SE8107554L - NEW SUBSTITUTED DIMETOXICINAZOLINE DERIVATIVES - Google Patents

NEW SUBSTITUTED DIMETOXICINAZOLINE DERIVATIVES

Info

Publication number
SE8107554L
SE8107554L SE8107554A SE8107554A SE8107554L SE 8107554 L SE8107554 L SE 8107554L SE 8107554 A SE8107554 A SE 8107554A SE 8107554 A SE8107554 A SE 8107554A SE 8107554 L SE8107554 L SE 8107554L
Authority
SE
Sweden
Prior art keywords
carbon atoms
dimetoxicinazoline
derivatives
dimethoxyquinazoline
compounds
Prior art date
Application number
SE8107554A
Other languages
Swedish (sv)
Other versions
SE450120B (en
Inventor
P D Hammen
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of SE8107554L publication Critical patent/SE8107554L/en
Publication of SE450120B publication Critical patent/SE450120B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compounds of the formula or of a hydrochloric or hydrobromic acid addition salt thereof, in which R1 is hydrogen or methoxy, and R2 denotes benzoyl, furoyl, thienylcarbonyl, alkoxycarbonyl having 2 to 5 carbon atoms or (2-hydroxyalkoxy)carbonyl having 4 or 5 carbon atoms, are prepared in accordance with a novel process. Initially, a 2-chloro-6,7-dimethoxyquinazoline or a 2-bromo-6,7-dimethoxyquinazoline, whose amino group situated in the 4 position is substituted, is reacted, in an inert organic solvent and at 50-200 DEG C, with a corresponding piperazine. In a second reaction step, the substituents of the amino group are removed by hydrogenolysis. The compounds which are obtained can be used as agents for lowering blood pressure.

Claims (1)

1. RATHNTKRAV 1, Intermediatfbrening for anvEndning yid framstEllning ay ett hYPotensivt medal, som her formeln vari X Er klor eller brom, R3 Er vate och R4 Er -000cH2c6H4 -00126, -000R2, -CEO eller -COON eller R3 och R4 tillsammant med den kvaveatom vartill de Er banana bildar en ftalimidograPP; Rs Er vate, klor, brom, metyl, metoxi eller nitro cot R, Er alkyl med 1-4 kolatomer eller -C6R4R5, saint syraadditionssalter darav. —(11 /e----\ /N-R 2 vari R2 Er furoyl, kannetecknaddarav, att den har formeln CR30RATHNT REQUIREMENT 1, Intermediate combustion for use in the preparation of a hypotensive medal, as in the formula wherein X is chlorine or bromine, R 3 is hydrogen and R 4 is -000cH 2 C 6 H 4 -00126, -000R the kvaveatom to which they your banana form a phthalimidograPP; R 5 Is hydrogen, chlorine, bromine, methyl, methoxy or nitro cot R, Is alkyl of 1-4 carbon atoms or -C 6 R 4 R 5, saint acid addition salts thereof. - (11 / e ---- \ / N-R 2 wherein R2 is furoyl, indicating that it has the formula CR30
SE8107554A 1976-06-15 1981-12-16 NEW DIMETOXICINAZOLINE DERIVATIVES TO USE FOR PREPARATION OF 2 (4-SUBSTITUTED PIPERAZIN-1-YL) -4-AMINO-6,7-DIMETOXICINAZOLINES SE450120B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69620176A 1976-06-15 1976-06-15

Publications (2)

Publication Number Publication Date
SE8107554L true SE8107554L (en) 1981-12-16
SE450120B SE450120B (en) 1987-06-09

Family

ID=24796111

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7705745A SE435380B (en) 1976-06-15 1977-05-16 PROCEDURE FOR THE PREPARATION OF CHINAZOLINE COMPOUNDS
SE8107554A SE450120B (en) 1976-06-15 1981-12-16 NEW DIMETOXICINAZOLINE DERIVATIVES TO USE FOR PREPARATION OF 2 (4-SUBSTITUTED PIPERAZIN-1-YL) -4-AMINO-6,7-DIMETOXICINAZOLINES

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7705745A SE435380B (en) 1976-06-15 1977-05-16 PROCEDURE FOR THE PREPARATION OF CHINAZOLINE COMPOUNDS

Country Status (34)

