BRPI0507429A - composição, meio condicionado de células estromais de medula óssea, métodos de modular a expressão da molécula do complexo principal de histocompatibilidade e da molécula de mhc sobre uma nsc isolada, nsc isolada, e, dispositivo de cultura de células neurais - Google Patents

composição, meio condicionado de células estromais de medula óssea, métodos de modular a expressão da molécula do complexo principal de histocompatibilidade e da molécula de mhc sobre uma nsc isolada, nsc isolada, e, dispositivo de cultura de células neurais

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Publication number
BRPI0507429A
BRPI0507429A BRPI0507429-0A BRPI0507429A BRPI0507429A BR PI0507429 A BRPI0507429 A BR PI0507429A BR PI0507429 A BRPI0507429 A BR PI0507429A BR PI0507429 A BRPI0507429 A BR PI0507429A
Authority
BR
Brazil
Prior art keywords
methods
isolated nsc
nsc
isolated
composition
Prior art date
Application number
BRPI0507429-0A
Other languages
English (en)
Inventor
Padmavathy Vanguri
Smita Savant-Bhonsale
Original Assignee
Theradigm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theradigm Inc filed Critical Theradigm Inc
Publication of BRPI0507429A publication Critical patent/BRPI0507429A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/235—Leukemia inhibitory factor [LIF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1352—Mesenchymal stem cells
    • C12N2502/1358—Bone marrow mesenchymal stem cells (BM-MSC)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

COMPOSIçãO, MEIO CONDICIONADO DE CéLULAS ESTROMAIS DE MEDULA óSSEA, MéTODOS DE MODULAR A EXPRESSãO DA MOLéCULA DO COMPLEXO PRINCIPAL DE HISTOCOMPATIBILIDADE E DA MOLéCULA DE MHC SOBRE UMA NSC ISOLADA, NSC ISOLADA, E DISPOSITIVO DE CULTURA DE CéLULAS NEURAIS A presente invenção abrange métodos e composições para intensificar o crescimento de células-tronco neurais. Métodos para modular a expressão de moléculas de MHC em uma célula-tronco neural (NSC) são também inclídos na invenção.
BRPI0507429-0A 2004-02-06 2005-02-01 composição, meio condicionado de células estromais de medula óssea, métodos de modular a expressão da molécula do complexo principal de histocompatibilidade e da molécula de mhc sobre uma nsc isolada, nsc isolada, e, dispositivo de cultura de células neurais BRPI0507429A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54258104P 2004-02-06 2004-02-06
US63352104P 2004-12-06 2004-12-06
PCT/US2005/002895 WO2005076845A2 (en) 2004-02-06 2005-02-01 Compositions and methods relating to culturing neural stem cells with bone marrow stromal cells

Publications (1)

Publication Number Publication Date
BRPI0507429A true BRPI0507429A (pt) 2007-06-26

Family

ID=34864500

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0507429-0A BRPI0507429A (pt) 2004-02-06 2005-02-01 composição, meio condicionado de células estromais de medula óssea, métodos de modular a expressão da molécula do complexo principal de histocompatibilidade e da molécula de mhc sobre uma nsc isolada, nsc isolada, e, dispositivo de cultura de células neurais

Country Status (12)

