WO2002080914A3 - VERWENDUNG VON SUBSTITUIERTEN IMIDAZO[1,2-a]-PYRIDINVERBINDUNGEN ALS ARZNEIMITTEL - Google Patents

VERWENDUNG VON SUBSTITUIERTEN IMIDAZO[1,2-a]-PYRIDINVERBINDUNGEN ALS ARZNEIMITTEL Download PDF

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Publication number
WO2002080914A3
WO2002080914A3 PCT/EP2002/003795 EP0203795W WO02080914A3 WO 2002080914 A3 WO2002080914 A3 WO 2002080914A3 EP 0203795 W EP0203795 W EP 0203795W WO 02080914 A3 WO02080914 A3 WO 02080914A3
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Prior art keywords
medicaments
pyridine compounds
substituted imidazo
substituted
imidazo
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PCT/EP2002/003795
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English (en)
French (fr)
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WO2002080914A2 (de
Inventor
Corinna Maul
Hagen-Heinrich Hennies
Bernd Sundermann
Original Assignee
Gruenenthal Gmbh
Corinna Maul
Hagen-Heinrich Hennies
Bernd Sundermann
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Application filed by Gruenenthal Gmbh, Corinna Maul, Hagen-Heinrich Hennies, Bernd Sundermann filed Critical Gruenenthal Gmbh
Priority to EP02727529A priority Critical patent/EP1372647A2/de
Priority to JP2002578953A priority patent/JP2004529141A/ja
Priority to HU0401302A priority patent/HUP0401302A2/hu
Priority to CA002442996A priority patent/CA2442996A1/en
Priority to MXPA03008965A priority patent/MXPA03008965A/es
Publication of WO2002080914A2 publication Critical patent/WO2002080914A2/de
Publication of WO2002080914A3 publication Critical patent/WO2002080914A3/de
Priority to US10/678,645 priority patent/US20040142961A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Obesity (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Die vorliegende Erfindung betrifft die Verwendung substituierter Imidazo[1,2-a]-pyridinverbindungen sowie ihrer physiologisch verträgliche Salze als Inhibitoren für die Stickstoffmonoxid-Synthase und zur Herstellung von Arzneimitteln.
PCT/EP2002/003795 2001-04-05 2002-04-05 VERWENDUNG VON SUBSTITUIERTEN IMIDAZO[1,2-a]-PYRIDINVERBINDUNGEN ALS ARZNEIMITTEL WO2002080914A2 (de)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP02727529A EP1372647A2 (de) 2001-04-05 2002-04-05 VERWENDUNG VON SUBSTITUIERTEN IMIDAZO 1,2-a]-PYRIDINVERBINDUNGEN ALS ARZNEIMITTEL
JP2002578953A JP2004529141A (ja) 2001-04-05 2002-04-05 置換されたイミダゾ［１，２−ａ］ピリジン化合物を医薬として使用する方法
HU0401302A HUP0401302A2 (hu) 2001-04-05 2002-04-05 Helyettesített imidazo[1,2-a]piridin-vegyületek felhasználása gyógyszerként
CA002442996A CA2442996A1 (en) 2001-04-05 2002-04-05 Use of substituted imidazo[1,2-a]-pyridine compounds as medicaments
MXPA03008965A MXPA03008965A (es) 2001-04-05 2002-04-05 Uso de compuestos de imidazo [1,2-a]-piridinas sustituidas como medicamentos.
US10/678,645 US20040142961A1 (en) 2001-04-05 2003-10-03 Utilization of substituted imidazo[1,2-a]-pyridine compounds in pharmaceutical formulations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10117183A DE10117183A1 (de) 2001-04-05 2001-04-05 Verwendung von substituierten Imidazo[1,2-a]-pyridinverbindungen als Arzneimittel
DE10117183.8 2001-04-05

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/678,645 Continuation US20040142961A1 (en) 2001-04-05 2003-10-03 Utilization of substituted imidazo[1,2-a]-pyridine compounds in pharmaceutical formulations

Publications (2)

Publication Number Publication Date
WO2002080914A2 WO2002080914A2 (de) 2002-10-17
WO2002080914A3 true WO2002080914A3 (de) 2003-01-03

Family

ID=7680630

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/003795 WO2002080914A2 (de) 2001-04-05 2002-04-05 VERWENDUNG VON SUBSTITUIERTEN IMIDAZO[1,2-a]-PYRIDINVERBINDUNGEN ALS ARZNEIMITTEL

Country Status (9)

