DE60024612D1 - Verfahren zur herstellung von konditionierten zellkulturmedium-zusammensetzungen - Google Patents

Verfahren zur herstellung von konditionierten zellkulturmedium-zusammensetzungen

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Publication number
DE60024612D1
DE60024612D1 DE60024612T DE60024612T DE60024612D1 DE 60024612 D1 DE60024612 D1 DE 60024612D1 DE 60024612 T DE60024612 T DE 60024612T DE 60024612 T DE60024612 T DE 60024612T DE 60024612 D1 DE60024612 D1 DE 60024612D1
Authority
DE
Germany
Prior art keywords
medium
conditioned
cell culture
culture medium
medium compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60024612T
Other languages
English (en)
Other versions
DE60024612T2 (de
Inventor
K Naughton
L Horwitz
A Applegate
Joan Zeltinger
N Mansbridge
Andreas Kern
K Landeen
Anthony Ratcliffe
Emmett Pinney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SkinMedica Inc
Original Assignee
SkinMedica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23216124&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60024612(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by SkinMedica Inc filed Critical SkinMedica Inc
Application granted granted Critical
Publication of DE60024612D1 publication Critical patent/DE60024612D1/de
Publication of DE60024612T2 publication Critical patent/DE60024612T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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Families Citing this family (320)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6667176B1 (en) * 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
US7410798B2 (en) * 2001-01-10 2008-08-12 Geron Corporation Culture system for rapid expansion of human embryonic stem cells
US20030007954A1 (en) * 1999-04-12 2003-01-09 Gail K. Naughton Methods for using a three-dimensional stromal tissue to promote angiogenesis
US6372494B1 (en) * 1999-05-14 2002-04-16 Advanced Tissue Sciences, Inc. Methods of making conditioned cell culture medium compositions
WO2001014527A1 (en) * 1999-08-23 2001-03-01 Organogenesis Inc. Skin care compositions and treatments
DE10005329A1 (de) * 2000-02-08 2001-09-20 Albert Scheller Humanisiertes, vitalisiertes Haarbewachsen und Haarwiederbewachsen mit subkutanen Kanüleneinstich-Haut-Färbungs-Zeichnungsverfahren
IL136232A0 (en) * 2000-05-18 2001-05-20 Bar Ilan University Res Author Measurements of enzymatic activity in a single, individual cell in population
WO2001091773A2 (en) * 2000-05-31 2001-12-06 Encelle, Inc. Method of stimulating hair growth
CA2435826A1 (en) * 2001-01-24 2002-08-01 The Government Of The United States Of America Differentiation of stem cells to pancreatic endocrine cells
US20030211605A1 (en) * 2001-05-01 2003-11-13 Lee Sang-Hun Derivation of midbrain dopaminergic neurons from embryonic stem cells
US7160726B2 (en) * 2001-06-07 2007-01-09 Skin Medica, Inc. Compositions comprising conditioned cell culture media and uses thereof
JP2003012525A (ja) * 2001-07-02 2003-01-15 Hoshizaki Electric Co Ltd 生体の損傷部位用の洗浄水およびその製造装置
US20030068297A1 (en) * 2001-08-18 2003-04-10 Deepak Jain Composition and methods for skin rejuvenation and repair
US20040265268A1 (en) * 2001-08-18 2004-12-30 Deepak Jain Compositions and methods for skin rejuvenation and repair
JP4192097B2 (ja) * 2001-10-25 2008-12-03 バル−イラン ユニバーシティ 相互作用型透明個別細胞バイオチッププロセッサー
JP2005519591A (ja) * 2001-12-31 2005-07-07 イソラゲン テクノロジーズ,インコーポレーテッド 毛包成長
EP1521821A2 (de) * 2002-07-16 2005-04-13 Biogentis Inc. Verfahren zur herstellung von artifiziellem gewebe
WO2004011631A2 (en) * 2002-07-26 2004-02-05 Ebi, L.P. Methods and compositions for treating tissue defects using pulsed electromagnetic field stimulus
US20050019747A1 (en) * 2002-08-07 2005-01-27 Anderson Daniel G. Nanoliter-scale synthesis of arrayed biomaterials and screening thereof
US7338433B2 (en) 2002-08-13 2008-03-04 Allergan, Inc. Remotely adjustable gastric banding method
CA2495535A1 (en) * 2002-08-22 2004-03-04 Celltran Limited Cell culture surface
DE60331457D1 (de) 2002-08-28 2010-04-08 Allergan Inc Ermüdungsfeste magenbandvorrichtung
WO2004044188A1 (en) * 2002-11-14 2004-05-27 Intercytex Limited Cultivation of hair inductive cells
IL154677A0 (en) * 2003-02-27 2003-09-17 Univ Bar Ilan A method and apparatus for manipulating an individual cell
DE602004029337D1 (de) * 2003-04-01 2010-11-11 Us Dept Of Veteran S Affaires Auf stammzellen, vorläuferzellen oder targetzellen basierende behandlung von multiorganversagen.
FR2861734B1 (fr) 2003-04-10 2006-04-14 Corneal Ind Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus
FR2853905A1 (fr) * 2003-04-15 2004-10-22 Corbin Assia Eljaafari Production de cellules dendritiques humaines derivees de monocytes, a l'aide de cellules souches mesenchymateuses
EP1475434A1 (de) * 2003-05-09 2004-11-10 Oncoscience AG Verfahren zur Lagerung von Tumorzellen
EP1635782A1 (de) * 2003-05-24 2006-03-22 JUVENA (International) AG Gewebekulturmedien als bestandteil von kosmetika
US9200245B2 (en) 2003-06-26 2015-12-01 Seng Enterprises Ltd. Multiwell plate
US8597597B2 (en) * 2003-06-26 2013-12-03 Seng Enterprises Ltd. Picoliter well holding device and method of making the same
US20060240548A1 (en) * 2003-06-26 2006-10-26 Mordechai Deutsch Materials for constructing cell-chips, cell-chip covers, cell-chips coats, processed cell-chips and uses thereof
US7888110B2 (en) * 2003-06-26 2011-02-15 Seng Enterprises Ltd. Pico liter well holding device and method of making the same
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells
US8518390B2 (en) 2003-06-27 2013-08-27 Advanced Technologies And Regenerative Medicine, Llc Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
US8790637B2 (en) * 2003-06-27 2014-07-29 DePuy Synthes Products, LLC Repair and regeneration of ocular tissue using postpartum-derived cells
US7875272B2 (en) * 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
PL1641914T3 (pl) 2003-06-27 2017-01-31 DePuy Synthes Products, Inc. Komórki pochodzące z poporodowej tkanki łożyska oraz sposoby uzyskiwania i zastosowania tych komórek
US8491883B2 (en) * 2003-06-27 2013-07-23 Advanced Technologies And Regenerative Medicine, Llc Treatment of amyotrophic lateral sclerosis using umbilical derived cells
WO2005008626A1 (en) * 2003-07-11 2005-01-27 University Of North Carolina At Chapel Hill Methods and systems for controlling a computer using a video image and for combining the video image with a computer desktop
IL156945A0 (en) * 2003-07-15 2004-02-08 Itzhak Tavori Device and a method for orthopedic delivery of bone reconstruction medium
US20050064524A1 (en) * 2003-08-11 2005-03-24 Mordechai Deutsch Population of cells utilizable for substance detection and methods and devices using same
ITRM20030395A1 (it) * 2003-08-12 2005-02-13 Istituto Naz Per Le Malattie Infettive Lazz Terreno di coltura per il mantenimento, la proliferazione e il differenziamento di cellule di mammifero.
