DE2725019A1 - Verfahren zur herstellung substituierter aminochinazolinderivate und zwischenprodukte dafuer - Google Patents

Verfahren zur herstellung substituierter aminochinazolinderivate und zwischenprodukte dafuer

Info

Publication number
DE2725019A1
DE2725019A1 DE19772725019 DE2725019A DE2725019A1 DE 2725019 A1 DE2725019 A1 DE 2725019A1 DE 19772725019 DE19772725019 DE 19772725019 DE 2725019 A DE2725019 A DE 2725019A DE 2725019 A1 DE2725019 A1 DE 2725019A1
Authority
DE
Germany
Prior art keywords
deep
formula
compound
reaction
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19772725019
Other languages
German (de)
English (en)
Inventor
Philip Dietrich Hammen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of DE2725019A1 publication Critical patent/DE2725019A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE19772725019 1976-06-15 1977-05-31 Verfahren zur herstellung substituierter aminochinazolinderivate und zwischenprodukte dafuer Pending DE2725019A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69620176A 1976-06-15 1976-06-15

Publications (1)

Publication Number Publication Date
DE2725019A1 true DE2725019A1 (de) 1977-12-22

Family

ID=24796111

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19772725019 Pending DE2725019A1 (de) 1976-06-15 1977-05-31 Verfahren zur herstellung substituierter aminochinazolinderivate und zwischenprodukte dafuer

Country Status (34)

Country Link
JP (1) JPS52153985A (da)
AR (1) AR218251A1 (da)
AT (1) AT356115B (da)
BE (1) BE855656A (da)
BG (3) BG35748A3 (da)
CA (1) CA1068698A (da)
CH (3) CH638203A5 (da)
CS (1) CS202069B2 (da)
DD (1) DD131021A5 (da)
DE (1) DE2725019A1 (da)
DK (1) DK146625C (da)
EG (1) EG12922A (da)
ES (1) ES459364A1 (da)
FI (1) FI66853C (da)
FR (1) FR2355015A1 (da)
GB (1) GB1548856A (da)
GR (1) GR72288B (da)
HK (1) HK31481A (da)
HU (1) HU177883B (da)
IE (1) IE45423B1 (da)
IL (1) IL52167A (da)
LU (1) LU77530A1 (da)
MY (1) MY8100270A (da)
NL (1) NL172543C (da)
NO (1) NO147838C (da)
NZ (1) NZ184168A (da)
PH (1) PH22196A (da)
PL (3) PL111221B1 (da)
PT (1) PT66617B (da)
RO (3) RO77330A (da)
SE (2) SE435380B (da)
SU (2) SU1033002A3 (da)
YU (1) YU40164B (da)
ZA (1) ZA773014B (da)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3346675A1 (de) * 1983-12-23 1985-07-04 Beiersdorf Ag, 2000 Hamburg Substituierte 1-(4-amino-6,7-dialkoxy-chinazolinyl)-4- cyclohexenyl-derivate des piperazins und homopiperazins, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen und zwischenprodukte
AT384218B (de) * 1985-12-04 1987-10-12 Gerot Pharmazeutika Verfahren zur herstellung von neuen chinazolin-derivaten
US5654307A (en) * 1994-01-25 1997-08-05 Warner-Lambert Company Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
US5675006A (en) * 1992-08-31 1997-10-07 Brantford Chemicals Inc. Methods of making ureas and guanidines, including, terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin, and bunazosin (exemplary of 2- substituted quinazoline compounds), and meobentine, and bethanidine and intermediates therefor
US6084095A (en) * 1994-01-25 2000-07-04 Warner-Lambert Company Substituted pyrido[3,2-d]pyrimidines capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
US6596726B1 (en) 1994-01-25 2003-07-22 Warner Lambert Company Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932538A (en) * 1996-02-02 1999-08-03 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3511836A (en) 1967-12-13 1970-05-12 Pfizer & Co C 2,4,6,7-tetra substituted quinazolines
US3669968A (en) 1970-05-21 1972-06-13 Pfizer Trialkoxy quinazolines
US3935213A (en) 1973-12-05 1976-01-27 Pfizer Inc. Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4966691A (da) * 1972-10-30 1974-06-27
JPS50126682A (da) * 1974-03-25 1975-10-04

