RU2496483C1 - Method for preparing microcapsules - Google Patents

Abstract

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to microcapsulation of drug preparations, vitamins, herbicides, flavouring agents and polysaccharides. The microcapsules are prepared by physical-chemical nonsolvent addition with using benzol as a precipitator.

EFFECT: invention provides simplifying and accelerating the process of preparing the microcapsules, reducing losses in preparing the microcapsules (higher weight yield).

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Description

The invention relates to the field of microencapsulation of drugs, vitamins, herbicides, flavors and polysaccharides.

Previously known methods for producing microcapsules. So, in US Pat. 2092155, IPC A61K 047/02, A61K 009/16, published on 10/10/1997, Russian Federation, a method for microencapsulation of drugs based on the use of special equipment using ultraviolet radiation was proposed.

The disadvantages of this method are the duration of the process and the use of ultraviolet radiation, which can affect the process of formation of microcapsules.

In US Pat. 2095055, IPC A61K 9/52, A61K 9/16, A61K 9/10, Russian Federation, published 10.11.1997, a method for producing solid non-porous microspheres, which includes the melting of a pharmaceutically inactive carrier substance, dispersion of the pharmaceutically active substance in a melt in an inert atmosphere, spraying the resulting dispersion in the form of fog in a freezing chamber under pressure, in an inert atmosphere, at a temperature of from -15 to -50 ° C, and dividing the resulting microspheres into fractions by size. A suspension intended for administration by parenteral injection contains an effective amount of said microspheres distributed in a pharmaceutically acceptable liquid vector, the pharmaceutically active substance of the microsphere being insoluble in said liquid medium.

The disadvantages of the proposed method: the duration of the process, the use of special equipment.

In US Pat. 2091071, IPC A61K 35/10, Russian Federation, published 09/27/1997, a method for producing the preparation by dispersion in a ball mill to obtain microcapsules is proposed.

The disadvantages of the proposed method is the duration of the process and the use of a ball mill, the use of which can lead to the destruction of microcapsules.

In US Pat. 2076765, IPC B01D 9/02, Russian Federation, published April 10, 1997, a method for producing dispersed particles of soluble compounds in microcapsules by crystallization from a solution is proposed, characterized in that the solution is dispersed in an inert matrix, cooled, and dispersed particles are obtained by changing the temperature.

The disadvantage of this method is the difficulty of execution: obtaining microcapsules by dispersion with subsequent change in temperature, which slows down the process.

In US Pat. 2101010, IPC A61K 9/52, A61K 9/50, A61K 9/22, A61K 9/20, A61K 31/19, Russian Federation, published 01/10/1998, a chewing form of the drug with a taste masking having the properties of a controlled release of the drug The preparation contains microcapsules with a size of 100-800 microns in diameter and consists of a pharmaceutical core with crystalline ibuprofen and a polymer coating, including a plasticizer, flexible enough to withstand chewing. The polymer coating is a methacrylic acid based copolymer.

The disadvantages of the invention: the use of a copolymer based on methacrylic acid, as these polymer coatings can cause cancerous tumors; complexity of execution; the duration of the process.

In US Pat. 2139046, IPC A61K 9/50, A61K 49/00, A61K 51/00, Russian Federation, published on 10/10/1999, a method for producing microcapsules as follows. An oil-in-water emulsion is prepared from an organic solution containing dissolved mono-, di-, triglyceride, preferably tripalmitin or tristearin, and possibly a therapeutically active substance, and an aqueous solution containing a surfactant, possibly a portion of the solvent is evaporated, a redispersing agent is added the agent and the mixture are freeze dried. The freeze-dried mixture is then redispersed in an aqueous carrier to separate the microcapsules from organic residues, and the hemispherical or spherical microcapsules are dried.

The disadvantages of the proposed method are the complexity and duration of the process, the use of freeze-drying, which takes a lot of time and slows down the process of obtaining microcapsules.

In US Pat. 2159037, IPC A01N 25/28, A01N 25/30, Russian Federation, published on 11/20/2000, a method for producing microcapsules by a polymerization reaction at the phase boundary containing solid agrochemical material 0.1-55 wt.% Suspended in a mixture with water organic liquid, 0.01-10 wt.% non-ionic dispersant, active at the phase boundary and not acting as an emulsifier.

The disadvantages of the proposed method: complexity, duration, the use of high shear mixer.

The article “Development of microencapsulated and gel-like products and materials for various industries”, Russian Chemical Journal, 2001, vol. XLV, No. 5-6, p.125-135, describes a method for producing microcapsules of drugs by gas-phase polymerization, as the authors the articles consider unsuitable the method of chemical coacervation from aqueous media for microencapsulation of drugs due to the fact that most of them are water-soluble. The microencapsulation process by gas phase polymerization using n-xylylene includes the following main stages: evaporation of the n-xylylene dimer (170 ° C), its thermal decomposition in a pyrolysis furnace (650 ° C at a residual pressure of 0.5 mm Hg), transfer of reaction products to the “cold” polymerization chamber (20 ° C, residual pressure 0.1 mm Hg), precipitation and polymerization on the surface of the protected object. The polymerization chamber is made in the form of a rotating drum, the optimum speed for coating the powder is 30 rpm. The thickness of the shell is regulated by the time of coating. This method is suitable for encapsulation of any solids (with the exception of prone to intense sublimation). The resulting poly-n-xylylene highly crystalline polymer, characterized by high orientation and tight packaging, provides a conformal coating.

The disadvantages of the proposed method are the complexity and duration of the process, the use of gas phase polymerization, which makes the method inapplicable for producing microcapsules of drugs in polymers of protein nature due to denaturation of proteins at high temperatures.