US20060198800A1 (en) * 2003-08-14 2006-09-07 Natalie Dilallo Skin care compositions including hexapeptide complexes and methods of their manufacture
WO2005016364A1 (en) * 2003-08-14 2005-02-24 Guthy-Renker Corporation Skin care composition including hexapeptide complexes and methods of their manufacture
WO2005062791A2 (en) * 2003-12-20 2005-07-14 Jeffrey Sebastian Utilization of stem cell and fibroblast combined products and nutrients in topical compositions
AU2005208721B2 (en) 2004-01-23 2010-09-23 Boston Scientific Scimed, Inc. Releasably-securable one-piece adjustable gastric band
CA2554927A1 (en) * 2004-02-03 2005-08-18 Chemagis Ltd. Stable amorphous forms of montelukast sodium
WO2005076845A2 (en) * 2004-02-06 2005-08-25 Theradigm, Inc. Compositions and methods relating to culturing neural stem cells with bone marrow stromal cells
CA2559056A1 (en) 2004-03-08 2005-09-22 Endoart S.A. Closure system for tubular organs
US20080063251A1 (en) * 2004-07-07 2008-03-13 Mordechai Deutsch Method and Device for Identifying an Image of a Well in an Image of a Well-Bearing
US7403647B2 (en) * 2004-09-13 2008-07-22 Seng Enterprises Ltd. Method for identifying an image of a well in an image of a well-bearing component
EP1781404A2 (de) * 2004-08-25 2007-05-09 Seng Enterprises Limited Verfahren und vorrichtung zur isolierung von zellen
WO2006026617A2 (en) * 2004-08-30 2006-03-09 Iken Tissue Therapeutics, Inc. Compositions and methods of promoting hair growth
EP1802742A2 (de) * 2004-08-30 2007-07-04 IKEN Tissue Therapeutics, Inc. Zusammensetzungen und verfahren zur förderung von haarwachstum
CN101432420A (zh) * 2004-09-08 2009-05-13 心肌治疗有限公司 用于血管生成治疗的自体或异源祖细胞的条件培养基
CA2584553A1 (en) * 2004-09-17 2006-03-23 Cellgentech, Inc. External agent for treatment of skin ulcer
US20060095121A1 (en) * 2004-10-28 2006-05-04 Medtronic Vascular, Inc. Autologous platelet gel on a stent graft
US7993578B2 (en) * 2004-10-29 2011-08-09 Depuy Spine, Inc. Methods and kits for aseptic filling of products
US20060171930A1 (en) * 2004-12-21 2006-08-03 Agnieszka Seyda Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same
WO2006083394A2 (en) * 2004-12-21 2006-08-10 Ethicon, Inc. Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same
US20060153815A1 (en) * 2004-12-21 2006-07-13 Agnieszka Seyda Tissue engineering devices for the repair and regeneration of tissue
ES2621847T3 (es) 2004-12-23 2017-07-05 DePuy Synthes Products, Inc. Células posparto derivadas de tejido de cordón umbilical, y métodos de elaboración y uso de las mismas
PL1835924T3 (pl) 2004-12-23 2014-01-31 Ethicon Incorporated Leczenie choroby Parkinsona i zaburzeń związanych z tą chorobą z użyciem komórek uzyskiwanych po porodzie
WO2006080000A1 (en) * 2005-01-25 2006-08-03 Seng Enterprises Ltd. Device for the studying individual cells
US8153430B2 (en) * 2005-03-31 2012-04-10 Stemnion, Inc. Methods related to surgery
CN103356703B (zh) 2005-03-31 2016-04-06 斯丹姆涅恩有限公司 制备用以治疗慢性感染伤口的药物的方法
US8251888B2 (en) 2005-04-13 2012-08-28 Mitchell Steven Roslin Artificial gastric valve
US20090075375A1 (en) * 2005-04-18 2009-03-19 Neurotrophincell Pty Limited Choroid plexus preparation and uses thereof
NZ536009A (en) * 2005-04-18 2007-01-26 Neurotrophincell Pty Ltd Choroid plexus preparation and uses thereof
BRPI0520280A2 (pt) * 2005-05-10 2009-04-28 Us Of America Dept Of Veteran terapia de disfunÇÕes renais e falÊncia méltipla de àrgços com cÉlulas-tronco mesenquimais e meio condicionado por exposiÇço a cÉlulas-tronco mesenquimais
NZ540597A (en) * 2005-06-08 2007-02-23 Neurotrophincell Pty Ltd A method for preventing the onset of type I diabetes comprising administering an implantable composition comprising living choroid plexus cells
WO2007001351A1 (en) * 2005-06-17 2007-01-04 Iken Tissue Therapeutics, Inc. Methods for treating ischemic tissue
US20070004036A1 (en) * 2005-07-01 2007-01-04 Rodolfo Faudoa Methods and compositions for keratinocyte culture
US20070003541A1 (en) * 2005-07-01 2007-01-04 Rodolfo Faudoa Methods and compositions for therapeutics
US20070128685A1 (en) * 2005-07-01 2007-06-07 Rodolfo Faudoa Methods and compositions for cell culture
DE102005034043B4 (de) * 2005-07-18 2019-12-12 Südzucker Aktiengesellschaft Mannheim/Ochsenfurt Gemisch, enthaltend L-Carnitin und Trehalulose, sowie Produkt enthaltend das Gemisch
US20070141555A1 (en) * 2005-10-11 2007-06-21 Mordechai Deutsch Current damper for the study of cells
WO2007052245A1 (en) * 2005-11-03 2007-05-10 Seng Enterprises Ltd. Method and device for studying floating, living cells
US20070231901A1 (en) * 2005-12-02 2007-10-04 Shuichi Takayama Microfluidic cell culture media
CN101379182A (zh) * 2005-12-14 2009-03-04 器官发生有限公司 皮肤护理组合物以及处理
EP1971681B1 (de) * 2005-12-16 2017-08-23 DePuy Synthes Products, Inc. Produkte und methoden zu verhinderung schädlicher immunantworten bei histo-incompatiblen transplantationen
US8741638B2 (en) * 2005-12-19 2014-06-03 DePuy Synthes Products, LLC In vitro expansion of postpartum-derived cells in roller bottles
AU2006330409B2 (en) * 2005-12-28 2012-07-19 Ethicon, Incorporated Treatment of peripheral vascular disease using postpartum-derived cells
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
US8043206B2 (en) 2006-01-04 2011-10-25 Allergan, Inc. Self-regulating gastric band with pressure data processing
US8871198B2 (en) * 2006-03-29 2014-10-28 Stemnion, Inc. Methods related to wound healing
KR100955212B1 (ko) * 2006-01-27 2010-04-29 (주)프로스테믹스 지방유래 줄기세포를 이용한 성장인자의 대량 생산방법
WO2007092902A2 (en) * 2006-02-07 2007-08-16 Organogenesis, Inc. Bioengineered tissue constructs and cardiac uses thereof
CA2642664A1 (en) * 2006-02-16 2007-08-30 Burnham Institute For Medical Research Media conditioned by human embryonic stem cells or other progenitor cells and uses therefor
US20110091568A1 (en) * 2006-02-16 2011-04-21 Lipton Stuart A Media conditioned by stem cells and uses therefor
WO2007114740A2 (fr) * 2006-04-04 2007-10-11 Trans-Technologies Ltd Transplant biologique destiné à la thérapie cellulaire à base de cellules souches mésenchymateuses, obtenues à partir de la moelle osseuse
US20060223999A1 (en) * 2006-05-10 2006-10-05 Chemagis Ltd. Process for preparing montelukast and precursors thereof
FR2901136B1 (fr) * 2006-05-18 2010-10-01 Centre Nat Rech Scient Utilisation de cellules derivees du tissu adipeux pour la preparation d'un medicament anti-tumoral
