ES2122905B1 - Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato). - Google Patents

Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).

Info

Publication number
ES2122905B1
ES2122905B1 ES009601561A ES9601561A ES2122905B1 ES 2122905 B1 ES2122905 B1 ES 2122905B1 ES 009601561 A ES009601561 A ES 009601561A ES 9601561 A ES9601561 A ES 9601561A ES 2122905 B1 ES2122905 B1 ES 2122905B1
Authority
ES
Spain
Prior art keywords
homoerythromycin
aza
dihydrate
methyl
desoxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES009601561A
Other languages
English (en)
Other versions
ES2122905A1 (es
Inventor
Jasanada Miguel Santos Bayod
Gonzalez Jose Ramon Fernandez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AsturPharma SA
Original Assignee
AsturPharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AsturPharma SA filed Critical AsturPharma SA
Priority to ES009601561A priority Critical patent/ES2122905B1/es
Priority to AT97500120T priority patent/ATE326477T1/de
Priority to EP97500120A priority patent/EP0827965B1/en
Priority to DE69735871T priority patent/DE69735871D1/de
Priority to JP09186157A priority patent/JP3101590B2/ja
Priority to US08/890,771 priority patent/US5869629A/en
Publication of ES2122905A1 publication Critical patent/ES2122905A1/es
Application granted granted Critical
Publication of ES2122905B1 publication Critical patent/ES2122905B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Síntesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina A. Un procedimiento para la preparación de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina A dihidrato (Azitromicina dihidrato). La preparación de azitromicina dihidrato a partir de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina A, obteniéndose un proceso por pasos desde 9-desoxo-6-desoxi-6,9-epoxi-9,9a-dihidro-9a-azahomoeritromicina A es un procedimiento que tiene lugar en condiciones suaves y con buenos rendimientos.
ES009601561A 1996-07-11 1996-07-11 Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato). Expired - Fee Related ES2122905B1 (es)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ES009601561A ES2122905B1 (es) 1996-07-11 1996-07-11 Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
AT97500120T ATE326477T1 (de) 1996-07-11 1997-07-07 Synthese von 9-deoxo-9a-aza 11,12-deoxy-9a-methyl-9a-homoerythromycin a 11,12-hydrogenorthoborat- dihydrat
EP97500120A EP0827965B1 (en) 1996-07-11 1997-07-07 Synthesis of 9-deoxo- 9a-aza 11,12-deoxy- 9a-methyl-9a-homoerythromycin A 11,12- hydrogenorthoborate dihydrate
DE69735871T DE69735871D1 (de) 1996-07-11 1997-07-07 Synthese von 9-Deoxo-9a-Aza 11,12-Deoxy-9a-Methyl-9a-Homoerythromycin A 11,12-hydrogenorthoborat-dihydrat
JP09186157A JP3101590B2 (ja) 1996-07-11 1997-07-11 アジトロマイシン・２水和物の製法及びその中間体
US08/890,771 US5869629A (en) 1996-07-11 1997-07-11 Synthesis of 9-deoxo-9a-aza-11,12-deoxy-9a-methyl-9a-homoerythromycin A 11,12 Hydrogenorthoborate dihydrate and a process for the preparation of azitromicin dihydrate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009601561A ES2122905B1 (es) 1996-07-11 1996-07-11 Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).

Publications (2)

Publication Number Publication Date
ES2122905A1 ES2122905A1 (es) 1998-12-16
ES2122905B1 true ES2122905B1 (es) 1999-11-16

Family

ID=8295476

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009601561A Expired - Fee Related ES2122905B1 (es) 1996-07-11 1996-07-11 Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).

