IE45423L - 2-piperazinyl-4-aminoquinazolines - Google Patents
2-piperazinyl-4-aminoquinazolinesInfo
- Publication number
- IE45423L IE45423L IE771212A IE121277A IE45423L IE 45423 L IE45423 L IE 45423L IE 771212 A IE771212 A IE 771212A IE 121277 A IE121277 A IE 121277A IE 45423 L IE45423 L IE 45423L
- Authority
- IE
- Ireland
- Prior art keywords
- dimethoxyquinazoline
- compounds
- carbon atoms
- amino group
- aminoquinazolines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Compounds of the formula <IMAGE> or of a hydrochloric or hydrobromic acid addition salt thereof, in which R1 is hydrogen or methoxy, and R2 denotes benzoyl, furoyl, thienylcarbonyl, alkoxycarbonyl having 2 to 5 carbon atoms or (2-hydroxyalkoxy)carbonyl having 4 or 5 carbon atoms, are prepared in accordance with a novel process. Initially, a 2-chloro-6,7-dimethoxyquinazoline or a 2-bromo-6,7-dimethoxyquinazoline, whose amino group situated in the 4 position is substituted, is reacted, in an inert organic solvent and at 50-200 DEG C, with a corresponding piperazine. In a second reaction step, the substituents of the amino group are removed by hydrogenolysis. The compounds which are obtained can be used as agents for lowering blood pressure.
[GB1548856A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69620176A | 1976-06-15 | 1976-06-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE45423L true IE45423L (en) | 1977-12-15 |
| IE45423B1 IE45423B1 (en) | 1982-08-25 |
Family
ID=24796111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1212/77A IE45423B1 (en) | 1976-06-15 | 1977-06-14 | Process for hypotensive 2-(4-substituted piperazin-1-yl)-4-aminoquinazolines |
Country Status (34)
| Country | Link |
|---|---|
| JP (1) | JPS52153985A (en) |
| AR (1) | AR218251A1 (en) |
| AT (1) | AT356115B (en) |
| BE (1) | BE855656A (en) |
| BG (3) | BG35748A3 (en) |
| CA (1) | CA1068698A (en) |
| CH (3) | CH638203A5 (en) |
| CS (1) | CS202069B2 (en) |
| DD (1) | DD131021A5 (en) |
| DE (1) | DE2725019A1 (en) |
| DK (1) | DK146625C (en) |
| EG (1) | EG12922A (en) |
| ES (1) | ES459364A1 (en) |
| FI (1) | FI66853C (en) |
| FR (1) | FR2355015A1 (en) |
| GB (1) | GB1548856A (en) |
| GR (1) | GR72288B (en) |
| HK (1) | HK31481A (en) |
| HU (1) | HU177883B (en) |
| IE (1) | IE45423B1 (en) |
| IL (1) | IL52167A (en) |
| LU (1) | LU77530A1 (en) |
| MY (1) | MY8100270A (en) |
| NL (1) | NL172543C (en) |
| NO (1) | NO147838C (en) |
| NZ (1) | NZ184168A (en) |
| PH (1) | PH22196A (en) |
| PL (3) | PL105558B1 (en) |
| PT (1) | PT66617B (en) |
| RO (3) | RO77308A (en) |
| SE (2) | SE435380B (en) |
| SU (2) | SU1033002A3 (en) |
| YU (1) | YU40164B (en) |
| ZA (1) | ZA773014B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3346675A1 (en) * | 1983-12-23 | 1985-07-04 | Beiersdorf Ag, 2000 Hamburg | SUBSTITUTED 1- (4-AMINO-6,7-DIALKOXY-CHINAZOLINYL) -4- CYCLOHEXENYL DERIVATIVES OF PIPERAZINE AND HOMOPIPERAZINE, METHODS FOR THE PRODUCTION THEREOF, AND THEIR USE, AND ITS RELATED PRODUCTS |
| AT384218B (en) * | 1985-12-04 | 1987-10-12 | Gerot Pharmazeutika | METHOD FOR PRODUCING NEW CHINAZOLINE DERIVATIVES |
| CA2077252C (en) * | 1992-08-31 | 2001-04-10 | Khashayar Karimian | Methods of making ureas and guanidines, and intermediates therefor |
| US5679683A (en) * | 1994-01-25 | 1997-10-21 | Warner-Lambert Company | Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