US20080027212A1 (en) * 2006-06-28 2008-01-31 Skinner Keith K Methods and compositions for improved uptake of biological molecules
WO2008008550A2 (en) * 2006-07-14 2008-01-17 National Stem Cell Inc. Compositions and methods for growing human embryonic stem cells
JP2007050263A (ja) * 2006-08-23 2007-03-01 Nipro Corp 生体組織または器官再生用器具
WO2008027984A1 (en) 2006-08-29 2008-03-06 Isolagen Technologies, Inc. Methods for culturing minimally-passaged fibroblasts and uses thereof
US9220803B2 (en) 2006-10-02 2015-12-29 Lars Lidgren Method of producing native components, such as growth factors or extracellular matrix proteins, through cell culturing of tissue samples for tissue repair
PL2578081T3 (pl) 2006-10-11 2016-09-30 Kompozycje, sposoby i urządzenia do leczenia chorób wątroby
WO2008067422A2 (en) * 2006-11-28 2008-06-05 Zgi, Inc. Replication of undifferentiated diploid cells in a weightless environment, uses thereof and a facility for such replication
WO2008066330A1 (en) 2006-11-30 2008-06-05 Medipost Co., Ltd. Use of a composition contaning human umbilical cord blood-derived mesenchymal stem cell for inducing differentiation and proliferation of neural precursor cells or neural stem cells to neural cells
US20080311093A1 (en) * 2006-12-07 2008-12-18 American Symbolic, Llc Stem cell secretions and related methods
WO2008070868A1 (en) * 2006-12-07 2008-06-12 American Symbolic, Llc Stem cell secretions and related methods
WO2008082524A1 (en) * 2006-12-19 2008-07-10 National Stem Cell Inc. Embryonic germ cell secreted product derived topical compositions and methods of use thereof
US20100130415A1 (en) * 2006-12-19 2010-05-27 Michael Cohen Stem cell secreted product derived compositions for wound treatment
RU2341270C2 (ru) * 2006-12-28 2008-12-20 Александр Сергеевич Ботин Композиция для стимулирования роста и регенерации клеток, а также способы ее получения
WO2008088738A2 (en) 2007-01-17 2008-07-24 Stemnion, Inc. Novel methods for modulating inflammatory and/or immune responses
KR100883565B1 (ko) * 2007-02-14 2009-02-13 (주)프로스테믹스 지방 줄기세포의 조직 재생 능력을 최적화한 조건 배지를 함유한 조직 재생용 주사제 첨가제
AU2008218998A1 (en) * 2007-02-23 2008-08-28 Advanced Cell Technology, Inc. Highly efficient methods for reprogramming differentiated cells and for generating animals and embryonic stem cells from reprogrammed cells
EP2139447A2 (de) * 2007-03-20 2010-01-06 Harold Brem Gm-csf-kosmezeutikazusammensetzungen und verfahren zu ihrer verwendung
RU2007112288A (ru) * 2007-04-03 2008-10-10 Александр Сергеевич Ботин (RU) Композиция для стимулирования роста и регенерации клеток, а также способ ее получения
CA2629652A1 (en) * 2007-04-24 2008-10-24 Yaojiong Wu Compositions for preventing or treating skin defects and methods of use thereof
EP2152743A2 (de) * 2007-05-23 2010-02-17 Allergan, Inc. Quervernetztes collagen und anwendungen davon
WO2008156659A1 (en) 2007-06-18 2008-12-24 Children's Hospital & Research Center At Oakland Method of isolating stem and progenitor cells from placenta
US20100129328A1 (en) * 2007-07-24 2010-05-27 Sing George L Methods for promoting hair growth
KR100848056B1 (ko) * 2007-07-30 2008-07-23 (주)프로스테믹스 줄기세포 배양액을 이용한 멜라닌 합성저해 방법
US8318695B2 (en) * 2007-07-30 2012-11-27 Allergan, Inc. Tunably crosslinked polysaccharide compositions
BRPI0818183A2 (pt) * 2007-10-05 2019-07-16 Ethicon Inc reparo e regeneração do tecido renal usando células derivadas do tecido do cordão umbilical humano
US8697044B2 (en) 2007-10-09 2014-04-15 Allergan, Inc. Crossed-linked hyaluronic acid and collagen and uses thereof
US9145540B1 (en) 2007-11-15 2015-09-29 Seng Enterprises Ltd. Device for the study of living cells
PL2818184T3 (pl) 2007-11-16 2019-06-28 Aclaris Therapeutics, Inc. Kompozycje i sposoby do leczenia plamicy
US8394784B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having multi-stage bioactive agent delivery
US8394782B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
US20090143348A1 (en) * 2007-11-30 2009-06-04 Ahmet Tezel Polysaccharide gel compositions and methods for sustained delivery of drugs
US8236538B2 (en) * 2007-12-20 2012-08-07 Advanced Technologies And Regenerative Medicine, Llc Methods for sterilizing materials containing biologically active agents
EP2237887A2 (de) 2007-12-26 2010-10-13 Seng Enterprises Ltd. Vorrichtung zur untersuchung von lebenden zellen
EP2222327B1 (de) * 2007-12-28 2017-02-15 Augustinus Bader Topische anwendung und formulierung von erythropoietin für die wundheilung der haut
US8530415B2 (en) * 2008-01-30 2013-09-10 Histogen, Inc. Repair and/or regeneration of cells with a composition produced by culturing fibroblast cells under hypoxic conditions
US20100166824A1 (en) * 2008-01-30 2010-07-01 Histogen, Inc. Extracellular matrix compositions
SG10201906494PA (en) * 2008-01-30 2019-09-27 Histogen Inc Extracellular matrix compositions
US8524494B2 (en) 2008-01-30 2013-09-03 Histogen, Inc. Low oxygen tension and BFGF generates a multipotent stem cell from a fibroblast in vitro
US8535913B2 (en) * 2008-01-30 2013-09-17 Histogen, Inc. Soluble composition for promoting hair growth produced by hypoxic culture of fibroblasts cells
CA2719981A1 (en) * 2008-03-31 2009-10-08 Scarcell Therapeutics Method for the cosmetic treatment of skin ageing
WO2009124170A1 (en) * 2008-04-04 2009-10-08 The Cleveland Clinic Foundation Use of epineural sheath grafts for neural regeneration and protection
KR101237430B1 (ko) * 2008-05-07 2013-02-26 남명진 줄기세포 배양액을 포함하는 화장료 조성물 및 이의 제조방법
EP2296672B1 (de) 2008-06-11 2015-09-16 Fresenius Medical Care Deutschland GmbH Konditioniertes medium von lebervorläuferzellen
CN105381506A (zh) * 2008-06-26 2016-03-09 耐贝医药株式会社 用于鼓膜或外耳道再生的试剂
US20110110888A1 (en) * 2008-06-27 2011-05-12 Hai-Qing Xian Scaffold Coated and/or Impregnated with at Least One Bioactive Agent for Tissue Repair and Other Medical Applications
WO2010003104A2 (en) * 2008-07-02 2010-01-07 Allergan, Inc. Compositions and methods for tissue filling and regeneration
US8450475B2 (en) * 2008-08-04 2013-05-28 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
US8497412B2 (en) * 2008-08-29 2013-07-30 Arborgen, Llc Loblolly pine tree named ‘96GE0034’
US20100058493A1 (en) * 2008-08-29 2010-03-04 Arborgen, Llc Loblolly pine tree named '01NQ0026'
JP5722217B2 (ja) 2008-09-02 2015-05-20 アラーガン・ホールディングス・フランス・ソシエテ・パール・アクシオン・サンプリフィエAllergan Holdings France S.A.S. ヒアルロン酸および/またはその誘導体の糸、その作製方法、ならびにその使用
US9216188B2 (en) * 2008-09-04 2015-12-22 The General Hospital Corporation Hydrogels for vocal cord and soft tissue augmentation and repair
