critical patent/LTIP441A/en
Publication of LT3278B publication Critical patent/LT3278B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/066—TRH, thyroliberin, thyrotropin releasing hormone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

This invention provides a microcapsule designed for zero order release of a physiologically active polypeptide over a period of at least two months, which is produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing about 20 to 70% (w/w) of said polypeptide and an oil layer containing a copolymer or homopolymer having a weight-average molecular weight of 7,000 to 30,000, the molar composition ratio of lactic acid/glycolic acid being 80/20 to 100/0, subjecting said water-in oil emulsion to microencapsulation.
LTIP441A 1990-02-13 1993-03-19 Microcapsules and process for preparing thereof LT3278B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP3313390 1990-02-13
JP889691 1991-01-29
JP3032302A JP2653255B2 (en) 1990-02-13 1991-01-31 Long-term sustained release microcapsules
CN91101017A CN1055618C (en) 1990-02-13 1991-02-12 Prolonged release microcapsules

Publications (2)

Publication Number Publication Date
LTIP441A true LTIP441A (en) 1994-11-25
LT3278B LT3278B (en) 1995-05-25

Family

ID=36754781

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP441A LT3278B (en) 1990-02-13 1993-03-19 Microcapsules and process for preparing thereof

Country Status (22)

Country Link
EP (1) EP0442671B1 (en)
JP (1) JP2653255B2 (en)
CN (1) CN1055618C (en)
AT (1) ATE123413T1 (en)
AU (1) AU645108B2 (en)
BR (1) BR9103553A (en)
CA (1) CA2036089C (en)
DE (1) DE69110150T2 (en)
DK (1) DK0442671T3 (en)
ES (1) ES2073117T3 (en)
FI (1) FI96278C (en)
HK (1) HK188095A (en)
HU (2) HU206986B (en)
IE (1) IE68436B1 (en)
LT (1) LT3278B (en)
LV (1) LV10041B (en)
MX (1) MX9100721A (en)
NO (1) NO301405B1 (en)
NZ (1) NZ239381A (en)
PT (1) PT96727B (en)
RU (2) RU2018306C1 (en)
UY (1) UY23276A1 (en)