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3511836A (en) 1967-12-13 1970-05-12 Pfizer & Co C 2,4,6,7-tetra substituted quinazolines
US3669968A (en) 1970-05-21 1972-06-13 Pfizer Trialkoxy quinazolines
US3935213A (en) 1973-12-05 1976-01-27 Pfizer Inc. Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3346675A1 (de) * 1983-12-23 1985-07-04 Beiersdorf Ag, 2000 Hamburg Substituierte 1-(4-amino-6,7-dialkoxy-chinazolinyl)-4- cyclohexenyl-derivate des piperazins und homopiperazins, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen und zwischenprodukte
AT384218B (de) * 1985-12-04 1987-10-12 Gerot Pharmazeutika Verfahren zur herstellung von neuen chinazolin-derivaten
US6080860A (en) * 1992-08-31 2000-06-27 Brantford Chemicalss Inc. Methods of making ureas and guanidines including, terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin and bunazosin (exemplary of 2-substituted quinazoline compounds), and meobentine, and bethanidine and intermediates therefor
US5675006A (en) * 1992-08-31 1997-10-07 Brantford Chemicals Inc. Methods of making ureas and guanidines, including, terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin, and bunazosin (exemplary of 2- substituted quinazoline compounds), and meobentine, and bethanidine and intermediates therefor
US5686612A (en) * 1992-08-31 1997-11-11 Brantford Chemicals Inc. Methods of making ureas and guanidines, including terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin, and bunazosin (exemplary of 2-substituted quinazoline compounds), and meobentine, and bethanidine and intermediates thereof
US5679683A (en) * 1994-01-25 1997-10-21 Warner-Lambert Company Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
US5654307A (en) * 1994-01-25 1997-08-05 Warner-Lambert Company Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
US6084095A (en) * 1994-01-25 2000-07-04 Warner-Lambert Company Substituted pyrido[3,2-d]pyrimidines capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
US6265410B1 (en) 1994-01-25 2001-07-24 Warner-Lambert Company Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
US6455534B2 (en) 1994-01-25 2002-09-24 Warner-Lambert Company Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
US6521620B1 (en) 1994-01-25 2003-02-18 Warner-Lambert Company Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
US6596726B1 (en) 1994-01-25 2003-07-22 Warner Lambert Company Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
US6713484B2 (en) 1994-01-25 2004-03-30 Warner-Lambert Company Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family

Also Published As

Publication number Publication date
JPS5543465B2 (da) 1980-11-06
PT66617B (en) 1978-10-27
SU946402A3 (ru) 1982-07-23
CH638203A5 (en) 1983-09-15
CS202069B2 (en) 1980-12-31
PL105558B1 (pl) 1979-10-31
NZ184168A (en) 1979-08-31
FR2355015A1 (fr) 1978-01-13
YU40164B (en) 1985-08-31
PL198874A1 (pl) 1978-04-10
LU77530A1 (fr) 1979-03-26
EG12922A (en) 1980-03-31
RO77308A (ro) 1981-08-17
DD131021A5 (de) 1978-05-24
HU177883B (en) 1982-01-28
PL111221B1 (en) 1980-08-30
AT356115B (de) 1980-04-10
BE855656A (fr) 1977-12-14
NO147838B (no) 1983-03-14
CH638517A5 (en) 1983-09-30
SE435380B (sv) 1984-09-24
FR2355015B1 (da) 1981-07-24
DK240877A (da) 1977-12-16
GB1548856A (en) 1979-07-18
NO771919L (no) 1977-12-16
CH638516A5 (en) 1983-09-30
HK31481A (en) 1981-07-10
MY8100270A (en) 1981-12-31
IE45423B1 (en) 1982-08-25
IL52167A (en) 1981-01-30
ATA386977A (de) 1979-09-15
PH22196A (en) 1988-06-28
FI771741A (da) 1977-12-16
SE8107554L (sv) 1981-12-16
ZA773014B (en) 1978-04-26
AR218251A1 (es) 1980-05-30
PL113012B1 (en) 1980-11-29
SE7705745L (sv) 1977-12-16
YU132677A (en) 1982-08-31
NL7705939A (nl) 1977-12-19
BG35594A3 (en) 1984-05-15
IE45423L (en) 1977-12-15
NO147838C (no) 1983-06-22
RO73050A (ro) 1981-08-30
NL172543C (nl) 1983-09-16
FI66853C (fi) 1984-12-10
SU1033002A3 (ru) 1983-07-30
GR72288B (da) 1983-10-17
NL172543B (nl) 1983-04-18
ES459364A1 (es) 1978-03-16
AU2558377A (en) 1978-09-07
JPS52153985A (en) 1977-12-21
CA1068698A (en) 1979-12-25
DK146625B (da) 1983-11-21
PT66617A (en) 1977-06-01
RO77330A (ro) 1981-06-22
DK146625C (da) 1984-06-04
BG35747A3 (en) 1984-06-15
FI66853B (fi) 1984-08-31
IL52167A0 (en) 1977-07-31
BG35748A3 (en) 1984-06-15
SE450120B (sv) 1987-06-09

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