DE3348333C2 - - Google Patents

Info

Publication number
DE3348333C2
DE3348333C2 DE3348333A DE3348333A DE3348333C2 DE 3348333 C2 DE3348333 C2 DE 3348333C2 DE 3348333 A DE3348333 A DE 3348333A DE 3348333 A DE3348333 A DE 3348333A DE 3348333 C2 DE3348333 C2 DE 3348333C2
Authority
DE
Germany
Prior art keywords
serotonin
compounds
formula
endo
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3348333A
Other languages
German (de)
English (en)
Inventor
Peter Dr. Allschweil Ch Donatsch
Guenter Dr. 7858 Weil De Engel
Bruno Dr. Pfeffingen Ch Huegi
Brian Peter Dr. Magden Ch Richardson
Paul Dr. Biel-Benken Ch Stadler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Sandoz Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Patent GmbH filed Critical Sandoz Patent GmbH
Application granted granted Critical
Publication of DE3348333C2 publication Critical patent/DE3348333C2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)
DE3348333A 1982-06-29 1983-06-23 Expired - Lifetime DE3348333C2 (OSRAM)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CH397982 1982-06-29
CH426782 1982-07-13
CH695082 1982-11-30
CH695182 1982-11-30
CH749582 1982-12-22
CH749482 1982-12-22
CH125683 1983-03-09

Publications (1)

Publication Number Publication Date
DE3348333C2 true DE3348333C2 (OSRAM) 1992-08-27

Family

ID=27561049

Family Applications (6)

Application Number Title Priority Date Filing Date
DE19833322574 Granted DE3322574A1 (de) 1982-06-29 1983-06-23 Benzoesaeurepiperidylester-derivate bzw. verfahren zu deren herstellung und deren verwendung
DE3348334A Expired - Lifetime DE3348334C2 (OSRAM) 1982-06-29 1983-06-23
DE1994175004 Active DE19475004I2 (de) 1982-06-29 1983-06-23 Indolylcarbonsaeuretropyl- und- chinuclidinylester
DE3348332A Expired - Lifetime DE3348332C2 (OSRAM) 1982-06-29 1983-06-23
DE3348331A Expired - Lifetime DE3348331C2 (OSRAM) 1982-06-29 1983-06-23
DE3348333A Expired - Lifetime DE3348333C2 (OSRAM) 1982-06-29 1983-06-23

Family Applications Before (5)

Application Number Title Priority Date Filing Date
DE19833322574 Granted DE3322574A1 (de) 1982-06-29 1983-06-23 Benzoesaeurepiperidylester-derivate bzw. verfahren zu deren herstellung und deren verwendung
DE3348334A Expired - Lifetime DE3348334C2 (OSRAM) 1982-06-29 1983-06-23
DE1994175004 Active DE19475004I2 (de) 1982-06-29 1983-06-23 Indolylcarbonsaeuretropyl- und- chinuclidinylester
DE3348332A Expired - Lifetime DE3348332C2 (OSRAM) 1982-06-29 1983-06-23
DE3348331A Expired - Lifetime DE3348331C2 (OSRAM) 1982-06-29 1983-06-23

Country Status (20)

Country Link
US (3) US4803199A (OSRAM)
AT (1) AT391136B (OSRAM)
AU (2) AU570002B2 (OSRAM)
CH (2) CH669792A5 (OSRAM)
CY (1) CY1500A (OSRAM)
DE (6) DE3322574A1 (OSRAM)
DK (1) DK172475B1 (OSRAM)
FI (1) FI74707C (OSRAM)
FR (1) FR2531083B1 (OSRAM)
GB (4) GB2125398B (OSRAM)
HK (1) HK60690A (OSRAM)
HU (1) HU191053B (OSRAM)
IL (1) IL69081A (OSRAM)
IT (1) IT1173724B (OSRAM)
NL (2) NL191991C (OSRAM)
NZ (1) NZ204714A (OSRAM)
PT (1) PT76937B (OSRAM)
SE (1) SE463210B (OSRAM)
SG (1) SG53789G (OSRAM)
WO (1) WO1984000166A1 (OSRAM)