The article “Development of micro- and nanosystems for drug delivery”, Russian Chemical Journal, 2008, vol. LII, No. 1, pp. 48-57, presents a method for producing microcapsules with included proteins, which does not significantly reduce their biological activity, carried out by the process interfacial crosslinking of soluble starch or hydroxyethyl starch and bovine serum albumin (BSA) using terephthaloyl chloride. The proteinase inhibitor, aprotinin, either native or with a protected active center, was microencapsulated when it was introduced into the aqueous phase. The flattened form of lyophilized particles indicates the preparation of microcapsules or particles of a reservoir type. Thus prepared microcapsules were not damaged after lyophilization and easily restored their spherical shape after rehydration in a buffer medium. The pH of the aqueous phase was decisive in the preparation of durable microcapsules in high yield.

The disadvantage of the proposed method for producing microcapsules is the complexity of the process, which leads to a decrease in the output of microcapsules.

In US Pat. 2173140, IPC A61K 009/50, A61K 009/127, Russian Federation, published September 10, 2001. A method for producing silicon organolipid microcapsules using a rotary-cavitation apparatus with high shear forces and powerful sonar acoustic and ultrasonic dispersion ranges is proposed.

The disadvantage of this method is the use of special equipment, a rotary-quittance installation, which has an ultrasonic effect, which affects the formation of microcapsules and can cause adverse reactions due to the fact that ultrasound destructively affects polymers of a protein nature, therefore, the proposed method is applicable when work with polymers of synthetic origin.

In US Pat. 2359662, IPC A61K 009/56, A61J 003/07, B01J 013/02, A23L 001/00, published June 27, 2009, Russian Federation, a method for producing microcapsules using spray cooling in a Niro spray cooling tower under the following conditions: air temperature inlet 10 ° C; outlet air temperature 28 ° C; spray drum rotation speed of 10,000 rpm. The microcapsules of the invention have improved stability and provide controlled and / or prolonged release of the active ingredient.

The disadvantages of the proposed method are the duration of the process and the use of special equipment, a set of certain conditions (air temperature at the inlet 10 ° C, air temperature at the outlet 28 ° C, rotation speed of the spray drum 10,000 rpm).

In US Pat. WO / 2009/148058 JP, IPC B01J 13/04, A23L 1/00, A61K 35/20, A61K 45/00, A61K 47/08), A61K 47/26, A61K 47/32, A61K 47/34, A61K 47/36, A61K 9/50, B01J 2/04, B01J 2/06, published December 10, 2009, describes a process for producing microcapsules applicable for industrial production in which a high content of hydrophilic biologically active substance is encapsulated. The proposed microcapsules can be used in food, pharmaceutical and other industries. Dispersing compositions consisting of hydrophilic biologically active substances and surfactants in solid fat are used in the manufacturing process. The temperature is not lower than the melting point of solid fat.

The disadvantages of this method are the complexity and duration of the process of obtaining microcapsules.

In US Pat. WO / 2009/153695 IB, IPC B01J 13/16; B01J 13/22; B01J 13/06; B01J 13/20, published December 23, 2009, describes a method for producing microcapsules, which includes the following steps: a) dissolving at least one polyisocyanate; b) to the resulting mixture in stage a) add colloidal stabilizers in the form of an aqueous solution from 0.1% to 0.4% polyvinyl alcohol and from 0.6% to 1% of the cationic vinylpyrrolidone copolymer; c) a reagent selected from the group consisting of water-soluble salts of guanidine and guanidine is added to the resulting mixture in paragraph b). The invention relates to a method for producing perfumes containing microcapsules with a polyurea shell, which can be used in personal care products. The invention uses features of colloidal stabilizers in aqueous solutions containing certain proportions of polymers.

The disadvantages of this method are the complexity and duration of the process, the use of polyisocyanates, which complicates the process and leads to a low yield of microcapsules.

In US Pat. WO / 2009/147973 JP, IPC B01J 13/14; A23L 1/00; A61K 9/50; A61K 47/02; A61K 47/36; A61K 47/44; A23L 1/30 describes a method for producing microcapsules, which includes an emulsification step: mixing a fat-soluble substance with an aqueous solution of sodium alginate to form an emulsion in which particles having an average particle size of 800 nm or less are emulsified and a spraying step: spraying the emulsion in a chloride solution calcium containing microcapsules.

The disadvantages of this method are the complexity and duration of the process, the use of spraying.

In US Pat. WO / 2010/076360 ES, IPC B01J 13/00; A61K 9/14; A61K 9/10; A61K 9/12, published July 8, 2010, proposes a new method for producing solid micro- and nanoparticles with a homogeneous structure with a particle size of less than 10 μm, where the treated solid compounds have a natural crystalline, amorphous, polymorphic and other states associated with the starting compound. The method allows one to obtain solid micro- and nanoparticles with substantially spheroidal morphology.

The disadvantage of the proposed method is the complexity of the process. In US Pat. WO / 2010/070602 IB, IPC A61K 8/11; A61K 8/84; A61K 8/87; A61Q 5/00; A61Q 13/00; A61Q 19/00; B01J 3/16; C11D 17/00, published July 29, 2010, describes a method for producing perfumes containing microcapsules that can be used in personal care products. Microcapsules include a core consisting of at least one aqueous phase dispersed in a continuous oil phase. Microcapsules are formed from the reaction products of at least one of the polyisocyanates and an organic compound containing a quaternary ammonium group and a primary amine or hydroxyl groups. The continuous oil phase is a) aromatization of the ingredients or composition and b) a shell formed from the reaction products of at least one polyisocyanate with one organic compound containing a quaternary ammonium group and a primary amine or hydroxyl groups, polyamines or polyol.

The disadvantages of the invention are the complexity and duration of the process, the use of dispersion in the oil phase, the use of polyisocyanates, which complicates the process and leads to a low yield of microcapsules.

