EP1490382A4 - Process of preparing azithromycin and crystalline 9-deoxo-9a-aza-9a-homoerythromycin a hydrate used therein - Google Patents

Process of preparing azithromycin and crystalline 9-deoxo-9a-aza-9a-homoerythromycin a hydrate used therein

Info

Publication number
EP1490382A4
EP1490382A4 EP02717187A EP02717187A EP1490382A4 EP 1490382 A4 EP1490382 A4 EP 1490382A4 EP 02717187 A EP02717187 A EP 02717187A EP 02717187 A EP02717187 A EP 02717187A EP 1490382 A4 EP1490382 A4 EP 1490382A4
Authority
EP
European Patent Office
Prior art keywords
homoerythromycin
deoxo
aza
crystalline
hydrate used
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02717187A
Other languages
German (de)
French (fr)
Other versions
EP1490382A1 (en
Inventor
Gi Jeong Kim
Mi Ra Seong
Sang Min Yun
Kwee Hyun Suh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hanmi Pharmaceutical Co Ltd
Hanmi Pharmaceutical Industries Co Ltd
Original Assignee
Hanmi Pharmaceutical Co Ltd
Hanmi Pharmaceutical Industries Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Pharmaceutical Co Ltd, Hanmi Pharmaceutical Industries Co Ltd filed Critical Hanmi Pharmaceutical Co Ltd
Priority claimed from PCT/KR2002/000588 external-priority patent/WO2003082889A1/en
Publication of EP1490382A1 publication Critical patent/EP1490382A1/en
Publication of EP1490382A4 publication Critical patent/EP1490382A4/en
Withdrawn legal-status Critical Current

Links

EP02717187A 2002-04-03 2002-04-03 Process of preparing azithromycin and crystalline 9-deoxo-9a-aza-9a-homoerythromycin a hydrate used therein Withdrawn EP1490382A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/KR2002/000588 WO2003082889A1 (en) 2001-03-21 2002-04-03 Process of preparing azithromycin and crystalline 9-deoxo-9a-aza-9a-homoerythromycin a hydrate used therein

Publications (2)

Publication Number Publication Date
EP1490382A1 EP1490382A1 (en) 2004-12-29
EP1490382A4 true EP1490382A4 (en) 2007-09-12

Family

ID=33411531

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02717187A Withdrawn EP1490382A4 (en) 2002-04-03 2002-04-03 Process of preparing azithromycin and crystalline 9-deoxo-9a-aza-9a-homoerythromycin a hydrate used therein

Country Status (3)

Country Link
EP (1) EP1490382A4 (en)
JP (1) JP2005522470A (en)
CN (1) CN1276919C (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101624412B (en) 2008-07-10 2012-07-04 刘力 Derivative of macrolides, method for preparing same and application thereof
CN101724000B (en) * 2008-10-29 2012-05-30 广东东阳光药业有限公司 Crystallization method of erythrocin
CN103159811A (en) * 2011-12-10 2013-06-19 山东方明药业集团股份有限公司 Preparation method for azithromycin intermediate 9a-deoxo-9a-aza-9a-homoerythromycin A
CN102417531B (en) * 2011-12-20 2014-06-11 浙江国邦药业有限公司 Method for preparing azithromycin monohydrate
CN105315316A (en) * 2014-07-21 2016-02-10 常州制药厂有限公司 Preparation method for azithromycin intermediate
CN106632543A (en) * 2016-12-20 2017-05-10 宁夏启元药业有限公司 Synthesis method of azithromycin
CN109293719A (en) * 2018-10-12 2019-02-01 浙江国邦药业有限公司 A kind of dihydro homoerythromycin crystal compound and preparation method thereof
CN114516895A (en) * 2020-11-19 2022-05-20 江苏威奇达药业有限公司 Azithromycin amine crystallization method

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0827965A2 (en) * 1996-07-11 1998-03-11 Astur-Pharma, S.A. Synthesis of 9-deoxo- 9a-aza 11,12-deoxy- 9a-methyl-9a-homoerythromycin A 11,12- hydrogenorthoborate dihydrate
EP0941999A2 (en) * 1998-03-13 1999-09-15 Hovione Inter Ltd. Preparation of azithromycin dihydrate
WO2001000640A1 (en) * 1999-06-29 2001-01-04 Biochemie S.A. Macrolides
WO2002015842A2 (en) * 2000-08-23 2002-02-28 Wockhardt Limited Process for preparation of anhydrous azithromycin

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0827965A2 (en) * 1996-07-11 1998-03-11 Astur-Pharma, S.A. Synthesis of 9-deoxo- 9a-aza 11,12-deoxy- 9a-methyl-9a-homoerythromycin A 11,12- hydrogenorthoborate dihydrate
EP0941999A2 (en) * 1998-03-13 1999-09-15 Hovione Inter Ltd. Preparation of azithromycin dihydrate
WO2001000640A1 (en) * 1999-06-29 2001-01-04 Biochemie S.A. Macrolides
WO2002015842A2 (en) * 2000-08-23 2002-02-28 Wockhardt Limited Process for preparation of anhydrous azithromycin

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO03082889A1 *

Also Published As

Publication number Publication date
EP1490382A1 (en) 2004-12-29
CN1625560A (en) 2005-06-08
CN1276919C (en) 2006-09-27
JP2005522470A (en) 2005-07-28

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

RIN1 Information on inventor provided before grant (corrected)

Inventor name: SEONG, MI RA

Inventor name: KIM, GI JEONG

Inventor name: SUH, KWEE HYUN

Inventor name: YUN, SANG MIN

RIN1 Information on inventor provided before grant (corrected)

Inventor name: KIM, GI JEONG

Inventor name: YUN, SANG MIN

Inventor name: SUH, KWEE HYUN

Inventor name: SEONG, MI RA

A4 Supplementary search report drawn up and despatched

Effective date: 20070813

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 31/7048 20060101ALI20070807BHEP

Ipc: A61P 31/04 20060101ALI20070807BHEP

Ipc: C07H 17/08 20060101AFI20031015BHEP

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