DE3868296D1 - Azithromycin-dihydrat. - Google Patents

Azithromycin-dihydrat.

Info

Publication number
DE3868296D1
DE3868296D1 DE8888305921T DE3868296T DE3868296D1 DE 3868296 D1 DE3868296 D1 DE 3868296D1 DE 8888305921 T DE8888305921 T DE 8888305921T DE 3868296 T DE3868296 T DE 3868296T DE 3868296 D1 DE3868296 D1 DE 3868296D1
Authority
DE
Germany
Prior art keywords
azithromycine
dihydrate
azithromycine dihydrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8888305921T
Other languages
English (en)
Inventor
Douglas John Meldrum Allen
Kevin Michael Nepveux
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer GmbH
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22202456&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3868296(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of DE3868296D1 publication Critical patent/DE3868296D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8888305921T 1987-07-09 1988-06-28 Azithromycin-dihydrat. Expired - Lifetime DE3868296D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1987/001612 WO1989000576A1 (en) 1987-07-09 1987-07-09 Azithromycin dihydrate

Publications (1)

Publication Number Publication Date
DE3868296D1 true DE3868296D1 (de) 1992-03-19

Family

ID=22202456

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888305921T Expired - Lifetime DE3868296D1 (de) 1987-07-09 1988-06-28 Azithromycin-dihydrat.

Country Status (45)

Country Link
US (1) US6268489B1 (de)
EP (1) EP0298650B1 (de)
JP (1) JPH0631300B2 (de)
KR (1) KR900006218B1 (de)
CN (1) CN1016785B (de)
AP (1) AP44A (de)
AR (1) AR243532A1 (de)
AT (1) ATE72446T1 (de)
AU (1) AU604553B2 (de)
BA (1) BA98213B1 (de)
BG (1) BG47348A3 (de)
CA (1) CA1314876C (de)
CS (1) CS272241B2 (de)
CY (1) CY1776A (de)
DD (1) DD271705A5 (de)
DE (1) DE3868296D1 (de)
DK (1) DK172573B1 (de)
EG (1) EG18527A (de)
ES (1) ES2038756T3 (de)
FI (1) FI91263C (de)
GR (1) GR3003737T3 (de)
HK (1) HK127594A (de)
HU (1) HU211862A9 (de)
IE (1) IE60354B1 (de)
IL (1) IL86979A (de)
IN (1) IN168879B (de)
IS (1) IS1540B (de)
LV (1) LV10624B (de)
MA (1) MA21323A1 (de)
MX (1) MX12213A (de)
MY (1) MY103744A (de)
NO (1) NO171556C (de)
NZ (1) NZ225338A (de)
OA (1) OA08743A (de)
PH (1) PH30953A (de)
PL (1) PL157145B1 (de)
PT (1) PT87933B (de)
RO (1) RO107257B1 (de)
RU (1) RU2066324C1 (de)
SG (1) SG27794G (de)
SI (1) SI8811325A8 (de)
UA (1) UA27040C2 (de)
WO (1) WO1989000576A1 (de)
YU (1) YU45075B (de)
ZA (1) ZA884925B (de)

