RU2001133453A - Композиции, содержащие кондиционированную клеточную культуральную среду, и способы их использования - Google Patents
Композиции, содержащие кондиционированную клеточную культуральную среду, и способы их использования Download PDFInfo
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- RU2001133453A RU2001133453A RU2001133453/13A RU2001133453A RU2001133453A RU 2001133453 A RU2001133453 A RU 2001133453A RU 2001133453/13 A RU2001133453/13 A RU 2001133453/13A RU 2001133453 A RU2001133453 A RU 2001133453A RU 2001133453 A RU2001133453 A RU 2001133453A
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- stromal
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Claims (60)
1. Фармацевтическая композиция, содержащая кондиционированную клеточную культуральную среду, где указанная среда включает среду, которая ранее поддерживала рост эукариотических клеток, культивированных в трех измерениях, и фармацевтический носитель.
2. Фармацевтическая композиция по п.1, где кондиционированная клеточная культуральная среда имеет форму жидкой среды, твердой среды, лиофилизованной среды, порошка, геля или пленки.
3. Фармацевтическая композиция по п.1, где композиция имеет пониженное или повышенное содержание одного или нескольких внеклеточных продуктов, происходящих от указанной кондиционированной среды, при помощи методов разделения белков, включая иммуноаффинную хроматографию, гель-хроматографию, ионообменную хроматографию, аффинную хроматографию на хелате металла, ВЭЖХ-очистку и гидрофобную хроматографию.
4. Фармацевтическая композиция по п.3, где внеклеточным(и) продуктом (ами) является белок внеклеточного матрикса.
5. Фармацевтическая композиция по п.3, где внеклеточным (и) продуктом(ами) является фактор роста, противовоспалительный медиатор, фермент, цитокин, гормон, фактор свертывания крови, регуляторный фактор, ангиогенный фактор или антиангиогенный фактор.
6. Фармацевтическая композиция по п.1, где клетки, культивированные в трех измерениях, представляют собой стромальные клетки и образуют трехмерную стромальную ткань.
7. Фармацевтическая композиция по п.6, где трехмерная стромальная ткань, содержащая стромальные клетки, прикрепленные к каркасу и, в основном, покрывающие этот каркас, состоящий из биологически совместимого "неживого" материала, образованного в трехмерной структуре.
8. Фармацевтическая композиция по п.7, где каркасная структура представляет собой сито, губку или полимеризованный гидрогель.
9. Фармацевтическая композиция по п.8, где каркасная структура включает мезенхимные стволовые клетки, резервные клетки печени, нервные стволовые клетки, панкреатические стволовые клетки, клетки, подобные фибробластам, фибробласты, клетки-предшественники хондроцитов, хондроциты, эмбриональные стволовые клетки, эндотелиальные клетки, перициты, макрофаги, моноциты, клетки плазмы, тучные клетки или любые их комбинации.
10. Фармацевтическая композиция по п.9, где стромальными клетками являются клетки человека.
11. Фармацевтическая композиция по п.9 или 10, где стромальные клетки представляют собой генетически сконструированные клетки.
12. Фармацевтическая композиция по п.6, где стромальные клетки культивированы на трехмерной стромальной ткани с образованием тканеспецифической трехмерной тканевой конструкции.
13. Фармацевтическая композиция по п.12, где паренхимными клетками являются клетки кожи, печени, почек, нервной
ткани, поджелудочной железы, тонкого кишечника, мочеполовых путей, сосудов, селезенки, кости, костного мозга или слизистой оболочки.
14. Фармацевтическая композиция по п.13, где паренхимные клетки представляют собой генетически сконструированные клетки.
15. Пищевой продукт с повышенным содержанием питательных веществ, содержащий кондиционированную клеточную культуральную среду, где указанная среда включает среду, которая ранее поддерживала рост эукариотических клеток, вместе с отдельным пищевым продуктом, предназначенным для употребления в пищу человеком.
16. Пищевой продукт по п.15, где отдельный пищевой продукт является пригодным для употребления в пищу человеком.
17. Питательная добавка, содержащая кондиционированную клеточную культуральную среду, где указанная среда включает среду, которая ранее поддерживала рост эукариотических клеток, в сочетании с фармацевтическим носителем, подходящим для употребления в пищу человеком, и где указанный носитель представлен в форме жидкости, таблетки или капсулы.