Families Citing this family (142)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI74707C (fi) * 1982-06-29 1988-03-10 Sandoz Ag Foerfarande foer framstaellning av terapeutiskt anvaendbara alkylenoeverbryggade piperidylestrar eller -amider av bicykliska karboxylsyror.
JPS5936675A (ja) * 1982-07-13 1984-02-28 サンド・アクチエンゲゼルシヤフト 二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド
EP0135545A1 (en) * 1983-02-19 1985-04-03 Beecham Group Plc Azabicycloalkyl benzamide and anilide derivatives
GB8315495D0 (en) * 1983-06-06 1983-07-13 Sumitomo Chemical Co Fungicidal aniline derivatives
WO1985001048A1 (en) * 1983-08-26 1985-03-14 Sandoz Ag Aromatic esters or amides of carboxylic acid and sulfonic acid
JPS6084281A (ja) * 1983-09-14 1985-05-13 Yoshitomi Pharmaceut Ind Ltd ３−インド−ルカルボキサミド類
US5175173A (en) * 1983-12-22 1992-12-29 Sun Jung Hui Carboxamides useful as antiemetic or antipsychotic agents
US4888353A (en) * 1986-02-28 1989-12-19 Erbamont, Inc. Carboxamides useful as antiemetic or antipsychotic agents
FR2557110B1 (fr) * 1983-12-23 1989-11-24 Sandoz Sa Nouveaux derives d'amines cycliques, leur preparation et leur utilisation comme medicaments
US4593034A (en) * 1984-04-06 1986-06-03 A. H. Robins Company, Inc. 2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamides and thiobenzamides
ATE86110T1 (de) * 1984-12-20 1993-03-15 Sandoz Ag Behandlung von gastrointestinalkrankheiten durch anwendung von 5-ht3-antagonisten.
CH667657A5 (de) * 1985-01-07 1988-10-31 Sandoz Ag Carbocyclische und heterocyclische carbonylmethylen- und methylpiperidine und -pyrrolidine.
US4605652A (en) * 1985-02-04 1986-08-12 A. H. Robins Company, Inc. Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes
DE3688296T2 (de) * 1985-03-14 1993-11-04 Beecham Group Plc Arzneimittel zur behandlung von erbrechen.
GB8623142D0 (en) * 1986-09-26 1986-10-29 Beecham Group Plc Compounds
US4937247A (en) * 1985-04-27 1990-06-26 Beecham Group P.L.C. 1-acyl indazoles
GB8525913D0 (en) * 1985-10-21 1985-11-27 Beecham Group Plc Compounds
EP0200444B1 (en) * 1985-04-27 1992-11-11 Beecham Group Plc Azabicyclononyl-indazole-carboxamide having 5-ht antagonist activity
GB8511988D0 (en) * 1985-05-11 1985-06-19 Beecham Group Plc Compounds
GB8515845D0 (en) * 1985-06-22 1985-07-24 Beecham Group Plc Treatment
GB8518658D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Medicaments
US5204356A (en) * 1985-07-24 1993-04-20 Glaxo Group Limited Treatment of anxiety
GB8520616D0 (en) * 1985-08-16 1985-09-25 Beecham Group Plc Compounds
GB8525844D0 (en) * 1985-10-19 1985-11-20 Beecham Group Plc Compounds
EP0247266B1 (en) * 1986-01-07 1993-03-10 Beecham Group Plc Indole derivatives having an azabicyclic side chain, process for their preparation, intermediates, and pharmaceutical compositions
EP0235878A3 (en) * 1986-01-16 1989-06-14 Beecham Group Plc Novel compounds
US4717563A (en) * 1986-03-05 1988-01-05 A. H. Robins Company, Inc. 2-alkoxy-N-(1-azabicyclo(2.2.2)oct-3-yl) benzamides and thiobenzamides in a method for alleviating emesis caused by non-platinum anticancer drugs
US4722834A (en) * 1986-03-05 1988-02-02 A. H. Robins Company, Incorporated Method of using 2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamide-N-oxides to control emesis caused by anticancer drugs
EP0254584B1 (en) * 1986-07-25 1992-10-07 Beecham Group Plc Azabicyclic compounds, process for their preparation, and their pharmaceutical use
NL8701682A (nl) * 1986-07-30 1988-02-16 Sandoz Ag Werkwijze voor het therapeutisch toepassen van serotonine antagonisten, aktieve verbindingen en farmaceutische preparaten die deze verbindingen bevatten.
DE3785507T2 (de) * 1986-07-31 1993-07-29 Beecham Group Plc Azabicyclische verbindungen, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung.
AT396870B (de) * 1986-08-07 1993-12-27 Sandoz Ag Verfahren zur herstellung einer galenischen formulierung zur nasalen verabreichung von serotoninantagonisten
US4772459A (en) * 1986-09-09 1988-09-20 Erbamont, Inc. Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein
EP0268309B1 (en) * 1986-09-22 1996-12-11 Janssen Pharmaceutica N.V. Serotonin antagonists for treating wounds
US4906755A (en) * 1986-11-03 1990-03-06 Merrell Dow Pharmaceuticals Inc. Esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3-(4H)-one and related compounds
ZA878096B (en) * 1986-11-03 1988-04-26 Merrell Dow Pharmaceuticals Inc. Esters of hexahydro-8-hydroxy-2,6-methano-2h-quinolizin-3(4h)-one and related compounds
ES2036587T5 (es) * 1986-11-21 1995-10-16 Glaxo Group Ltd Medicamentos para el tratamiento o prevencion del sindrome de abstinencia.
US5198447A (en) * 1986-11-21 1993-03-30 Glaxo Group Limited Medicaments
ES2051753T3 (es) * 1986-12-16 1994-07-01 Robins Co Inc A H N-(1-azabiciclo(2.2.2)octo-3-il) benzamidas y tiobenzamidas ansioliticas.
US5200414A (en) * 1986-12-17 1993-04-06 Glaxo Group Limited Methods for the treatment of cognitive disorders
