WO1997015555A3 - Imidazolderivate und deren verwendung als stickstoffmonoxid-synthase-inhibitoren - Google Patents
Imidazolderivate und deren verwendung als stickstoffmonoxid-synthase-inhibitoren Download PDFInfo
- Publication number
- WO1997015555A3 WO1997015555A3 PCT/DE1996/002079 DE9602079W WO9715555A3 WO 1997015555 A3 WO1997015555 A3 WO 1997015555A3 DE 9602079 W DE9602079 W DE 9602079W WO 9715555 A3 WO9715555 A3 WO 9715555A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nitrogen monoxide
- imidazole derivatives
- synthase inhibitors
- monoxide synthase
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9516208A JPH11515008A (ja) | 1995-10-25 | 1996-10-24 | イミダゾール誘導体及びその一酸化窒素合成酵素阻害剤としての使用 |
AU13009/97A AU1300997A (en) | 1995-10-25 | 1996-10-24 | Imidazole derivatives and the use thereof as nitrogen monoxide synthase inhibitors |
EP96944573A EP0857171A2 (de) | 1995-10-25 | 1996-10-24 | Imidazolderivate und deren verwendung als stickstoffmonoxid-synthase-inhibitoren |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19541146.3 | 1995-10-25 | ||
DE19541146A DE19541146A1 (de) | 1995-10-25 | 1995-10-25 | Imidazolderivate und deren Verwendung als Stickstoffmonoxid-Synthase-Inhibitoren |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1997015555A2 WO1997015555A2 (de) | 1997-05-01 |
WO1997015555A3 true WO1997015555A3 (de) | 1997-07-10 |
Family
ID=7776625
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DE1996/002079 WO1997015555A2 (de) | 1995-10-25 | 1996-10-24 | Imidazolderivate und deren verwendung als stickstoffmonoxid-synthase-inhibitoren |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0857171A2 (de) |
JP (1) | JPH11515008A (de) |
AU (1) | AU1300997A (de) |
CA (1) | CA2235621A1 (de) |
DE (1) | DE19541146A1 (de) |
WO (1) | WO1997015555A2 (de) |
ZA (1) | ZA969019B (de) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19627310A1 (de) * | 1996-06-27 | 1998-01-02 | Schering Ag | Imidazolderivate als Stickstoffmonoxid-Synthase-Inhibitoren |
PT839810E (pt) | 1996-11-04 | 2003-01-31 | Bayer Cropscience Sa | 1-poliarilpirazois como pesticidas |
CZ20014203A3 (cs) * | 1999-05-25 | 2002-06-12 | Mitsubishi Pharma Corporation | Prostředek a způsob podpory exprese glykoproteinu spojeného s myelinem |
AUPQ142599A0 (en) * | 1999-07-05 | 1999-07-29 | Fujisawa Pharmaceutical Co., Ltd. | New amide compounds |
US6525051B2 (en) * | 2000-03-27 | 2003-02-25 | Schering Aktiengesellschaft | N-heterocyclic derivatives as NOS inhibitors |
KR20030017511A (ko) * | 2000-06-28 | 2003-03-03 | 에스에스 세야쿠 가부시키 가이샤 | 이미다졸 유도체 또는 그의 염 및 이를 함유하는 의약 |
EP1178038A1 (de) | 2000-08-04 | 2002-02-06 | Aventis Cropscience S.A. | Fungizide Phenylamidin Derivative |
US7718650B2 (en) | 2001-05-11 | 2010-05-18 | Biovitrum Ab | Aryl sulfonamide compounds for treating obesity |
KR20090092832A (ko) | 2001-05-11 | 2009-09-01 | 바이오비트럼 에이비(피유비엘) | 비만, 제 ⅱ 형 당뇨병 및 cns 장애의 치료를 위한 신규한 아릴술폰아미드 화합물 |
EP1528921A2 (de) * | 2002-08-02 | 2005-05-11 | Pharmacia Corporation | Methoden zur behandlung und vorbeugung von magen-darm-krankheiten |