In US Pat. WO / 2010/025988 EP, IPC B01J 13/04, B01J 13/14 published March 11, 2010, a method and apparatus for producing microparticles of microencapsulation are described. It should be noted the use of microfluids in the method and device according to the invention. One of the goals of the proposed method and device is to provide means for the rapid production of a large volume of monodisperse microparticles using the encapsulation technique with the ability to control the shell wall thickness. An advantage that allows you to control the wall thickness of the shell is that the release rate can be in accordance with the needs, for example, by adjusting the resistance to bursting of the wall. The method consists of the following steps: a) placing the first liquid composition in microfluidic channels, b) placing the second liquid composition in microfluidic channels in such a way as to transfer droplets of the liquid composition of the first to the second liquid composition, the second liquid composition; c) introducing a third liquid composition into microfluidic channels to a second node downstream of the first transition; g) coating a second liquid dispersed in a third liquid composition; (e) polymerization or gelation.

The disadvantages of this method are the complexity, duration of the process, as well as the use of a special installation according to the invention, the method consists of several stages, which additionally complicates it.

In US Pat. WO / 2010/014011 NL, IPC A61K 9/50; B01J 13/02; A61K 9/50; B01J 3/02, published February 4, 2010, describes a method for producing microcapsules with a diameter of 0.1 μm to 25 μm, including: a core of a particle with a diameter of 90 nm to 23 μm containing at least 3% of the active component by weight of the particle; a coating that completely covers the main particles containing at least 20% by weight of a hydrophobic polymer selected from cellulose ethers, cellulose esters, shellac, gluten, polylacryl, hydrophobic starch derivatives, polyvinyl acetate, polymers or copolymers based on acrylic acid ester and / or methacrylic acid ester and combinations thereof. The active component is not released when introduced into aqueous foods, drinks, food or pharmaceutical compositions. After oral administration, however, the active component is released rapidly.

The disadvantages of this method are the complexity, duration of the process, as well as the use of ultrasound and special equipment, the use of acrylic or methacrylic acid copolymers as microcapsule shells that can cause cancerous tumors.

In US Pat. WO / 2010/119041 EP, IPC A23L 1/00, published October 21, 2010, a method for producing beads containing the active component encapsulated in a gel matrix of a whey protein including denatured protein, serum and active components is proposed. The invention relates to a method for producing beads that contain components such as probiotic bacteria. The method of producing microspheres includes the stage of production of microspheres in accordance with the method of the invention, and the subsequent curing of the microspheres in a solution of an anionic polysaccharide with a pH of 4.6 or lower for at least 10, 30, 60, 90, 120, 180 minutes. Examples of suitable anionic polysaccharides: pectins, alginates, carrageenans. Ideally, whey protein is heat-denaturing, although other denaturation methods are also applicable, for example, pressure-induced denaturation. In a preferred embodiment, the whey protein is denatured at a temperature of from 75 ° C to 80 ° C, appropriately for from 30 minutes to 50 minutes. As a rule, whey protein is mixed with heat denaturation. Accordingly, the concentration of whey protein is from 5 to 15%, preferably from 7 to 12%, and ideally from 9 to 11% (weight / volume). Typically, the suspension is subject to a filtering process through a variety of filters with a gradual reduction in pore size. Ideally, a fine filter has submicron pore sizes, for example, from 0.1 to 0.9 microns. A preferred method for producing beads is a method using vibratory encapsulators (Inotech, Switzerland) and machines manufactured by Nisco Engineering AG ,. As a rule, nozzles have openings of 100 and 600 microns, and ideally about 150 microns.

The disadvantage of this method is the use of special equipment (vibration encapsulators (Inotech, Switzerland)), obtaining microcapsules by protein denaturation, the difficulty of isolating microcapsules obtained by this method - filtering using a variety of filters, which makes the process of isolating microcapsules long.

In US Pat. WO / 2011/003805 EP, IPC B01J 13/18; B65D 83/14; C08G 18/00, published January 13, 2011, describes a method for producing microcapsules that are suitable for use in formulations of sealants, foams, coatings or adhesives.

The disadvantage of the proposed method is the use of centrifugation to separate from the process fluid, the duration of the process, as well as the use of this method not in the pharmaceutical industry.

In US Pat. 20110223314, IPC B05D 7/00 20060101 B05D 007/00, B05C 3/02 20060101 B05C 003/02; B05C 11/00 20060101 B05C 011/00; B05D 1/18 20060101 B05D 001/18; B05D 3/02 20060101 B05D 003/02; B05D 3/06 20060101 B05D 003/06 dated 03/10/2011 US describes a method for producing microcapsules by suspension polymerization, which belongs to the group of chemical methods using a new device and ultraviolet radiation.

The disadvantage of this method is the complexity and duration of the process, the use of special equipment, obtaining microcapsules by the chemical method of suspension polymerization, the use of ultraviolet radiation.

In US Pat. WO / 2011/150138 US, IPC C11D 3/37; B01J 13/08; C11D 17/00, published 01.12.2011, describes a method for producing microcapsules of solid water-soluble agents by polymerization.

The disadvantages of this method are the complexity of execution and the duration of the process.

In US Pat. WO / 2011/127030 US, IPC A61K 8/11; B01J 2/00; B01J 13/06; C11D 3/37; C11D 3/39; C11D 17/00, published October 13, 2011, several methods for producing microcapsules are proposed: interfacial polymerization, thermally induced phase separation, spray drying, evaporation of the solvent, etc.

The disadvantages of the proposed methods are the complexity, duration of the processes, as well as the use of special equipment (filter (Albet, Dassel, Germany), a spray dryer for collecting particles (Spray-4M8 Dryer from ProCepT, Belgium)).