US5190954A (en) * 1986-12-17 1993-03-02 Glaxo Group Limited Methods for the treatment of cognitive disorders
DE3788057T2 (de) * 1986-12-17 1994-03-03 Glaxo Group Ltd Verwendung von heterocyclischen Verbindungen zur Behandlung von Depressionen.
US5246941A (en) * 1986-12-17 1993-09-21 Glaxo Group Limited Method for the treatment of depression
JP2608079B2 (ja) * 1986-12-17 1997-05-07 グラクソ、グループ、リミテッド 医 薬
US5244909A (en) * 1986-12-17 1993-09-14 Glaxo Group Limited Methods for the treatment of cognitive disorders
AU618520B2 (en) * 1986-12-17 1992-01-02 Glaxo Group Limited Medicaments
GB8806990D0 (en) * 1988-03-23 1988-04-27 Beecham Group Plc Novel compounds
GB8701022D0 (en) * 1987-01-19 1987-02-18 Beecham Group Plc Treatment
DE3852145T2 (de) * 1987-02-18 1995-04-06 Beecham Group Plc Indolderivate, Verfahren zu deren Herstellung und pharmazeutische Präparate, die diese enthalten.
EP0289170B1 (en) * 1987-04-25 1993-06-23 Beecham Group Plc Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them
FR2616149B1 (fr) * 1987-06-04 1990-10-19 Adir Nouveau derive de l'acide benzo (b) thiophene - 7 carboxylique, son procede de preparation et les compositions pharmaceutiques qui le contiennent
DE3822792C2 (de) * 1987-07-11 1997-11-27 Sandoz Ag Neue Verwendung von 5HT¶3¶-Antagonisten
CA1307790C (en) * 1987-08-04 1992-09-22 Ian Anthony Cliffe Ethers
GB8718445D0 (en) * 1987-08-04 1987-09-09 Wyeth John & Brother Ltd Pyridyl-ethers
DE3827253A1 (de) * 1987-08-20 1989-03-02 Sandoz Ag Ester und amide von cyclischen carbonsaeuren und cyclischen alkoholen und aminen sowie verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen
GB8720805D0 (en) * 1987-09-04 1987-10-14 Naylor R J 2-alkoxy-n-(1-azabicyclo(2 2 2)oct-3-yl)benzamides & thiobenzamides
US4921982A (en) * 1988-07-21 1990-05-01 Eli Lilly And Company 5-halo-2,3-dihydro-2,2-dimethylbenzofuran-7-carboxylic acids useful as intermediates for 5-HT3 antagonists
US5364863A (en) * 1987-09-08 1994-11-15 Eli Lilly And Company Specific 5-HT3 antagonists
GB8723157D0 (en) * 1987-10-02 1987-11-04 Beecham Group Plc Compounds
EP0311724A1 (en) * 1987-10-16 1989-04-19 Synthelabo Anxiolytic-R-N-(1-azabicyclo[2.2.2]oct-3-yl) benzamides and thiobenzamides
CA1304082C (en) * 1987-10-22 1992-06-23 Tetsuya Tahara Benzoxazine compounds and pharmaceutical use thereof
US4985420A (en) * 1987-12-10 1991-01-15 Duphar International Research B.V. 1,7-annelated indolecarboxylic acid esters and -amides
US4863919A (en) * 1988-02-01 1989-09-05 A. H. Robins Company, Incorporated Method of enhancing memory or correcting memory deficiency with arylamido(and arylthiomido)-azabicycloalkanes
ATE129153T1 (de) * 1988-02-23 1995-11-15 Merrell Dow Pharma Verwendung von chinolizin- und chinolizinon- derivaten zur herstellung von arzneimitteln.
IT1226389B (it) * 1988-07-12 1991-01-15 Angeli Inst Spa Nuovi derivati ammidinici e guanidinici
US5166341A (en) * 1988-07-29 1992-11-24 Dainippon Pharmaceutical Co., Ltd. 6-amino-1,4-hexahydro-1H-diazepine derivatives
US5017573A (en) * 1988-07-29 1991-05-21 Dainippon Pharmaceutical Co., Ltd. Indazole-3-carboxylic acid derivatives
DE3878235T2 (de) * 1988-08-04 1993-06-03 Synthelabo Antischizophren-wirksame s-n-(1-azabicyclo (2.2.2.)oct-3-yl)benzamide und thiobenzamide.
CA2004911A1 (en) * 1988-12-22 1990-06-22 Mitsuaki Ohta 4,5,6,7-tetrahydrobenzimidazole derivatives
ES2095855T3 (es) * 1989-02-02 1997-03-01 Yamanouchi Pharma Co Ltd Derivados de tetrahidrobencimidazol.
GB8904551D0 (en) * 1989-02-28 1989-04-12 Glaxo Group Ltd Chemical compounds
US4914207A (en) * 1989-05-09 1990-04-03 Pfizer Inc. Arylthiazolylimidazoles
GB8913646D0 (en) * 1989-06-14 1989-08-02 Glaxo Group Ltd Chemical compounds
US5126343A (en) * 1989-09-11 1992-06-30 G. D. Searle & Co. N-azabicyclo [3.3.0]octane amides of aromatic acids
GB2236751B (en) 1989-10-14 1993-04-28 Wyeth John & Brother Ltd Heterocyclic compounds
US5225419A (en) * 1989-10-14 1993-07-06 John Wyeth & Brother, Limited Certain 1,8-ethano or propano-1,4-dihydro-4-oxo-quinoline-3-carboxamides and derivatives thereof
CA2030051C (en) * 1989-11-17 2001-08-07 Haruhiko Kikuchi Indole derivatives
US5446050A (en) * 1989-11-17 1995-08-29 Pfizer Inc. Azabicyclo amides and esters as 5-HT3 receptor antagonists
GB8928837D0 (en) * 1989-12-21 1990-02-28 Beecham Group Plc Pharmaceuticals
GB9009542D0 (en) * 1990-04-27 1990-06-20 Beecham Group Plc Novel compounds
US5140023A (en) * 1990-04-27 1992-08-18 G. D. Searle & Co. Azatetracycle compounds
US5223613A (en) * 1990-04-27 1993-06-29 G. D. Searle & Co. Azatetracycle compounds and process of preparing same
US5187166A (en) * 1990-07-31 1993-02-16 Nisshin Flour Milling Co., Ltd. Azabicyclo derivatives and their use as antiemetics
US5189041A (en) * 1990-11-16 1993-02-23 Syntex (U.S.A.) Inc. Tricyclic 5-ht3 receptor antagonists
WO1992009284A1 (en) * 1990-11-29 1992-06-11 Rhone-Poulenc Rorer International (Holdings), Inc. 2,6-methano-2h-1-benzoxocincarboxamides as 5-ht3-antagonists
JP3026845B2 (ja) * 1991-02-20 2000-03-27 日清製粉株式会社 ピペリジン誘導体