US7449481B2 (en) | 2004-04-13 | 2008-11-11 | Cephalon, Inc. | Thio-substituted biaryl-methanesulfinyl derivatives |
US20070123572A1 (en) * | 2005-11-28 | 2007-05-31 | Kalypsys, Inc. | Novel method of preparation of 5-chloro-3-imidazol-1-yl-[1,2,4]thiadiazole and (3-imidazol-1-yl-[1,2,4]thiadiazol-5yl)-dialkyl-amines |
WO2006060424A2 (en) * | 2004-12-01 | 2006-06-08 | Kalypsys, Inc. | Inducible nitric oxide synthase dimerization inhibitors |
EP1741708A1 (de) | 2005-06-28 | 2007-01-10 | Sanofi-Aventis Deutschland GmbH | Heteroaryl substituierte Amide mit ungesättigtem oder zyklischem Linker, und deren Verwendung als Pharmaka |
WO2007039578A1 (en) * | 2005-10-05 | 2007-04-12 | Nycomed Gmbh | Imidazolyl-substituted azabenzophenone compounds |
WO2007039580A1 (en) * | 2005-10-05 | 2007-04-12 | Nycomed Gmbh | Imidazolyl-substituted benzophenone compounds |
EP2222639A1 (de) * | 2007-11-21 | 2010-09-01 | Decode Genetics EHF | Biaryle als pde4-inhibitoren zur behandlung von lungen- und herz-kreislauf-erkrankungen |
CN102448951B (zh) | 2009-04-06 | 2017-05-10 | 安吉奥斯医药品有限公司 | 丙酮酸激酶m2调节剂、治疗组合物和相关使用方法 |
EP2448581B1 (de) | 2009-06-29 | 2016-12-07 | Agios Pharmaceuticals, Inc. | Therapeutische zusammensetzungen und verfahren zu ihrer verwendung |
PL2448582T3 (pl) | 2009-06-29 | 2017-09-29 | Agios Pharmaceuticals, Inc. | Pochodne chinolino-8-sulfonamidowe mające działanie przeciwnowotworowe |
JP5837091B2 (ja) | 2010-12-17 | 2015-12-24 | アジオス ファーマシューティカルズ, インコーポレイテッド | ピルビン酸キナーゼm2(pkm2)調節剤としての新規n−(4−(アゼチジン−1−カルボニル)フェニル)−(ヘテロ−)アリールスルホンアミド誘導体 |
US9328077B2 (en) | 2010-12-21 | 2016-05-03 | Agios Pharmaceuticals, Inc | Bicyclic PKM2 activators |
TWI549947B (zh) | 2010-12-29 | 2016-09-21 | 阿吉歐斯製藥公司 | 治療化合物及組成物 |
CN103764147B (zh) | 2011-05-03 | 2018-05-22 | 安吉奥斯医药品有限公司 | 用于治疗的丙酮酸激酶活化剂 |
WO2012151440A1 (en) | 2011-05-03 | 2012-11-08 | Agios Pharmaceuticals, Inc. | Pyruvate kinase activators for use for increasing lifetime of the red blood cells and treating anemia |
WO2014139144A1 (en) | 2013-03-15 | 2014-09-18 | Agios Pharmaceuticals, Inc. | Therapeutic compounds and compositions |
US9206211B2 (en) | 2013-04-17 | 2015-12-08 | Massachusetts Institute Of Technology | Metathesis catalysts and methods thereof |
CN105439946B (zh) * | 2014-08-13 | 2018-02-02 | 益方生物科技(上海)有限公司 | 羧酸化合物及其制备方法和用途 |
MA44392B1 (fr) | 2015-06-11 | 2023-10-31 | Agios Pharmaceuticals Inc | Procédés d'utilisation d'activateurs de la pyruvate kinase |
TWI780281B (zh) * | 2017-12-14 | 2022-10-11 | 丹麥商Nmd藥品公司 | 用於治療神經肌肉病症的化合物 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3541109A (en) * | 1968-06-25 | 1970-11-17 | Du Pont | 1-substituted imidazoles useful in acth reserve assay |
FR2267101A1 (de) * | 1974-04-11 | 1975-11-07 | Schering Ag | |
EP0270091A1 (de) * | 1986-12-02 | 1988-06-08 | Tanabe Seiyaku Co., Ltd. | Imidazol-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Zubereitungen, welche diese enthalten, Verwendung dieser zur Herstellung therapeutisch wirksamer Arzneimittel und Zwischenprodukte, welche beim Herstellungsverfahren entstehen |
