RU2554741C2 - Method of ferrocene encapsulation - Google Patents

Abstract

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to the field of medicine and describes a method of obtaining ferrocene microcapsules, where xanthan gum is used as an envelope for the microcapsules, characterised by the fact that a suspension of 100 mg of ferrocene in 2 ml of benzene is dispersed into a suspension of xanthan gum in the presence of 0.01 g of E472 c preparation with mixing, with the addition of 5 ml of acetone and 0.5 ml of water; the obtained suspension is filtered and dried at room temperature.

EFFECT: invention provides the simplification and acceleration of the process of obtaining the microcapsules and increase of output by weight.

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Description

The invention relates to the field of encapsulation.

Previously known methods for producing microcapsules of salts.

In US Pat. 2359662, IPC A61K 009/56, A61J 003/07, B01J 013/02, A23L 001/00, published June 27, 2009. The Russian Federation proposes a method for producing microcapsules of sodium chloride using spray cooling in a Niro spray cooling tower under the following conditions: air temperature at the inlet 10 ° C, outlet air temperature 28 ° C, the rotation speed of the spray drum 10,000 rpm. The microcapsules of the invention have improved stability and provide controlled and / or prolonged release of the active ingredient.

The disadvantages of the proposed method are the duration of the process and the use of special equipment, a set of certain conditions (air temperature at the inlet 10 ° C, air temperature at the outlet 28 ° C, rotation speed of the spray drum 10,000 rpm).

The closest method is the method proposed in US Pat. 2134967, IPC A01N 53/00, A01N 25/28, published on 08.27.1999, Russian Federation (1999). A solution of a mixture of natural lipids and a pyrethroid insecticide in a weight ratio of 2-4: 1 in an organic solvent is dispersed in water, which simplifies the microencapsulation method.

The disadvantage of this method is dispersion in an aqueous medium, which makes the proposed method inapplicable for producing microcapsules of water-soluble preparations in water-soluble polymers.

The technical task is to simplify and accelerate the process of obtaining microcapsules, reducing losses when receiving microcapsules (increase in yield by mass).

The solution of the technical problem is achieved by the method of encapsulation of ferrocene, characterized in that xanthan gum is used as the shell of the microcapsules in the preparation of encapsulated particles by non-solvent deposition using benzene and acetone as precipitators, the microcapsule production process is carried out without special equipment.

A distinctive feature of the proposed method is the preparation of microcapsules by non-solvent precipitation using benzene and acetone as precipitators, as well as the use of xanthan gum as a particle shell and which have supramolecular properties.

The result of the proposed method is the preparation of microcapsules of salts in a water-soluble polymer shell.

Figure 1 - confocal image of the fractal composition from a solution of microcapsules of ferrocene in the shell of xanthan gum at a concentration of 0.125%, an increase of 1200 times.

EXAMPLE 1. Obtaining microcapsules of ferrocene

A suspension of 100 mg of ferrocene in 2 ml of benzene is dispersed in a suspension of xanthan gum in benzene containing 300 mg of the polymer in the presence of 0.01 g of the preparation E472 s (glycerol ester with one or two molecules of food fatty acids and one or two molecules of citric acid, moreover citric acid, as tribasic, can be esterified with other glycerides and as an acid with other fatty acids. Free acid groups can be neutralized with sodium) with stirring at 1200 r / sec. Next, 5 ml of acetone and 0.5 ml of water are poured. The resulting suspension is filtered and dried at room temperature.

0.368 g of microcapsule powder obtained. The yield was 92%.

EXAMPLE 2. The study of self-organization of microcapsules from solutions

From the microcapsule powder obtained by the procedure described in example 1, aqueous solutions were prepared with concentrations of 1%, 0.5%, 0.25%, 0.125%, etc. by diluting the solution in half. A drop of each of the prepared solutions was placed on a glass slide until completely dried, and confocal scanning microscopy was performed on the dried surface.

Thus, microcapsules of ferrocene were obtained in high yield without special equipment for 10 min. The formation of microcapsules occurs spontaneously due to non-covalent interactions and this suggests that they are characterized by self-assembly. The structures shown in FIG. 1 are ordered, which means they have self-organization. Therefore, ferrocene encapsulated with carrageenan has supramolecular properties.

Microcapsules of salts with sufficiently high yields were obtained. The proposed technique is quite suitable for use on an industrial scale due to minimal losses and ease of implementation.

Claims (1)

A method for producing microcapsules of ferrocene, where xanthan gum is used as a shell of microcapsules, characterized in that a suspension of 100 mg of ferrocene in 2 ml of benzene is dispersed in a suspension of xanthan gum in the presence of 0.01 g of the preparation E472 s with stirring, 5 ml of acetone and 0 are added, 5 ml of water, the resulting suspension is filtered and dried at room temperature.

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