In US Pat. WO / 2011/104526 GB, IPC B01J 13/00; B01J 13/14; С09В 67/00; C09D 11/02, published 01.09.2011, a method for producing a dispersion of encapsulated solid particles in a liquid medium is proposed, comprising: a) grinding a composition comprising solid, liquid media and polyurethane dispersants with an acid number from 0.55 to 3.5 mmol per gram dispersant, the composition includes from 5 to 40 parts of a polyurethane dispersant per 100 parts of solid, products, by weight; and b) crosslinking the polyurethane dispersant in the presence of a solid and liquid medium, for the encapsulation of solid particles of which the polyurethane dispersant contains less than 10% by weight of repeating elements from polymer alcohols.

The disadvantages of the proposed method are the complexity and duration of the process for producing microcapsules, as well as the fact that the encapsulated particles of the proposed method are useful as dyes in ink, especially inkjet inks, this technique is not applicable to the pharmaceutical industry.

In US Pat. WO / 2011/056935 US, IPC 3 C11D 17/00; A61K 8/11; B01J 13/02; C11D 3/50, published May 12, 2011, describes a method for producing microcapsules with a size of 15 microns or more. Polymers of the group consisting of polyethylene, polyamides, polystyrenes, polyisoprenes, polycarbonates, polyesters, polyacrylates, polyureas, polyurethanes, polyolefins, polysaccharides, epoxies, vinyl polymers and mixtures thereof are proposed as a shell material. The proposed polymer shells are sufficiently impervious to core material and materials in an environment in which an agent encapsulated benefit will be used to provide benefits to be obtained. The core of encapsulated agents may include perfumes, silicone oils, waxes, hydrocarbons, higher fatty acids, essential oils, lipids, skin cooling fluids, vitamins, sunscreens, antioxidants, glycerin, catalysts, whitening particles, particles of silicon dioxide, etc.

The disadvantages of the proposed method are the complexity, duration of the process, the use as shells of microcapsules of polymers of synthetic origin and their mixtures.

In US Pat. WO / 2011/154893 IB, IPC B01J 13/16; C11D 3/50 published December 15, 2011 describes a method for producing microcapsules, comprising the following stages:

a) dissolving the mixture (one aliphatic polyisocyanate and at least one aromatic polyisocyanate containing at least two isocyanate functional groups);

b) adding to the solution obtained in stage a) an aqueous solution of an emulsifier or colloidal stabilizers;

C) adding to the mixture obtained in stage b), a polyamine to form a suspension of microcapsules. The invention relates to a method for producing perfumes that can be used in personal care products and the like. The process of the invention uses a combination of aliphatic and aromatic polyisocyanates in specific molar ratios: from 80:20 to 10:90

The disadvantages of this method are the complexity and duration of the process, the multi-stage process for producing microcapsules.

The closest method is the method proposed in US Pat. 2134967, IPC A01N 53/00, A01N 25/28, published on 08.27.1999, Russian Federation (1999). A solution of a mixture of natural lipids and a pyrethroid insecticide in a weight ratio of 2-4: 1 in an organic solvent is dispersed in water, which simplifies the microencapsulation method.

The disadvantage of this method is dispersion in an aqueous medium, which makes the proposed method inapplicable for producing microcapsules of water-soluble preparations in water-soluble polymers.

The technical task is to simplify and accelerate the process of obtaining microcapsules, reducing losses when receiving microcapsules (increase in yield by mass).

The solution of the technical problem is achieved by the method of producing microcapsules, characterized in that the production of microcapsules is carried out by the physicochemical method of precipitation with a non-solvent using benzene as a precipitant, the production process is carried out without special equipment.

A distinctive feature of the proposed method is the production of microcapsules by the physicochemical method of precipitation with a non-solvent using benzene as a precipitant.

The result of the proposed method is to obtain microcapsules of drugs, herbicides, flavors, polysaccharides within 10 minutes.

Sodium carboxymethyl cellulose, xanthan, kappa-carrageenan, necessary for microencapsulation, were industrially produced and are widely used in the food industry.

EXAMPLE 1. Obtaining microcapsules of metribuzin in sodium carboxymethyl cellulose, the ratio of 1: 3

To 6 g of a 5% solution of sodium carboxymethyl cellulose in benzene, 0.01 g of the preparation E472c was added as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of metribuzin is dissolved in 0.5 ml of DMSO and transferred to a solution of sodium carboxymethyl cellulose in benzene. After the formation of an independent solid phase after the formation of metribuzin, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.396 g of microcapsules obtained. The yield was 99%.

EXAMPLE 2. Obtaining microcapsules of haloxifop-p-methyl in sodium carboxymethyl cellulose, ratio 1: 3

To 6 g of a 5% solution of sodium carboxymethyl cellulose in benzene, 0.01 g of the preparation E472c was added as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of haloxifop-p-methyl is dissolved in 0.5 ml of DMSO and transferred to a solution of sodium carboxymethyl cellulose in benzene. After the formation of haloxifopom-p-methyl independent solid phase, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.392 g of microcapsules obtained. The yield was 98%.

EXAMPLE 3. Obtaining microcapsules of celodime in sodium carboxymethyl cellulose, ratio 1: 3

To 6 g of a 5% solution of sodium carboxymethyl cellulose in benzene, 0.01 g of the preparation E472c was added as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of celodime is dissolved in 0.5 ml of DMSO and transferred to a solution of sodium carboxymethyl cellulose in benzene. After the formation of an independent solid phase after the formation of the cadodyme, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.352 g of microcapsules obtained. The yield was 88%.

EXAMPLE 4. Obtaining microcapsules of metolachlor in sodium carboxymethyl cellulose, ratio 1: 3

To 6 g of a 5% solution of sodium carboxymethyl cellulose in benzene, 0.01 g of the preparation E472 c as a surfactant is added. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of metolachlor is dissolved in 0.5 ml of DMSO and transferred to a solution of sodium carboxymethyl cellulose in benzene. After the formation of an independent solid phase after the formation of metolachlor, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

Received 0.360 g of microcapsules. The yield was 90%.

