DD271705A5 - Verfahren zum herstellen von azithromycin-dihydrat - Google Patents

Verfahren zum herstellen von azithromycin-dihydrat Download PDF

Info

Publication number
DD271705A5
DD271705A5 DD88317672A DD31767288A DD271705A5 DD 271705 A5 DD271705 A5 DD 271705A5 DD 88317672 A DD88317672 A DD 88317672A DD 31767288 A DD31767288 A DD 31767288A DD 271705 A5 DD271705 A5 DD 271705A5
Authority
DD
German Democratic Republic
Prior art keywords
dihydrate
water
water content
azithromycin
hydrocarbon
Prior art date
Application number
DD88317672A
Other languages
German (de)
English (en)
Inventor
Douglas J M Allen
Kevin M Nepveux
Original Assignee
������@���Kk��
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22202456&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DD271705(A5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ������@���Kk�� filed Critical ������@���Kk��
Publication of DD271705A5 publication Critical patent/DD271705A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DD88317672A 1987-07-09 1988-07-07 Verfahren zum herstellen von azithromycin-dihydrat DD271705A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1987/001612 WO1989000576A1 (en) 1987-07-09 1987-07-09 Azithromycin dihydrate

Publications (1)

Publication Number Publication Date
DD271705A5 true DD271705A5 (de) 1989-09-13

Family

ID=22202456

Family Applications (1)

Application Number Title Priority Date Filing Date
DD88317672A DD271705A5 (de) 1987-07-09 1988-07-07 Verfahren zum herstellen von azithromycin-dihydrat

Country Status (45)