18. Способ получения фармацевтической композиции, предусматривающий:
(a) культивирование эукариотических клеток в трех измерениях в клеточной культуральной среде, удовлетворяющей потребностям в питательных веществах, необходимых для роста клеток ip vitro;
(b) культивирование клеток in vitro до тех пор, пока данная клеточная среда не будет содержать нужный уровень внеклеточных продуктов, необходимых для образования кондиционированной среды;
(c) отделение кондиционированной среды от клеток, использованных для кондиционирования среды;
(d) объединение указанной кондиционированной среды с фармацевтически приемлемым носителем.
19. Способ по п.18, где кондиционированную среду выделяют из системы с непрерывным потоком.
20. Способ по п.18 или 19, где кондиционированную среду культивируют в асептических условиях.
21. Способ по п.18, где кондиционированную среду обрабатывают до состояния жидкой среды, твердой среды, лиофилизованной среды, порошка, геля или пленки.
22. Способ по п.18, где кондиционированную среду, кроме того, обрабатывают для увеличения или снижения концентрации одного или нескольких продуктов, содержащихся в данной среде.
23. Способ по п.22, где композиция включает пониженное или повышенное количество одного или нескольких внеклеточных продуктов, происходящих от указанной кондиционированной среды, при помощи методов разделения белков, включая иммуномаффинную хроматографию, гель-хроматографию, ионообменную хроматографию, аффинную хроматографию на хелате металла, ВЭЖХ-очистку и гидрофобную хроматографию.
24. Способ по п.22, где внеклеточным(и) продуктом(ами) является белок внеклеточного матрикса.
25. Способ по п.22, где внеклеточным(и) продуктом (ами) является фактор роста, противовоспалительный медиатор, фермент, цитокин, гормон, антиген, антитело, фактор свертывания крови, регуляторный фактор, ангиогенный фактор или антиангиогенный фактор.
26. Способ по п.18, где клетки, культивированные в трех измерениях, представляют собой стромальные клетки и образуют трехмерную стромальную ткань.
27. Способ по п.26, предусматривающий прикрепление стромальных клеток к каркасу и, в основном, покрытие ими этого каркаса, состоящего из биологически совместимого "неживого" материала, образованного в трехмерной структуре.
28. Способ по п.27, где трехмерный каркас представляет собой сито, губку или полимеризованный гидрогель.
29. Способ по п.26 или 27, где каркасная структура включает мезенхимные стволовые клетки, резервные клетки печени, нервные стволовые клетки, панкреатические стволовые клетки, клетки, подобные фибробластам, фибробласты, клетки-предшественники хондроцитов, хондроциты, эмбриональные стволовые клетки, эндотелиальные клетки, перициты, макрофаги, моноциты, клетки плазмы, тучные клетки или любые их комбинации.
30. Способ по п.26, где стромальные клетки представляют собой генетически сконструированные клетки.
31. Способ по п.30, где генетически сконструированные клетки подвергают трансфекции экзогенным геном, находящимся под контролем экспрессионного элемента так, чтобы продукт указанного экзогенного гена экспрессировался и секретировался в кондиционированной среде.
32. Способ по п.26, где паренхимные клетки культивируют на трехмерной стромальной ткани с образованием тканеспецифической трехмерной тканевой культуры.
33. Способ по п.32, где паренхимными клетками являются клетки кожи, печени, почек, нервной ткани, поджелудочной железы, тонкого кишечника, мочеполовых путей, селезенки, кости, костного мозга или слизистой оболочки.
34. Способ по п.33, где паренхимные клетки представляют собой генетически сконструированные клетки.
35. Способ по п.34, где генетически сконструированные клетки подвергают трансфекции экзогенным геном, находящимся под контролем экспрессионного элемента так, чтобы продукт указанного экзогенного гена экспрессировался и секретировался в кондиционированной среде.
36. Способ стимуляции заживления ран и лечения ожогов, предусматривающий введение пациенту, нуждающемуся в лечении ран или ожогов, композиции, содержащей клеточную культуральную среду, где указанная среда включает среду, которая ранее поддерживала рост эукариотических клеток, культивированных в трех измерениях, вместе с отдельным терапевтическим компонентом так, чтобы у указанного пациента наблюдалось снижение площади травматизированной ткани или рубцовой ткани, и, кроме того, наблюдалась повышенная регенерация здоровой ткани в месте локализации раны.
