CA2235621A1 - Imidazole derivatives and their use as nitrogen monoxide synthase inhibitors - Google Patents

Imidazole derivatives and their use as nitrogen monoxide synthase inhibitors Download PDF

Info

Publication number
CA2235621A1
CA2235621A1 CA002235621A CA2235621A CA2235621A1 CA 2235621 A1 CA2235621 A1 CA 2235621A1 CA 002235621 A CA002235621 A CA 002235621A CA 2235621 A CA2235621 A CA 2235621A CA 2235621 A1 CA2235621 A1 CA 2235621A1
Authority
CA
Canada
Prior art keywords
alkyl
phenyl
imidazolyl
yield
mult
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002235621A
Other languages
English (en)
French (fr)
Inventor
Peter Holscher
Hartmut Rehwinkel
Gerardine Burton
Gary Phillips
John Parkinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2235621A1 publication Critical patent/CA2235621A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002235621A 1995-10-25 1996-10-24 Imidazole derivatives and their use as nitrogen monoxide synthase inhibitors Abandoned CA2235621A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19541146A DE19541146A1 (de) 1995-10-25 1995-10-25 Imidazolderivate und deren Verwendung als Stickstoffmonoxid-Synthase-Inhibitoren
DE19541146.3 1995-10-25

Publications (1)

Publication Number Publication Date
CA2235621A1 true CA2235621A1 (en) 1997-05-01

Family

ID=7776625

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002235621A Abandoned CA2235621A1 (en) 1995-10-25 1996-10-24 Imidazole derivatives and their use as nitrogen monoxide synthase inhibitors

Country Status (7)

Country Link
EP (1) EP0857171A2 (de)
JP (1) JPH11515008A (de)
AU (1) AU1300997A (de)
CA (1) CA2235621A1 (de)
DE (1) DE19541146A1 (de)
WO (1) WO1997015555A2 (de)
ZA (1) ZA969019B (de)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7166630B2 (en) 1999-05-25 2007-01-23 Mitsubishi Pharma Corporation MAG expression promoters
US8642620B2 (en) 2005-06-28 2014-02-04 Sanofi Heteroaryl-substituted amides comprising an unsaturated or cyclic linker group, and their use as pharmaceuticals
US8889667B2 (en) 2010-12-29 2014-11-18 Agios Pharmaceuticals, Inc Therapeutic compounds and compositions
US9115086B2 (en) 2009-06-29 2015-08-25 Agios Pharmaceuticals, Inc. Therapeutic compositions and related methods of use
US9181231B2 (en) 2011-05-03 2015-11-10 Agios Pharmaceuticals, Inc Pyruvate kinase activators for use for increasing lifetime of the red blood cells and treating anemia
US9221792B2 (en) 2010-12-17 2015-12-29 Agios Pharmaceuticals, Inc N-(4-(azetidine-1-carbonyl) phenyl)-(hetero-) arylsulfonamide derivatives as pyruvate kinase M2 (PMK2) modulators
US9328077B2 (en) 2010-12-21 2016-05-03 Agios Pharmaceuticals, Inc Bicyclic PKM2 activators
US9365545B2 (en) 2013-03-15 2016-06-14 Agios Pharmaceuticals, Inc Therapeutic compounds and compositions
US9657004B2 (en) 2009-04-06 2017-05-23 Agios Pharmaceuticals, Inc Pyruvate kinase M2 modulators, therapeutic compositions and related methods of use
US9980961B2 (en) 2011-05-03 2018-05-29 Agios Pharmaceuticals, Inc. Pyruvate kinase activators for use in therapy
US10029987B2 (en) 2009-06-29 2018-07-24 Agios Pharmaceuticals, Inc. Therapeutic compounds and compositions
US11234976B2 (en) 2015-06-11 2022-02-01 Agios Pharmaceuticals, Inc. Methods of using pyruvate kinase activators