EP0385850A2 (de) * | 1989-03-03 | 1990-09-05 | Laboratoires Upsa | Benzimidazol- und Azabenzimidazol-Derivate, Verfahren zu deren Herstellung, Synthese-Zwischenprodukte, diese enthaltende pharmazeutische Zusammensetzungen, verwendbar bei der Behandlung von Herzgefässerkrankungen und duodenalem Ulcus |
DE3942475A1 (de) * | 1989-12-22 | 1991-06-27 | Basf Ag | Substituierte salicylsaeurealkylester und verfahren zu ihrer herstellung |
-
1995
- 1995-10-25 DE DE19541146A patent/DE19541146A1/de not_active Withdrawn
-
1996
- 1996-10-24 CA CA002235621A patent/CA2235621A1/en not_active Abandoned
- 1996-10-24 AU AU13009/97A patent/AU1300997A/en not_active Abandoned
- 1996-10-24 WO PCT/DE1996/002079 patent/WO1997015555A2/de not_active Application Discontinuation
- 1996-10-24 EP EP96944573A patent/EP0857171A2/de not_active Withdrawn
- 1996-10-24 JP JP9516208A patent/JPH11515008A/ja active Pending
- 1996-10-25 ZA ZA969019A patent/ZA969019B/xx unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3541109A (en) * | 1968-06-25 | 1970-11-17 | Du Pont | 1-substituted imidazoles useful in acth reserve assay |
FR2267101A1 (de) * | 1974-04-11 | 1975-11-07 | Schering Ag | |
EP0270091A1 (de) * | 1986-12-02 | 1988-06-08 | Tanabe Seiyaku Co., Ltd. | Imidazol-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Zubereitungen, welche diese enthalten, Verwendung dieser zur Herstellung therapeutisch wirksamer Arzneimittel und Zwischenprodukte, welche beim Herstellungsverfahren entstehen |
EP0385850A2 (de) * | 1989-03-03 | 1990-09-05 | Laboratoires Upsa | Benzimidazol- und Azabenzimidazol-Derivate, Verfahren zu deren Herstellung, Synthese-Zwischenprodukte, diese enthaltende pharmazeutische Zusammensetzungen, verwendbar bei der Behandlung von Herzgefässerkrankungen und duodenalem Ulcus |
DE3942475A1 (de) * | 1989-12-22 | 1991-06-27 | Basf Ag | Substituierte salicylsaeurealkylester und verfahren zu ihrer herstellung |
Non-Patent Citations (15)
Title |
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A. L. JOHNSON ET. AL.: "The Synthesis of 1-Arylimidazoles, a New Class of Steroid Hydroxylation Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 12, no. 6, November 1969 (1969-11-01), WASHINGTON DC, US, pages 1024 - 8, XP000653294 * |
BRITISH JOURNAL OF PHARMACOLOGY, vol. 119, no. 2, 1996, pages 423 - 31 * |
C. ESCOLASTICO ET. AL.: "Imidazole and Benzimidazole Addition to Quinones. Formation of meso and d,l Isomers and Crystal Structure of the d,l Isomer of 2,3-Bis(benzimidazol-1'-yl)- 1,4-Dihydroxybenzene.", TETRAHEDRON, vol. 50, no. 43, 1994, OXFORD, GB, pages 12489 - 12510, XP000652111 * |
CHEMICAL ABSTRACTS, vol. 125, no. 21, 18 November 1996, Columbus, Ohio, US; abstract no. 265016r, R. L. HANDY ET. AL.: "Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole." page 38; column 1; XP002029806 * |
D. J. WOLFFE ET. AL.: "Calmodulin-dependent Nitric-oxide Synthase", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 268, no. 13, 5 May 1993 (1993-05-05), ROCKVILLE PIKE, US, pages 9425 - 9, XP000652112 * |
