ES459364A1 - Process for hypotensive 2-(4-substituted piperazin 1-yl)-j-aminopainazolines - Google Patents
Process for hypotensive 2-(4-substituted piperazin 1-yl)-j-aminopainazolinesInfo
- Publication number
- ES459364A1 ES459364A1 ES459364A ES459364A ES459364A1 ES 459364 A1 ES459364 A1 ES 459364A1 ES 459364 A ES459364 A ES 459364A ES 459364 A ES459364 A ES 459364A ES 459364 A1 ES459364 A1 ES 459364A1
- Authority
- ES
- Spain
- Prior art keywords
- dimethoxyquinazoline
- compounds
- carbon atoms
- amino group
- aminopainazolines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compounds of the formula < IMAGE > or of a hydrochloric or hydrobromic acid addition salt thereof, in which R1 is hydrogen or methoxy, and R2 denotes benzoyl, furoyl, thienylcarbonyl, alkoxycarbonyl having 2 to 5 carbon atoms or (2-hydroxyalkoxy)carbonyl having 4 or 5 carbon atoms, are prepared in accordance with a novel process. Initially, a 2-chloro-6,7-dimethoxyquinazoline or a 2-bromo-6,7-dimethoxyquinazoline, whose amino group situated in the 4 position is substituted, is reacted, in an inert organic solvent and at 50-200 DEG C, with a corresponding piperazine. In a second reaction step, the substituents of the amino group are removed by hydrogenolysis. The compounds which are obtained can be used as agents for lowering blood pressure.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69620176A | 1976-06-15 | 1976-06-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES459364A1 true ES459364A1 (en) | 1978-03-16 |
Family
ID=24796111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES459364A Expired ES459364A1 (en) | 1976-06-15 | 1977-06-01 | Process for hypotensive 2-(4-substituted piperazin 1-yl)-j-aminopainazolines |
Country Status (34)
| Country | Link |
|---|---|
| JP (1) | JPS52153985A (en) |
| AR (1) | AR218251A1 (en) |
| AT (1) | AT356115B (en) |
| BE (1) | BE855656A (en) |
| BG (3) | BG35747A3 (en) |
| CA (1) | CA1068698A (en) |
| CH (3) | CH638203A5 (en) |
| CS (1) | CS202069B2 (en) |
| DD (1) | DD131021A5 (en) |
| DE (1) | DE2725019A1 (en) |
| DK (1) | DK146625C (en) |
| EG (1) | EG12922A (en) |
| ES (1) | ES459364A1 (en) |
| FI (1) | FI66853C (en) |
| FR (1) | FR2355015A1 (en) |
| GB (1) | GB1548856A (en) |
| GR (1) | GR72288B (en) |
| HK (1) | HK31481A (en) |
| HU (1) | HU177883B (en) |
| IE (1) | IE45423B1 (en) |
| IL (1) | IL52167A (en) |
| LU (1) | LU77530A1 (en) |
| MY (1) | MY8100270A (en) |
| NL (1) | NL172543C (en) |
| NO (1) | NO147838C (en) |
| NZ (1) | NZ184168A (en) |
| PH (1) | PH22196A (en) |
| PL (3) | PL113012B1 (en) |
| PT (1) | PT66617B (en) |
| RO (3) | RO73050A (en) |
| SE (2) | SE435380B (en) |
| SU (2) | SU1033002A3 (en) |
| YU (1) | YU40164B (en) |
| ZA (1) | ZA773014B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3346675A1 (en) * | 1983-12-23 | 1985-07-04 | Beiersdorf Ag, 2000 Hamburg | SUBSTITUTED 1- (4-AMINO-6,7-DIALKOXY-CHINAZOLINYL) -4- CYCLOHEXENYL DERIVATIVES OF PIPERAZINE AND HOMOPIPERAZINE, METHODS FOR THE PRODUCTION THEREOF, AND THEIR USE, AND ITS RELATED PRODUCTS |
| AT384218B (en) * | 1985-12-04 | 1987-10-12 | Gerot Pharmazeutika | METHOD FOR PRODUCING NEW CHINAZOLINE DERIVATIVES |
| CA2077252C (en) * | 1992-08-31 | 2001-04-10 | Khashayar Karimian | Methods of making ureas and guanidines, and intermediates therefor |
| US5654307A (en) * | 1994-01-25 | 1997-08-05 | Warner-Lambert Company | Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
| IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
| IL112249A (en) | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| US5932538A (en) * | 1996-02-02 | 1999-08-03 | Nitromed, Inc. | Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3511836A (en) | 1967-12-13 | 1970-05-12 | Pfizer & Co C | 2,4,6,7-tetra substituted quinazolines |
| US3669968A (en) | 1970-05-21 | 1972-06-13 | Pfizer | Trialkoxy quinazolines |
| JPS4966691A (en) * | 1972-10-30 | 1974-06-27 | ||
| US3935213A (en) | 1973-12-05 | 1976-01-27 | Pfizer Inc. | Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives |
| JPS50126682A (en) * | 1974-03-25 | 1975-10-04 |
-
1977
- 1977-05-16 SE SE7705745A patent/SE435380B/en not_active IP Right Cessation
- 1977-05-18 CA CA278,728A patent/CA1068698A/en not_active Expired
- 1977-05-20 NZ NZ184168A patent/NZ184168A/en unknown
- 1977-05-20 ZA ZA00773014A patent/ZA773014B/en unknown
- 1977-05-20 GR GR53521A patent/GR72288B/el unknown
- 1977-05-25 IL IL52167A patent/IL52167A/en unknown
- 1977-05-27 YU YU1326/77A patent/YU40164B/en unknown
- 1977-05-31 NL NLAANVRAGE7705939,A patent/NL172543C/en not_active IP Right Cessation
- 1977-05-31 PT PT66617A patent/PT66617B/en unknown
- 1977-05-31 DE DE19772725019 patent/DE2725019A1/en active Pending
- 1977-05-31 JP JP6391877A patent/JPS52153985A/en active Granted
- 1977-06-01 FI FI771741A patent/FI66853C/en not_active IP Right Cessation
- 1977-06-01 EG EG338/77A patent/EG12922A/en active
- 1977-06-01 NO NO771919A patent/NO147838C/en unknown
- 1977-06-01 DK DK240877A patent/DK146625C/en not_active IP Right Cessation
- 1977-06-01 ES ES459364A patent/ES459364A1/en not_active Expired
- 1977-06-01 CH CH673777A patent/CH638203A5/en not_active IP Right Cessation
- 1977-06-01 AT AT386977A patent/AT356115B/en not_active IP Right Cessation
- 1977-06-02 AR AR267927A patent/AR218251A1/en active
- 1977-06-03 BG BG8257395A patent/BG35747A3/en unknown
- 1977-06-03 BG BG8257396A patent/BG35748A3/en unknown
- 1977-06-03 BG BG7736493A patent/BG35594A3/en unknown
- 1977-06-13 LU LU77530A patent/LU77530A1/en unknown
- 1977-06-14 BE BE178416A patent/BE855656A/en not_active IP Right Cessation
- 1977-06-14 IE IE1212/77A patent/IE45423B1/en not_active IP Right Cessation
- 1977-06-14 RO RO7790683A patent/RO73050A/en unknown
- 1977-06-14 RO RO7798087A patent/RO77308A/en unknown
- 1977-06-14 SU SU772497901A patent/SU1033002A3/en active
- 1977-06-14 HU HU77PI578A patent/HU177883B/en not_active IP Right Cessation
- 1977-06-14 GB GB24841/77A patent/GB1548856A/en not_active Expired
- 1977-06-14 RO RO7798088A patent/RO77330A/en unknown
- 1977-06-14 FR FR7718206A patent/FR2355015A1/en active Granted
- 1977-06-15 DD DD7700199502A patent/DD131021A5/en unknown
- 1977-06-15 PL PL1977211797A patent/PL113012B1/en unknown
- 1977-06-15 CS CS773960A patent/CS202069B2/en unknown
- 1977-06-15 PL PL1977198874A patent/PL105558B1/en unknown
- 1977-06-15 PL PL1977211798A patent/PL111221B1/en unknown
-
1978
- 1978-01-03 PH PH20606A patent/PH22196A/en unknown
- 1978-06-28 SU SU782630798A patent/SU946402A3/en active
-
1981
- 1981-07-02 HK HK314/81A patent/HK31481A/en unknown
- 1981-12-16 SE SE8107554A patent/SE450120B/en not_active IP Right Cessation
- 1981-12-30 MY MY270/81A patent/MY8100270A/en unknown
-
1982
- 1982-04-22 CH CH245682A patent/CH638516A5/en not_active IP Right Cessation
- 1982-04-22 CH CH245782A patent/CH638517A5/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19971103 |