WO2010038232A1 (en) * 2008-10-05 2010-04-08 Hymie Friedlander Extract from conditioned medium cultured by regenerative cells
US20100305397A1 (en) * 2008-10-06 2010-12-02 Allergan Medical Sarl Hydraulic-mechanical gastric band
US8431801B2 (en) * 2008-10-08 2013-04-30 Arborgen Inc. Loblolly pine tree named ‘01PM0212’
US20100185049A1 (en) 2008-10-22 2010-07-22 Allergan, Inc. Dome and screw valves for remotely adjustable gastric banding systems
AU2009314506B2 (en) 2008-11-14 2015-07-23 Histogen, Inc. Extracellular matrix compositions for the treatment of cancer
KR20100054711A (ko) * 2008-11-14 2010-05-25 메디포스트(주) 간엽 줄기세포 또는 이의 배양액을 포함하는 신경질환의 예방 또는 치료용 조성물
US20100143313A1 (en) * 2008-12-10 2010-06-10 The General Hospital Corporation Homogeneous differentiation of hepatocyte-like cells from embryonic stem cells
EP2198873A1 (de) * 2008-12-18 2010-06-23 Aposcience AG Pharmazeutisches Präparat, enthaltend den Überstand einer Blutmononuklearzellkultur
CA2747794C (en) 2008-12-19 2018-10-30 Advanced Technologies And Regenerative Medicine, Llc Treatment of lung and pulmonary diseases and disorders
EP2379089B1 (de) * 2008-12-19 2019-04-17 DePuy Synthes Products, Inc. Regeneration und reparatur von nervengeweben nach einer verletzung
US10179900B2 (en) * 2008-12-19 2019-01-15 DePuy Synthes Products, Inc. Conditioned media and methods of making a conditioned media
BRPI0923177A2 (pt) * 2008-12-19 2020-08-25 Advanced Technologies And Regenerative Medicine, Llc usos de composições para tratar dor neuropática e espacidade, as referidas composições, e kit
CA2748147C (en) * 2008-12-24 2017-06-20 Augustinus Bader Rapid preparation and use of engineered tissue and scaffolds as individual implants
US8771677B2 (en) * 2008-12-29 2014-07-08 Vladimir B Serikov Colony-forming unit cell of human chorion and method to obtain and use thereof
US20110294731A1 (en) * 2009-02-13 2011-12-01 Invitrx, Inc. Skin cream
KR101422690B1 (ko) * 2009-02-27 2014-07-23 (주)차바이오앤디오스텍 배아줄기세포 유래 혈관형성전구세포의 배양 분비물을 포함하는 피부재생용 조성물 및 이의 용도
US8574902B2 (en) 2009-03-05 2013-11-05 Macrocure Ltd. Activated leukocyte composition and uses for wound healing
KR101078419B1 (ko) * 2009-03-20 2011-10-31 주식회사 스템메디언스 양수 내 태아 유래 중간엽줄기세포를 이용한 피부 상태개선용 조성물
CA2756600C (en) 2009-03-26 2019-08-20 Advanced Technologies And Regenerative Medicine, Llc Human umbilical cord tissue cells as therapy for alzheimer's disease
FI20095355A0 (fi) * 2009-04-01 2009-04-01 Helsingin Yliopisto Regeneroituva aktiivinen matriisi ja sen käytöt
KR101422453B1 (ko) * 2009-04-16 2014-07-28 (주)차바이오앤디오스텍 제대혈 줄기세포 유래 혈관전구세포 배양액 또는 배양 분비물을 이용한 피부재생용 조성물 및 이의 용도
US8390326B2 (en) * 2009-05-05 2013-03-05 William Marsh Rice University Method for fabrication of a semiconductor element and structure thereof
PT2451964T (pt) * 2009-07-10 2018-05-07 Histogen Inc Meio condiconado e composições de matriz extracelular de células cultivadas sob condições hipóxicas
EP2456862A4 (de) * 2009-07-20 2013-02-27 Janssen Biotech Inc Differenzierung menschlicher embryonischer stammzellen
EP2473193A4 (de) * 2009-09-04 2013-05-01 Cleveland Clinic Foundation Verfahren zur nervengewebemanipulation
GB0916370D0 (en) 2009-09-18 2009-10-28 Avecia Biolog Ltd Compositions
US8790710B1 (en) 2009-10-02 2014-07-29 Novo Solutions, MD, L.L.C. Topical composition comprising umbilical cord blood serum
US20130058903A1 (en) * 2009-12-10 2013-03-07 Techung Lee Stem-Cell Material and Method of Use
US9114188B2 (en) 2010-01-13 2015-08-25 Allergan, Industrie, S.A.S. Stable hydrogel compositions including additives
US20110172180A1 (en) 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
US20110171311A1 (en) * 2010-01-13 2011-07-14 Allergan Industrie, Sas Stable hydrogel compositions including additives
US20110171286A1 (en) * 2010-01-13 2011-07-14 Allergan, Inc. Hyaluronic acid compositions for dermatological use
MX354068B (es) * 2010-01-14 2018-02-09 Organogenesis Inc Construcciones de tejido bio-diseñadas por ingenieria y metodos para la produccion y uso de las mismas.
MD191Z5 (ro) * 2010-01-21 2010-11-30 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Mediu nutritiv pentru cultivarea celulelor de origine animală
WO2011101760A1 (en) * 2010-02-18 2011-08-25 Biocell International Incorporated A method and composition for skin care comprising cord blood serum or plasma or components thereof
KR20110097064A (ko) * 2010-02-24 2011-08-31 (주) 아크스템 무혈청 줄기 세포 배양 조성물, 이를 함유한 조직 재생용 조성물 및 이를 이용한 조직 재생 방법
US8840541B2 (en) 2010-02-25 2014-09-23 Apollo Endosurgery, Inc. Pressure sensing gastric banding system
US9198568B2 (en) 2010-03-04 2015-12-01 The General Hospital Corporation Methods and systems of matching voice deficits with a tunable mucosal implant to restore and enhance individualized human sound and voice production
EP2544652A2 (de) 2010-03-12 2013-01-16 Allergan Industrie SAS Fluidzusammensetzung mit einem hyaluronanpolymer und mannitol zur verbesserung des hautzustandes
EP3520827B1 (de) 2010-03-22 2022-05-25 Allergan, Inc. Vernetzte hydrogele zur weichgewebevergrösserung
US8911963B2 (en) * 2010-04-05 2014-12-16 Medstar Health Research Institute, Inc. Conditioned medium obtained from stem cells and its use in therapy
US20110270024A1 (en) 2010-04-29 2011-11-03 Allergan, Inc. Self-adjusting gastric band having various compliant components
US9044298B2 (en) 2010-04-29 2015-06-02 Apollo Endosurgery, Inc. Self-adjusting gastric band
US9028394B2 (en) 2010-04-29 2015-05-12 Apollo Endosurgery, Inc. Self-adjusting mechanical gastric band
US20110300097A1 (en) * 2010-06-04 2011-12-08 Al-Qahtani Ahmed H Method And Composition For The Treatment Of Moderate To Severe Keratoconjunctivitis Sicca
US8877494B2 (en) * 2010-06-04 2014-11-04 Ahmed H. Al-Qahtani Human corneal epithelial cell line PTA-120527
US8517915B2 (en) 2010-06-10 2013-08-27 Allergan, Inc. Remotely adjustable gastric banding system
CN101879329A (zh) * 2010-06-21 2010-11-10 蒋明军 含基底膜的人工皮肤构建方法及人工皮肤
US8889123B2 (en) 2010-08-19 2014-11-18 Allergan, Inc. Compositions and soft tissue replacement methods
US9005605B2 (en) 2010-08-19 2015-04-14 Allergan, Inc. Compositions and soft tissue replacement methods
US8883139B2 (en) 2010-08-19 2014-11-11 Allergan Inc. Compositions and soft tissue replacement methods
US8697057B2 (en) 2010-08-19 2014-04-15 Allergan, Inc. Compositions and soft tissue replacement methods