Country Link
US (1) US20050176141A1 (pt)
EP (1) EP1718733A4 (pt)
JP (1) JP2007520233A (pt)
KR (1) KR20070001171A (pt)
AU (1) AU2005213326A1 (pt)
BR (1) BRPI0507429A (pt)
CA (1) CA2555376A1 (pt)
CR (1) CR8547A (pt)
MX (1) MXPA06008932A (pt)
NO (1) NO20063772L (pt)
RU (1) RU2006132068A (pt)
WO (1) WO2005076845A2 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2001997A4 (en) * 2006-03-31 2010-05-05 Jozef Bizik METHOD AND DEVICE FOR TREATMENT OR SELECTION OF CELLS
EP2617428A1 (en) 2006-08-15 2013-07-24 Agency for Science, Technology and Research Mesenchymal stem cell conditioned medium
KR100980849B1 (ko) * 2007-04-25 2010-09-10 가톨릭대학교 산학협력단 인터루킨(ｉｌ)-10을 포함하는 조혈모세포의 자가 재생산을촉진하는 조성물
US20100291042A1 (en) * 2007-05-03 2010-11-18 The Brigham And Women's Hospital, Inc. Multipotent stem cells and uses thereof
US8318485B2 (en) * 2008-02-25 2012-11-27 Natalie Gavrilova Stem cell therapy for the treatment of diabetic retinopathy and diabetic optic neuropathy
KR101077042B1 (ko) * 2008-03-28 2011-10-26 경희대학교 산학협력단 중배엽 줄기세포의 증식을 촉진하기 위한 ｃｄ45+ 세포 또는 ｃｄ45+ 세포 배양액의 용도
US20100158878A1 (en) 2008-12-23 2010-06-24 Alexandra Capela Target populations of oligodendrocyte precursor cells and methods of making and using same
CN101735980B (zh) * 2010-02-11 2011-07-27 中国人民解放军总医院 体外培养骨髓间充质干细胞的完全培养基
US9428730B2 (en) * 2012-02-29 2016-08-30 Mead Johnson Nutrition Company Coatings and culture media for promoting neurogenesis in adipose tissue derived stem cells
CN104324053B (zh) * 2014-09-28 2018-09-11 严玉霖 一种快速愈合犬创伤组织的犬干细胞分泌因子修复液
CN105420193B (zh) * 2015-12-07 2019-04-09 中国科学院广州生物医药与健康研究院 分化培养基及其在制备神经干细胞中的用途
WO2020153687A1 (ko) * 2019-01-22 2020-07-30 고려대학교 산학협력단 직접 세포전환을 기반으로한 신경줄기세포의 성상교세포로의 분화방법

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750376A (en) * 1991-07-08 1998-05-12 Neurospheres Holdings Ltd. In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
US5849553A (en) * 1992-07-27 1998-12-15 California Institute Of Technology Mammalian multipotent neural stem cells
ES2246085T3 (es) * 1998-05-07 2006-02-01 University Of South Florida Celulas de medula osea como fuente de neuronas util para reparar la medula espinal y el cerebro.
AU4336599A (en) * 1998-06-08 1999-12-30 Osiris Therapeutics, Inc. (in vitro) maintenance of hematopoietic stem cells
US5958767A (en) * 1998-08-14 1999-09-28 The Children's Medical Center Corp. Engraftable human neural stem cells
US6372494B1 (en) * 1999-05-14 2002-04-16 Advanced Tissue Sciences, Inc. Methods of making conditioned cell culture medium compositions
EP1335972A2 (en) * 2000-11-22 2003-08-20 Geron Corporation Tolerizing allografts of pluripotent stem cells
US20030082153A1 (en) * 2001-10-22 2003-05-01 The Government Of The United States Of America Stem cells that transform to beating cardiomyocytes
US20060252150A1 (en) * 2002-11-08 2006-11-09 Linzhao Cheng Human embryonic stem cell cultures, and compositions and methods for growing same

Also Published As

Publication number Publication date
JP2007520233A (ja) 2007-07-26
AU2005213326A1 (en) 2005-08-25
WO2005076845A3 (en) 2005-10-06
US20050176141A1 (en) 2005-08-11
RU2006132068A (ru) 2008-03-20
KR20070001171A (ko) 2007-01-03
EP1718733A2 (en) 2006-11-08
EP1718733A4 (en) 2007-02-07
CR8547A (es) 2007-09-07
CA2555376A1 (en) 2005-08-25
MXPA06008932A (es) 2007-01-26
WO2005076845A2 (en) 2005-08-25
NO20063772L (no) 2006-10-03

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A E 6A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2099 DE 29/03/2011.

B15K Others concerning applications: alteration of classification

Free format text: PROCEDIMENTO AUTOMATICO DE RECLASSIFICACAO. AS CLASSIFICACOES IPC ANTERIORES ERAM: C12N 5/00; C12N 5/02; C12N 5/06; C12N 5/08.

Ipc: C12N 5/0797 (2010.01)

Ipc: C12N 5/0797 (2010.01)