Country Link
JP (1) JPS52153985A (en)
AR (1) AR218251A1 (en)
AT (1) AT356115B (en)
BE (1) BE855656A (en)
BG (3) BG35747A3 (en)
CA (1) CA1068698A (en)
CH (3) CH638203A5 (en)
CS (1) CS202069B2 (en)
DD (1) DD131021A5 (en)
DE (1) DE2725019A1 (en)
DK (1) DK146625C (en)
EG (1) EG12922A (en)
ES (1) ES459364A1 (en)
FI (1) FI66853C (en)
FR (1) FR2355015A1 (en)
GB (1) GB1548856A (en)
GR (1) GR72288B (en)
HK (1) HK31481A (en)
HU (1) HU177883B (en)
IE (1) IE45423B1 (en)
IL (1) IL52167A (en)
LU (1) LU77530A1 (en)
MY (1) MY8100270A (en)
NL (1) NL172543C (en)
NO (1) NO147838C (en)
NZ (1) NZ184168A (en)
PH (1) PH22196A (en)
PL (3) PL113012B1 (en)
PT (1) PT66617B (en)
RO (3) RO73050A (en)
SE (2) SE435380B (en)
SU (2) SU1033002A3 (en)
YU (1) YU40164B (en)
ZA (1) ZA773014B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3346675A1 (en) * 1983-12-23 1985-07-04 Beiersdorf Ag, 2000 Hamburg SUBSTITUTED 1- (4-AMINO-6,7-DIALKOXY-CHINAZOLINYL) -4- CYCLOHEXENYL DERIVATIVES OF PIPERAZINE AND HOMOPIPERAZINE, METHODS FOR THE PRODUCTION THEREOF, AND THEIR USE, AND ITS RELATED PRODUCTS
AT384218B (en) * 1985-12-04 1987-10-12 Gerot Pharmazeutika METHOD FOR PRODUCING NEW CHINAZOLINE DERIVATIVES
CA2077252C (en) * 1992-08-31 2001-04-10 Khashayar Karimian Methods of making ureas and guanidines, and intermediates therefor
US5654307A (en) * 1994-01-25 1997-08-05 Warner-Lambert Company Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
IL112248A0 (en) 1994-01-25 1995-03-30 Warner Lambert Co Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
IL112249A (en) 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
US5932538A (en) * 1996-02-02 1999-08-03 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3511836A (en) 1967-12-13 1970-05-12 Pfizer & Co C 2,4,6,7-tetra substituted quinazolines
US3669968A (en) 1970-05-21 1972-06-13 Pfizer Trialkoxy quinazolines
JPS4966691A (en) * 1972-10-30 1974-06-27
US3935213A (en) 1973-12-05 1976-01-27 Pfizer Inc. Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives
JPS50126682A (en) * 1974-03-25 1975-10-04

Also Published As

Publication number Publication date
JPS5543465B2 (en) 1980-11-06
CS202069B2 (en) 1980-12-31
RO77308A (en) 1981-08-17
CH638517A5 (en) 1983-09-30
ATA386977A (en) 1979-09-15
SE7705745L (en) 1977-12-16
PH22196A (en) 1988-06-28
FI66853B (en) 1984-08-31
RO77330A (en) 1981-06-22
CH638203A5 (en) 1983-09-15
BG35594A3 (en) 1984-05-15
AU2558377A (en) 1978-09-07
FI771741A (en) 1977-12-16
CA1068698A (en) 1979-12-25
SE450120B (en) 1987-06-09
NL172543C (en) 1983-09-16
CH638516A5 (en) 1983-09-30
DE2725019A1 (en) 1977-12-22
IL52167A (en) 1981-01-30
NL7705939A (en) 1977-12-19
NO147838C (en) 1983-06-22
PL111221B1 (en) 1980-08-30
GB1548856A (en) 1979-07-18
SU946402A3 (en) 1982-07-23
RO73050A (en) 1981-08-30
FR2355015B1 (en) 1981-07-24
YU40164B (en) 1985-08-31
DD131021A5 (en) 1978-05-24
BG35748A3 (en) 1984-06-15
JPS52153985A (en) 1977-12-21
LU77530A1 (en) 1979-03-26
PL198874A1 (en) 1978-04-10
EG12922A (en) 1980-03-31
PL113012B1 (en) 1980-11-29
DK146625B (en) 1983-11-21
FR2355015A1 (en) 1978-01-13
IE45423L (en) 1977-12-15
NZ184168A (en) 1979-08-31
YU132677A (en) 1982-08-31
PL105558B1 (en) 1979-10-31
BG35747A3 (en) 1984-06-15
IE45423B1 (en) 1982-08-25
NL172543B (en) 1983-04-18
NO147838B (en) 1983-03-14
PT66617A (en) 1977-06-01
HK31481A (en) 1981-07-10
SE435380B (en) 1984-09-24
ZA773014B (en) 1978-04-26
AR218251A1 (en) 1980-05-30
NO771919L (en) 1977-12-16
IL52167A0 (en) 1977-07-31
DK146625C (en) 1984-06-04
GR72288B (en) 1983-10-17
BE855656A (en) 1977-12-14
FI66853C (en) 1984-12-10
ES459364A1 (en) 1978-03-16
DK240877A (en) 1977-12-16
AT356115B (en) 1980-04-10
PT66617B (en) 1978-10-27
MY8100270A (en) 1981-12-31
HU177883B (en) 1982-01-28
SU1033002A3 (en) 1983-07-30

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