| IL112249A (en) | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
| US5932538A (en) * | 1996-02-02 | 1999-08-03 | Nitromed, Inc. | Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3511836A (en) | 1967-12-13 | 1970-05-12 | Pfizer & Co C | 2,4,6,7-tetra substituted quinazolines |
| US3669968A (en) | 1970-05-21 | 1972-06-13 | Pfizer | Trialkoxy quinazolines |
| JPS536156B2 (en) * | 1972-10-30 | 1978-03-04 | ||
| US3935213A (en) | 1973-12-05 | 1976-01-27 | Pfizer Inc. | Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives |
| JPS50126682A (en) * | 1974-03-25 | 1975-10-04 |
-
1977
- 1977-05-16 SE SE7705745A patent/SE435380B/en not_active IP Right Cessation
- 1977-05-18 CA CA278,728A patent/CA1068698A/en not_active Expired
- 1977-05-20 GR GR53521A patent/GR72288B/el unknown
- 1977-05-20 ZA ZA00773014A patent/ZA773014B/en unknown
- 1977-05-20 NZ NZ184168A patent/NZ184168A/en unknown
- 1977-05-25 IL IL52167A patent/IL52167A/en unknown
- 1977-05-27 YU YU1326/77A patent/YU40164B/en unknown
- 1977-05-31 PT PT66617A patent/PT66617B/en unknown
- 1977-05-31 NL NLAANVRAGE7705939,A patent/NL172543C/en not_active IP Right Cessation
- 1977-05-31 JP JP6391877A patent/JPS52153985A/en active Granted
- 1977-05-31 DE DE19772725019 patent/DE2725019A1/en active Pending
- 1977-06-01 FI FI771741A patent/FI66853C/en not_active IP Right Cessation
- 1977-06-01 AT AT386977A patent/AT356115B/en not_active IP Right Cessation
- 1977-06-01 NO NO771919A patent/NO147838C/en unknown
- 1977-06-01 DK DK240877A patent/DK146625C/en not_active IP Right Cessation
- 1977-06-01 EG EG338/77A patent/EG12922A/en active
- 1977-06-01 CH CH673777A patent/CH638203A5/en not_active IP Right Cessation
- 1977-06-01 ES ES459364A patent/ES459364A1/en not_active Expired
- 1977-06-02 AR AR267927A patent/AR218251A1/en active
- 1977-06-03 BG BG057396A patent/BG35748A3/en unknown
- 1977-06-03 BG BG036493A patent/BG35594A3/en unknown
- 1977-06-03 BG BG057395A patent/BG35747A3/en unknown
- 1977-06-13 LU LU77530A patent/LU77530A1/en unknown
- 1977-06-14 BE BE178416A patent/BE855656A/en not_active IP Right Cessation
- 1977-06-14 FR FR7718206A patent/FR2355015A1/en active Granted
- 1977-06-14 HU HU77PI578A patent/HU177883B/en not_active IP Right Cessation
- 1977-06-14 GB GB24841/77A patent/GB1548856A/en not_active Expired
- 1977-06-14 RO RO7798087A patent/RO77308A/en unknown
- 1977-06-14 RO RO7790683A patent/RO73050A/en unknown
- 1977-06-14 SU SU772497901A patent/SU1033002A3/en active
- 1977-06-14 IE IE1212/77A patent/IE45423B1/en not_active IP Right Cessation
- 1977-06-14 RO RO7798088A patent/RO77330A/en unknown
- 1977-06-15 DD DD7700199502A patent/DD131021A5/en unknown
- 1977-06-15 PL PL1977198874A patent/PL105558B1/en unknown
- 1977-06-15 PL PL1977211798A patent/PL111221B1/en unknown
- 1977-06-15 CS CS773960A patent/CS202069B2/en unknown
- 1977-06-15 PL PL1977211797A patent/PL113012B1/en unknown
-
1978
- 1978-01-03 PH PH20606A patent/PH22196A/en unknown
- 1978-06-28 SU SU782630798A patent/SU946402A3/en active
-
1981
- 1981-07-02 HK HK314/81A patent/HK31481A/en unknown
- 1981-12-16 SE SE8107554A patent/SE450120B/en not_active IP Right Cessation
- 1981-12-30 MY MY270/81A patent/MY8100270A/en unknown
-
1982
- 1982-04-22 CH CH245782A patent/CH638517A5/en not_active IP Right Cessation
- 1982-04-22 CH CH245682A patent/CH638516A5/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |