ES2172417B1 - Nueva forma mejorada de azitromicina monohidrato de menor higroscopicidad, procedimiento de preparacion y composiciones farmaceuticas que la comprenden. - Google Patents
Nueva forma mejorada de azitromicina monohidrato de menor higroscopicidad, procedimiento de preparacion y composiciones farmaceuticas que la comprenden.Info
- Publication number
- ES2172417B1 ES2172417B1 ES200001934A ES200001934A ES2172417B1 ES 2172417 B1 ES2172417 B1 ES 2172417B1 ES 200001934 A ES200001934 A ES 200001934A ES 200001934 A ES200001934 A ES 200001934A ES 2172417 B1 ES2172417 B1 ES 2172417B1
- Authority
- ES
- Spain
- Prior art keywords
- improved form
- pharmaceutical compositions
- azithromycin monohydrate
- monohidrate
- azitromycin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Nueva forma mejorada de azitromicina monohidrato de menor higroscopicidad, procedimiento de preparación y composiciones farmacéuticas que la comprenden. La forma mejorada de azitromicina monohidrato de menor higroscopicidad se caracteriza por ser más densa y fuerte y por poseer unos valores de: densidad aparente de llenado no inferior a 0,35 g/ml; y densidad aparente golpeada no inferior a 0,50 g/ml. El procedimiento de preparación de una forma mejorada de azitromicina monohidrato, se caracteriza por someter la azitromicina monohidrato higroscópica a un proceso de compactación mediante presión. La invención también se refiere a una composición farmacéutica que comprende una cantidad terapéuticamente efectiva de la forma mejorada de azitromicina monohidrato en asociación con al menos un diluyente inerte adecuado farmacéuticamente aceptable.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200001934A ES2172417B1 (es) | 2000-07-31 | 2000-07-31 | Nueva forma mejorada de azitromicina monohidrato de menor higroscopicidad, procedimiento de preparacion y composiciones farmaceuticas que la comprenden. |
AU2001272695A AU2001272695A1 (en) | 2000-07-31 | 2001-07-25 | Azithromocin monohydrate with lower hygroscopicity, preparation method and pharmaceutical compositions which include it |
PCT/IB2001/001327 WO2002010181A1 (en) | 2000-07-31 | 2001-07-25 | Azithromocin monohydrate with lower hygroscopicity, preparation method and pharmaceutical compositions which include it |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200001934A ES2172417B1 (es) | 2000-07-31 | 2000-07-31 | Nueva forma mejorada de azitromicina monohidrato de menor higroscopicidad, procedimiento de preparacion y composiciones farmaceuticas que la comprenden. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2172417A1 ES2172417A1 (es) | 2002-09-16 |
ES2172417B1 true ES2172417B1 (es) | 2003-09-16 |
Family
ID=8494518
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200001934A Expired - Fee Related ES2172417B1 (es) | 2000-07-31 | 2000-07-31 | Nueva forma mejorada de azitromicina monohidrato de menor higroscopicidad, procedimiento de preparacion y composiciones farmaceuticas que la comprenden. |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2001272695A1 (es) |
ES (1) | ES2172417B1 (es) |
WO (1) | WO2002010181A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6861413B2 (en) | 2001-05-22 | 2005-03-01 | Pfizer Inc. | Stable non-dihydrate azithromycin oral suspensions |
AP2003002906A0 (en) | 2001-05-22 | 2003-12-31 | Pfizer Prod Inc | Crystal forms of azithromycin |
GB0214277D0 (en) * | 2002-06-20 | 2002-07-31 | Biochemie Gmbh | Organic compounds |
GB0224197D0 (en) * | 2002-10-17 | 2002-11-27 | Biochemie Gmbh | Organic compounds |
WO2005002592A2 (en) * | 2003-07-01 | 2005-01-13 | Ranbaxy Laboratories Limited | Stable oral compositions of azithromycin monohydrate |
US20050101547A1 (en) * | 2003-11-06 | 2005-05-12 | Sadatrezaei Mohsen | Stabilized azithromycin composition |
US7683162B2 (en) | 2004-08-30 | 2010-03-23 | Taro Pharmaceutical Industries Limited | Process of preparing a crystalline azithromycin monohydrate |
MX2011009548A (es) | 2009-03-13 | 2011-12-14 | Da Volterra | Composiciones y metodos para la eliminacion de bacterias gram-negativas. |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX12213A (es) * | 1987-07-09 | 1993-05-01 | Pfizer | Metodo de preparacion de dihidrato de azitromicina cristalino |
ATE469910T1 (de) * | 1999-06-29 | 2010-06-15 | Sandoz Ag | Azithromycinmonohydrat |
-
2000
- 2000-07-31 ES ES200001934A patent/ES2172417B1/es not_active Expired - Fee Related
-
2001
- 2001-07-25 AU AU2001272695A patent/AU2001272695A1/en not_active Abandoned
- 2001-07-25 WO PCT/IB2001/001327 patent/WO2002010181A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
ES2172417A1 (es) | 2002-09-16 |
WO2002010181A1 (en) | 2002-02-07 |
AU2001272695A1 (en) | 2002-02-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 20020916 Kind code of ref document: A1 Effective date: 20020916 |
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FD2A | Announcement of lapse in spain |
Effective date: 20110819 |