D. M. ZIMMERMANN ET. AL.: "Structure-activity Relationships of trans-3,4-Dimethyl-4-(3-hydroxyphenyl)-piperidine Antagonists for mu and kappa-Opioid Receptors.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 36, no. 20, 1 October 1993 (1993-10-01), WASHINGTON DC, US, pages 2964 - 72, XP002029805 * |
D. POORANCHAND ET. AL.: "Reaction of Dimethyl N-aryl and N-alkylcarbonimidodithioates with Aminoacetaldehyde Diethyl Acetal. A Direct Synthesis of 1-Aryl and 1-Alkyl-2-methylthioimidazoles.", SYNTHESIS, no. 12, December 1987 (1987-12-01), STUTTGART, DE, pages 1136 - 8, XP002029808 * |
E. L. PLUMMER ET. AL.: "Heterocyclic Analogues of Substituted (1,1'-Biphenyl)-3-methyl pyrethroid Insecticides.", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 32, no. 5, September 1984 (1984-09-01), WASHINGTON DC, US, pages 1116 - 21, XP000653215 * |
J. F. K. WILSHIRE: "The Preparation of 2-Fluoro-5-nitrobenzonitrile and the Proton Magnetic Resonance Spectra of some Compounds Containing the N-(2-Cyano-4-nitrophenyl) Group.", AUSTRALIAN JOURNAL OF CHEMISTRY, vol. 20, no. 10, October 1967 (1967-10-01), MELBOURNE, AU, pages 1663 - 70, XP000653236 * |
J. F. K. WILSHIRE: "The Preparation of 4-Fluoro-3-nitrobenzonitrile and the Proton Magnetic Resonance Spectra of some Compounds Containing the N-4-Cyano-2-nitrophenyl Group.", AUSTRALIAN JOURNAL OF CHEMISTRY, vol. 20, no. 10, October 1967 (1967-10-01), MELBOURNE, AU, pages 2269 - 73, XP000653235 * |
J. OHMORI ET. AL.: "6-(1H-Imidazol-1-yl)-7-nitro-2,3-(1H,4H) quinoxazolinedione Hydrochloride (YM90K) and Related Compounds. Structure-activity Relationships for the AMPA-Type Non-NMDA Receptor.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 37, no. 4, 18 February 1994 (1994-02-18), WASHINGTON DC, US, pages 467 - 75, XP002029804 * |
J. W. LAMPE ET. AL.: "A Novel Rearangement of 1-(2-Aminoaryl)imidazoles.", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 31, no. 2, March 1994 (1994-03-01), pages 287 - 91, XP000653292 * |
P. FRANCHETTI ET. AL.: "Structure-Activity Relationships in Reactions of Organophosphorus Inhibited Acetylcholinesterase. 7. 1-Aryl-2-hydroxyiminomethyl-3-methylimidazolium Iodides.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 17, no. 1, January 1974 (1974-01-01), WASHINGTON DC, US, pages 18 - 22, XP000653251 * |
P. STREHLKE: "Antifungale Imidazolverbindungen II. Äther von (1-Imidazolyl)- phenolen.", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, CHIMICA THERAPEUTICA, vol. 14, no. 3, May 1979 (1979-05-01), pages 227 - 30, XP000653317 * |
R. G. R. BACON ET. AL.: "Metal Ions and Complexes in Organic Reactions. Part XVIII.", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS I, no. 16, 1974, OXFORD, GB, pages 1970 - 5, XP000653267 * |
Also Published As
Publication number | Publication date |
---|---|
CA2235621A1 (en) | 1997-05-01 |
EP0857171A2 (de) | 1998-08-12 |
AU1300997A (en) | 1997-05-15 |
DE19541146A1 (de) | 1997-04-30 |
ZA969019B (en) | 1997-05-29 |
WO1997015555A2 (de) | 1997-05-01 |
JPH11515008A (ja) | 1999-12-21 |
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