US5516782A (en) * 1991-03-07 1996-05-14 G. D. Searle & Co. New meso-azacyclic aromatic acid amides and esters as novel serotonergic agents
US5219850A (en) * 1991-03-07 1993-06-15 G. D. Searle & Co. Pharmaceutically useful meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof
US5137893A (en) * 1991-03-07 1992-08-11 G. D. Searle & Co. Pharmaceutically useful meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof
US5196547A (en) * 1991-03-07 1993-03-23 G. D. Searle & Co. Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof
US5260303A (en) * 1991-03-07 1993-11-09 G. D. Searle & Co. Imidazopyridines as serotonergic 5-HT3 antagonists
EP0528026A1 (en) * 1991-03-07 1993-02-24 G.D. Searle & Co. New meso-azacyclic aromatic acid amides and esters as novel serotonergic agents
US5234921A (en) * 1991-03-07 1993-08-10 G. D. Searle & Co. Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof as pharmaceuticals
US5227377A (en) * 1991-03-07 1993-07-13 G. D. Searle & Co. Meso-azacyclic amides of certain bicyclic carboxylic acids
AU2435092A (en) * 1991-08-20 1993-03-16 Smithkline Beecham Plc 5-ht4 receptor antagonists
WO1993005040A1 (en) * 1991-09-12 1993-03-18 Smithkline Beecham Plc Azabicyclic compounds as 5-ht4 receptor antagonists
US5344831A (en) * 1992-01-31 1994-09-06 Nisshin Flour Milling Co., Ltd. Diazabicyclo derivatives
JP2699794B2 (ja) * 1992-03-12 1998-01-19 三菱化学株式会社 チエノ〔３，２−ｂ〕ピリジン誘導体
US5852014A (en) * 1992-03-12 1998-12-22 Smithkline Beecham P.L.C. Condensed indole derivatives as 5HT4 -receptor antagonists
JPH05310732A (ja) * 1992-03-12 1993-11-22 Mitsubishi Kasei Corp シンノリン−３−カルボン酸誘導体
US5236931A (en) * 1992-03-26 1993-08-17 A. H. Robins Company, Incorporated 2-substituted benzamide and benzoate derivatives of 3-aminoquinuclidine and 3-quinuclidinol
US5748825A (en) * 1992-08-03 1998-05-05 Rockwell, Iii; Marshall A. Liquid crystal optical waveguide display system
GR1001378B (el) * 1992-10-08 1993-10-29 Smithkline Beecham Plc Ανταγωνιστές 5-ΗΤ4 πιπεριδυλαλκυλίου.
ES2056728B1 (es) * 1992-10-28 1995-05-01 Smithkline Beecham Plc Nuevos derivados de piperidilo y aminoalquilo con actividad antagonista del receptor 5-ht4
GB9414900D0 (en) * 1994-07-23 1994-09-14 Smithkline Beecham Plc Novel process
US5723103A (en) * 1994-12-09 1998-03-03 Vanderbilt University Substituted benzamides and radioligand analogs and methods of use
AU2319100A (en) * 1999-01-28 2000-08-18 Nippon Shinyaku Co. Ltd. Amide derivatives and drug compositions
KR20010112673A (ko) * 2000-06-09 2001-12-21 김환기 트로피세트론 염산염(일반식ⅰ)의 제조방법
EP1381603A2 (en) 2000-08-18 2004-01-21 PHARMACIA &amp; UPJOHN COMPANY Quinuclidine-substituedaryl moieties for treatment of disease ( nicotinic acetylcholine receptor ligands )
US6486172B2 (en) 2000-08-18 2002-11-26 Pharmacia & Upjohn Company Quinuclidine-substituted aryl compounds for treatment of disease
US6492385B2 (en) 2000-08-18 2002-12-10 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
WO2002015662A2 (en) 2000-08-21 2002-02-28 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists
AU2001282875A1 (en) 2000-08-21 2002-03-04 Pharmacia And Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
AR036040A1 (es) 2001-06-12 2004-08-04 Upjohn Co Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen
AR036041A1 (es) * 2001-06-12 2004-08-04 Upjohn Co Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen
AUPR701101A0 (en) * 2001-08-14 2001-09-06 Commonwealth Scientific And Industrial Research Organisation Agonists and antagonists of 5ht3-like receptors of invertebrates as pesticides
JP2005504059A (ja) * 2001-08-24 2005-02-10 ファルマシア アンド アップジョン カンパニー リミティド ライアビリティー カンパニー 疾患を処置するための置換アリール７−アザ［２．２．１］ビシクロヘプタン
DE60218493D1 (de) * 2001-09-12 2007-04-12 Pharmacia & Upjohn Co Llc Substituierte 7-aza-ä2.2.1übicycloheptane für die behandlung von krankheiten
SK1562004A3 (sk) 2001-10-02 2005-05-05 Pharmacia & Upjohn Company Azabicyklické substituované anelované heteroarylové zlúčeniny na liečenie chorôb
US6849620B2 (en) 2001-10-26 2005-02-01 Pfizer Inc N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease
ES2307902T3 (es) * 2002-02-12 2008-12-01 N.V. Organon Derivados de indolina e indol 1-arilsulfonil-3- sustituidos utilizados en el tratamiento de transtornos del sistema nervioso central.
EP1480977A2 (en) 2002-02-15 2004-12-01 PHARMACIA &amp; UPJOHN COMPANY Substituted aryl compounds for treatment of disease
US6858613B2 (en) * 2002-02-19 2005-02-22 Pfizer Inc. Fused bicyclic-N-bridged-heteroaromatic carboxamides for the treatment of disease
BR0307782A (pt) * 2002-02-19 2005-01-04 Upjohn Co Compostos azabiciclo para o tratamento de doença
JP2005525357A (ja) * 2002-02-20 2005-08-25 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー α７ニコチン性アセチルコリン受容体活性を伴うアザ二環式化合物
AU2003253686A1 (en) 2002-08-01 2004-02-23 Pharmacia & Upjohn Company Llc 1h-pyrazole and 1h-pyrrole-azabicyclic compounds with alfa-7 nachr activity
CN100484937C (zh) 2002-09-25 2009-05-06 记忆药物公司 吲唑、苯并噻唑和苯并异噻唑，以及它们的制备和用途