Country Link
US (1) US6268489B1 (pl)
EP (1) EP0298650B1 (pl)
JP (1) JPH0631300B2 (pl)
KR (1) KR900006218B1 (pl)
CN (1) CN1016785B (pl)
AP (1) AP44A (pl)
AR (1) AR243532A1 (pl)
AT (1) ATE72446T1 (pl)
AU (1) AU604553B2 (pl)
BA (1) BA98213B1 (pl)
BG (1) BG47348A3 (pl)
CA (1) CA1314876C (pl)
CS (1) CS272241B2 (pl)
CY (1) CY1776A (pl)
DD (1) DD271705A5 (pl)
DE (1) DE3868296D1 (pl)
DK (1) DK172573B1 (pl)
EG (1) EG18527A (pl)
ES (1) ES2038756T3 (pl)
FI (1) FI91263C (pl)
GR (1) GR3003737T3 (pl)
HK (1) HK127594A (pl)
HU (1) HU211862A9 (pl)
IE (1) IE60354B1 (pl)
IL (1) IL86979A (pl)
IN (1) IN168879B (pl)
IS (1) IS1540B (pl)
LV (1) LV10624B (pl)
MA (1) MA21323A1 (pl)
MX (1) MX12213A (pl)
MY (1) MY103744A (pl)
NO (1) NO171556C (pl)
NZ (1) NZ225338A (pl)
OA (1) OA08743A (pl)
PH (1) PH30953A (pl)
PL (1) PL157145B1 (pl)
PT (1) PT87933B (pl)
RO (1) RO107257B1 (pl)
RU (1) RU2066324C1 (pl)
SG (1) SG27794G (pl)
SI (1) SI8811325A8 (pl)
UA (1) UA27040C2 (pl)
WO (1) WO1989000576A1 (pl)
YU (1) YU45075B (pl)
ZA (1) ZA884925B (pl)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020231A2 (en) * 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
US5985844A (en) * 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers
EP0539223A1 (en) * 1991-10-25 1993-04-28 Ono Pharmaceutical Co., Ltd. Glycine derivative monosodium salt tetrahydrate having an inhibitory effect on elastase
US5215980A (en) * 1992-01-17 1993-06-01 Merck & Co., Inc. 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
CN1034734C (zh) * 1993-12-10 1997-04-30 北京市集才药物研究所 一种新的阿齐红霉素结晶及其制备方法
US5605889A (en) 1994-04-29 1997-02-25 Pfizer Inc. Method of administering azithromycin
JP2977907B2 (ja) 1994-05-06 1999-11-15 ファイザー・インコーポレーテッド アジスロマイシンの放出調節された剤形
ES2122905B1 (es) * 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
US6369035B1 (en) * 1997-10-16 2002-04-09 Pliva, Farmaceutska Industrja, Dioni{Haeck Over (C)}Ko Dru{Haeck Over (S)}Tvo 3,6-hemiketals from the class of 9A-azalides
US6861411B1 (en) 1997-12-02 2005-03-01 Pfizer, Inc. Method of treating eye infections with azithromycin
PT102130A (pt) * 1998-03-13 1999-09-30 Hovione Sociedade Quimica S A Processo de preparacao de dihidrato de azitromicina
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
PT1152765E (pt) * 1998-11-30 2004-12-31 Teva Pharma Etanolato de azitromicina, processo de preparacao e composicoes farmaceuticas que os contem
US7056893B2 (en) 1999-03-31 2006-06-06 Insite Vision, Inc. Topical treatment for prevention of ocular infections
US6239113B1 (en) 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
OA11876A (en) * 1999-05-18 2006-03-27 Pfizer Prod Inc Novel crystalline forms of a macrolide antibiotic.
KR100700475B1 (ko) 1999-06-29 2007-03-28 바이오케미 에스.에이. 마크롤라이드
ES2177373B1 (es) * 1999-11-26 2003-11-01 Astur Pharma Sa Preparacion de azitromicina en su forma no cristalina
DE60133083D1 (de) 2000-01-04 2008-04-17 Teva Pharma Verfahren zur herstellung von azithromycin-dihydrat
ES2162764B1 (es) * 2000-05-17 2003-04-01 Ercros Ind Sa Forma polimorfica del dihidrato de azitromicina, y su procedimiento deobtencion.
DE60026718T2 (de) 2000-07-25 2006-11-16 Laboratorio Silanes, S.A. De C.V. Einstufiges verfahren zur herstellung von 7,16-deoxy-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihydroxi-6-ethyl-3,5,9,11,13,15-hexamethylbicycle(11.2.11)hexadeca-1(2)-en-8-ona undeine neue form von 9-desoxo-9a-methyl-9a-aza-9a-homoerythromycin a
ES2172417B1 (es) * 2000-07-31 2003-09-16 Sint Quimica Sa Nueva forma mejorada de azitromicina monohidrato de menor higroscopicidad, procedimiento de preparacion y composiciones farmaceuticas que la comprenden.
ATE306491T1 (de) 2000-08-23 2005-10-15 Wockhardt Ltd Verfahren zur herstellung von wasserfreiem azithromycin
CZ303343B6 (cs) * 2000-11-27 2012-08-08 Sandoz Ag Zpusob prípravy azithromycinu ve forme monohydrátu
IN190080B (pl) * 2001-01-29 2003-06-07 Alembic Ltd
KR100491183B1 (ko) * 2001-03-21 2005-05-25 한미약품 주식회사 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
EP1671979B1 (en) 2001-05-22 2008-08-13 Pfizer Products Inc. New Cristal Form of Azithromycin
EA007618B1 (ru) 2001-05-22 2006-12-29 Пфайзер Продактс Инк. Кристаллический полуторогидрат азитромицина, содержащая его фармацевтическая композиция и способ лечения на его основе
US6861413B2 (en) 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
SK1012004A3 (sk) * 2001-08-21 2005-04-01 Pfizer Products Inc. Použitie azitromycínu na výrobu liečiva na liečenie respiračných infekcií u človeka
BR0215175A (pt) * 2001-12-21 2004-12-28 Pfizer Prod Inc Métodos para a granulação úmida de azitromicina
NZ532707A (en) * 2001-12-21 2006-07-28 Pfizer Prod Inc Directly compressible formulations of azithromycin
JP2005526020A (ja) * 2002-02-01 2005-09-02 ファイザー・プロダクツ・インク アジスロマイシンの乾式造粒配合物
US7376064B2 (en) 2002-02-25 2008-05-20 Samsung Electronics Co., Ltd. Method and apparatus for recording data on optical recording medium
