RU2552343C1 - Method of producing lithium chloride microcapsules having supramolecular properties - Google Patents

Abstract

FIELD: chemistry.

SUBSTANCE: invention relates to encapsulation. A method of producing lithium chloride microcapsules in a sodium alginate envelope comprises: adding a suspension of lithium chloride in benzene to a suspension of sodium alginate in butanol in the presence of an E472c preparation while stirring at 1200 rps; the lithium chloride and said polymer are taken in weight ratio of 1:1 or 1:3; adding chloroform; and filtering and drying the obtained suspension of microcapsules. The process of producing the microcapsules is carried out at room temperature for 10 minutes.

EFFECT: method provides a simple and fast process of producing microcapsules and increases mass output.

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Description

The invention relates to the field of encapsulation and can be used in pharmaceuticals and animal husbandry.

Previously known methods for producing microcapsules of salts.

In US Pat. 2359662, IPC A61K 009/56, A61J 003/07, B01J 013/02, A23L 001/00, published June 27, 2009, Russian Federation, a method for producing sodium chloride microcapsules using spray cooling in a Niro spray cooling tower under the following conditions: inlet air temperature 10 ° C; outlet air temperature 28 ° C; spray drum rotation speed 10,000 rpm. The microcapsules of the invention have improved stability and provide controlled and / or prolonged release of the active ingredient.

The disadvantages of the proposed method are the duration of the process and the use of special equipment, a set of certain conditions (air temperature at the inlet 10 ° C, air temperature at the outlet 28 ° C, rotation speed of the spray drum 10,000 rpm).

The closest method is the method proposed in US Pat. 2134967, IPC A01N 53/00, A01N 25/28, publ. 27.08.1999, Russian Federation (1999). A solution of a mixture of natural lipids and a pyrethroid insecticide in a weight ratio of 2-4: 1 in an organic solvent is dispersed in water, which simplifies the microencapsulation method.

The disadvantage of this method is dispersion in an aqueous medium, which makes the proposed method inapplicable for producing microcapsules of water-soluble preparations in water-soluble polymers.

The technical task is to simplify and accelerate the process of obtaining microcapsules, reducing losses when receiving microcapsules (increase in yield by mass).

The solution of the technical problem is achieved by the method of producing lithium chloride microcapsules with supramolecular properties, characterized in that sodium alginate is used as the shell of the microcapsules in the preparation of encapsulated particles by non-solvent deposition using chloroform as a precipitant, the process of producing microcapsules is carried out without special equipment.

A distinctive feature of the proposed method is the preparation of microcapsules by non-solvent precipitation using chloroform as a precipitant, as well as the use of sodium alginate as a particle shell.

The result of the proposed method is to obtain microcapsules of salts in a biopolymer shell.

Figure 1 shows the self-organization of microcapsules of lithium chloride in sodium alginate at a concentration of 0.5%: an increase of 505 times.

Figure 2 shows the self-organization of microcapsules of lithium chloride in sodium alginate at a concentration of 0.25%: an increase of 505 times.

Figure 3 presents the self-organization of microcapsules of lithium chloride in sodium alginate at a concentration of 0.125%: an increase of 505 times.

EXAMPLE 1. Obtaining microcapsules of lithium chloride in sodium alginate

A suspension of 1 g of lithium chloride in benzene is added to a suspension of sodium alginate in butanol containing the indicated 3 g of polymer in the presence of 0.01 g of the preparation E472c (glycerol ester with one or two molecules of food fatty acids and one or two molecules of citric acid, with citric the acid, as tribasic, can be esterified with other glycerides and as the acid with other fatty acids. Free acid groups can be neutralized with sodium) with stirring 1200 r / s. Then 10 ml of chloroform are poured. The resulting suspension is filtered and dried at room temperature.

0.396 g of microcapsule powder obtained. The yield was 99%.

EXAMPLE 2. Obtaining microcapsules of lithium chloride in sodium alginate

A suspension of 1 g of lithium chloride in benzene is added to a suspension of sodium alginate in butanol containing the indicated 1 g of polymer in the presence of 0.01 g of the preparation E472c (glycerol ester with one or two molecules of food fatty acids and one or two molecules of citric acid, with citric the acid, as tribasic, can be esterified with other glycerides and as the acid with other fatty acids. Free acid groups can be neutralized with sodium) with stirring 1200 r / s. Then pour 6 ml of chloroform. The resulting suspension is filtered and dried at room temperature.

Received 2 g of microcapsule powder. The yield was 100%.

EXAMPLE 3. The study of self-organization of microcapsules from solutions

Aqueous solutions of concentrations of 1%, 0.5%, 0.25%, 0.125%, etc., were prepared from the microcapsule powder obtained by the methods described in examples 1, 2 by diluting the solution in half. A drop of each of the prepared solutions was placed on a glass slide until completely dried, and confocal scanning microscopy was performed on the dried surface.

Thus, microcapsules of lithium chloride were obtained in high yields without special equipment for 10 minutes. The formation of microcapsules occurs spontaneously due to non-covalent interactions and this suggests that they are characterized by self-assembly. Presented in FIG. 1-3 structures are ordered, which means they have self-organization. Therefore, lithium chloride encapsulated with sodium alginate has supramolecular properties.

Claims (1)

A method of producing microcapsules of lithium chloride in a shell of sodium alginate, characterized in that a suspension of lithium chloride in benzene is added to a suspension of sodium alginate in butanol in the presence of E472c with stirring at 1200 r / s, lithium chloride and the specified polymer are taken in a mass ratio of 1: 1 or 1: 3, then chloroform is poured, the resulting suspension of microcapsules is filtered off and dried, while the process of obtaining microcapsules is carried out at room temperature for 10 minutes.

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