EP1562959A2 (en) * 2002-11-01 2005-08-17 Pharmacia & Upjohn Company LLC Compounds having both alpha7 nachr agonist and 5ht antagonist activity for treatment of cns diseases
BRPI0409924A (pt) 2003-04-30 2006-04-25 Inst For Pharm Discovery Inc ácidos amino carboxìlicos substituìdos
EP1697378B1 (en) 2003-12-22 2007-11-21 Memory Pharmaceuticals Corporation Indoles, 1h-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof
MXPA06010852A (es) 2004-03-25 2007-01-16 Memory Pharm Corp Indazoles, benzotiazoles, benzoisotiazoles, bencisoxazoles y preparacion y usos de los mismos.
US7488737B2 (en) 2004-04-22 2009-02-10 Memory Pharmaceutical Corporation Indoles, 1H-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof
AU2005243147A1 (en) 2004-05-07 2005-11-24 Memory Pharmaceuticals Corporation 1H-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparation and uses thereof
CN100390172C (zh) * 2004-09-10 2008-05-28 成都欣捷高新技术开发有限公司 一种甲磺酸多拉司琼晶型及其制备方法
EP1814869A2 (en) 2004-11-18 2007-08-08 The Institutes for Pharmaceutical Discovery, LLC Substituted amino acids as protein tyrosine phosphatase inhibitors
BRPI0517494A (pt) * 2004-12-22 2008-10-14 Memory Pharm Corp composto, composição farmacêutica, método de ativação/estimulação seletiva de receptores nicotìnicos de a-7 em um paciente em que tal ativação/estimulação tem um efeito terapêutico, método de tratamento de um paciente que sofre de uma doença psicótica, uma doença neurodegenerativa que envolve uma disfunção do sistema colinérgico, e/ou uma condição de debilitação da memória e/ou da cognição, método de tratamento de um paciente que sofre de demência e/ou uma outra condição com perda da memória, método de tratamento de um paciente que sofre de debilitação da memória devido à debilitação cognitiva suave devido ao envelhecimento, mal de alzheimer, esquizofrenia, mal de parkinson, mal de huntington, mal de pick, mal de creutzfeldt-jakob, depressão, envelhecimento, trauma na cabeça, acidente vascular cerebral, hipoxia do snc, senilidade cerebral, demência de multiinfarto, hiv e/ou doença cardiovascular, método de tratamento e/ou prevenção da demência em um paciente com o mal de alzheimer, método de tratamento de um paciente para cortar o vìcio do álcool ou o tratamento de um paciente com a terapia anti-intoxicação, método de tratamento de um paciente para propiciar neuroproteção contra os danos associados com acidentes vasculares cerebrais e isquemia e excitotoxicidade induzida por glutamatos, método de tratamento de um paciente que sofre do vìcio da nicotina, dor, tontura do fuso horário, obesidade e/ou diabetes, método de indução do ato de parar fumar em um paciente, método de tratamento de um paciente que sofre de debilitação cognitiva suave (mci), demência vascular (vad), declìnio cognitivo associado com a idade (aacd), amnésia associada com a cirurgia com o coração aberto, parada cardìaca, anestesia geral, deficiências da memória devido à exposição a agentes anestésicos, debilitação cognitiva induzida pela privação do sono, sìndrome de fadiga crÈnica, narcolepsia, demência relacionada com a aids, debilitação cognitiva relacionada com a epilepsia, sìndrome de down, demência relacionada ao alcoolismo, debilitações da memória induzidas por drogas/substáncias, demência pugilìstica (sìndrome do boxeador), ou demência animal, método para o tratamento da perda da memória, método para o tratamento de um paciente que sofre de debilitação da memória, método para o tratamento ou a profilaxia de uma doença ou de uma condição resultante da disfunção da transmissão do receptor nicotìnico de acetilcolina em um paciente, método para o tratamento ou a profilaxia de uma doença ou de uma condição resultante de receptores nicotìnicos de acetilcolina defeituosos ou funcionando mal em um paciente, método para o tratamento ou a profilaxia de uma doença ou de uma condição resultante da transmissão suprimida do receptor nicotìnico de acetilcolina em um paciente, método para o tratamento ou a profilaxia de uma doença ou de uma condição resultante da perda de sinapses colinérgicas em um paciente, método para a proteção dos neurÈnios em um paciente com neurotoxicidade induzi
US8106066B2 (en) 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
EP2253316B1 (en) 2009-05-20 2013-08-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of an inner ear pathology with vestibular deficits
CN102458400B (zh) 2009-05-20 2014-10-08 国立健康与医学研究所 用于治疗病灶性前庭功能障碍的血清素5-ht3受体拮抗剂
JOP20130213B1 (ar) 2012-07-17 2021-08-17 Takeda Pharmaceuticals Co معارضات لمستقبلht3-5
WO2016053947A1 (en) 2014-09-29 2016-04-07 Takeda Pharmaceutical Company Limited Crystalline form of 1-(1-methyl-1h-pyrazol-4-yl)-n-((1r,5s,7s)-9-methyl-3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-1h-indole-3-carboxamide
RU2681931C2 (ru) * 2017-08-01 2019-03-14 Фарид Шамилевич Шагиахметов Фармацевтическая комбинация для лечения алкогольной зависимости