EXAMPLE 5. Obtaining microcapsules of clopyralide in sodium carboxymethyl cellulose, ratio 1: 3

To 6 g of a 5% solution of sodium carboxymethyl cellulose in benzene, 0.01 g of the preparation E472 c as a surfactant is added. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of clopyralid is dissolved in 0.5 ml of DMSO and transferred to a solution of sodium carboxymethyl cellulose in benzene. After formation of an independent solid phase after clopyralid formation, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

Received 0.360 g of microcapsules. The yield was 90%.

EXAMPLE 6. Obtaining microcapsules Quinto Duo in sodium carboxymethyl cellulose, the ratio of 1: 3

To 6 g of a 5% solution of sodium carboxymethyl cellulose in benzene, 0.01 g of the preparation E472c was added as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of Quinto Duo is dissolved in 0.5 ml of DMSO and transferred to a solution of sodium carboxymethyl cellulose in benzene. After the formation of an independent solid phase after the formation of Quinto Duo, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.320 g of microcapsules obtained. The yield was 88%.

EXAMPLE 7. Obtaining microcapsules trebicida methyl in sodium carboxymethyl cellulose, the ratio of 1: 3

To 6 g of a 5% solution of sodium carboxymethyl cellulose in benzene, 0.01 g of the preparation E472c was added as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g methyl trebiside is dissolved in 0.5 ml DMSO and transferred to a solution of sodium carboxymethyl cellulose in benzene. After the formation of a methyl independent solid phase after the formation of trebicide, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride. 0.368 g of microcapsules obtained. The yield was 92%.

EXAMPLE 8. Obtaining microcapsules of propiconazole and trebuconazole in sodium carboxymethyl cellulose, ratio 1: 3

To 6 g of a 5% solution of sodium carboxymethyl cellulose in benzene, 0.01 g of the preparation E472c was added as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of propiconazole and trebuconazole are dissolved in 0.5 ml of DMSO and transferred to a solution of sodium carboxymethyl cellulose in benzene. After the formation of an independent solid phase after the formation of propiconazole and trebuconazole, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.340 g of microcapsules obtained. The yield was 90%.

EXAMPLE 9. Obtaining microcapsules fenoxaprop-p-ethyl in sodium carboxymethyl cellulose, the ratio of 1: 3

To 6 g of a 5% solution of sodium carboxymethyl cellulose in benzene, 0.01 g of the preparation E472c was added as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of phenoxaprop-p-ethyl is dissolved in 0.5 ml of DMSO and transferred to a solution of sodium carboxymethyl cellulose in benzene. After the formation of phenoxaprop-p-ethyl independent solid phase after formation, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride. 0.368 g of microcapsules obtained. The yield was 92%.

EXAMPLE 10. Obtaining microcapsules of dioctyl phthalate in sodium carboxymethyl cellulose, the ratio of 1: 3

To 6 g of a 5% solution of sodium carboxymethyl cellulose in benzene, 0.01 g of the preparation E472c was added as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of dioctyl phthalate is dissolved in 0.5 ml of DMSO and transferred to a solution of sodium carboxymethyl cellulose in benzene. After the formation of an independent solid phase after the formation of dioctyl phthalate, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.375 g of microcapsules obtained. The yield was 94%.

EXAMPLE 11. Obtaining microcapsules of sorbitol in kappa-carrhagenan, the ratio of 1: 3

To 6 g of a 5% solution of kappa-carrageenan in benzene, add 0.01 g of the preparation E472c as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of sorbitol is dissolved in 0.5 ml of DMSO and transferred to a solution of kappa-carrageenan in benzene. After the formation of an independent solid phase after the formation of sorbitol, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.325 g of microcapsules obtained. The yield was 81%.

EXAMPLE 12. Obtaining microcapsules of sorbitol in carrageenan, the ratio of 1: 3

To 6 g of a 5% solution of carrageenan in benzene add 0.01 g of the preparation E472c as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of sorbitol is dissolved in 0.5 ml of DMSO and transferred to a solution of carrageenan in benzene. After the formation of an independent solid phase after the formation of sorbitol, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.375 g of microcapsules obtained. The yield was 94%.

EXAMPLE 13. Obtaining microcapsules of kanamycin in kappa-carrhagenan, the ratio of 1: 3

To 6 g of a 5% solution of kappa-carrageenan in benzene, add 0.01 g of the preparation E472c as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of kanamycin is dissolved in 0.5 ml of DMSO and transferred to a solution of kappa-carrageenan in benzene. After formation of an independent solid phase after the formation of kanamycin, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.345 g of microcapsules obtained. The yield was 86%.

EXAMPLE 14. Obtaining microcapsules of vitamin D in sodium carboxymethyl cellulose, the ratio of 1: 3

To 6 g of a 5% solution of sodium carboxymethyl cellulose in benzene, 0.01 g of the preparation E472c was added as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of vitamin D is dissolved in 0.5 ml of DMSO and transferred to a solution of sodium carboxymethyl cellulose in benzene. After the formation of an independent solid phase after the formation of vitamin D, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.340 g of microcapsules obtained. The yield was 85%.

EXAMPLE 15. Obtaining microcapsules of a flavor with the smell of mandarin in sodium carboxymethyl cellulose, the ratio of 1: 3

To 6 g of a 5% solution of sodium carboxymethyl cellulose in benzene, 0.01 g of the preparation E472c was added as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of a mandarin odor flavor is dissolved in 0.5 ml of DMSO and transferred to a solution of sodium carboxymethyl cellulose in benzene. After the formation of an independent solid phase with a mandarin odor flavoring, 1 ml of distilled water is added dropwise very slowly. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.330 g of microcapsules obtained. The yield was 83%.