CN103269684A (zh) * 2010-08-27 2013-08-28 法布罗赛尔科技公司 局部皮肤制剂
US20120059216A1 (en) 2010-09-07 2012-03-08 Allergan, Inc. Remotely adjustable gastric banding system
US9168287B2 (en) * 2010-09-09 2015-10-27 Macrocure, Ltd. Activated leukocyte conditioned supernatant and uses for wound healing
EP2625577B1 (de) 2010-10-08 2019-06-26 Terumo BCT, Inc. Anpassbares verfahren und systeme für züchtung und ernte von zellen in einem hohlfaser-bioreaktorsystem
WO2012051505A1 (en) * 2010-10-14 2012-04-19 Fibrocell Science, Inc. Treatment of vocal cords with autologous dermal fibroblast formulation
EP3527214A1 (de) 2010-11-12 2019-08-21 Allergan, Inc. Verstoffwechseltes konditioniertes wachstumsmedium und verfahren zur verwendung
RU2455354C1 (ru) * 2010-12-29 2012-07-10 Антонина Ивановна Колесникова Композиция для регенерации клеток кожи и слизистых оболочек
CN103732234A (zh) 2011-01-18 2014-04-16 斯丹姆涅恩有限公司 使伤口愈合的装置和方法
EP2670421B1 (de) 2011-02-02 2017-12-06 Medipost Co., Ltd. Verwendung von icam-1 zur prävention oder behandlung neurologischer erkrankungen
JP5981947B2 (ja) * 2011-03-04 2016-08-31 アル−カタニ, アーメッド・エイチAl−Qahtani, Ahmed H. スキンクリーム
US9119974B2 (en) * 2011-03-04 2015-09-01 Ahmed H. Al-Qahtani Skin cream
KR101349183B1 (ko) * 2011-03-14 2014-01-08 서울대학교산학협력단 3차원 세포배양으로 수득한 조건 배지를 유효성분으로 포함하는 허혈성 질환 치료용 약학적 조성물
US9446075B2 (en) 2011-05-06 2016-09-20 Bioregenerative Sciences Compositions derived from stem cell released molecules and methods for formulation thereof
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
KR102015676B1 (ko) 2011-06-03 2019-10-21 알러간, 인코포레이티드 항산화제를 포함하는 피부 충전제 조성물
CN102266586B (zh) * 2011-06-28 2013-12-04 江苏省人民医院 白癜风黑素细胞移植涂布载体系统的制备方法
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
US8876694B2 (en) 2011-12-07 2014-11-04 Apollo Endosurgery, Inc. Tube connector with a guiding tip
US8961394B2 (en) 2011-12-20 2015-02-24 Apollo Endosurgery, Inc. Self-sealing fluid joint for use with a gastric band
ES2676556T3 (es) 2011-12-23 2018-07-20 Depuy Synthes Products Llc Detección de células derivadas de tejido del cordón umbilical humano
US9782440B2 (en) * 2012-02-16 2017-10-10 The Cleveland Clinic Foundation Methods for treating genitourinary disorders
KR102126331B1 (ko) * 2012-02-23 2020-06-25 주식회사 탑셀바이오 컨디션드 배지 분말의 제조방법
US20130236427A1 (en) 2012-03-07 2013-09-12 Fibrocell Technologies, Inc. Topical Dermal Formulations and Methods of Personalized Treatment of Skin
US20130244948A1 (en) * 2012-03-15 2013-09-19 Scharp Technologies, Inc. Compositions of cells, media, and methods thereof
CN102600057B (zh) * 2012-03-16 2013-05-01 广州赛莱拉生物科技有限公司 人胎盘干细胞提取物冻干粉及其制备方法与应用
US11744856B1 (en) * 2012-04-11 2023-09-05 Medicell Technologies, Llc Compositions and methods to improve skin quality and appearance, cure skin and tissue damage, and use in therapy
US9445980B2 (en) * 2012-04-18 2016-09-20 Mark Laney Methods for stimulating hair growth
RU2530614C2 (ru) * 2012-05-04 2014-10-10 Владимир Петрович Швецов Биологический активный комплекс для органогенеза и продукт секреции клеток, содержащихся в этом комплексе
US9545370B2 (en) 2012-05-08 2017-01-17 BioRegenerative Sciences, Inc. Bioactive compositions and methods for their preparation and use
US9354237B2 (en) 2012-05-18 2016-05-31 Purdue Research Foundation Methods for isolating proteins
EP2682168A1 (de) 2012-07-02 2014-01-08 Millipore Corporation Reinigung biologischer Moleküle
EP3409761A1 (de) * 2012-07-24 2018-12-05 Nissan Chemical Corporation Kulturmedienzusammensetzung und verfahren zur kultivierung von zellen oder geweben unter verwendung der besagten zusammensetzung
RU2512681C2 (ru) * 2012-08-22 2014-04-10 Антонина Ивановна Колесникова Способ лечения длительно незаживающей раны и/или раневой полости
PL2972193T3 (pl) * 2013-03-13 2020-08-24 University Of Miami Sposób izolacji i oczyszczania mikropącherzyków z supernatantów hodowli komórkowej i płynów biologicznych
WO2014164669A1 (en) 2013-03-13 2014-10-09 Stemnion, Inc. Improved medical device
WO2014153294A1 (en) * 2013-03-17 2014-09-25 The Regents Of The University Of California Method to expand and transduce cultured human small and large intestinal stem cells
CN105246494B (zh) * 2013-04-19 2020-02-07 高丽大学校产学协力团 刺激毛发生长或防止毛发脱落的包括神经干细胞的提取物的组合物及其制造方法
EP2801613A1 (de) * 2013-05-08 2014-11-12 Ecole Polytechnique Fédérale de Lausanne (EPFL) Anordnungen abgetrennter Zellkultur-Mikroumgebungen, Verfahren zur Herstellung solcher Anordnungen und Verwendungen davon
RU2526814C1 (ru) * 2013-06-17 2014-08-27 Государственное бюджетное учреждение здравоохранения города Москвы Научно-исследовательский институт скорой помощи имени Н.В. Склифосовского Департамента здравоохранения г. Москвы Способ восстановления кожного покрова у пациентов с обширными ранами с дефектом мягких тканей (варианты)
EP3068874B1 (de) * 2013-11-14 2022-04-06 Dermaforce Holdings, LLC Fibroblastenmischungen und verfahren zur herstellung und verwendung davon
JP6633522B2 (ja) 2013-11-16 2020-01-22 テルモ ビーシーティー、インコーポレーテッド バイオリアクターにおける細胞増殖
CN103736080B (zh) * 2013-11-29 2016-06-22 焦阳 用于伤口愈合的制剂、制备方法及其用途
GB201322869D0 (en) 2013-12-23 2014-02-12 Ucl Business Plc Therapeutic agents and delivery with microspheres
US20160325499A1 (en) * 2014-01-05 2016-11-10 David Muller Systems and methods for producing and applying tissue-related structures
US10533191B2 (en) 2014-01-15 2020-01-14 Serucell Corporation Therapeutic serum obtained from co-cultured cells
US9907745B2 (en) 2014-01-15 2018-03-06 Serucell Corporation Cosmetic compositions and method of making the same
US9974813B1 (en) 2014-01-15 2018-05-22 Serucell Corporation Therapeutic serum obtained from co-cultured cells
EP3107995B1 (de) * 2014-02-18 2019-10-30 Massachusetts Institute Of Technology Biophysikalisch geordnete osteoprogenitoren aus mesenchymalen stromazellen (mscs), die aus kulturexpandiertem knochenmark abgeleitet sind
TWI558421B (zh) * 2014-03-06 2016-11-21 芯芮生技開發股份有限公司 幹細胞條件培養基用於製備抑制氧化作用達到皮膚抗老化之組成物的用途
KR101623189B1 (ko) * 2014-03-14 2016-05-20 (주)세포바이오 중간엽 줄기세포 유래 단백질을 함유하는 조직 재생용 조성물
WO2015148704A1 (en) 2014-03-25 2015-10-01 Terumo Bct, Inc. Passive replacement of media
US9284528B2 (en) 2014-04-18 2016-03-15 Growgene Biotech Inc. Use of stem cell conditioned medium to inhibit oxidation for anti-aging skin
US20150328263A1 (en) * 2014-05-14 2015-11-19 University Of Maryland, Baltimore Cardiac stem cells for cardiac repair
US20160000698A1 (en) * 2014-07-07 2016-01-07 Medipost Co., Ltd. Capability of small-sized stem cells to stimulate hair growth and use thereof