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0067770A2 (en) * 1981-06-13 1982-12-22 Merrell Dow France Et Cie Treatment of migraine with tropyl benzoate derivatives

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3170927A (en) * 1965-02-23 O chzoh
US2478134A (en) * 1947-11-25 1949-08-02 Samuel W Smith Simulated bowling target
GB774858A (en) * 1954-10-20 1957-05-15 Sandoz Ltd Tropane and -Î-tropane derivatives and process for preparation thereof
AT198771B (de) * 1956-03-09 1958-07-25 Boehringer Sohn Ingelheim Verfahren zur Herstellung von neuen Estern und deren Salzen
US3342826A (en) * 1964-01-13 1967-09-19 Ile De France Heterocyclic aminoalkyl benzamides
US3405134A (en) * 1965-08-17 1968-10-08 Colgate Palmolive Co Quinuclidyl esters of aromatic acids
SE331841B (OSRAM) * 1967-05-23 1971-01-18 Astra Ab
US3702324A (en) * 1970-06-24 1972-11-07 Stanford Research Inst 3,4,5-trimethoxybenzamides of substituted anilines and of alkylpiperidines
GB1293446A (en) * 1970-07-23 1972-10-18 Rech S Et D Applic Scient Soge Quinuclidine derivatives, the preparation thereof and pharmaceutical compositions containing them
CH614709A5 (OSRAM) * 1975-09-25 1979-12-14 Ciba Geigy Ag
DE2548968A1 (de) * 1975-11-03 1977-05-12 Thomae Gmbh Dr K Neue amino-benzoesaeureamide
FI763021A7 (OSRAM) * 1975-11-03 1977-05-04 Thomae Gmbh Dr K
GB1593146A (en) * 1976-11-05 1981-07-15 Beecham Group Ltd Octahydro-quinolizinyl benzamide derivatives
IL59004A0 (en) * 1978-12-30 1980-03-31 Beecham Group Ltd Substituted benzamides their preparation and pharmaceutical compositions containing them
FR2476088A2 (fr) * 1979-01-16 1981-08-21 Delalande Sa Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique
NZ197356A (en) * 1980-06-18 1984-05-31 Beecham Group Ltd Ar-alkylsulphinyl-n-(azaicycloalkyl(alkyl)) benzamides
FR2493848B2 (fr) * 1980-11-07 1986-05-16 Delalande Sa Nouveaux derives des nor-tropane et granatane, leur procede de preparation et leur application en therapeutique
FR2499570A1 (fr) * 1981-02-11 1982-08-13 Delalande Sa Nouveaux derives du b-amino-3 nor-tropane et leur procede de preparation
GB2100259B (en) * 1981-06-13 1984-10-31 Merrell Toraude & Co Treatment of migraine with tropyl benzoate derivatives
DE3268378D1 (en) * 1981-06-17 1986-02-20 Beecham Group Plc Alkylthio derivatives of azabicyclobenzamides, their preparation and pharmaceutical compositions
EP0069482A1 (en) * 1981-06-29 1983-01-12 Beecham Group Plc Azabicycloalkyl benzamides, process for their preparation and pharmaceutical compositions containing them
EP0068700A1 (en) * 1981-06-29 1983-01-05 Beecham Group Plc Azobicycloalkylbenzamides, process for their preparation and pharmaceutical compositions containing them
NZ200981A (en) * 1981-07-17 1984-10-19 Recordati Chem Pharm 3-methylflavone-8-carboxylic acid derivatives and pharmaceutical compositions
EP0076592B1 (en) * 1981-10-01 1987-01-28 Beecham Group Plc Azabicyclo-(3,3,1)-nonylbenzamide derivatives, processes for their preparation, and pharmaceutical compositions containing them
FI74707C (fi) * 1982-06-29 1988-03-10 Sandoz Ag Foerfarande foer framstaellning av terapeutiskt anvaendbara alkylenoeverbryggade piperidylestrar eller -amider av bicykliska karboxylsyror.
FR2529548A1 (fr) * 1982-07-02 1984-01-06 Delalande Sa Nouveaux derives de l'amino-3 quinuclidine, leur procede et leur application en therapeutique
ATE19881T1 (de) * 1982-12-10 1986-06-15 Merrell Toraude & Co Tropyl- und pseudotropylalkylbenzoate und ihre verwendung in der behandlung von migraene.
GB8302483D0 (en) * 1983-01-29 1983-03-02 Beecham Group Plc Compounds
EP0135545A1 (en) * 1983-02-19 1985-04-03 Beecham Group Plc Azabicycloalkyl benzamide and anilide derivatives
FR2546169B1 (fr) * 1983-05-20 1986-03-21 Delalande Sa N-oxydes de derives aminocycliques, leur procede de preparation et leur application en therapeutique