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU221294B1 (en) * 1989-07-07 2002-09-28 Novartis Ag Process for producing retarde compositions containing the active ingredient in a polymeric carrier
FR2693905B1 (en) * 1992-07-27 1994-09-02 Rhone Merieux Process for the preparation of microspheres for the sustained release of the hormone LHRH and its analogs, microspheres and formulations obtained.
JP3277342B2 (en) * 1992-09-02 2002-04-22 武田薬品工業株式会社 Manufacturing method of sustained release microcapsules
TW333456B (en) 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
US6284727B1 (en) 1993-04-07 2001-09-04 Scios, Inc. Prolonged delivery of peptides
US5744155A (en) * 1993-08-13 1998-04-28 Friedman; Doron Bioadhesive emulsion preparations for enhanced drug delivery
US5514670A (en) * 1993-08-13 1996-05-07 Pharmos Corporation Submicron emulsions for delivery of peptides
EP0724432B1 (en) * 1993-10-22 2002-09-18 Genentech, Inc. Methods and compositions for microencapsulation of antigens for use as vaccines
US5643605A (en) * 1993-10-25 1997-07-01 Genentech, Inc. Methods and compositions for microencapsulation of adjuvants
US6080429A (en) * 1993-10-25 2000-06-27 Genentech, Inc. Method for drying microspheres
US6913767B1 (en) 1993-10-25 2005-07-05 Genentech, Inc. Compositions for microencapsulation of antigens for use as vaccines
DE4342091A1 (en) * 1993-12-09 1995-06-14 Asta Medica Ag Products for the application of initially high doses of Cetrorelix and manufacture of a combination pack for use in the treatment of diseases
IL113812A (en) * 1994-05-24 2000-06-29 Yeda Res & Dev Copolymer-1 pharmaceutical compositions containing it and its use
JPH10511095A (en) * 1994-12-19 1998-10-27 ベス イスラエル ディーコネス メディカル センター インコーポレイテッド Low dose continuous administration of parathyroid hormone or its agonist
CN1069827C (en) * 1995-06-09 2001-08-22 浙江大学 Polypeptide protein micro-beads medicine prepn. method
TW448055B (en) * 1995-09-04 2001-08-01 Takeda Chemical Industries Ltd Method of production of sustained-release preparation
DE19545257A1 (en) * 1995-11-24 1997-06-19 Schering Ag Process for the production of morphologically uniform microcapsules and microcapsules produced by this process
CA2192773C (en) 1995-12-15 2008-09-23 Hiroaki Okada Production of sustained-release preparation for injection
IE960308A1 (en) 1996-04-23 1997-11-05 Kinerton Ltd Sustained release ionic conjugate
US6419961B1 (en) 1996-08-29 2002-07-16 Takeda Chemical Industries, Ltd. Sustained release microcapsules of a bioactive substance and a biodegradable polymer
ES2221019T3 (en) 1996-10-31 2004-12-16 Takeda Chemical Industries, Ltd. PREPARATION OF MAINTENANCE RELEASE.
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
AU7134898A (en) * 1997-04-17 1998-11-11 Amgen, Inc. Biodegradable microparticles for the sustained delivery of therapeutic drugs
TW577758B (en) 1997-10-27 2004-03-01 Ssp Co Ltd Intra-articular preparation for the treatment of arthropathy
EP1028746B1 (en) 1997-11-07 2003-02-26 Chiron Corporation Method for producing igf-i sustained-release formulations
RU2147923C1 (en) * 1997-12-02 2000-04-27 Ивановский государственный университет Technology of production of microcapsules
AU1982599A (en) 1998-01-21 1999-08-09 Takeda Chemical Industries Ltd. Lyophilization method for sustained-release preparations
US7128927B1 (en) * 1998-04-14 2006-10-31 Qlt Usa, Inc. Emulsions for in-situ delivery systems
GB9810236D0 (en) * 1998-05-13 1998-07-08 Microbiological Res Authority Improvements relating to encapsulation of bioactive agents
WO2000028942A1 (en) * 1998-11-17 2000-05-25 F. Hoffmann-La Roche Ag Process for the manufacture of liquid filled capsules
WO2001058426A1 (en) * 2000-02-09 2001-08-16 White Spot Ag Sustained release composition comprising insuline like growth factor
US6998393B2 (en) * 2000-06-23 2006-02-14 Biopharm Solutions, Inc. Aquespheres, their preparation and uses thereof
WO2002002144A1 (en) 2000-07-05 2002-01-10 Takeda Chemical Industries, Ltd. Medicinal preparations for treating sex hormone-dependent diseases
US8470359B2 (en) 2000-11-13 2013-06-25 Qlt Usa, Inc. Sustained release polymer
TWI225416B (en) * 2001-06-29 2004-12-21 Takeda Chemical Industries Ltd Sustained-release composition and process for producing the same
CN1278675C (en) 2001-07-10 2006-10-11 佳能株式会社 Granular material comprising polyhydroxyalkanoate and method for producing the same
EP1444988A4 (en) 2001-11-13 2007-04-25 Takeda Pharmaceutical ANTICANCING AGENTS
EP1344520B1 (en) 2002-03-15 2007-10-03 Alrise Biosystems GmbH Microparticles and method for their production
US6884432B2 (en) 2002-04-25 2005-04-26 Mayo Foundation For Medical Education And Research Blend, cross-linkable poly(propylene fumarate) for immobilization and controlled drug delivery
CN1938040A (en) * 2003-03-05 2007-03-28 Pr药品有限公司 Oxytocin controlled release formulations and methods of using same
JP2004331750A (en) 2003-05-02 2004-11-25 Canon Inc Magnetic structure containing polyhydroxyalkanoate, method for producing the same, and use thereof
TW200529890A (en) * 2004-02-10 2005-09-16 Takeda Pharmaceutical Sustained-release preparations
FR2867075B1 (en) * 2004-03-03 2006-07-14 Ethypharm Sa PROCESS FOR PREPARING CALIBRATED BIODEGRADABLE MICROSPHERES
ATE382337T1 (en) * 2005-04-28 2008-01-15 Nipro Corp BIOABSORBABLE PHARMACEUTICAL COMPOSITION CONTAINING A PLGA COPOLYMER
US8932633B2 (en) 2005-08-29 2015-01-13 Biopharm Solutions Inc. Polysaccharide microparticles containing biological agents: their preparation and applications
JP4564098B2 (en) 2006-12-18 2010-10-20 武田薬品工業株式会社 Sustained release composition and method for producing the same
WO2009005718A1 (en) * 2007-06-28 2009-01-08 Surmodics, Inc. Polypeptide microparticles having sustained release characteristics, methods and uses
ES2319054B1 (en) * 2007-08-06 2010-02-12 Gp Pharm S.A. ORAL PHARMACEUTICAL COMPOSITION OF DESMOPRESINA.
KR100845009B1 (en) * 2007-08-07 2008-07-08 한국생명공학연구원 Porous polymer particles to which charge-carrying material is fixed and a method of manufacturing the same
WO2010053492A1 (en) * 2008-11-10 2010-05-14 Colgate-Palmolive Company Shelf stable capsules
US20100310726A1 (en) * 2009-06-05 2010-12-09 Kraft Foods Global Brands Llc Novel Preparation of an Enteric Release System
US9968564B2 (en) 2009-06-05 2018-05-15 Intercontinental Great Brands Llc Delivery of functional compounds
US8859003B2 (en) 2009-06-05 2014-10-14 Intercontinental Great Brands Llc Preparation of an enteric release system
RU2488395C1 (en) * 2012-01-10 2013-07-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Юго-Западный государственный университет" (ЮЗ ГУ) Method for preparing microcapsules of rivanol in water-soluble polymers
RU2496483C1 (en) * 2012-03-20 2013-10-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Юго-Западный государственный университет" (ЮЗ ГУ) Method for preparing microcapsules
RU2482849C1 (en) * 2012-04-09 2013-05-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Юго-Западный государственный университет" (ЮЗ ГУ) Method for preparing pharmaceutical microcapsules of cephalosporins