WO2016044555A1 (en) 2014-09-17 2016-03-24 Massachusetts Institute Of Technology System and method for inertial focusing microfiltration for intra-operative blood salvage autotransfusion
WO2016049421A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled feed
EP3620184A1 (de) 2014-09-30 2020-03-11 Allergan Industrie, SAS Stabile hydrogelzusammensetzungen mit additiven
RU2574017C1 (ru) * 2014-09-30 2016-01-27 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Средство для лечения ожогов и ран на основе цитокинов и факторов роста, секретируемых мезенхимными клетками человека, способ получения средства и способ лечения ожогов и ран
EP3224341B1 (de) 2014-11-25 2021-05-19 Corning Incorporated Zellkulturmedium erweiternde materialien und verfahren
KR101570004B1 (ko) * 2014-11-28 2015-11-17 안동현 발모촉진용 조성물
US10842735B2 (en) 2014-11-28 2020-11-24 Dong Hyun AHN Hair growth-promoting composition
RU2644650C2 (ru) 2014-12-01 2018-02-13 Общество с ограниченной ответственностью "Т-Хелпер Клеточные Технологии" Материал стволовых клеток и способ его получения
WO2016128783A1 (en) 2015-02-09 2016-08-18 Allergan Industrie Sas Compositions and methods for improving skin appearance
RU2745413C2 (ru) * 2015-06-04 2021-03-24 Фондационе Ирккс Ка' Гранда - Оспедале Маджоре Поликлинико Система из множества пакетов и способ приготовления компонентов крови
RU2587755C1 (ru) * 2015-06-10 2016-06-20 Федеральное государственное бюджетное учреждение "Государственный научный центр Российской Федерации - Федеральный Медицинский биофизический центр имени А.И. Бурназяна Федерального Медико-биологического агентства" (ФГБУ ГНЦ ФМБЦ им. А.И. Бурназяна ФМБА России) Способ получения действующего вещества из пантов марала
BE1023155B1 (nl) 2015-06-30 2016-12-02 Guido Wouters Samenstelling voor wondheling
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
US20170151149A1 (en) * 2015-11-30 2017-06-01 Dermaforce Holdings, LLC Topical skin compositions having proteins and methods of use
EP3388512B1 (de) 2015-12-11 2023-08-23 Lei Guo Verfahren zur trennung und kultivierung mesenchymaler stammzellen aus wharton-sulze der nabelschnur
US11098280B2 (en) * 2015-12-11 2021-08-24 Lei Guo Serum-free culture medium and preparation method and application therefor
RU2620167C1 (ru) * 2015-12-21 2017-05-23 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ получения средства для стимуляции регенерации на основе продуктов секреции мультипотентных мезенхимных стромальных клеток человека
EP4349972A3 (de) * 2016-02-22 2024-05-29 Osaka University Verfahren zur herstellung von dreidimensionalem zellgewebe
CN115350115B (zh) * 2016-04-01 2024-03-22 佰可姿国际私人有限公司 包含在细胞培养基中的白蛋白、透明质酸或胶原蛋白作为活性成分的化妆品组合物
US11111480B2 (en) 2016-04-29 2021-09-07 Hope Biosctences, Llc Culture media for multipotent stem cells
US10894947B1 (en) * 2016-04-29 2021-01-19 Hope Biosciences, Llc Method for generating protein rich conditioned medium
RU2620342C1 (ru) * 2016-05-11 2017-05-24 Общество С Ограниченной Ответственностью "Генная И Клеточная Терапия" (Ооо "Генная И Клеточная Терапия") Косметическое средство на основе продуктов секреции мезенхимных стволовых/стромальных клеток жировой ткани человека и способ его получения
JP2019522042A (ja) * 2016-05-12 2019-08-08 インシツ バイオロジクス、インク. ヒドロゲル系生体送達ビヒクル
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
RU2708329C2 (ru) 2016-05-31 2019-12-05 Общество с ограниченной ответственностью "Т-Хелпер Клеточные Технологии" Материал стволовых клеток, композиции и способы применения
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
CN106754669B (zh) * 2016-11-23 2020-04-17 河海大学常州校区 基于反应-扩散模型的多细胞结构的制备方法及制备系统
RU2644278C1 (ru) * 2016-12-21 2018-02-08 Федеральное государственное автономное учреждение "Национальный медицинский исследовательский центр нейрохирургии имени академика Н.Н.Бурденко" Министерства здравоохранения Российской Федерации (ФГАУ "НМИЦ нейрохирургии им. акад. Н.Н.Бурденко" Минздрава России Способ микрохирургической реконструкции спинного мозга на животной модели с использованием биодеградируемого гидрогеля на основе поливинилового спирта
AR111512A1 (es) * 2017-02-23 2019-07-24 Japan Vam & Poval Co Ltd Dispositivo de integración celular o tisular
JP7204730B2 (ja) * 2017-03-31 2023-01-16 セラム バイオメディカル, インコーポレイテッド 生体適合性馴化細胞培地組成物およびその使用
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
EP3656841A1 (de) 2017-03-31 2020-05-27 Terumo BCT, Inc. Zellexpansion
JP6438527B2 (ja) * 2017-06-01 2018-12-12 Ncメディカルリサーチ株式会社 神経変性の治療のための細胞療法
CN107261213A (zh) * 2017-06-13 2017-10-20 北京恒峰铭成生物科技有限公司 一种活性水凝胶及其制备方法和在手术创伤修复中的应用
US11718829B2 (en) 2017-07-28 2023-08-08 Breakthrough Tech Llc Methods and compositions for manufacturing extracellular matrix
US11696929B2 (en) 2017-09-20 2023-07-11 The Regents Of The University Of California Methods and systems for conserving highly expanded cells
WO2019140267A1 (en) * 2018-01-12 2019-07-18 Histogen, Inc. Nutraceutical products from cell conditioned medium from cells cultured under hypoxic conditions
CN108486045A (zh) * 2018-01-23 2018-09-04 广东颜值科技有限公司 一种人成纤维细胞的培养组合物
FR3078541B1 (fr) * 2018-03-05 2022-07-08 Genoskin Modele d’injection sous-cutanee ex vivo
RU2716159C2 (ru) * 2018-03-06 2020-03-06 Андрей Александрович Темнов Композиция для профилактического или терапевтического лечения состояний, связанных с изменением количества волос
EP3801028A4 (de) * 2018-05-30 2022-04-13 Direct Biologics LLC Gefrorenes oder pulverförmiges wachstumsfaktor- und extrazelluläre-vesikel-additiv mit einem präparat aus mesenchymalen stammzellen (msc) und verwendungsverfahren
US11369718B1 (en) * 2018-08-24 2022-06-28 Ariasa LLC Method and use of cryopreserved mesenchymal stem cells via liquid suspension from the amniotic sac for rejuvenation of the midface
WO2020130800A1 (en) * 2018-12-21 2020-06-25 Cytonex Sdn. Bhd. Stem cell conditioned media
SG11202106836UA (en) * 2018-12-26 2021-07-29 Direct Biologics Llc Methods and compositions for treating skin and hair disorders
AU2020247621A1 (en) * 2019-03-27 2021-07-22 Pluri Biotech Ltd Methods and compositions for aesthetic and cosmetic treatment and stimulating hair growth
US10758571B1 (en) 2019-04-09 2020-09-01 Combangio, Inc. Processes for making and using a mesenchymal stem cell derived secretome
WO2020223543A1 (en) * 2019-05-02 2020-11-05 Histogen, Inc. Conditioned medium and methods of use thereof