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19627310A1 (de) * 1996-06-27 1998-01-02 Schering Ag Imidazolderivate als Stickstoffmonoxid-Synthase-Inhibitoren
ATE224878T1 (de) 1996-11-04 2002-10-15 Aventis Cropscience Sa 1-polyarylpyrazole als pestizide
AUPQ142599A0 (en) * 1999-07-05 1999-07-29 Fujisawa Pharmaceutical Co., Ltd. New amide compounds
US6525051B2 (en) * 2000-03-27 2003-02-25 Schering Aktiengesellschaft N-heterocyclic derivatives as NOS inhibitors
CN1228338C (zh) * 2000-06-28 2005-11-23 久光医药股份有限公司 咪唑衍生物或其盐以及含有该衍生物或其盐的药物
EP1178038A1 (de) * 2000-08-04 2002-02-06 Aventis Cropscience S.A. Fungizide Phenylamidin Derivative
WO2002092585A1 (en) 2001-05-11 2002-11-21 Biovitrum Ab Novel, arylsusfonamide compounds for the treatment of obesity, type ii diabetes and cns-disorders
US7718650B2 (en) 2001-05-11 2010-05-18 Biovitrum Ab Aryl sulfonamide compounds for treating obesity
BR0313204A (pt) * 2002-08-02 2005-06-28 Pharmacia Corp Métodos para tratamento e prevenção de condições gastrointestinais
US7449481B2 (en) 2004-04-13 2008-11-11 Cephalon, Inc. Thio-substituted biaryl-methanesulfinyl derivatives
US20070123572A1 (en) * 2005-11-28 2007-05-31 Kalypsys, Inc. Novel method of preparation of 5-chloro-3-imidazol-1-yl-[1,2,4]thiadiazole and (3-imidazol-1-yl-[1,2,4]thiadiazol-5yl)-dialkyl-amines
KR20070084574A (ko) * 2004-12-01 2007-08-24 칼립시스, 인코포레이티드 유도가능 산화질소 신타제 이량체화 억제제
WO2007039580A1 (en) * 2005-10-05 2007-04-12 Nycomed Gmbh Imidazolyl-substituted benzophenone compounds
WO2007039578A1 (en) * 2005-10-05 2007-04-12 Nycomed Gmbh Imidazolyl-substituted azabenzophenone compounds
EP2222639A1 (de) 2007-11-21 2010-09-01 Decode Genetics EHF Biaryle als pde4-inhibitoren zur behandlung von lungen- und herz-kreislauf-erkrankungen
WO2014172534A1 (en) * 2013-04-17 2014-10-23 Massachusetts Institute Of Technology Metathesis catalysts and methods thereof
CN105439946B (zh) * 2014-08-13 2018-02-02 益方生物科技（上海）有限公司 羧酸化合物及其制备方法和用途
TWI780281B (zh) * 2017-12-14 2022-10-11 丹麥商Ｎｍｄ藥品公司 用於治療神經肌肉病症的化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3541109A (en) * 1968-06-25 1970-11-17 Du Pont 1-substituted imidazoles useful in acth reserve assay
IE40911B1 (en) * 1974-04-11 1979-09-12 Schering Ag Imidazole derivatives and process for their manufacture
FI91754C (fi) * 1986-12-02 1994-08-10 Tanabe Seiyaku Co Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi
FR2643903A1 (fr) * 1989-03-03 1990-09-07 Union Pharma Scient Appl Nouveaux derives de benzimidazole, leurs procedes de preparation, intermediaires de synthese, compositions pharmaceutiques les contenant, utiles notamment pour le traitement des maladies cardiovasculaires, et des ulceres duodenaux
DE3942475A1 (de) * 1989-12-22 1991-06-27 Basf Ag Substituierte salicylsaeurealkylester und verfahren zu ihrer herstellung

