NO20014728L - Derivater av pyrimido[6,1-a]isokinolin-4-on - Google Patents

Derivater av pyrimido[6,1-a]isokinolin-4-on

Info

Publication number
NO20014728L
NO20014728L NO20014728A NO20014728A NO20014728L NO 20014728 L NO20014728 L NO 20014728L NO 20014728 A NO20014728 A NO 20014728A NO 20014728 A NO20014728 A NO 20014728A NO 20014728 L NO20014728 L NO 20014728L
Authority
NO
Norway
Prior art keywords
pyrimido
isoquinolin
derivatives
relates
isoenzymes
Prior art date
Application number
NO20014728A
Other languages
English (en)
Other versions
NO20014728D0 (no
Inventor
Alexander William Oxford
David Jack
Original Assignee
Vernalis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9907454.4A external-priority patent/GB9907454D0/en
Priority claimed from GBGB9909802.2A external-priority patent/GB9909802D0/en
Application filed by Vernalis Ltd filed Critical Vernalis Ltd
Publication of NO20014728D0 publication Critical patent/NO20014728D0/no
Publication of NO20014728L publication Critical patent/NO20014728L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
NO20014728A 1999-03-31 2001-09-28 Derivater av pyrimido[6,1-a]isokinolin-4-on NO20014728L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9907454.4A GB9907454D0 (en) 1999-03-31 1999-03-31 Compounds
GBGB9909802.2A GB9909802D0 (en) 1999-04-28 1999-04-28 Compounds
PCT/GB2000/001193 WO2000058308A1 (en) 1999-03-31 2000-03-29 DERIVATIVES OF PYRIMIDO[6,1-a]ISOQUINOLIN-4-ONE

Publications (2)

Publication Number Publication Date
NO20014728D0 NO20014728D0 (no) 2001-09-28
NO20014728L true NO20014728L (no) 2001-11-23

Family

ID=26315369

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20014728A NO20014728L (no) 1999-03-31 2001-09-28 Derivater av pyrimido[6,1-a]isokinolin-4-on

Country Status (16)