Country Status (6)

Country Link
US (1) US5869629A (es)
EP (1) EP0827965B1 (es)
JP (1) JP3101590B2 (es)
AT (1) ATE326477T1 (es)
DE (1) DE69735871D1 (es)
ES (1) ES2122905B1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020231A2 (en) * 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
ES2122905B1 (es) * 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
PT102130A (pt) * 1998-03-13 1999-09-30 Hovione Sociedade Quimica S A Processo de preparacao de dihidrato de azitromicina
TW546302B (en) 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
DE20023815U1 (de) * 1999-06-29 2006-06-08 Sandoz Ag Azithromycin enthaltende Zusammensetzungen
ES2177373B1 (es) * 1999-11-26 2003-11-01 Astur Pharma Sa Preparacion de azitromicina en su forma no cristalina
US6787342B2 (en) * 2000-02-16 2004-09-07 Merial Limited Paste formulations
ES2162764B1 (es) * 2000-05-17 2003-04-01 Ercros Ind Sa Forma polimorfica del dihidrato de azitromicina, y su procedimiento deobtencion.
ATE320441T1 (de) * 2000-07-25 2006-04-15 Silanes Sa De Cv Lab Einstufiges verfahren zur herstellung von 7,16-
DE60114028T2 (de) * 2000-08-23 2006-07-13 Wockhardt Ltd. Verfahren zur herstellung von wasserfreiem azithromycin
CN100413879C (zh) * 2001-04-27 2008-08-27 辉瑞产品公司 4″-取代-9-脱氧-9a-氮杂-9a-高红霉素A衍生物的制备方法
EP1490382A4 (en) * 2002-04-03 2007-09-12 Hanmi Pharm Ind Co Ltd PROCESS FOR PREPARING AZITHROMYXIN AND HYDRATE CRYSTALLINE 9-DEOXO-9A-HOMOERYTHROMYCIN
ITMI20021209A1 (it) * 2002-06-04 2003-12-04 Chemi Spa Processo di preparazione di azitromicina ad elevata purezza
HRP20020614A2 (en) 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
GB2395482A (en) * 2003-07-03 2004-05-26 Jubilant Organosys Ltd Process for preparing non-hygroscopic azithromycin dihydrate
US7468428B2 (en) 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7683162B2 (en) * 2004-08-30 2010-03-23 Taro Pharmaceutical Industries Limited Process of preparing a crystalline azithromycin monohydrate
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
CN103214531B (zh) * 2013-04-24 2017-12-01 菏泽市方明制药有限公司 一种阿奇霉素前体氮红霉素的制备方法
EP2868652A1 (de) * 2013-11-05 2015-05-06 Evonik Industries AG Katalytische Hydrierung zur Herstellung von Aminen aus Amidacetalen, Keten-N,O-acetalen oder Esterimiden

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4153788A (en) * 1974-04-09 1979-05-08 Zyma S.A. Process of preparing mono-O-β-hydroxyethyl-7 rutoside
NL7806452A (nl) * 1978-06-14 1979-12-18 Tno Werkwijze voor de behandeling van aromatische polya- midevezels, die geschikt zijn voor gebruik in construc- tiematerialen en rubbers, alsmede aldus behandelde vezels en met deze vezels gewapende gevormde voort- brengsels.
YU43116B (en) * 1979-04-02 1989-04-30 Pliva Pharm & Chem Works Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox
YU43006B (en) * 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
RU2066324C1 (ru) * 1987-07-09 1996-09-10 Пфайзер Инк. Кристаллический дигидрат азитромицина и способ его получения
US5300634A (en) * 1991-05-07 1994-04-05 Wako Pure Chemical Industries, Ltd. Process for producing maltooligosaccharide derivative
EP0699207B1 (en) * 1993-05-19 1997-06-25 Pfizer Inc. Intermediate for azithromycin
ECSP951389A (es) 1995-02-21 1996-05-10 Un procedimiento de obtencion de hidrato de azitromicina
ES2122905B1 (es) * 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).

Also Published As

Publication number Publication date
JPH1072482A (ja) 1998-03-17
ATE326477T1 (de) 2006-06-15
US5869629A (en) 1999-02-09
EP0827965B1 (en) 2006-05-17
JP3101590B2 (ja) 2000-10-23
EP0827965A2 (en) 1998-03-11
DE69735871D1 (de) 2006-06-22
EP0827965A3 (en) 1998-06-03
ES2122905A1 (es) 1998-12-16

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