37. Способ по п.36, где рана представляет собой сосудистую рану.
38. Способ по п.36, где рана находится в головном мозге или спинном мозге.
39. Способ по п.36, где рана находится в ткани кожи, печени, почек, поджелудочной железы, тонкого кишечника, селезенки, мочеполовых путей, кости, костного мозга или слизистой оболочки.
40. Способ по п.36, где компонентом является повязка.
41. Способ по п.36, где компонентом является мазь или крем, а указанная композиция предназначена для местного применения.
42. Способ по п.36, где компонентом является хирургический клей или наполнитель для ран.
43. Способ по п.36, где компонентом является шов или имплантат, покрытый кондиционированной средой перед использованием.
44. Способ по п.36, где компонентом является фармацевтический носитель, такой, чтобы указанная кондиционированная среда представлялась в форме инъекции, таблетки или капсулы.
45. Способ по п.36, где композиция, кроме того, включает антибиотик, противовоспалительный агент, противовирусный агент, противогрибковый агент, гормон, противоопухолевый агент, аналгетик, анестезирующее средство или любую их комбинацию.
46. Способ по п.36, где клетки, культивированные в трех измерениях, содержат стромальные клетки и образуют трехмерную стромальную ткань.
47. Способ по п.46, где трехмерная стромальная ткань содержит стромальные клетки, прикрепленные к каркасу и, в основном, покрывающие этот каркас, состоящий из биологически совместимого "неживого" материала, образованного в трехмерной структуре.
48. Способ по п.47, где каркасная структура представляет собой губку или гидрогель.
49. Способ по п.46, где стромальными клетками являются мезенхимные стволовые клетки, клетки подобные фибробластам, фибробласты, клетки-предшественники хондроцидов, хондроциты, эмбриональные стволовые клетки, эндотелиальные клетки, перициты, макрофаги, моноциты, клетки плазмы, тучные клетки или любые их комбинации.
50. Способ по п.49, где стромальные клетки представляют собой генетически сконструированные клетки.
51. Способ по п.46, где паренхимные клетки культивируют на трехмерной стромальной ткани с образованием тканеспецифической трехмерной тканевой конструкции.
52. Способ по п.51, где паренхимными клетками являются клетки кожи, печени, почек, нервной ткани, поджелудочной железы, тонкого кишечника, мочеполовых путей, сосудов, селезенки, кости, костного мозга или слизистой оболочки.
53. Способ по п.52, где паренхимные клетки представляют собой генетически сконструированные клетки.
54. Способ по п.53, где генетически сконструированные клетки подвергают трансфекции экзогенным геном, находящимся под контролем экспрессионного элемента, так, чтобы продукт указанного экзогенного гена экспрессировался и секретировался в кондиционированной среде.
55. Способ коррекции косметического дефекта, предусматривающий введение индивидууму композиции, содержащей кондиционированную клеточную культуральную среду, где указанная среда включает среду, которая ранее поддерживала рост эукариотических клеток, культивированных в трех измерениях, вместе с компонентом, используемым в косметических целях так, чтобы у указанного пациента наблюдалось исправление косметического дефекта.
56. Способ ингибирования или устранения неблагоприятного действия на клетки индивидуума, где указанное действие, индуцируется внутриклеточным окислением, где указанный способ предусматривает нанесение индивидууму, нуждающемуся в этом, аппликации, содержащей кондиционированную клеточную культуральную среду, где указанная среда включает среду, которая ранее поддерживала рост эукариотическик клеток, культивированных в трех измерениях, так, чтобы у указанного пациента наблюдалось уменьшение степени внутриклеточного окисления.
57. Способ по п.56, где неблагоприятным действием является внешний вид старения кожи.
58. Способ стимуляции роста волос, предусматривающий местное нанесение индивидууму композиции, содержащей кондиционированную клеточную культуральную среду, где указанная среда включает среду, которая ранее поддерживала рост эукариотических клеток, культивированных в трех измерениях, вместе с носителем для местного применения, так, чтобы у указанного индивидуума наблюдалась повышенная стимуляция роста волос.
59. Способ по пп.36, 55, 56 и 57, где указанную кондиционированную среду обрабатывают с получением жидкой среды, твердой среды, лиофилизованной среды, порошка, геля или пленки.