EXAMPLE 16. Obtaining microcapsules of flavoring with the smell of tomato in kappa-carrhagenan, the ratio of 1: 3

To 6 g of a 5% solution of kappa-carrageenan in benzene, add 0.01 g of the preparation E472c as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of kanamycin is dissolved in 0.5 ml of DMSO and transferred to a solution of kappa-carrageenan in benzene. After formation of an independent solid phase after the formation of kanamycin, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

Received 0.310 g of microcapsules. The yield was 78%.

EXAMPLE 17. Obtaining microcapsules of flavoring with the smell of hazelnuts in kappa-carrhagenan, the ratio of 1: 3

To 6 g of a 5% solution of kappa-carrageenan in benzene, add 0.01 g of the preparation E472c as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of hazelnut flavor is dissolved in 0.5 ml of DMSO and transferred to a solution of kappa-carrageenan in benzene. After the formation of an independent solid phase after the formation of a hazelnut flavoring agent with a scent of hazelnut, 1 ml of distilled water is added dropwise very slowly. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride. 0.345 g of microcapsules obtained. The yield was 86%.

EXAMPLE 18. Obtaining microcapsules of kanamycin in xanthan, ratio 1: 3

To 6 g of a 5% solution of xanthan in benzene add 0.01 g of the preparation E472c as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of kanamycin is dissolved in 0.5 ml of DMSO and transferred to a solution of xanthan in benzene. After formation of an independent solid phase after the formation of kanamycin, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

Received 0.235 g of microcapsules. The yield was 59%.

EXAMPLE 19. Obtaining microcapsules of flavoring with the smell of coffee in kappa-carrhagenan, the ratio of 1: 3

To 6 g of a 5% solution of kappa-carrageenan in benzene, add 0.01 g of the preparation E472 s as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of coffee-flavored aroma is dissolved in 0.5 ml of DMSO and transferred to a solution of kappa-carrageenan in benzene. After the formation of an independent solid phase by the aroma with the smell of coffee, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride. 0.340 g of microcapsules obtained. The yield was 85%.

EXAMPLE 20. Obtaining microcapsules of coenzyme Q ₁₀ in sodium carboxymethyl cellulose, the ratio of 1: 3

To 6 g of a 5% solution of sodium carboxymethyl cellulose in benzene, 0.01 g of the preparation E472c was added as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of coenzyme Q _{10 is} dissolved in 0.5 ml of DMSO and transferred to a solution of sodium carboxymethyl cellulose in benzene. After the formation of an independent solid phase after the formation of coenzyme Q ₁₀ , 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.335 g of microcapsules obtained. The yield was 84%.

EXAMPLE 21. Obtaining microcapsules of sorbitol in sodium carboxymethyl cellulose, the ratio of 1: 3

To 6 g of a 5% solution of sodium carboxymethyl cellulose in benzene, 0.01 g of the preparation E472c was added as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of sorbitol is dissolved in 0.5 ml of DMSO and transferred to a solution of sodium carboxymethyl cellulose in benzene. After the formation of an independent solid phase after the formation of sorbitol, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.330 g of microcapsules obtained. The yield was 83%.

EXAMPLE 22. Obtaining microcapsules of mannitol in kappa-carrageenan, the ratio of 1: 3

To 6 g of a 5% solution of kappa-carrageenan in benzene, add 0.01 g of the preparation E472c as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of mannitol is dissolved in 0.5 ml of DMSO and transferred to a solution of kappa-carrageenan in benzene. After the formation of an independent solid phase after the formation of mannitol, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.345 g of microcapsules obtained. The yield was 86%.

EXAMPLE 23. Obtaining microcapsules of flavoring with the smell of green apple in kappa-carrhagenan, the ratio of 1: 3

To 6 g of a 5% solution of kappa-carrageenan in benzene, add 0.01 g of the preparation E472c as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of a green apple flavor is dissolved in 0.5 ml of DMSO and transferred to a solution of kappa-carrageenan in benzene. After the formation of an independent solid phase after flavoring with a green apple flavor, very slowly 1 ml of distilled water is added dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.375 g of microcapsules obtained. The yield was 94%.

EXAMPLE 24. Obtaining microcapsules of flavor with the smell of paprika in kappa-carrhagenan, the ratio of 1: 1

To 6 g of a 5% solution of kappa-carrageenan in benzene, add 0.01 g of the preparation E472c as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of paprika flavoring is dissolved in 0.5 ml of DMSO and transferred to a solution of kappa-carrageenan in benzene. After the formation of an independent solid phase after the formation of paprika with a paprika flavor, very slowly 1 ml of distilled water is added dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.430 g of microcapsules obtained. The yield was 72%.

EXAMPLE 25. Obtaining microcapsules of flavoring with the smell of cappuccino in kappa-carrhagenan, the ratio of 1: 1

To 6 g of a 5% solution of kappa-carrageenan in benzene, add 0.01 g of the preparation E472c as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of a cappuccino flavor is dissolved in 0.5 ml of DMSO and transferred to a solution of kappa-carrageenan in benzene. After formation of an independent solid phase after the formation of a cappuccino flavoring agent with a cappuccino flavor, very slowly 1 ml of distilled water is added dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.430 g of microcapsules obtained. The yield was 72%.

EXAMPLE 26. Obtaining microcapsules of flavoring with the smell of apple in kappa-carrhagenan, the ratio of 1: 1

To 6 g of a 5% solution of kappa-carrageenan in benzene, add 0.01 g of the preparation E472c as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of apple-flavored flavor is dissolved in 0.5 ml of DMSO and transferred to a solution of kappa-carrageenan in benzene. After the formation of an independent solid phase by flavoring with an apple flavor, very slowly 1 ml of distilled water is added dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.420 g of microcapsules obtained. The yield was 70%.