RU2502510C1 (en) * 2012-04-24 2013-12-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования Курская государственная сельскохозяйственная академия имени профессора И.И. Иванова Министерства сельского хозяйства Российской Федерации Method for preparing drug microcapsules of cephalosporin in konjak gum in carbon tetrachloride
RU2500403C1 (en) * 2012-05-03 2013-12-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования Курская государственная сельскохозяйственная академия имени профессора И.И. Иванова Министерства сельского хозяйства Российской Федерации Physicochemical method for preparing cephalosporin microcapsules
RU2491939C1 (en) * 2012-05-10 2013-09-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования Курская государственная сельскохозяйственная академия имени профессора И.И. Иванова Министерства сельского хозяйства Российской Федерации Method for preparing drug microcapsules of cephalosporin in konjac gum in chloroform
RU2525158C2 (en) * 2012-05-18 2014-08-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования Курская государственная сельскохозяйственная академия имени профессора И.И. Иванова Министерства сельского хозяйства Российской Федерации Method of obtaining microcapsules of medications of cephalosporin group in konjac gum in toluene
RU2522267C2 (en) * 2012-08-28 2014-07-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования Курская государственная сельскохозяйственная академия имени профессора И.И. Иванова Министерства сельского хозяйства Российской Федерации Fenbendazole encapsulation method
US8859005B2 (en) 2012-12-03 2014-10-14 Intercontinental Great Brands Llc Enteric delivery of functional ingredients suitable for hot comestible applications
RU2522229C1 (en) * 2013-03-26 2014-07-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Юго-Западный государственный университет" (ЮЗ ГУ) Fenbendazole encapsulation method
RU2540479C2 (en) * 2013-05-24 2015-02-10 Александр Александрович Кролевец Method for fenbendazole encapsulation
RU2546516C2 (en) * 2013-07-08 2015-04-10 Александр Александрович Кролевец Method for producing penicillin microcapsules in kappa-carageenan
RU2545742C2 (en) * 2013-07-23 2015-04-10 Александр Александрович Кролевец Lactobifadol encapsulation method
RU2555782C1 (en) * 2014-03-03 2015-07-10 Александр Александрович Кролевец Method of producing glucosamine sulphate nanocapsules in konjac gum in hexane
RU2556202C1 (en) * 2014-03-18 2015-07-10 Александр Александрович Кролевец Method of obtaining l-arginine nanocapsules in sodium alginate
RU2558084C1 (en) * 2014-03-18 2015-07-27 Александр Александрович Кролевец Method of producing aspirin nanocapsules in carrageenan
RU2563118C1 (en) * 2014-03-18 2015-09-20 Александр Александрович Кролевец Method of producing of microcapsules of aminoglycoside antibiotics in sodium alginate
RU2555055C1 (en) * 2014-03-18 2015-07-10 Александр Александрович Кролевец Method of obtaining nanocapsules of glucoamine sulphate in xanthan gum
RU2557941C1 (en) * 2014-03-20 2015-07-27 Александр Александрович Кролевец Method of production of nanocapsules of aspirin in sodium alginate
RU2557900C1 (en) * 2014-03-25 2015-07-27 Александр Александрович Кролевец Method of production of nanocapsules of vitamins
RU2557903C1 (en) * 2014-03-26 2015-07-27 Александр Александрович Кролевец Method of production of nanocapsules of l-arginine in pectin
RU2565408C1 (en) * 2014-04-02 2015-10-20 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Белгородский государственный национальный исследовательский университет" Method of obtaining microcapsules of amino acids in sodium alginate
RU2554759C1 (en) * 2014-04-07 2015-06-27 Александр Александрович Кролевец Method of obtaining potassium losartan nanocapsules
RU2558856C1 (en) * 2014-04-15 2015-08-10 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Белгородский государственный национальный исследовательский университет" Method of production of microcapsules of amino acids in konjac gum
RU2568832C1 (en) * 2014-07-01 2015-11-20 Александр Александрович Кролевец Method of producing nanocapsules of metal salts
RU2569735C1 (en) * 2014-07-17 2015-11-27 Александр Александрович Кролевец Method for obtaining nanocapsules of metal salts in konjac gum
RU2569736C1 (en) * 2014-07-28 2015-11-27 Александр Александрович Кролевец Method of production of nanocapsules of adenine in sodium alginate
RU2573502C1 (en) * 2014-09-18 2016-01-20 Александр Александрович Кролевец Method of production of nanocapsules of resveratrol in sodium alginate
RU2619329C2 (en) * 2014-10-06 2017-05-15 Александр Александрович Кролевец Method of producing aspirin nanocapsules in sodium alginate
RU2605850C2 (en) * 2014-10-10 2016-12-27 Александр Александрович Кролевец Method for tannin nanocapsules producing
CN104473904B (en) * 2014-11-10 2018-06-05 苏州蔻美新材料有限公司 Slow-release microcapsule and its application
RU2578411C1 (en) * 2015-03-11 2016-03-27 Александр Александрович Кролевец Method of producing nanocapsules of riboflavin
RU2590666C1 (en) * 2015-04-14 2016-07-10 Александр Александрович Кролевец Method of producing nano capsules of medicinal plants having immunostimulating effect
RU2592202C1 (en) * 2015-05-29 2016-07-20 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Method of producing nanocapsules of creatine
RU2590693C1 (en) * 2015-06-02 2016-07-10 Александр Александрович Кролевец Method of producing nano capsules of adaptogens in pectin
RU2599841C1 (en) * 2015-08-24 2016-10-20 Александр Александрович Кролевец Method of aminoglycoside antibiotics in sodium alginate nano-capsules producing
RU2599007C1 (en) * 2015-08-24 2016-10-10 Александр Александрович Кролевец Method of producing nanocapsules of ciprofloxacin hydrochloride in sodium alginate
JP5938762B1 (en) 2015-09-01 2016-06-22 日揮株式会社 Microcapsule preparation and production method thereof
RU2624533C1 (en) * 2016-03-18 2017-07-04 Александр Александрович Кролевец Method of obtaining chia seeds nanocapules (salvia hispanica) in carageenan
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RU2654229C1 (en) * 2017-02-16 2018-05-17 Александр Александрович Кролевец Method for producing nanocapsules of vitamins in pectin
RU2655877C1 (en) * 2017-03-24 2018-05-29 Александр Александрович Кролевец Method for producing nanocapsules of biopag-d in carrageenan
JP6788171B1 (en) 2019-03-14 2020-11-25 エム・テクニック株式会社 PLGA fine particles, sustained-release preparation thereof, and method for producing the same
WO2021224999A1 (en) 2020-05-08 2021-11-11 エム・テクニック株式会社 Microspheres in which bioactive substance is uniformly dispersed, and sustained-release preparation containing same
CN115551485B (en) 2020-05-08 2024-09-24 M技术株式会社 Microspheres uniformly dispersed with physiologically active substances and sustained-release preparations containing the same
US11617720B2 (en) 2020-05-08 2023-04-04 M. Technique Co., Ltd. Main agent uniformly dispersed microsphere and a sustained release formulation comprising the same