60. Способ выделения коллагена, предусматривающий:
(а) осаждение проколлагена из среды, кондиционированной трехмерной культурой при высокой концентрации соли и при нейтральном рН;
(b) удаление пропептидов в кислотных условиях так, чтобы тройная спираль указанного коллагена оставалась неповрежденной; и
(c) осаждение указанного коллагена при высоких концентрациях соли.
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US09/313,538 US6372494B1 (en) | 1999-05-14 | 1999-05-14 | Methods of making conditioned cell culture medium compositions |
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JP2002530059A (ja) | 1998-11-13 | 2002-09-17 | サイクラセル・リミテッド | 輸送ベクター |
MXPA01007820A (es) | 1999-02-04 | 2003-06-19 | Technion Res & Dev Foundation | Metodo y aparato para mantenimiento y expansion de celulas de tallo hemopoyeticas y/o celulas progenitoras. |
US6372494B1 (en) | 1999-05-14 | 2002-04-16 | Advanced Tissue Sciences, Inc. | Methods of making conditioned cell culture medium compositions |
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US6930470B2 (en) * | 2001-03-01 | 2005-08-16 | Nortel Networks Limited | System and method for code division multiple access communication in a wireless communication environment |
AU2002345603B2 (en) | 2001-06-07 | 2006-10-12 | Skinmedica, Inc. | Conditioned cell culture media and uses thereof |
-
1999
- 1999-05-14 US US09/313,538 patent/US6372494B1/en not_active Expired - Lifetime
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2000
- 2000-05-12 CA CA2373302A patent/CA2373302C/en not_active Expired - Lifetime
- 2000-05-12 HU HU0201887A patent/HUP0201887A2/hu unknown
- 2000-05-12 AU AU48430/00A patent/AU772829C/en not_active Expired
- 2000-05-12 MX MXPA01011487A patent/MXPA01011487A/es active IP Right Grant
- 2000-05-12 CN CNB008103453A patent/CN1198628C/zh not_active Expired - Lifetime
- 2000-05-12 JP JP2000617908A patent/JP5138129B2/ja not_active Expired - Lifetime
- 2000-05-12 DE DE60024612T patent/DE60024612T2/de not_active Expired - Lifetime
- 2000-05-12 EP EP00930643A patent/EP1178812B1/en not_active Expired - Lifetime
- 2000-05-12 ES ES00930643T patent/ES2254176T3/es not_active Expired - Lifetime
- 2000-05-12 BR BR0010568-6A patent/BR0010568A/pt not_active Application Discontinuation
- 2000-05-12 US US09/979,813 patent/US7118746B1/en not_active Expired - Lifetime
- 2000-05-12 NZ NZ515476A patent/NZ515476A/xx not_active IP Right Cessation
- 2000-05-12 WO PCT/US2000/013016 patent/WO2000069449A2/en active IP Right Grant
- 2000-05-12 RU RU2001133453/13A patent/RU2280459C2/ru active
- 2000-05-12 AT AT00930643T patent/ATE311894T1/de not_active IP Right Cessation
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2001
- 2001-11-14 ZA ZA200109381A patent/ZA200109381B/en unknown
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2006
- 2006-10-03 US US11/538,380 patent/US8361485B2/en not_active Expired - Fee Related
-
2009
- 2009-01-06 US US12/349,451 patent/US8138147B2/en not_active Expired - Fee Related
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2012
- 2012-03-09 US US13/417,017 patent/US8476231B2/en not_active Expired - Fee Related
- 2012-09-06 JP JP2012196046A patent/JP5526352B2/ja not_active Expired - Lifetime
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2013
- 2013-03-15 US US13/841,342 patent/US20130203169A1/en not_active Abandoned
- 2013-03-15 US US13/842,243 patent/US20130210076A1/en not_active Abandoned
- 2013-03-15 US US13/842,324 patent/US20130217129A1/en not_active Abandoned
- 2013-03-15 US US13/841,139 patent/US20130217069A1/en not_active Abandoned
- 2013-03-15 US US13/841,466 patent/US20130210725A1/en not_active Abandoned
- 2013-03-15 US US13/842,129 patent/US9458486B2/en not_active Expired - Fee Related
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2016
- 2016-10-03 US US15/284,223 patent/US20170055561A1/en not_active Abandoned
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