EXAMPLE 27. Obtaining microcapsules of flavoring with the smell of green tea in kappa-carrhagenan, the ratio of 1: 1

To 6 g of a 5% solution of kappa-carrageenan in benzene, add 0.01 g of the preparation E472c as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of a flavor with the smell of green tea is dissolved in 0.5 ml of DMSO and transferred to a solution of kappa-carrageenan in benzene. After the formation of an independent solid phase after flavoring with a green tea aroma, it is added very slowly dropwise 1 ml of distilled water. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.425 g of microcapsules obtained. The yield was 71%.

EXAMPLE 28. Obtaining microcapsules of flavoring with the smell of whiskey in kappa-carrhagenan, the ratio of 1: 1

To 6 g of a 5% solution of kappa-carrageenan in benzene, add 0.01 g of the preparation E472c as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of whiskey flavoring is dissolved in 0.5 ml of DMSO and transferred to a solution of kappa-carrageenan in benzene. After the formation of an independent solid phase after the formation of an aromatic whiskey aroma, it is added very slowly dropwise 1 ml of distilled water. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

Received 0.500 g of microcapsules. The yield was 83%.

EXAMPLE 29. Obtaining microcapsules of kanamycin in sodium carboxymethyl cellulose, ratio 1: 3

To 6 g of a 5% solution of sodium carboxymethyl cellulose in benzene, 0.01 g of the preparation E472c was added as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of kanamycin is dissolved in 0.5 ml of DMSO and transferred to a solution of sodium carboxymethyl cellulose in benzene. After formation of an independent solid phase after the formation of kanamycin, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.320 g of microcapsules obtained. The yield was 80%.

EXAMPLE 30. Obtaining microcapsules of sorbitol in sodium alginate, the ratio of 1: 3

To 6 g of a 5% solution of sodium alginate in benzene, add 0.01 g of the preparation E472c as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of sorbitol is dissolved in 0.5 ml of DMSO and transferred to a solution of sodium alginate in benzene. After the formation of an independent solid phase after the formation of sorbitol, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.320 g of microcapsules obtained. The yield was 80%.

EXAMPLE 31. Obtaining microcapsules of fructose in sodium carboxymethyl cellulose, the ratio of 1: 3

To 6 g of a 5% solution of sodium carboxymethyl cellulose in benzene, 0.01 g of the preparation E472c was added as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of fructose is dissolved in 0.5 ml of DMSO and transferred to a solution of sodium carboxymethyl cellulose in benzene. After the formation of an independent solid phase after the formation of fructose, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.380 g of microcapsules obtained. The yield was 95%.

EXAMPLE 32. Obtaining microcapsules of lactose in sodium carboxymethyl cellulose, the ratio of 1: 3

To 6 g of a 5% solution of sodium carboxymethyl cellulose in benzene, 0.01 g of the preparation E472 c as a surfactant is added. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of lactose is dissolved in 0.5 ml of DMSO and transferred to a solution of sodium carboxymethyl cellulose in benzene. After the formation of an independent solid phase after the formation of lactose, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

Received 0.350 g of microcapsules. The yield was 88%.

EXAMPLE 33. Obtaining microcapsules of mannitol in sodium carboxymethyl cellulose, ratio 1: 3

To 6 g of a 5% solution of sodium carboxymethyl cellulose in benzene, 0.01 g of the preparation E472c was added as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of mannitol is dissolved in 0.5 ml of DMSO and transferred to a solution of sodium carboxymethyl cellulose in benzene. After the formation of an independent solid phase after the formation of mannitol, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

Received 0.360 g of microcapsules. The yield was 90%.

EXAMPLE 34. Obtaining microcapsules of fructose in sodium alginate, the ratio of 1: 1

To 6 g of a 5% solution of sodium alginate in benzene, add 0.01 g of the preparation E472c as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of fructose is dissolved in 0.5 ml of DMSO and transferred to a solution of sodium alginate in benzene. After the formation of an independent solid phase after the formation of fructose, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.450 g of microcapsules obtained. The yield was 75%.

EXAMPLE 35. Obtaining microcapsules of lactose in sodium alginate, the ratio of 1: 3

To 6 g of a 5% solution of sodium alginate in benzene, add 0.01 g of the preparation E472c as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of lactose is dissolved in 0.5 ml of DMSO and transferred to a solution of sodium alginate in benzene. After the formation of an independent solid phase after the formation of lactose, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered off on a 16-pore Schott filter, washed with acetone, dried in a desiccator over calcium chloride.

Received 0.310 g of microcapsules. The yield was 78%.

EXAMPLE 36. Obtaining microcapsules of mannitol in sodium alginate, the ratio of 1: 3

To 6 g of a 5% solution of sodium alginate in benzene, add 0.01 g of the preparation E472c as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of mannitol is dissolved in 0.5 ml of DMSO and transferred to a solution of sodium alginate in benzene. After the formation of an independent solid phase after the formation of mannitol, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

Received 0.350 g of microcapsules. The yield was 88%.

EXAMPLE 37. Obtaining microcapsules of kanamycin in sodium alginate, ratio 1: 3

To 6 g of a 5% solution of sodium alginate in benzene, add 0.01 g of the preparation E472c as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of kanamycin is dissolved in 0.5 ml of DMSO and transferred to a solution of sodium alginate in benzene. After the formation of an independent solid phase after the formation of kanamycin, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.320 g of microcapsules obtained. The yield was 80%.

EXAMPLE 38. Obtaining microcapsules of ampicillin in kappa-carrhagenan, the ratio of 1: 1

To 6 g of a 5% solution of kappa-carrageenan in benzene, add 0.01 g of the preparation E472 s as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of ampicillin is dissolved in 0.5 ml of DMSO and transferred to a solution of kappa-carrageenan in benzene. After the formation of an independent solid phase after ampicillin formation, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.340 g of microcapsules obtained. The yield was 85%.