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO139560C (en) 1972-04-29 1979-04-04 Takeda Chemical Industries Ltd ANALOGICAL PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY EFFECTIVE NONAPEPTIDAMIDE DERIVATIVES
JPS528375B2 (en) 1973-07-02 1977-03-09
FR2238700B1 (en) 1973-07-24 1977-10-14 Takeda Chemical Industries Ltd
AT347054B (en) 1973-09-29 1978-12-11 Takeda Chemical Industries Ltd PROCESS FOR THE PRODUCTION OF NEW NONAPEPTIDAMIDE DERIVATIVES
JPS5726506B2 (en) 1974-03-08 1982-06-04
CH583404A5 (en) 1975-03-18 1976-12-31 Patelhold Patentverwertung
GB1542703A (en) 1975-10-29 1979-03-21 Parke Davis & Co Nonapeptides and methods for their production
US4087390A (en) 1977-02-02 1978-05-02 Eli Lilly And Company Somatostatin analogs and intermediates thereto
US4124577A (en) 1977-06-13 1978-11-07 Warner-Lambert Nonapeptides and methods for their production
US4234571A (en) 1979-06-11 1980-11-18 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone
US4317815A (en) 1979-06-13 1982-03-02 Coy David Howard LH-RH Antagonists
US4253997A (en) 1979-12-17 1981-03-03 American Home Products Corporation Anti-ovulatory decapeptides
JPS5692846A (en) 1979-12-27 1981-07-27 Takeda Chem Ind Ltd Tetrapeptide derivative and its preparation
JPS5772950A (en) 1980-10-24 1982-05-07 Takeda Chem Ind Ltd Tetrapeptide derivative, its preparation and analgesic agent
PH19942A (en) 1980-11-18 1986-08-14 Sintex Inc Microencapsulation of water soluble polypeptides
JPS60100516A (en) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd Preparation of sustained release microcapsule
EP0190833B1 (en) * 1985-02-07 1991-03-27 Takeda Chemical Industries, Ltd. Method for producing microcapsule
JP2551756B2 (en) * 1985-05-07 1996-11-06 武田薬品工業株式会社 Polyoxycarboxylic acid ester and method for producing the same
JPS6228799A (en) 1985-07-31 1987-02-06 富士通株式会社 Voice analyzer
JP2526589B2 (en) * 1986-08-08 1996-08-21 武田薬品工業株式会社 Peptide-containing microcapsule and method for producing the same
JPS6341416A (en) * 1986-08-08 1988-02-22 Takeda Chem Ind Ltd Production of microcapsule containing analgesic peptide
JPS63201816A (en) * 1987-02-18 1988-08-19 Hitachi Ltd cursor display device
JP2827287B2 (en) * 1988-07-05 1998-11-25 武田薬品工業株式会社 Sustained release microcapsules containing water-soluble drugs