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0067770A2 (en) * 1981-06-13 1982-12-22 Merrell Dow France Et Cie Treatment of migraine with tropyl benzoate derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Chem.Abstr. 89, 1978, 167x *

Also Published As

Publication number Publication date
NZ204714A (en) 1986-08-08
GB8317365D0 (en) 1983-07-27
GB2166726A (en) 1986-05-14
US5017582A (en) 1991-05-21
GB2166727B (en) 1986-11-26
CH669792A5 (OSRAM) 1989-04-14
DE3348332C2 (OSRAM) 1992-08-06
NL8302253A (nl) 1984-01-16
NL191991C (nl) 1996-12-03
FI832293L (fi) 1983-12-30
PT76937A (en) 1983-07-01
SE463210B (sv) 1990-10-22
AU1628683A (en) 1984-01-05
HU191053B (en) 1986-12-28
AU8243487A (en) 1988-04-28
GB2125398B (en) 1986-11-26
GB8520186D0 (en) 1985-09-18
DK295183D0 (da) 1983-06-27
SG53789G (en) 1989-12-08
SE8303651L (sv) 1983-12-30
GB2125398A (en) 1984-03-07
IT8348580A1 (it) 1984-12-27
DE19475004I2 (de) 2003-06-12
DK172475B1 (da) 1998-09-14
WO1984000166A1 (fr) 1984-01-19
CY1500A (en) 1990-08-03
GB8520188D0 (en) 1985-09-18
SE8303651D0 (sv) 1983-06-27
IL69081A0 (en) 1983-10-31
AT391136B (de) 1990-08-27
DE3348331C2 (OSRAM) 1992-08-06
HK60690A (en) 1990-08-17
DE3322574A1 (de) 1983-12-29
GB2166727A (en) 1986-05-14
NL970021I2 (nl) 1998-01-05
ATA235883A (de) 1990-02-15
GB2166728A (en) 1986-05-14
DE3322574C2 (OSRAM) 1992-07-30
DE3348334C2 (OSRAM) 1992-08-06
AU603399B2 (en) 1990-11-15
IL69081A (en) 1987-02-27
PT76937B (en) 1986-03-11
AU570002B2 (en) 1988-03-03
CH669954A5 (en) 1989-04-28
NL191991B (nl) 1996-08-01
US4910207A (en) 1990-03-20
US4803199A (en) 1989-02-07
FI832293A0 (fi) 1983-06-22
IT8348580A0 (it) 1983-06-27
FR2531083B1 (fr) 1986-11-28
GB2166726B (en) 1986-11-26
IT1173724B (it) 1987-06-24
FI74707B (fi) 1987-11-30
FI74707C (fi) 1988-03-10
GB2166728B (en) 1986-11-26
FR2531083A1 (fr) 1984-02-03
GB8520187D0 (en) 1985-09-18
DK295183A (da) 1983-12-30
NL970021I1 (nl) 1997-08-01