Country Link
US (5) US6794391B2 (no)
EP (1) EP1165558B1 (no)
JP (1) JP4685243B2 (no)
CN (1) CN100415743C (no)
AT (1) ATE250602T1 (no)
AU (1) AU773504B2 (no)
BR (1) BRPI0009446B8 (no)
CA (1) CA2368413C (no)
DE (1) DE60005493T2 (no)
DK (1) DK1165558T3 (no)
ES (1) ES2208310T3 (no)
MX (1) MXPA01009846A (no)
NO (1) NO20014728L (no)
NZ (1) NZ514158A (no)
PT (1) PT1165558E (no)
WO (1) WO2000058308A1 (no)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2368413C (en) * 1999-03-31 2008-07-29 Vernalis Limited Derivatives of pyrimido[6,1-a]isoquinolin-4-one
CA2611907A1 (en) * 2005-06-17 2006-12-21 Boehringer Ingelheim International Gmbh Mrp iv inhibitors for the treatment of respiratory diseases
EP2138495A1 (en) * 2008-06-26 2009-12-30 sanofi-aventis Substituted pyrimido[2,1-a]isoquinolin-4-one derivatives
KR101860968B1 (ko) * 2010-08-09 2018-05-24 베로나 파마 피엘씨 피리미도[6,1-ａ]이소퀴놀린-4-원 화합물의 결정 형태
US8883857B2 (en) 2012-12-07 2014-11-11 Baylor College Of Medicine Small molecule xanthine oxidase inhibitors and methods of use
EP2968313B1 (en) 2013-03-15 2018-01-31 Verona Pharma PLC Drug combination
HUE048020T2 (hu) * 2014-05-12 2020-05-28 Verona Pharma Plc Új kezelés
CN111249260B (zh) 2014-09-15 2023-01-10 维罗纳制药公司 包含rpl554的液体吸入制剂
GB201502260D0 (en) * 2015-02-11 2015-04-01 Verona Pharma Plc Salt of Pyrimido[6,1-A]Isoquinolin-4-one compound
GB201613054D0 (en) * 2016-07-28 2016-09-14 Verona Pharma Plc New compound and process
EP3822272A4 (en) 2018-07-13 2022-04-06 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. CONDENSED TRICYCLIC COMPOUND AS PDE3/PDE4 DOUBLE INHIBITOR
GB2578093B (en) 2018-10-09 2020-11-18 Verona Pharma Plc Liquid pharmaceutical composition comprising RPL554 and HFA-134A
GB201911517D0 (en) 2019-08-12 2019-09-25 Verona Pharma Plc Pharmaceutical composition
WO2021143843A1 (zh) * 2020-01-15 2021-07-22 正大天晴药业集团股份有限公司 一种pde3/pde4双重抑制剂的结晶及其应用
WO2021143841A1 (zh) 2020-01-15 2021-07-22 正大天晴药业集团股份有限公司 三并环类pde3/pde4双重抑制剂化合物的药物组合物
GB202002786D0 (en) 2020-02-27 2020-04-15 Verona Pharma Plc Liquid pharmaceutical composition
GB2594480A (en) * 2020-04-28 2021-11-03 Verona Pharma Plc New treatment
KR20240004495A (ko) 2021-04-29 2024-01-11 쑤저우 선카디아 바이오파마수티컬즈 컴퍼니 리미티드 이소퀴놀론 화합물과 이의 용도
WO2023076205A1 (en) 2021-10-29 2023-05-04 Teva Pharmaceuticals International Gmbh Solid state forms of ensifentrine and process for preparation thereof
WO2023109802A1 (zh) * 2021-12-14 2023-06-22 海思科医药集团股份有限公司 三环稠杂环类pde3/4双重抑制及其用途
WO2023138676A1 (zh) * 2022-01-21 2023-07-27 四川海思科制药有限公司 三环稠杂环类pde3/4双重抑制及其用途
GB202202297D0 (en) 2022-02-21 2022-04-06 Verona Pharma Plc Formulation production process
WO2024033624A1 (en) 2022-08-08 2024-02-15 Verona Pharma Plc Ensifentrine (rpl-554) for the treatment of moderate chronic obstructive pulmonary disease (copd)
WO2024033627A1 (en) 2022-08-08 2024-02-15 Verona Pharma Plc Liquid pharmaceutical composition
WO2024084212A1 (en) 2022-10-20 2024-04-25 Verona Pharma Plc Treatment of idiopatic pulmonary fibrosis with ensifentrine
WO2024088402A1 (zh) * 2022-10-28 2024-05-02 江苏恒瑞医药股份有限公司 一种异喹啉酮类化合物的晶型及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ185900A (en) * 1976-12-10 1981-04-24 Hoechst Ag Pyrimido (6,1-a) isoquinolin-4-ones medicaments intermediate isoquinolines
FI64370C (fi) * 1977-05-05 1983-11-10 Hoechst Ag Foerfarande foer framstaellning av terapeutiskt anvaendbara pyimido-(6,1-a)isokinolin-2-imino-4-onderivat
DE2847693A1 (de) * 1978-11-03 1980-05-22 Hoechst Ag Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen
US4254121A (en) * 1979-08-13 1981-03-03 Ayerst, Mckenna & Harrison Inc. 3-Oxo-5H-pyrimido[2,1-c][1,4 ]benzoxazines
US4307092A (en) * 1979-08-13 1981-12-22 Ayerst Mckenna & Harrison, Inc. 1-Oxo-5H-pyrimido[2,1-C]benzoxazine-2-carboxylic acid esters
US4254118A (en) * 1979-08-13 1981-03-03 Ayerst, Mckenna & Harrison Inc. 1-Oxo-5H-pyrimido[2,1-c][1,4]benzthiazine-2-carboxylic acid esters
CA1237429A (en) * 1983-05-05 1988-05-31 Frank Kienzle Pyrimidone derivatives
CZ280738B6 (cs) * 1988-02-10 1996-04-17 F. Hoffmann - La Roche And Co., Aktiengesellschaft Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi
DE3816995A1 (de) * 1988-05-19 1989-11-23 Hoechst Ag Verwendung von pyrimido-(6,1-a)-isochinolin-4-on-derivaten und medizinische zubereitungen auf basis dieser verbindungen
US5728705A (en) * 1993-10-04 1998-03-17 The Trustees Of Columbia University In The City Of New York Method of inducing vasorelaxation to treat pulmonary hypertension
DE4430128A1 (de) * 1994-08-25 1996-02-29 Hoechst Ag Kombinationspräparat mit immunsuppressiven, kardiovaskulären und cerebralen Wirkungen
US5665737B1 (en) * 1994-10-12 1999-02-16 Euro Celtique Sa Substituted benzoxazoles
JPH10287655A (ja) * 1997-04-10 1998-10-27 Kaken Pharmaceut Co Ltd ピラゾール誘導体
CA2368413C (en) * 1999-03-31 2008-07-29 Vernalis Limited Derivatives of pyrimido[6,1-a]isoquinolin-4-one

Also Published As

Publication number Publication date
BRPI0009446B1 (pt) 2016-11-01
US20040171828A1 (en) 2004-09-02
CN100415743C (zh) 2008-09-03
CA2368413A1 (en) 2000-10-05
DE60005493T2 (de) 2004-07-01
US7378424B2 (en) 2008-05-27
AU4127400A (en) 2000-10-16
DK1165558T3 (da) 2004-02-09
ES2208310T3 (es) 2004-06-16
AU773504B2 (en) 2004-05-27
BRPI0009446B8 (pt) 2021-05-25
NO20014728D0 (no) 2001-09-28
MXPA01009846A (es) 2003-06-24
JP4685243B2 (ja) 2011-05-18
WO2000058308A1 (en) 2000-10-05
EP1165558B1 (en) 2003-09-24
US6794391B2 (en) 2004-09-21
EP1165558A1 (en) 2002-01-02
DE60005493D1 (de) 2003-10-30
US7105663B2 (en) 2006-09-12
JP2002540207A (ja) 2002-11-26
US20040176353A1 (en) 2004-09-09
CA2368413C (en) 2008-07-29
PT1165558E (pt) 2004-02-27
BR0009446A (pt) 2002-01-15
CN1348453A (zh) 2002-05-08
US20030036542A1 (en) 2003-02-20
ATE250602T1 (de) 2003-10-15
US8242127B2 (en) 2012-08-14
NZ514158A (en) 2000-03-29
US20120302533A1 (en) 2012-11-29
US20080206163A1 (en) 2008-08-28

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