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7166630B2 (en) 1999-05-25 2007-01-23 Mitsubishi Pharma Corporation MAG expression promoters
US8642620B2 (en) 2005-06-28 2014-02-04 Sanofi Heteroaryl-substituted amides comprising an unsaturated or cyclic linker group, and their use as pharmaceuticals
US9657004B2 (en) 2009-04-06 2017-05-23 Agios Pharmaceuticals, Inc Pyruvate kinase M2 modulators, therapeutic compositions and related methods of use
US9938259B2 (en) 2009-04-06 2018-04-10 Agios Pharmaceuticals, Inc. Therapeutic compositions and related methods of use
US10988448B2 (en) 2009-06-29 2021-04-27 Agios Pharmaceuticals, Inc. Therapeutic compounds and compositions
US11866411B2 (en) 2009-06-29 2024-01-09 Agios Pharmaceutical, Inc. Therapeutic compounds and compositions
USRE49582E1 (en) 2009-06-29 2023-07-18 Agios Pharmaceuticals, Inc. Therapeutic compounds and compositions
US9115086B2 (en) 2009-06-29 2015-08-25 Agios Pharmaceuticals, Inc. Therapeutic compositions and related methods of use
US10029987B2 (en) 2009-06-29 2018-07-24 Agios Pharmaceuticals, Inc. Therapeutic compounds and compositions
US9221792B2 (en) 2010-12-17 2015-12-29 Agios Pharmaceuticals, Inc N-(4-(azetidine-1-carbonyl) phenyl)-(hetero-) arylsulfonamide derivatives as pyruvate kinase M2 (PMK2) modulators
US9328077B2 (en) 2010-12-21 2016-05-03 Agios Pharmaceuticals, Inc Bicyclic PKM2 activators
US10087169B2 (en) 2010-12-21 2018-10-02 Agios Pharmaceuticals, Inc. Bicyclic PKM2 activators
US9199968B2 (en) 2010-12-29 2015-12-01 Agios Pharmaceuticals, Inc. Therapeutic compounds and compositions
US8889667B2 (en) 2010-12-29 2014-11-18 Agios Pharmaceuticals, Inc Therapeutic compounds and compositions
US10632114B2 (en) 2011-05-03 2020-04-28 Agios Pharmaceuticals, Inc. Pyruvate kinase activators for use in therapy
US9980961B2 (en) 2011-05-03 2018-05-29 Agios Pharmaceuticals, Inc. Pyruvate kinase activators for use in therapy
US9181231B2 (en) 2011-05-03 2015-11-10 Agios Pharmaceuticals, Inc Pyruvate kinase activators for use for increasing lifetime of the red blood cells and treating anemia
US11793806B2 (en) 2011-05-03 2023-10-24 Agios Pharmaceuticals, Inc. Pyruvate kinase activators for use in therapy
US9365545B2 (en) 2013-03-15 2016-06-14 Agios Pharmaceuticals, Inc Therapeutic compounds and compositions
US11234976B2 (en) 2015-06-11 2022-02-01 Agios Pharmaceuticals, Inc. Methods of using pyruvate kinase activators

Also Published As

Publication number Publication date
WO1997015555A2 (de) 1997-05-01
WO1997015555A3 (de) 1997-07-10
ZA969019B (en) 1997-05-29
AU1300997A (en) 1997-05-15
EP0857171A2 (de) 1998-08-12
DE19541146A1 (de) 1997-04-30
JPH11515008A (ja) 1999-12-21

Similar Documents

Publication Publication Date Title
CA2235621A1 (en) Imidazole derivatives and their use as nitrogen monoxide synthase inhibitors
RU2280025C9 (ru) Новые производные аминодикарбоновых кислот, обладающие фармацевтическими свойствами
US8492437B2 (en) 4-substituted phenoxyphenylacetic acid derivatives
EP1776347B1 (de) Sulfonamidderivate, ihre herstellung und ihre therapeutische anwendung
KR940003494B1 (ko) 벤젠, 피리딘 및 피리미딘 유도체
US20020006948A1 (en) 1,2 diarylbenzimdazoles and their pharmaceutical use
US20010008898A1 (en) Ether and amide compounds and preparation of thereof as antidiadetics.
CA2482382A1 (en) Pyrazole compounds as anti-inflammatory and analgesic agents
US7345075B2 (en) 1,2 diarylbenzimidazoles and their pharmaceutical use
US4598077A (en) Amidine derivatives and cardiotonic compositions
EP0344577A2 (de) Buten- oder Propensäure-Derivate
KR850000682B1 (ko) 헤테로사이클릭 화합물의 제조방법
HUT73431A (en) Process for preparing novel bisoxadiazolidine derivatives and pharmaceutical compositions containing them
SK59096A3 (en) Benzoylguanidine derivative containing fluor, preparation method thereof and pharmaceutical composition containing them
KR920006823B1 (ko) 부텐산 유도체
US4902698A (en) Benzenesulphonamidopyridyl compounds which are useful as thromboxane A.sub.2
HU196373B (en) Process for production of of derivatives of heteroaromatic acetilene and medical preparatives containing them
AU2004293189A1 (en) Nitroso derivatives of diphenylamine
WO1998000430A1 (de) Imidazolderivate als stickstoffmonoxid-synthase-inhibitoren
HRP20000564A2 (en) Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems

Legal Events

Date Code Title Description
FZDE Dead