ITMI20021209A1 (it) * 2002-06-04 2003-12-04 Chemi Spa Processo di preparazione di azitromicina ad elevata purezza
US6855813B2 (en) * 2002-07-19 2005-02-15 Alembic Limited Process for the preparation of azithromycin monohydrate
HRP20020614A2 (en) 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
GB2395482A (en) * 2003-07-03 2004-05-26 Jubilant Organosys Ltd Process for preparing non-hygroscopic azithromycin dihydrate
US20050013835A1 (en) * 2003-07-15 2005-01-20 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
CA2549225A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Spray-congeal process using an extruder for preparing multiparticulate crystalline drug compositions containing preferably a poloxamer and a glyceride
RU2006119453A (ru) * 2003-12-04 2007-12-20 Пфайзер Продактс Инк. (Us) Получение посредством основанных на применении жидкостей способов лекарственные формы азитромицина с большим количеством частиц
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
WO2005053639A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Controlled release multiparticulates formed with dissolution enhancers
EP1691787B1 (en) * 2003-12-04 2008-07-02 Pfizer Products Inc. Method for making pharmaceutical multiparticulates
WO2005053653A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Spray-congeal process using an extruder for preparing multiparticulate azithromycin compositions containing preferably a poloxamer and a glyceride
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
BRPI0416534A (pt) * 2003-12-04 2007-01-09 Pfizer Prod Inc composições multiparticuladas com estabilidade melhorada
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7235646B2 (en) 2004-06-28 2007-06-26 Alembic Limited Process for the preparation of azithromycin monohydrate isopropanol clathrate
CN1308361C (zh) * 2004-08-09 2007-04-04 大连振邦氟涂料股份有限公司 乙烯－三氟氯乙烯共聚物的制备方法
US7683162B2 (en) * 2004-08-30 2010-03-23 Taro Pharmaceutical Industries Limited Process of preparing a crystalline azithromycin monohydrate
TWI315310B (en) * 2004-12-01 2009-10-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Methods of preparing pimecrolimus
US20080199527A1 (en) * 2004-12-21 2008-08-21 Pfizer Inc. Enteric Coated Azithromycin Multiparticulates
US8546423B2 (en) 2005-05-18 2013-10-01 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
CN100366686C (zh) * 2006-01-12 2008-02-06 济南瑞氟化工科技有限公司 一种氟硅超双疏不粘涂料
JP2009539866A (ja) * 2006-06-05 2009-11-19 オースペックス・ファーマシューティカルズ・インコーポレイテッド 置換エリスロマイシンアナログの調製および有用性
US7704959B2 (en) 2006-10-03 2010-04-27 Dow Pharmaceutical Sciences Azithromycin for the treatment of nodular acne
US20090062220A1 (en) * 2007-08-29 2009-03-05 Protia, Llc Deuterium-enriched azithromycin
CN101177441B (zh) * 2007-12-05 2012-05-23 浙江耐司康药业有限公司 一种稳定的阿奇霉素一水合物结晶的制备方法
CN101624412B (zh) * 2008-07-10 2012-07-04 刘力 大环内酯类衍生物及其制备和用途
NZ592717A (en) 2008-10-07 2013-03-28 Mpex Pharmaceuticals Inc Aerosol fluoroquinolone formulations for improved pharmacokinetics comprising levofloxacin or ofloxacin and a di- or trivalent cation
SI2346509T1 (sl) 2008-10-07 2020-08-31 Horizon Orphan Llc Inhalacija levofloksacina za zmanjšanje vnetja pljuč
CN101418026B (zh) * 2008-10-09 2011-05-18 南京工业大学 一种晶型和粒度可控的阿奇霉素结晶工艺
CN101787063B (zh) * 2009-01-23 2012-12-19 刘力 抗感染药物及其制备和用途
BRPI1009823A2 (pt) 2009-03-13 2019-09-24 Da Volterra Assistance Publique Hopitaux De Paris E Univ Paris Diderot Paris 7 "composição compreendendo um sistema de dispensação de droga, conjunto de uma primeira e uma segunda composição, e, kit."
RU2563809C2 (ru) 2009-09-04 2015-09-20 Мпекс Фармасьютикалс, Инк. Применение левофлоксацина в форме аэрозоля для лечения муковисцидоза
CN102911219A (zh) * 2011-08-03 2013-02-06 山东方明药业集团股份有限公司 一种阿齐霉素在水相直接结晶的方法
CN103159811A (zh) * 2011-12-10 2013-06-19 山东方明药业集团股份有限公司 一种阿齐霉素中间体9a-脱氧-9a-氮杂-9a-高红霉素A的制备方法
WO2013088274A1 (en) 2011-12-14 2013-06-20 Wockhardt Limited Anhydrous amorphous azithromycin composition free of azithromycin dihydrate
CN102417531B (zh) * 2011-12-20 2014-06-11 浙江国邦药业有限公司 一种阿奇霉素一水合物的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4020270A (en) * 1974-05-02 1977-04-26 Societa' Farmaceutici Italia S.P.A. L-lyxohex-1-enopyranose derivative
US4219641A (en) * 1979-06-14 1980-08-26 The Upjohn Company Process for preparing erythromycin succinate
SI8110592A8 (en) 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
US4526889A (en) * 1982-11-15 1985-07-02 Pfizer Inc. Epimeric azahomoerythromycin A derivative, intermediates and method of use
PH19293A (en) * 1982-11-15 1986-03-04 Pfizer Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof
US4512982A (en) * 1984-04-13 1985-04-23 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
YU43402B (en) * 1985-03-04 1989-06-30 Pliva Pharm & Chem Works Process for preparation of 11-aza-10-deoxo-10-dihydroeritromycin "a" by using electro-chemical reduction
WO1989002271A1 (en) 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents

Also Published As

Publication number Publication date
EG18527A (en) 1993-10-30
KR890002137A (ko) 1989-04-08
IE60354B1 (en) 1994-06-29
MX12213A (es) 1993-05-01
NO171556B (no) 1992-12-21
UA27040C2 (uk) 2000-02-28
HK127594A (en) 1994-11-25
DE3868296D1 (de) 1992-03-19
LV10624A (lv) 1995-04-20
SI8811325A8 (en) 1996-12-31
YU132588A (en) 1990-02-28
CN1016785B (zh) 1992-05-27
EP0298650B1 (en) 1992-02-05
AP8800093A0 (en) 1988-05-01
AU604553B2 (en) 1990-12-20
OA08743A (fr) 1989-03-31
DK380688A (da) 1989-01-10
IS1540B (is) 1994-01-28
SG27794G (en) 1994-10-14
JPH0631300B2 (ja) 1994-04-27
CS489688A2 (en) 1990-03-14
KR900006218B1 (ko) 1990-08-25
FI900087A (fi) 1990-01-08
CY1776A (en) 1995-10-20
HU211862A9 (en) 1995-12-28
NO900077D0 (no) 1990-01-08
IL86979A0 (en) 1988-12-30
FI91263B (fi) 1994-02-28
EP0298650A2 (en) 1989-01-11
PT87933B (pt) 1994-09-30
GR3003737T3 (pl) 1993-03-16
DK380688D0 (da) 1988-07-08
AP44A (en) 1989-07-27
BG47348A3 (en) 1990-06-15
ZA884925B (en) 1990-02-28
PL157145B1 (en) 1992-04-30
ES2038756T3 (es) 1993-08-01
FI900087A0 (fi) 1990-01-08
YU45075B (en) 1991-08-31
CA1314876C (en) 1993-03-23
IE882108L (en) 1989-01-09
NZ225338A (en) 1990-02-26
IL86979A (en) 1992-11-15
PH30953A (en) 1997-12-23
RU2066324C1 (ru) 1996-09-10
IS3370A7 (is) 1989-01-10
US6268489B1 (en) 2001-07-31
WO1989000576A1 (en) 1989-01-26
BA98213B1 (bs) 1999-08-02
AR243532A1 (es) 1993-08-31
EP0298650A3 (en) 1989-11-08
NO900077L (no) 1990-01-08
CS272241B2 (en) 1991-01-15
ATE72446T1 (de) 1992-02-15
MY103744A (en) 1993-09-30
PT87933A (pt) 1989-06-30
NO171556C (no) 1993-03-31
CN1030422A (zh) 1989-01-18
IN168879B (pl) 1991-06-29
DK172573B1 (da) 1999-01-25
LV10624B (en) 1995-10-20
JPS6438096A (en) 1989-02-08
FI91263C (fi) 1994-06-10
RO107257B1 (ro) 1993-10-30
PL273590A1 (en) 1989-03-20
AU1883988A (en) 1989-01-12
MA21323A1 (fr) 1989-04-01