EXAMPLE 39. Obtaining microcapsules of streptocide in kappa-carrhagenan, the ratio of 1: 1

To 6 g of a 5% solution of kappa-carrageenan in benzene, add 0.01 g of the preparation E472c as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of streptocide is dissolved in 0.5 ml of DMSO and transferred to a solution of kappa-carrageenan in benzene. After the formation of an independent solid phase after streptocide formation, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.335 g of microcapsules obtained. The yield was 84%.

EXAMPLE 40. Obtaining microcapsules of benzylpenicillin in kappa-carrhagenan, the ratio of 1: 1

To 6 g of a 5% solution of kappa-carrageenan in benzene, add 0.01 g of the preparation E472c as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of benzylpenicillin is dissolved in 0.5 ml of DMSO and transferred to a solution of kappa-carrageenan in benzene. After the formation of an independent solid phase after the formation of benzylpenicillin, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.345 g of microcapsules obtained. The yield was 86%.

EXAMPLE 41. Obtaining microcapsules of streptocide in sodium carboxymethyl cellulose, ratio 1: 3

To 6 g of a 5% solution of sodium carboxymethyl cellulose in benzene, 0.01 g of the preparation E472c was added as a surfactant.

The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of streptocide is dissolved in 0.5 ml of DMSO and transferred to a solution of sodium carboxymethyl cellulose in benzene. After the formation of an independent solid phase after streptocide formation, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.325 g of microcapsules obtained. The yield was 81%.

EXAMPLE 42. Obtaining microcapsules of ampicillin in sodium carboxymethyl cellulose, ratio 1: 3

To 6 g of a 5% solution of sodium carboxymethyl cellulose in benzene, 0.01 g of the preparation E472c was added as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of ampicillin is dissolved in 0.5 ml of DMSO and transferred to a solution of sodium carboxymethyl cellulose in benzene. After the formation of an independent solid phase after ampicillin formation, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride. 0.330 g of microcapsules obtained. The yield was 83%.

EXAMPLE 43. Obtaining microcapsules of benzylpenicillin in sodium carboxymethyl cellulose, ratio 1: 3

To 6 g of a 5% solution of sodium carboxymethyl cellulose in benzene, 0.01 g of the preparation E472c was added as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of benzylpenicillin is dissolved in 0.5 ml of DMSO and transferred to a solution of sodium carboxymethyl cellulose in benzene. After formation of an independent solid phase after the formation of benzylpenicillin, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.320 g of microcapsules obtained. The yield was 80%.

EXAMPLE 44. Obtaining microcapsules of streptomycin in sodium carboxymethyl cellulose, ratio 1: 3

To 6 g of a 5% solution of sodium carboxymethyl cellulose in benzene, 0.01 g of the preparation E472c was added as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of streptomycin is dissolved in 0.5 ml of DMSO and transferred to a solution of sodium carboxymethyl cellulose in benzene. After the formation of an independent solid phase after streptomycin formation, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.340 g of microcapsules obtained. The yield was 85%.

EXAMPLE 45. Obtaining microcapsules of streptocide in sodium alginate, ratio 1: 3

To 6 g of a 5% solution of sodium alginate in benzene, add 0.01 g of the preparation E472c as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of streptocide is dissolved in 0.5 ml of DMSO and transferred to a solution of sodium alginate in benzene. After the formation of an independent solid phase after streptocide formation, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.320 g of microcapsules obtained. The yield was 80%.

EXAMPLE 46. Obtaining microcapsules of streptomycin in sodium alginate, ratio 1: 3

To 6 g of a 5% solution of sodium alginate in benzene, add 0.01 g of the preparation E472c as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of streptomycin is dissolved in 0.5 ml of DMSO and transferred to a solution of sodium alginate in benzene. After the formation of an independent solid phase after streptomycin formation, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.330 g of microcapsules obtained. The yield was 83%.

EXAMPLE 47. Obtaining microcapsules of ampicillin in sodium alginate, the ratio of 1: 3

To 6 g of a 5% solution of sodium alginate in benzene, add 0.01 g of the preparation E472c as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of ampicillin is dissolved in 0.5 ml of DMSO and transferred to a solution of sodium alginate in benzene. After the formation of an independent solid phase after the formation of ampicillin, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

0.345 g of microcapsules obtained. The yield was 86%.

EXAMPLE 48. Obtaining microcapsules of benzylpenicillin in sodium alginate, ratio 1: 3

To 6 g of a 5% solution of sodium alginate in benzene, add 0.01 g of the preparation E472c as a surfactant. The resulting mixture is placed on a magnetic stirrer and include stirring. 0.1 g of benzylpenicillin is dissolved in 0.5 ml of DMSO and transferred to a solution of sodium alginate in benzene. After the formation of an independent solid phase after the formation of benzylpenicillin, 1 ml of distilled water is added very slowly dropwise. The resulting suspension of microcapsules is filtered on a 16-class pore filter, washed with acetone, dried in a desiccator over calcium chloride.

Received 0.350 g of microcapsules. The yield was 88%.

Received microcapsules of drugs, polysaccharides, herbicides, flavorings, vitamins. In the above examples, casings suitable for use in the food industry were used. Most of the preparations whose microencapsulation is given in the examples are liquids. Microencapsulation of liquids is a rather difficult task, since it is necessary to select the conditions for the formation of microcapsules of a liquid substance. In this case, this problem is solved.

The proposed method is suitable for the pharmaceutical, agricultural, food industry due to minimal losses, speed, ease of obtaining and isolation of microcapsules in high yield. Thus, it is universal.

Claims (1)

A method of producing microcapsules, characterized in that the preparation of microcapsules is carried out by the physicochemical method of precipitation with a non-solvent using benzene as a precipitant.