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US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
US5985844A (en) * 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers
CA2081268A1 (en) * 1991-10-25 1993-04-26 Katsuhiro Imaki Glycine derivative monosodium salt tetrahydrate
US5215980A (en) * 1992-01-17 1993-06-01 Merck & Co., Inc. 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
CN1034734C (zh) * 1993-12-10 1997-04-30 北京市集才药物研究所 一种新的阿齐红霉素结晶及其制备方法
US5605889A (en) 1994-04-29 1997-02-25 Pfizer Inc. Method of administering azithromycin
PL179910B1 (pl) 1994-05-06 2000-11-30 Pfizer Postac dawkowania o kontrolowanym uwalnianiu zawierajaca azytromycyne PL PL PL PL PL PL PL PL
ES2122905B1 (es) * 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
NZ503897A (en) * 1997-10-16 2002-10-25 Pliva Pharm & Chem Works 3,6-hemiketals from the class of 9a-azalides
US6861411B1 (en) 1997-12-02 2005-03-01 Pfizer, Inc. Method of treating eye infections with azithromycin
PT102130A (pt) * 1998-03-13 1999-09-30 Hovione Sociedade Quimica S A Processo de preparacao de dihidrato de azitromicina
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
EP1152765B1 (de) * 1998-11-30 2004-10-13 Teva Pharmaceutical Industries Ltd. Ethanolate des azithromycin, herstllungsverfahren und deren pharmazeutische zusammenstellungen
US6239113B1 (en) 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
US7056893B2 (en) 1999-03-31 2006-06-06 Insite Vision, Inc. Topical treatment for prevention of ocular infections
UA67842C2 (uk) * 1999-05-18 2004-07-15 Пфайзер Продактс Інк. Кристалічні форми макролідного антибіотика
DE20023815U1 (de) 1999-06-29 2006-06-08 Sandoz Ag Azithromycin enthaltende Zusammensetzungen
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WO2002010144A1 (es) 2000-07-25 2002-02-07 Laboratorio Silanes, S.A. De C.V. PROCESO PARA LA PREPARACION EN UN SOLO PASO DE 7,16-DIOXA-2-AZA-10-O-CLADINOSIL-12-O-DESOSAMINIL-4,5-DIHIDROXI-6-ETIL-3,5,9,11,13,15-HEXAMETILBICICLO[11.2.1]HEXADECA-1(2)-EN-8-ONA Y OBTENCION DE UNA FORMA NUEVA DE 9-DESOXO-9a-AZA-9a-METIL-9a-HOMOERITROMICINA A
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Also Published As

Publication number Publication date
DD271705A5 (de) 1989-09-13
ATE72446T1 (de) 1992-02-15
YU45075B (en) 1991-08-31
SG27794G (en) 1994-10-14
JPS6438096A (en) 1989-02-08
DK380688A (da) 1989-01-10
NO900077L (no) 1990-01-08
WO1989000576A1 (en) 1989-01-26
SI8811325A8 (en) 1996-12-31
FI900087A (fi) 1990-01-08
IL86979A (en) 1992-11-15
RU2066324C1 (ru) 1996-09-10
AU1883988A (en) 1989-01-12
CS489688A2 (en) 1990-03-14
HU211862A9 (en) 1995-12-28
IE60354B1 (en) 1994-06-29
AP8800093A0 (en) 1988-05-01
AU604553B2 (en) 1990-12-20
IS1540B (is) 1994-01-28
OA08743A (fr) 1989-03-31
CS272241B2 (en) 1991-01-15
BG47348A3 (en) 1990-06-15
CA1314876C (en) 1993-03-23
NO900077D0 (no) 1990-01-08
ES2038756T3 (es) 1993-08-01
IL86979A0 (en) 1988-12-30
AR243532A1 (es) 1993-08-31
PT87933B (pt) 1994-09-30
US6268489B1 (en) 2001-07-31
NO171556C (no) 1993-03-31
CN1030422A (zh) 1989-01-18
PL273590A1 (en) 1989-03-20
LV10624B (en) 1995-10-20
JPH0631300B2 (ja) 1994-04-27
LV10624A (lv) 1995-04-20
DK380688D0 (da) 1988-07-08
NZ225338A (en) 1990-02-26
FI91263B (fi) 1994-02-28
PT87933A (pt) 1989-06-30
IN168879B (de) 1991-06-29
FI900087A0 (fi) 1990-01-08
YU132588A (en) 1990-02-28
AP44A (en) 1989-07-27
UA27040C2 (uk) 2000-02-28
MX12213A (es) 1993-05-01
PL157145B1 (en) 1992-04-30
FI91263C (fi) 1994-06-10
GR3003737T3 (de) 1993-03-16
CY1776A (en) 1995-10-20
IS3370A7 (is) 1989-01-10
HK127594A (en) 1994-11-25
CN1016785B (zh) 1992-05-27
MY103744A (en) 1993-09-30
EP0298650B1 (de) 1992-02-05
NO171556B (no) 1992-12-21
DK172573B1 (da) 1999-01-25
EG18527A (en) 1993-10-30
IE882108L (en) 1989-01-09
EP0298650A3 (en) 1989-11-08
KR890002137A (ko) 1989-04-08
PH30953A (en) 1997-12-23
KR900006218B1 (ko) 1990-08-25
MA21323A1 (fr) 1989-04-01
BA98213B1 (bs) 1999-08-02
EP0298650A2 (de) 1989-01-11
RO107257B1 (ro) 1993-10-30
ZA884925B (en) 1990-02-28

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