Similar Documents

Publication Publication Date Title
DD271705A5 (de) Verfahren zum herstellen von azithromycin-dihydrat
AT392472B (de) Verfahren zur herstellung eines stabilen kristallinen di- oder trihydrats der 7beta- ((z)-2-(2-aminothiazol-4-yl)-4-carboxybut-2- enoylamino)-3-cephem-4-carbonsaeure
DE2432644A1 (de) Derivate von desoxystreptamin enthaltenden aminoglykosid-antibiotikumderivaten und verfahren zu ihrer herstellung
DE2614669C2 (de) Gamma-kristalline wasserfreie Form von 7-(D-alpha-Formyloxy-alpha-phenylacetamido)-3-(1-methyl-1H-tetrazol-5- ylthiomethyl)-3-cephem-4-natriumcarboxylat und Verfahren zu ihrer Herstellung
DE2515629A1 (de) Paromomycin-derivate, verfahren zu ihrer herstellung und arzneimittel
DE2953969C2 (pl)
EP0411408A1 (de) Monoklines Metazachlor und Verfahren zu seiner Herstellung
DE2310329A1 (de) Arabinofuranosylcytosine und verfahren zu ihrer herstellung
DE1143817C2 (de) Verfahren zur Herstellung von 6-Phenoxyacylamidopenicillansaeure-derivaten und von nicht giftigen Salzen derselben
DE69508962T2 (de) Diclavulanat-salze mit diaminoether und verfahren zu deren herstellung
DE2116066A1 (de) Alkyl-7-deoxy-7 (S) -OR-alpha thiolincosaminide und Verfahren zu deren Herstellung
DE932670C (de) Verfahren zur Herstellung von Tetracyclin und seinen Salzen
DE3102984A1 (de) Verfahren zur herstellung von cysteamin-s-substituierten verbindungen und deren derivaten
DE1294383B (de) Penicilline und deren Salze sowie Verfahren zu ihrer Herstellung
AT239440B (de) Verfahren zur Herstellung von neuen Derivaten der 6-Amino-Penicillansäure
DE2019145C3 (de) Kristallines Monohydrat und Verfahren zu seiner Herstellung
DE830243C (de) Verfahren zur Herstellung kristalliner Ammoniumsalze der Penicilline
DE948158C (de) Verfahren zur Herstellung von Zink-Komplexsalzen von Tripeptiden
DE1011417B (de) Verfahren zur Herstellung von Anhydrodesdimethylaminochlortetracyclin bzw. Anhydrodesdimethylaminotetracyclin
DE1545708C (de) N- eckige Klammer auf 3-(5-Nitrofurfuryliden-methyl)-6-pyridazinyl eckige Klammer zu -N,N-dimethylformamidin und seine Salze
DE916207C (de) Verfahren zur Herstellung von Penicillinsalzen
DE938670C (de) Verfahren zur Spaltung von D, L-threo-1-p-Nitrophenyl-2-aminopropan-1, 3-diol in seine optisch aktiven Isomeren
DE1121608B (de) Verfahren zur Herstellung neuer antibakteriell wirksamer Tetracyclinverbindungen
DE946444C (de) Verfahren zur Herstellung von Desdimethylaminooxytetracyclin und seinen Salzen
DE2418435A1 (de) Nitroimidazolyl-triazolo-pyridazine und verfahren zu ihrer herstellung

Legal Events

Date Code Title Description
IF04 In force in the year 2004

Expiry date: 20080708