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NO910555D0 (en) 1991-02-12
RU2098121C1 (en) 1997-12-10
CA2036089A1 (en) 1991-08-14
CN1054009A (en) 1991-08-28
NO910555L (en) 1991-08-14
IE910474A1 (en) 1991-08-14
LV10041B (en) 1994-10-20
JPH04321622A (en) 1992-11-11
FI96278C (en) 1996-06-10
AU645108B2 (en) 1994-01-06
UY23276A1 (en) 1992-01-15
BR9103553A (en) 1992-09-29
EP0442671A3 (en) 1992-09-02
JP2653255B2 (en) 1997-09-17
CA2036089C (en) 2000-12-05
HUT56268A (en) 1991-08-28
NO301405B1 (en) 1997-10-27
EP0442671B1 (en) 1995-06-07
IE68436B1 (en) 1996-06-12
PT96727A (en) 1991-10-31
LV10041A (en) 1994-05-10
HU211586A9 (en) 1995-12-28
HK188095A (en) 1995-12-22
DE69110150D1 (en) 1995-07-13
FI910674A0 (en) 1991-02-12
RU2018306C1 (en) 1994-08-30
ATE123413T1 (en) 1995-06-15
PT96727B (en) 1998-07-31
NZ239381A (en) 1992-12-23
MX9100721A (en) 1992-07-31
AU8179491A (en) 1992-08-06
EP0442671A2 (en) 1991-08-21
LT3278B (en) 1995-05-25
DK0442671T3 (en) 1995-07-24
DE69110150T2 (en) 1996-01-25
CN1055618C (en) 2000-08-23
FI910674L (en) 1991-08-14
HU206986B (en) 1993-03-01
ES2073117T3 (en) 1995-08-01
FI96278B (en) 1996-02-29

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