Country Link
US (1) US20040142961A1 (de)
EP (1) EP1372647A2 (de)
JP (1) JP2004529141A (de)
CA (1) CA2442996A1 (de)
DE (1) DE10117183A1 (de)
HU (1) HUP0401302A2 (de)
MX (1) MXPA03008965A (de)
PL (1) PL366858A1 (de)
WO (1) WO2002080914A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10247271A1 (de) * 2002-10-10 2004-08-26 Grünenthal GmbH Substituierte C-Imidazo[1,2-a]pyridin-3-yle
US8114874B2 (en) 2005-12-23 2012-02-14 Ariad Pharmaceuticals, Inc. Substituted acetylenic imidazo[1,2-B]pyridazine compounds as kinase inhibitors
GB2452660A (en) * 2006-06-02 2009-03-11 Cbb Internat Pty Ltd A monitoring system
WO2008032764A1 (fr) * 2006-09-13 2008-03-20 Kyowa Hakko Kirin Co., Ltd. Dérivé hétérocyclique fusionné
AU2007337886C1 (en) 2006-12-22 2014-10-16 Astex Therapeutics Limited Bicyclic heterocyclic compounds as FGFR inhibitors
PL2121687T3 (pl) 2006-12-22 2016-03-31 Astex Therapeutics Ltd Pochodne amin tricyklicznych jako inhibitory białkowej kinazy tyrozynowej
GB0720038D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New compounds
GB0720041D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New Compounds
EA201000615A1 (ru) * 2007-10-17 2010-12-30 Новартис Аг Производные имидазо[1,2-а]пиридина, применимые в качестве ингибиторов апк (активиноподобной киназы)
GB0810902D0 (en) 2008-06-13 2008-07-23 Astex Therapeutics Ltd New compounds
EP2348018A4 (de) * 2008-09-25 2012-04-25 Kyorin Seiyaku Kk Heterocyclisches biarylderivat und dieses als wirkstoff enthaltender pde-hemmer
GB0906470D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
GB0906472D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
US9173887B2 (en) 2010-12-22 2015-11-03 Abbvie Inc. Hepatitis C inhibitors and uses thereof
WO2014021383A1 (ja) 2012-07-31 2014-02-06 協和発酵キリン株式会社 縮環複素環化合物
KR20240021746A (ko) * 2021-03-11 2024-02-19 저지앙 대학 융합고리 헤테로사이클릭 화합물 및 용도, 이를 함유하는 약학적 조성물 및 용도

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4382938A (en) * 1980-10-22 1983-05-10 Synthelabo Imidazo[1,2-a] pyridine derivatives and their application as pharmaceuticals
WO1996025414A1 (en) * 1995-02-15 1996-08-22 Pharmacia & Upjohn Company Imidazo[1,2-a]pyridines for the treatment of cns and cardiac diseases
US5614531A (en) * 1994-02-19 1997-03-25 Merck Patent Gesellschaft Mit Beschrankter Haftung Adhesion receptor antagonists
US5891891A (en) * 1995-04-07 1999-04-06 Clarendon-Trading & Investimentos Lda Use of imidazo 1, 2-A! pyridine-3-acetamide derivatives for the therapeutic treatment of neuropsychiatric syndromes associated with disfunction of the neural circuits of the basal ganglia
US6013654A (en) * 1997-08-14 2000-01-11 Pharmacia & Upjohn Company Imidazo[1,2-A]pyridines for the treatment of CNS and cardiac diseases
WO2001027109A2 (de) * 1999-10-08 2001-04-19 Grünenthal GmbH Tert.-butyl-(7-methyl-imidazo[1,2-a]pyridin-3-yl)-amin-derivate
DE10050663A1 (de) * 2000-10-13 2002-04-18 Gruenenthal Gmbh Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0068378B1 (de) * 1981-06-26 1986-03-05 Schering Corporation Imidazo(1,2-a)pyridine und -pyrazine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
US4791117A (en) * 1986-09-22 1988-12-13 Ortho Pharmaceutical Corporation 2- or 3-aryl substituted imidazo[1,2-a]pyridines and their use as calcium channel blockers
NZ221996A (en) * 1986-10-07 1989-08-29 Yamanouchi Pharma Co Ltd Imidazo-pyridine derivatives and pharmaceutical compositions
CA2060309A1 (en) * 1989-06-13 1990-12-14 Alison M. Badger Inhibition of interleukin-1 and tumor necrosis factor production by monocytes and/or macrophages
US5912248A (en) * 1995-11-16 1999-06-15 Eli Lilly And Company Excitatory amino acid receptor antagonists
DE19602855A1 (de) * 1996-01-26 1997-07-31 Byk Gulden Lomberg Chem Fab Neue 3-Methylimidazopyridine

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4382938A (en) * 1980-10-22 1983-05-10 Synthelabo Imidazo[1,2-a] pyridine derivatives and their application as pharmaceuticals
US5614531A (en) * 1994-02-19 1997-03-25 Merck Patent Gesellschaft Mit Beschrankter Haftung Adhesion receptor antagonists
WO1996025414A1 (en) * 1995-02-15 1996-08-22 Pharmacia & Upjohn Company Imidazo[1,2-a]pyridines for the treatment of cns and cardiac diseases
US5912246A (en) * 1995-02-15 1999-06-15 Pharmacia & Upjohn Company Imidazo 1,2-a!pyridines for the treatment of CNS and cardiac diseases
US5891891A (en) * 1995-04-07 1999-04-06 Clarendon-Trading & Investimentos Lda Use of imidazo 1, 2-A! pyridine-3-acetamide derivatives for the therapeutic treatment of neuropsychiatric syndromes associated with disfunction of the neural circuits of the basal ganglia
US6013654A (en) * 1997-08-14 2000-01-11 Pharmacia & Upjohn Company Imidazo[1,2-A]pyridines for the treatment of CNS and cardiac diseases
WO2001027109A2 (de) * 1999-10-08 2001-04-19 Grünenthal GmbH Tert.-butyl-(7-methyl-imidazo[1,2-a]pyridin-3-yl)-amin-derivate
DE10050663A1 (de) * 2000-10-13 2002-04-18 Gruenenthal Gmbh Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung

Also Published As

Publication number Publication date
DE10117183A1 (de) 2002-10-10
HUP0401302A2 (hu) 2004-12-28
EP1372647A2 (de) 2004-01-02
MXPA03008965A (es) 2004-02-12
CA2442996A1 (en) 2002-10-17
PL366858A1 (en) 2005-02-07
WO2002080914A2 (de) 2002-10-17
JP2004529141A (ja) 2004-09-24
US20040142961A1 (en) 2004-07-22

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