BA98213B1 - Postupak za dobijanje kristalnog azitromicin dihidrata - Google Patents

Postupak za dobijanje kristalnog azitromicin dihidrata

Info

Publication number
BA98213B1
BA98213B1 BA980213A BA980213A BA98213B1 BA 98213 B1 BA98213 B1 BA 98213B1 BA 980213 A BA980213 A BA 980213A BA 980213 A BA980213 A BA 980213A BA 98213 B1 BA98213 B1 BA 98213B1
Authority
BA
Bosnia and Herzegovina
Prior art keywords
preparation
azithromycin dihydrate
crystalline azithromycin
crystalline
dihydrate
Prior art date
Application number
BA980213A
Other languages
English (en)
Inventor
Douglas John Meldrum Allen
Kevin Michael Nepveux
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22202456&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BA98213(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of BA98213B1 publication Critical patent/BA98213B1/bs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BA980213A 1987-07-09 1998-03-30 Postupak za dobijanje kristalnog azitromicin dihidrata BA98213B1 (bs)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1987/001612 WO1989000576A1 (en) 1987-07-09 1987-07-09 Azithromycin dihydrate
YU1325/88A YU45075B (en) 1987-07-09 1988-07-08 Process for obtaining crystalline azitromycine dihydrate

Publications (1)

Publication Number Publication Date
BA98213B1 true BA98213B1 (bs) 1999-08-02

Family

ID=22202456

Family Applications (1)

Application Number Title Priority Date Filing Date
BA980213A BA98213B1 (bs) 1987-07-09 1998-03-30 Postupak za dobijanje kristalnog azitromicin dihidrata

Country Status (45)

Country Link
US (1) US6268489B1 (bs)
EP (1) EP0298650B1 (bs)
JP (1) JPH0631300B2 (bs)
KR (1) KR900006218B1 (bs)
CN (1) CN1016785B (bs)
AP (1) AP44A (bs)
AR (1) AR243532A1 (bs)
AT (1) ATE72446T1 (bs)
AU (1) AU604553B2 (bs)
BA (1) BA98213B1 (bs)
BG (1) BG47348A3 (bs)
CA (1) CA1314876C (bs)
CS (1) CS272241B2 (bs)
CY (1) CY1776A (bs)
DD (1) DD271705A5 (bs)
DE (1) DE3868296D1 (bs)
DK (1) DK172573B1 (bs)
EG (1) EG18527A (bs)
ES (1) ES2038756T3 (bs)
FI (1) FI91263C (bs)
GR (1) GR3003737T3 (bs)
HK (1) HK127594A (bs)
HU (1) HU211862A9 (bs)
IE (1) IE60354B1 (bs)
IL (1) IL86979A (bs)
IN (1) IN168879B (bs)
IS (1) IS1540B (bs)
LV (1) LV10624B (bs)
MA (1) MA21323A1 (bs)
MX (1) MX12213A (bs)
MY (1) MY103744A (bs)
NO (1) NO171556C (bs)
NZ (1) NZ225338A (bs)
OA (1) OA08743A (bs)
PH (1) PH30953A (bs)
PL (1) PL157145B1 (bs)
PT (1) PT87933B (bs)
RO (1) RO107257B1 (bs)
RU (1) RU2066324C1 (bs)
SG (1) SG27794G (bs)
SI (1) SI8811325A8 (bs)
UA (1) UA27040C2 (bs)
WO (1) WO1989000576A1 (bs)
YU (1) YU45075B (bs)
ZA (1) ZA884925B (bs)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020231A2 (en) * 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
US5985844A (en) * 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers
CA2081268A1 (en) * 1991-10-25 1993-04-26 Katsuhiro Imaki Glycine derivative monosodium salt tetrahydrate
US5215980A (en) * 1992-01-17 1993-06-01 Merck & Co., Inc. 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
CN1034734C (zh) * 1993-12-10 1997-04-30 北京市集才药物研究所 一种新的阿齐红霉素结晶及其制备方法
US5605889A (en) 1994-04-29 1997-02-25 Pfizer Inc. Method of administering azithromycin
CZ292360B6 (cs) 1994-05-06 2003-09-17 Pfizer Inc. Dávkovací forma s řízeným uvolňováním obsahující azithromycin a způsob její výroby
ES2122905B1 (es) * 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
ATE267835T1 (de) * 1997-10-16 2004-06-15 Pliva Pharm & Chem Works Neue 9a-azalide
US6861411B1 (en) 1997-12-02 2005-03-01 Pfizer, Inc. Method of treating eye infections with azithromycin
PT102130A (pt) * 1998-03-13 1999-09-30 Hovione Sociedade Quimica S A Processo de preparacao de dihidrato de azitromicina
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
EP1152765B1 (en) 1998-11-30 2004-10-13 Teva Pharmaceutical Industries Ltd. Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof
US7056893B2 (en) 1999-03-31 2006-06-06 Insite Vision, Inc. Topical treatment for prevention of ocular infections
US6239113B1 (en) 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
JP3897983B2 (ja) * 1999-05-18 2007-03-28 ファイザー・プロダクツ・インク マクロライド系抗生物質の新規結晶
US6703372B1 (en) * 1999-06-29 2004-03-09 Biochemie S.A. Macrolides
ES2177373B1 (es) * 1999-11-26 2003-11-01 Astur Pharma Sa Preparacion de azitromicina en su forma no cristalina
US6586576B2 (en) 2000-01-04 2003-07-01 Teva Pharmaceutical Industries Ltd Preparation method of azithromycin hydrates
ES2162764B1 (es) * 2000-05-17 2003-04-01 Ercros Ind Sa Forma polimorfica del dihidrato de azitromicina, y su procedimiento deobtencion.
DE60026718T2 (de) 2000-07-25 2006-11-16 Laboratorio Silanes, S.A. De C.V. Einstufiges verfahren zur herstellung von 7,16-deoxy-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihydroxi-6-ethyl-3,5,9,11,13,15-hexamethylbicycle(11.2.11)hexadeca-1(2)-en-8-ona undeine neue form von 9-desoxo-9a-methyl-9a-aza-9a-homoerythromycin a
ES2172417B1 (es) * 2000-07-31 2003-09-16 Sint Quimica Sa Nueva forma mejorada de azitromicina monohidrato de menor higroscopicidad, procedimiento de preparacion y composiciones farmaceuticas que la comprenden.
EP1313749B1 (en) * 2000-08-23 2005-10-12 Wockhardt Limited Process for preparation of anhydrous azithromycin
SK287814B6 (sk) * 2000-11-27 2011-11-04 Sandoz Ag Azithromycin in the form of a monohydrate, a process for its preparation and pharmaceutical compositions comprising same
IN190080B (bs) * 2001-01-29 2003-06-07 Alembic Ltd
KR100491183B1 (ko) 2001-03-21 2005-05-25 한미약품 주식회사 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
SI1390377T1 (sl) 2001-05-22 2006-06-30 Pfizer Prod Inc Nova kristalna oblika azitromicina
EA007618B1 (ru) * 2001-05-22 2006-12-29 Пфайзер Продактс Инк. Кристаллический полуторогидрат азитромицина, содержащая его фармацевтическая композиция и способ лечения на его основе
US6861413B2 (en) 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
CZ2004232A3 (cs) * 2001-08-21 2005-10-12 Pfizer Products Inc. Jednorázová dávka azithromycinu
CN1606433A (zh) * 2001-12-21 2005-04-13 辉瑞产品公司 阿齐霉素湿法制粒法
CN1668282A (zh) 2001-12-21 2005-09-14 辉瑞产品公司 可直接压制的阿齐霉素配方
WO2003063838A1 (en) * 2002-02-01 2003-08-07 Pfizer Products Inc. Dry granulated formulations of azithromycin