US11065188B2 (en) 2019-05-29 2021-07-20 Av Laboratories Llc Applications and formulations of optimized, modified human embryonic fertility culture media with biguanides and/or functional equivalents
JP2022546909A (ja) * 2019-08-09 2022-11-10 アクスオロトル バイオロジックス,インコーポレイテッド ヒト羊膜細胞に由来する組成物及び関連する方法
CN114555776A (zh) * 2019-09-19 2022-05-27 生命技术公司 细胞培养基片剂和制造方法
CN110607279B (zh) * 2019-10-18 2023-09-19 深圳优圣康医学检验实验室 一种原代肿瘤细胞的3d培养体系及其培养方法和应用
CN112980796A (zh) * 2019-12-17 2021-06-18 东莞市东阳光生物药研发有限公司 用于降低cho细胞中表达重组蛋白的氧化的液体培养基
IL272145A (en) 2020-01-20 2021-07-29 Stem Cell Medicine Ltd Cosmetic preparations with protein concentrate from a conditioned growth medium of stem cells from adipose tissue
US12077780B2 (en) 2020-02-14 2024-09-03 Allergan Sales, Llc Conditioned medium from cells cultured under hypoxic conditions and uses thereof
CN111658672A (zh) * 2020-06-20 2020-09-15 河南和泽干细胞基因工程有限公司 一种人胎盘干细胞提取物冻干粉及其制备方法
US12043823B2 (en) 2021-03-23 2024-07-23 Terumo Bct, Inc. Cell capture and expansion
EP4363442A1 (de) 2021-07-02 2024-05-08 Combangio, Inc. Verfahren zur herstellung und verwendung einer zellulären fibronektinzusammensetzung
US20230043556A1 (en) 2021-07-30 2023-02-09 L'oreal Compositions comprising extracellular vesicles, secreted biomolecules, and/or conditioned media, and methods of producing and using the same
FR3126617B1 (fr) 2021-09-06 2023-12-29 Oreal compositions comprenant des vésicules extracellulaires, des biomolécules sécrétées et/ou des milieux conditionnés, et procédés pour les produire
CN115074322B (zh) * 2022-07-01 2024-01-26 江南大学 一种高效获取多种生物活性功能因子的鼻黏膜外胚层间充质干细胞三维培养方法
BR102022016233A2 (pt) * 2022-08-16 2024-02-27 Omics Biotecnologia Animal Ltda Concentrado de proteínas e peptídeos derivados de células estromais mesenquimais, método de obtenção e uso de concentrado
CN115518198B (zh) * 2022-10-11 2024-01-16 青岛大学 一种负载双向梯度ecm涂层的血管修复支架及其制备方法
WO2024137677A1 (en) 2022-12-19 2024-06-27 FUJIFILM Holdings America Corporation Extracellular vesicle-enriched secretome composition derived from induced pluripotent stem cell derived-microglia and methods of use thereof
CN118255874B (zh) * 2024-05-31 2024-08-20 北京鑫康辰医学科技发展有限公司 一种天然活性胶原蛋白及其制备方法

Family Cites Families (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2004A (en) * 1841-03-12 Improvement in the manner of constructing and propelling steam-vessels
US564381A (en) * 1896-07-21 Prune or fruit dipper
US2007A (en) * 1841-03-16 Improvement in the mode of harvesting grain
US4458678A (en) 1981-10-26 1984-07-10 Massachusetts Institute Of Technology Cell-seeding procedures involving fibrous lattices
US4485096A (en) 1982-02-26 1984-11-27 Massachusetts Institute Of Technology Tissue-equivalent and method for preparation thereof
ES8503941A1 (es) * 1982-10-27 1985-04-16 Crinos Industria Farmaco Procedimiento de obtencion de composiciones para promover el trofismo de la piel y de foliculos piliferosos relacionados
US4911720A (en) 1983-03-10 1990-03-27 Collier John P Particular surface replacement prosthesis
JPS6133124A (ja) * 1983-11-04 1986-02-17 ラルフ シルヴア−マン 異性々疾患を治療するための培養間葉細胞から抽出した巨大分子
US4757017A (en) * 1984-09-14 1988-07-12 Mcw Research Foundation, Inc. In vitro cell culture system
US4861714A (en) * 1985-04-04 1989-08-29 Verax Corporation Weighted collagen microsponge for immobilizing bioactive material
US4806523A (en) * 1985-08-06 1989-02-21 Collagen Corporation Method of treating inflammation
FR2586703B1 (fr) * 1985-09-02 1989-12-01 Merieux Inst Procede d'extraction de collagenes placentaires, collagenes obtenus notamment sous forme de gels ou de solutions et leurs applications
US5266480A (en) 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
US5460939A (en) * 1986-04-18 1995-10-24 Advanced Tissue Sciences, Inc. Temporary living skin replacement
CA1282725C (en) * 1986-04-18 1991-04-09 Brian A. Naughton Process for replicating bone marrow in vitro and using the same
US4963489A (en) 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5863531A (en) * 1986-04-18 1999-01-26 Advanced Tissue Sciences, Inc. In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework
US5032508A (en) 1988-09-08 1991-07-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5902741A (en) 1986-04-18 1999-05-11 Advanced Tissue Sciences, Inc. Three-dimensional cartilage cultures
US5565347A (en) * 1986-06-10 1996-10-15 Calgene, Inc. Transformation and foreign gene expression with plant species
JPH0618781B2 (ja) * 1986-10-18 1994-03-16 中外製薬株式会社 感染症治療剤
US5736372A (en) 1986-11-20 1998-04-07 Massachusetts Institute Of Technology Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure
US5759830A (en) 1986-11-20 1998-06-02 Massachusetts Institute Of Technology Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo
CA1340581C (en) 1986-11-20 1999-06-08 Joseph P. Vacanti Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices
US4885163A (en) * 1987-02-24 1989-12-05 Eli Lilly And Company Topical use of IGF-II for wound healing
ATE120485T1 (de) 1988-05-23 1995-04-15 Univ Minnesota Bioreaktor.
WO1990008771A1 (en) * 1989-01-31 1990-08-09 Rubin Jeffrey S Dna encoding a growth factor specific for epithelial cells
US5693625A (en) * 1989-03-09 1997-12-02 Therapeutiques Substitutives Method of regenerating cells and tissues using functionalized dextrans
US5091173A (en) * 1989-06-29 1992-02-25 The University Of Dundee Hair growth composition
US5830709A (en) * 1989-10-27 1998-11-03 Benson; Roger E. Detection method for homologous portions of a class of substances
US5292655A (en) * 1990-01-29 1994-03-08 Wille Jr John J Method for the formation of a histologically-complete skin substitute
USRE35399E (en) 1990-04-24 1996-12-10 Eisenberg; Mark Composite living skin equivalents
CA2051796A1 (en) 1990-09-21 1992-03-22 Marvin L. Bayne Vascular endothelial cell growth factor ii
US5478560A (en) * 1990-10-19 1995-12-26 Shiseido Company Ltd. External dermatological composition
US5229493A (en) 1990-10-26 1993-07-20 Children's Medical Center Corporation Smooth muscle mitogen
US7208179B1 (en) 1990-11-27 2007-04-24 The American National Red Cross Methods for treating disease and forming a supplemented fibrin matrix
US5763367A (en) * 1991-03-28 1998-06-09 Bottom Line Industries, Inc. Well fluid additive, well fluid made therefrom, method of treating a well fluid, method of circulating a well fluid
ES2053410T1 (es) 1991-06-17 1994-08-01 Life Technologies Inc Metodo para la preparacion de un medio de cultivo de celulas.