Similar Documents

Publication Publication Date Title
DE3348333C2 (OSRAM)
WO1985001048A1 (en) Aromatic esters or amides of carboxylic acid and sulfonic acid
DE69332095T2 (de) Thieno(3,2-b)Pyridinderivate zur Behandlung von Magen-Darmstörungen
US4789673A (en) Heterocyclic carboxylic acid amides and esters
WO1985002847A1 (fr) Esters et amides d&#39;acides carboniques carbocycliques et heterocycliques d&#39;amines ou d&#39;alcools azotes cycliques portes et non portes
Clarke et al. Compounds affecting the central nervous system. 4. 3. beta.-phenyltropane-2-carboxylic esters and analogs
DE69325167T2 (de) Kondensierte indol-derivate als 5-ht4-rezeptor-antagonisten
CH667657A5 (de) Carbocyclische und heterocyclische carbonylmethylen- und methylpiperidine und -pyrrolidine.
DE3650772T2 (de) Derivate von Indazole-3-carboxamide und -3-carboxylsäure
DE3689974T2 (de) Arzneimittel zur Behandlung von Emesis.
DE3850203T2 (de) Benzimidazolin-2-oxo-1-carboxylsäure-Derivate, verwendbar als Antagonisten von 5-HT-Rezeptoren.
DE69024381T2 (de) Benzo-annellierte-N-enthaltende heterocyclische Derivate
DE69009195T2 (de) Isoxazol-Derivate mit Anti-Serotonin-Aktivität, deren Herstellungsverfahren und diese enthaltende Zusammensetzungen.
DE3852145T2 (de) Indolderivate, Verfahren zu deren Herstellung und pharmazeutische Präparate, die diese enthalten.
DE3750359T2 (de) Ester des Hexahydro-8-hydroxy-2,6-methano-2H-chinolizin-3(4H)-ons und verwandte Verbindungen.
DE69116185T2 (de) Azabicyclo- und Azacyclooxime und -amine mit cholinergischer Wirkung und ihre pharmazeutisch annehmbaren Salze
DE69828508T2 (de) Tropananloga und methoden zur hemmung des transportes von monoaminen
DE69307749T2 (de) Cinnolin-3-Carbonsäurederivate als 5-HT3-Antagonisten
DE69133295T2 (de) 3,9-diazabicyclo-[3.3.1]-nonanylderivate, verfahren und intermediate für ihre darstellung und sie enthaltende pharmazeutische zusammensetzungen
DE69112594T2 (de) Dihydrobenzofurancarboxamide und Verfahren zu ihrer Herstellung.
DE69918046T2 (de) Neue basische Derivate von Benz(e)isoindol-1-onen und Pyrrolo(3,4-c)chinolin-1-onen mit 5-HT3-antagonistischer Aktivität, ihre Herstellung und ihre therapeutische Verwendung
DE68924545T2 (de) Verwendung von Chinolizin- und Chinolizinon-Derivaten zur Herstellung von Arzneimitteln.
DE2935685C2 (de) 2-Brom-9,10-dihydroergosin und seine Säureadditonssalze, Verfahren zu deren Herstellung sowie diese Verbindung enthaltende Arzneimittel
JPH0570634B2 (OSRAM)
DE3545981A1 (de) Neue carbocyclische und heterocyclische carbonylmethylen und methylpiperidine und -pyrrolidine

Legal Events

Date Code Title Description
Q172 Divided out of (supplement):

Ref country code: DE

Ref document number: 3322574

8181 Inventor (new situation)

Free format text: DONATSCH, PETER, DR., ALLSCHWEIL, CH ENGEL, GUENTER, DR., 7858 WEIL, DE HUEGI, BRUNO, DR., PFEFFINGEN, CH RICHARDSON, BRIAN PETER, DR., MAGDEN, CH STADLER, PAUL, DR., BIEL-BENKEN, CH

8110 Request for examination paragraph 44
AC Divided out of

Ref country code: DE

Ref document number: 3322574

Format of ref document f/p: P

AC Divided out of

Ref country code: DE

Ref document number: 3322574

Format of ref document f/p: P

D2 Grant after examination
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NOVARTIS AG, BASEL, CH

8328 Change in the person/name/address of the agent

Free format text: SPOTT WEINMILLER & PARTNER, 80336 MUENCHEN