PT87933A - Processo para a preparacao de di-hidrato de azitromicina - Google Patents

Processo para a preparacao de di-hidrato de azitromicina

Info

Publication number
PT87933A
PT87933A PT87933A PT8793388A PT87933A PT 87933 A PT87933 A PT 87933A PT 87933 A PT87933 A PT 87933A PT 8793388 A PT8793388 A PT 8793388A PT 87933 A PT87933 A PT 87933A
Authority
PT
Portugal
Prior art keywords
azithromycine
dihydrate
preparation
azithromycine dihydrate
Prior art date
Application number
PT87933A
Other languages
English (en)
Other versions
PT87933B (pt
Inventor
John Meldrum Allen Douglas
Michael Nepveux Kevin
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22202456&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT87933(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of PT87933A publication Critical patent/PT87933A/pt
Publication of PT87933B publication Critical patent/PT87933B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT87933A 1987-07-09 1988-07-07 Processo para a preparacao de di-hidrato de azitromicina PT87933B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1987/001612 WO1989000576A1 (en) 1987-07-09 1987-07-09 Azithromycin dihydrate

Publications (2)

Publication Number Publication Date
PT87933A true PT87933A (pt) 1989-06-30
PT87933B PT87933B (pt) 1994-09-30

Family

ID=22202456

Family Applications (1)

Application Number Title Priority Date Filing Date
PT87933A PT87933B (pt) 1987-07-09 1988-07-07 Processo para a preparacao de di-hidrato de azitromicina

Country Status (45)

Country Link
US (1) US6268489B1 (pt)
EP (1) EP0298650B1 (pt)
JP (1) JPH0631300B2 (pt)
KR (1) KR900006218B1 (pt)
CN (1) CN1016785B (pt)
AP (1) AP44A (pt)
AR (1) AR243532A1 (pt)
AT (1) ATE72446T1 (pt)
AU (1) AU604553B2 (pt)
BA (1) BA98213B1 (pt)
BG (1) BG47348A3 (pt)
CA (1) CA1314876C (pt)
CS (1) CS272241B2 (pt)
CY (1) CY1776A (pt)
DD (1) DD271705A5 (pt)
DE (1) DE3868296D1 (pt)
DK (1) DK172573B1 (pt)
EG (1) EG18527A (pt)
ES (1) ES2038756T3 (pt)
FI (1) FI91263C (pt)
GR (1) GR3003737T3 (pt)
HK (1) HK127594A (pt)
HU (1) HU211862A9 (pt)
IE (1) IE60354B1 (pt)
IL (1) IL86979A (pt)
IN (1) IN168879B (pt)
IS (1) IS1540B (pt)
LV (1) LV10624B (pt)
MA (1) MA21323A1 (pt)
MX (1) MX12213A (pt)
MY (1) MY103744A (pt)
NO (1) NO171556C (pt)
NZ (1) NZ225338A (pt)
OA (1) OA08743A (pt)
PH (1) PH30953A (pt)
PL (1) PL157145B1 (pt)
PT (1) PT87933B (pt)
RO (1) RO107257B1 (pt)
RU (1) RU2066324C1 (pt)
SG (1) SG27794G (pt)
SI (1) SI8811325A8 (pt)
UA (1) UA27040C2 (pt)
WO (1) WO1989000576A1 (pt)
YU (1) YU45075B (pt)
ZA (1) ZA884925B (pt)

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US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
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US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers
EP0539223A1 (en) * 1991-10-25 1993-04-28 Ono Pharmaceutical Co., Ltd. Glycine derivative monosodium salt tetrahydrate having an inhibitory effect on elastase
US5215980A (en) * 1992-01-17 1993-06-01 Merck & Co., Inc. 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
CN1034734C (zh) * 1993-12-10 1997-04-30 北京市集才药物研究所 一种新的阿齐红霉素结晶及其制备方法
US5605889A (en) 1994-04-29 1997-02-25 Pfizer Inc. Method of administering azithromycin
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US6861411B1 (en) 1997-12-02 2005-03-01 Pfizer, Inc. Method of treating eye infections with azithromycin
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CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
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CA2417353C (en) 2000-07-25 2009-09-01 Laboratorio Silanes,S.A. De C.V. Single-step process for preparing 7,16-deoxy-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihydroxi-6-ethyl-3,5,9,11,13,15-hexamethylbicycle (11.2.1)hexadeca-1(2)-en-8-one, and obtaining a new form of 9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin a
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Also Published As

Publication number Publication date
OA08743A (fr) 1989-03-31
DE3868296D1 (de) 1992-03-19
PL273590A1 (en) 1989-03-20
DK380688D0 (da) 1988-07-08
ES2038756T3 (es) 1993-08-01
PT87933B (pt) 1994-09-30
FI91263B (fi) 1994-02-28
KR900006218B1 (ko) 1990-08-25
AP8800093A0 (en) 1988-05-01
AU604553B2 (en) 1990-12-20
MA21323A1 (fr) 1989-04-01
RO107257B1 (ro) 1993-10-30
GR3003737T3 (pt) 1993-03-16
WO1989000576A1 (en) 1989-01-26
JPH0631300B2 (ja) 1994-04-27
AU1883988A (en) 1989-01-12
BG47348A3 (en) 1990-06-15
AR243532A1 (es) 1993-08-31
LV10624A (lv) 1995-04-20
NO171556C (no) 1993-03-31
IL86979A0 (en) 1988-12-30
JPS6438096A (en) 1989-02-08
PH30953A (en) 1997-12-23
EP0298650B1 (en) 1992-02-05
NO900077L (no) 1990-01-08
ATE72446T1 (de) 1992-02-15
IS3370A7 (is) 1989-01-10
EG18527A (en) 1993-10-30
CN1030422A (zh) 1989-01-18
DK380688A (da) 1989-01-10
NO900077D0 (no) 1990-01-08
BA98213B1 (bs) 1999-08-02
AP44A (en) 1989-07-27
US6268489B1 (en) 2001-07-31
HU211862A9 (en) 1995-12-28
HK127594A (en) 1994-11-25
NZ225338A (en) 1990-02-26
CA1314876C (en) 1993-03-23
ZA884925B (en) 1990-02-28
MY103744A (en) 1993-09-30
MX12213A (es) 1993-05-01
UA27040C2 (uk) 2000-02-28
CN1016785B (zh) 1992-05-27
IS1540B (is) 1994-01-28
NO171556B (no) 1992-12-21
YU132588A (en) 1990-02-28
CS272241B2 (en) 1991-01-15
DD271705A5 (de) 1989-09-13
IE60354B1 (en) 1994-06-29
SI8811325A8 (en) 1996-12-31
IE882108L (en) 1989-01-09
EP0298650A2 (en) 1989-01-11
PL157145B1 (en) 1992-04-30
FI900087A (fi) 1990-01-08
SG27794G (en) 1994-10-14
IN168879B (pt) 1991-06-29
LV10624B (en) 1995-10-20
FI91263C (fi) 1994-06-10
IL86979A (en) 1992-11-15
CS489688A2 (en) 1990-03-14
EP0298650A3 (en) 1989-11-08
RU2066324C1 (ru) 1996-09-10
CY1776A (en) 1995-10-20
KR890002137A (ko) 1989-04-08
FI900087A0 (fi) 1990-01-08
YU45075B (en) 1991-08-31
DK172573B1 (da) 1999-01-25

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