WO1993004164A1 (en) * 1991-08-26 1993-03-04 THE STATE OF OREGON acting by and through THE STATE OF BOARD OF HIGHER EDUCATION on behalf of THE OREGON HEALTH SCIENCES UNIVERSITY Keratinocyte-derived conditioned medium as a source of growth factors
US5235633A (en) * 1991-12-26 1993-08-10 Everett Dennison Cellular telephone system that uses position of a mobile unit to make call management decisions
US6324404B1 (en) * 1991-12-26 2001-11-27 Sycord Limited Partnership Cellular telephone system that uses position of a mobile unit to make call management decisions
KR100266912B1 (ko) 1992-02-28 2000-12-01 파라비 레이 조직접촉물질이며 방출조절운반체인 광중합성 생분해성 하이드로겔
US5255307A (en) * 1992-05-07 1993-10-19 Sony Electronics Inc. Status indicator control for cellular mobile telephone system
US5618544A (en) 1992-08-12 1997-04-08 Bays-Brown Dermatologics, Inc. Method of decreasing cutaneous senescence
US5774193A (en) 1992-10-05 1998-06-30 Vaughan; Thomas J. Digital television (HDTV) and analog television (NTSC) broadcast systems combined for simultaneous broadcast
JPH06133124A (ja) 1992-10-20 1994-05-13 Fuji Xerox Co Ltd 画像記録装置
US5478739A (en) 1992-10-23 1995-12-26 Advanced Tissue Sciences, Inc. Three-dimensional stromal cell and tissue culture system
RU2054924C1 (ru) 1992-12-30 1996-02-27 Акционерное общество "Биотехнология" Препарат для лечения инфицированных вялозаживающих ран и язв
JPH09502161A (ja) 1993-03-12 1997-03-04 ジ・アメリカン・ナショナル・レッド・クロス 補足された及び補足されていない組織シーラント、その製造法及び使用法
US5407912A (en) * 1993-04-19 1995-04-18 Akzo, N.V. Method of treating bladder cancer with a keyhole limpet hemocyanin composition with enhanced anti-tumor activity
US5709854A (en) 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
RU2063743C1 (ru) 1993-06-01 1996-07-20 Акционерное общество закрытого типа "Химбио" Крем для питания, защиты и предотвращения старения кожи
CA2134729C (en) * 1993-11-01 1999-09-07 Thomas E. Buss Location dependent information receiving device and method
US6084724A (en) 1993-12-30 2000-07-04 Eastman Kodak Company Glass coated cemented plastic doublets and method for making
US5935849A (en) * 1994-07-20 1999-08-10 Cytotherapeutics, Inc. Methods and compositions of growth control for cells encapsulated within bioartificial organs
US5516532A (en) 1994-08-05 1996-05-14 Children's Medical Center Corporation Injectable non-immunogenic cartilage and bone preparation
FI96558C (fi) * 1994-09-27 1996-07-10 Nokia Telecommunications Oy Menetelmä datasiirtoa varten TDMA-matkaviestinjärjestelmässä sekä menetelmän toteuttava matkaviestinjärjestelmä
CN1092876C (zh) * 1994-12-12 2002-10-16 艾利森公司 移动通信系统中的定向分集信道分配
WO1996018726A1 (en) 1994-12-15 1996-06-20 THE UNITED STATES GOVERNMENT, represented by THE SECRETARY OF THE NAVY Compositions and methods for stimulating hematopoietic cell expansion
US5900245A (en) 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants
US5830708A (en) 1995-06-06 1998-11-03 Advanced Tissue Sciences, Inc. Methods for production of a naturally secreted extracellular matrix
US5843766A (en) 1995-06-07 1998-12-01 Advanced Tissue Sciences, Inc. Apparatus for the growth and packaging of three dimensional tissue cultures
AU6169896A (en) 1995-06-07 1996-12-30 American National Red Cross, The Supplemented and unsupplemented tissue sealants, methods of their production and use
US5654381A (en) 1995-06-16 1997-08-05 Massachusetts Institute Of Technology Functionalized polyester graft copolymers
GB2304497A (en) * 1995-08-19 1997-03-19 Northern Telecom Ltd Cellular communications system with provision of services to visiting mobiles
WO1997009997A1 (en) * 1995-09-12 1997-03-20 Genentech, Inc. Cystic fibrosis therapy
FR2739621B1 (fr) 1995-10-05 1997-12-05 Centre Nat Rech Scient Peptides utilisables comme vecteurs pour l'adressage intracellulaire de molecules actives
US5965125A (en) * 1995-10-25 1999-10-12 Transkaryotic Therapies, Inc. Hybrid matrix implants and explants
JP2679694B2 (ja) 1995-11-08 1997-11-19 コクヨ株式会社 ホルダー
US5787348A (en) * 1995-12-06 1998-07-28 Motorola, Inc. Method of measuring speed of a mobile unit and a receiver for use in a wireless communication system
US5888551A (en) * 1995-12-11 1999-03-30 University Of Miami Hair growth stimulating composition
US6048964A (en) * 1995-12-12 2000-04-11 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
US5708854A (en) * 1996-01-24 1998-01-13 Eastman Kodak Company One-time-use camera has driver for closing film cassette which is removed with closed cassette to disable camera after completed use
US5826014A (en) * 1996-02-06 1998-10-20 Network Engineering Software Firewall system for protecting network elements connected to a public network
US5770448A (en) * 1996-03-29 1998-06-23 Northwestern University Human epithelial cell matrix and uses therefor
US5763267A (en) 1996-04-16 1998-06-09 Advanced Tissue Sciences Apparatus for the large scale growth and packaging of cell suspensions and three-dimensional tissue cultures
WO1997041899A1 (en) * 1996-05-03 1997-11-13 Innogenetics N.V. New medicaments containing gelatin cross-linked with oxidized polysaccharides
US5667791A (en) * 1996-05-31 1997-09-16 Thione International, Inc. X-ray induced skin damage protective composition
US5857201A (en) * 1996-06-18 1999-01-05 Wright Strategies, Inc. Enterprise connectivity to handheld devices
ES2251740T3 (es) 1996-08-23 2006-05-01 Ludwig Institute For Cancer Research Factor de crecimiento de celulas de endotelio vascular d recombinante (vegf-d).
US5914668A (en) * 1996-08-30 1999-06-22 Lucent Technologies Inc. Wireless terminal controlled mobility operational parameters
DE69728415T2 (de) 1996-10-15 2004-08-12 Amgen Inc., Thousand Oaks Produkte des keratinocyten-wachstumsfaktors 2 (kgf-2)
WO1998021312A1 (en) * 1996-11-08 1998-05-22 Rpms Technology Limited Human hepatocytes in three-dimensional support systems
US6044273A (en) * 1996-12-10 2000-03-28 Northern Telecom Limited Method and apparatus for designing a communication system by modeling spatial and temporal behavior of user mobility demand
US5814328A (en) * 1997-01-13 1998-09-29 Gunasekaran; Subramanian Preparation of collagen using papain and a reducing agent
US5970403A (en) * 1997-03-04 1999-10-19 Ericsson Inc. Load based charging within a mobile telecommunications network
RU2142783C1 (ru) 1997-03-06 1999-12-20 Децина Анатолий Николаевич Регенерирующее косметическое средство для ухода за кожей
US6044261A (en) * 1997-03-19 2000-03-28 Ericsson, Inc. Multiple home zone areas within a mobile telecommunications network
US6224893B1 (en) 1997-04-11 2001-05-01 Massachusetts Institute Of Technology Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering
IL121041A0 (en) * 1997-06-09 1997-11-20 Yeda Res & Dev Immunogenic compositions for induction of anti-tumor immunity
US6091956A (en) * 1997-06-12 2000-07-18 Hollenberg; Dennis D. Situation information system
US6070184A (en) * 1997-08-28 2000-05-30 International Business Machines Corporation Server-side asynchronous form management
GB9718609D0 (en) 1997-09-02 1997-11-05 Imp College Innovations Ltd Fusion protein
US6075797A (en) * 1997-10-17 2000-06-13 3Com Corporation Method and system for detecting mobility of a wireless-capable modem to minimize data transfer rate renegotiations
RU2141814C1 (ru) 1997-11-28 1999-11-27 Беляков Юрий Иванович Шампунь на основе молочной сыворотки
US6291240B1 (en) * 1998-01-29 2001-09-18 Advanced Tissue Sciences, Inc. Cells or tissues with increased protein factors and methods of making and using same
KR100658293B1 (ko) * 1998-04-03 2006-12-14 텔레폰악티에볼라겟엘엠에릭슨(펍) 범용 이동 전화 시스템에서 유연한 무선 액세스 및 자원할당
US6258782B1 (en) 1998-05-20 2001-07-10 Trimeris, Inc. Hybrid polypeptides with enhanced pharmacokinetic properties
RU2123837C1 (ru) 1998-05-27 1998-12-27 Бритун Юлия Анатольевна Способ устранения морщин
US6169898B1 (en) * 1998-07-16 2001-01-02 Nokia Mobile Phones Ltd Apparatus, and associated method, for maintaining a selected quality of service level in a radio communication system
CA2350919A1 (en) 1998-11-13 2000-05-25 Cyclacel Limited Antennapedia homeodomain helix 3 derived translocation vectors
RU2249039C2 (ru) 1999-02-04 2005-03-27 Текнион Рисерч Энд Дивелопмент Фаундейшн Лтд. Способ размножения/поддержания недифференцированных гемопоэтических стволовых клеток или клеток-предшественников (варианты), способ приготовления кондиционированной среды стромальных клеток, способ трансплантации недифференцированных гемопоэтических стволовых клеток или клеток-предшественников (варианты)
US6372494B1 (en) 1999-05-14 2002-04-16 Advanced Tissue Sciences, Inc. Methods of making conditioned cell culture medium compositions
WO2001014527A1 (en) 1999-08-23 2001-03-01 Organogenesis Inc. Skin care compositions and treatments
US6463274B1 (en) * 1999-10-26 2002-10-08 Denso Corporation Multiple class of service determination for digital cellular telephones
US6930470B2 (en) * 2001-03-01 2005-08-16 Nortel Networks Limited System and method for code division multiple access communication in a wireless communication environment
US7160726B2 (en) * 2001-06-07 2007-01-09 Skin Medica, Inc. Compositions comprising conditioned cell culture media and uses thereof

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