US7376064B2 (en) 2002-02-25 2008-05-20 Samsung Electronics Co., Ltd. Method and apparatus for recording data on optical recording medium
ITMI20021209A1 (it) * 2002-06-04 2003-12-04 Chemi Spa Processo di preparazione di azitromicina ad elevata purezza
US6855813B2 (en) * 2002-07-19 2005-02-15 Alembic Limited Process for the preparation of azithromycin monohydrate
HRP20020614A2 (en) 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
GB2395482A (en) * 2003-07-03 2004-05-26 Jubilant Organosys Ltd Process for preparing non-hygroscopic azithromycin dihydrate
US20050013835A1 (en) * 2003-07-15 2005-01-20 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
WO2005053639A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Controlled release multiparticulates formed with dissolution enhancers
ES2308274T3 (es) * 2003-12-04 2008-12-01 Pfizer Products Inc. Procedimiento para fabricar multiparticulados farmaceuticos.
MXPA06005913A (es) * 2003-12-04 2006-06-27 Pfizer Prod Inc Formas de dosificacion de multiparticulas de azitromicina por procedimientos basados en liquidos.
CA2547597A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate compositions with improved stability
BRPI0417348A (pt) * 2003-12-04 2007-03-13 Pfizer Prod Inc processo de gelatinização por spray com utilização de uma extrusora para preparação de composições de droga cristalina multiparticulada contendo preferencialmente um poloxámero e um glicerìdeo
CN1889931A (zh) * 2003-12-04 2007-01-03 辉瑞产品公司 利用挤压器制备优选含泊洛沙姆和甘油酯的多重粒子阿奇霉素组合物的喷雾－冻凝方法
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
WO2006011160A1 (en) 2004-06-28 2006-02-02 Alembic Limited Process for the preparation of azithromycin monohydrate isopropanol clathrate
CN1308361C (zh) * 2004-08-09 2007-04-04 大连振邦氟涂料股份有限公司 乙烯－三氟氯乙烯共聚物的制备方法
US7683162B2 (en) * 2004-08-30 2010-03-23 Taro Pharmaceutical Industries Limited Process of preparing a crystalline azithromycin monohydrate
WO2006060614A1 (en) * 2004-12-01 2006-06-08 Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg Methods for preparing pimecrolimus
CA2591923A1 (en) * 2004-12-21 2006-06-29 Pfizer Products Inc. Enteric coated azithromycin multiparticulates
US8524735B2 (en) 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
CN100366686C (zh) * 2006-01-12 2008-02-06 济南瑞氟化工科技有限公司 一种氟硅超双疏不粘涂料
EP2023721A2 (en) * 2006-06-05 2009-02-18 Auspex Pharmaceuticals Inc. Preparation and utility of substituted erythromycin analogs
US7704959B2 (en) 2006-10-03 2010-04-27 Dow Pharmaceutical Sciences Azithromycin for the treatment of nodular acne
US20090062220A1 (en) * 2007-08-29 2009-03-05 Protia, Llc Deuterium-enriched azithromycin
CN101177441B (zh) * 2007-12-05 2012-05-23 浙江耐司康药业有限公司 一种稳定的阿奇霉素一水合物结晶的制备方法
CN101624412B (zh) * 2008-07-10 2012-07-04 刘力 大环内酯类衍生物及其制备和用途
PL2344129T3 (pl) 2008-10-07 2018-07-31 Horizon Orphan Llc Formulacje fluorochinolonu w aerozolu dla poprawy właściwości farmakokinetycznych
JP2012505222A (ja) 2008-10-07 2012-03-01 エムペックス・ファーマシューティカルズ・インコーポレーテッド 肺炎症を低減するためのレボフロキサシンの吸入
CN101418026B (zh) * 2008-10-09 2011-05-18 南京工业大学 一种晶型和粒度可控的阿奇霉素结晶工艺
CN101787063B (zh) * 2009-01-23 2012-12-19 刘力 抗感染药物及其制备和用途
EA201101319A1 (ru) 2009-03-13 2012-04-30 Да Волтерра Композиции и способы элиминации грамотрицательных бактерий
ES2739979T3 (es) 2009-09-04 2020-02-05 Horizon Orphan Llc Uso de levofloxacino en aerosol para el tratamiento de la fibrosis quística
CN102911219A (zh) * 2011-08-03 2013-02-06 山东方明药业集团股份有限公司 一种阿齐霉素在水相直接结晶的方法
CN103159811A (zh) * 2011-12-10 2013-06-19 山东方明药业集团股份有限公司 一种阿齐霉素中间体9a-脱氧-9a-氮杂-9a-高红霉素A的制备方法
WO2013088274A1 (en) 2011-12-14 2013-06-20 Wockhardt Limited Anhydrous amorphous azithromycin composition free of azithromycin dihydrate
CN102417531B (zh) * 2011-12-20 2014-06-11 浙江国邦药业有限公司 一种阿奇霉素一水合物的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4020270A (en) * 1974-05-02 1977-04-26 Societa' Farmaceutici Italia S.P.A. L-lyxohex-1-enopyranose derivative
US4219641A (en) * 1979-06-14 1980-08-26 The Upjohn Company Process for preparing erythromycin succinate
SI8110592A8 (en) 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
PH19293A (en) * 1982-11-15 1986-03-04 Pfizer Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof
US4526889A (en) * 1982-11-15 1985-07-02 Pfizer Inc. Epimeric azahomoerythromycin A derivative, intermediates and method of use
US4512982A (en) * 1984-04-13 1985-04-23 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
YU43402B (en) * 1985-03-04 1989-06-30 Pliva Pharm & Chem Works Process for preparation of 11-aza-10-deoxo-10-dihydroeritromycin "a" by using electro-chemical reduction
WO1989002271A1 (en) 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents

Also Published As

Publication number Publication date
CN1016785B (zh) 1992-05-27
EG18527A (en) 1993-10-30
SI8811325A8 (en) 1996-12-31
CY1776A (en) 1995-10-20
US6268489B1 (en) 2001-07-31
NO171556C (no) 1993-03-31
EP0298650B1 (en) 1992-02-05
GR3003737T3 (bs) 1993-03-16
FI91263C (fi) 1994-06-10
ZA884925B (en) 1990-02-28
MA21323A1 (fr) 1989-04-01
DD271705A5 (de) 1989-09-13
MX12213A (es) 1993-05-01
DK380688A (da) 1989-01-10
ATE72446T1 (de) 1992-02-15
CN1030422A (zh) 1989-01-18
PT87933A (pt) 1989-06-30
KR900006218B1 (ko) 1990-08-25
LV10624A (lv) 1995-04-20
IS3370A7 (is) 1989-01-10
PT87933B (pt) 1994-09-30
CS489688A2 (en) 1990-03-14
LV10624B (en) 1995-10-20
AP8800093A0 (en) 1988-05-01
AU604553B2 (en) 1990-12-20
JPH0631300B2 (ja) 1994-04-27
PL157145B1 (en) 1992-04-30
PL273590A1 (en) 1989-03-20
IE882108L (en) 1989-01-09
EP0298650A3 (en) 1989-11-08
WO1989000576A1 (en) 1989-01-26
DK380688D0 (da) 1988-07-08
NO900077L (no) 1990-01-08
FI900087A (fi) 1990-01-08
IL86979A0 (en) 1988-12-30
IN168879B (bs) 1991-06-29
JPS6438096A (en) 1989-02-08
ES2038756T3 (es) 1993-08-01
NZ225338A (en) 1990-02-26
FI91263B (fi) 1994-02-28
IE60354B1 (en) 1994-06-29
UA27040C2 (uk) 2000-02-28
SG27794G (en) 1994-10-14
HU211862A9 (en) 1995-12-28
RO107257B1 (ro) 1993-10-30
FI900087A0 (fi) 1990-01-08
DE3868296D1 (de) 1992-03-19
YU132588A (en) 1990-02-28
AR243532A1 (es) 1993-08-31
IL86979A (en) 1992-11-15
OA08743A (fr) 1989-03-31
PH30953A (en) 1997-12-23
IS1540B (is) 1994-01-28
MY103744A (en) 1993-09-30
DK172573B1 (da) 1999-01-25
AP44A (en) 1989-07-27
CS272241B2 (en) 1991-01-15
HK127594A (en) 1994-11-25
NO900077D0 (no) 1990-01-08
EP0298650A2 (en) 1989-01-11
CA1314876C (en) 1993-03-23
KR890002137A (ko) 1989-04-08
AU1883988A (en) 1989-01-12
BG47348A3 (en) 1990-06-15
YU45075B (en) 1991-08-31
RU2066324C1 (ru) 1996-09-10
NO171556B (no) 1992-12-21

Similar Documents

Publication Publication Date Title
BA98213B1 (bs) Postupak za dobijanje kristalnog azitromicin dihidrata
PT88596A (pt) Process for preparing 2-anilinopyrimidine derivatives useful aspesticidas
PT86866A (pt) Process for preparing piperazinyl-heterocyclic compounds
PT86934A (pt) Process for the preparation of a thiazepine compound
MD108B1 (ro) Procedeu de obtinere a sucralozei cristalice
PT88481A (pt) Process for the preparation of a new cephem compound
PT86660A (pt) Process for preparing adenosine 5:-carboxamide derivatives
PT87191A (pt) Process for the preparation of nucleosides
FI872517A (fi) Menetelmä terapeuttisesti käyttökelpoisten makrolidiyhdisteiden valmistamiseksi
FR2594727B1 (fr) Procede de preparation de noyaux ceramiques
PT87153A (pt) Process for the preparation of acid ribofuranuronic derivatives
FI883672A (fi) Menetelmä terapeuttisesti käyttökelpoisten aminoalkoksifenyylijohdannaisten valmistamiseksi
PT86631A (pt) Process for the preparation of a novel crystalline form of potassium clavulanate
FI880842A0 (fi) Menetelmä kiteisen kefeemisulfaatin valmistamiseksi
FI92064C (fi) Menetelmä terapeuttisesti käyttökelpoisten N-bentsopyranyylilaktaamien valmistamiseksi
PT86938A (pt) Process for the preparation of a macrocyclic compound
FI884473A (fi) Menetelmä terapeuttisesti käyttökelpoisten fenoksialkyylipyrokatekolijohdannaisten valmistamiseksi
PT88158A (pt) Process for the preparation of a novel diosmin derivative
HU885893D0 (en) Process for the preparation of substituted azaciclohexyl derivatives
HUT45957A (en) Process for producing diphenyl-ether derivatives
PT88523A (pt) Process for the production of a glycopeptide antibiotic
PT86899A (pt) Process for preparing 27-halo derivatives of ll-f28249 compounds
PT88465A (pt) Process for the preparation of macrolide compounds
PT88467A (pt) Process for the preparation of macrolide compounds
PT86829A (pt) Process for preparing thienothiopyran derivatives