ATE326477T1 - Synthese von 9-deoxo-9a-aza 11,12-deoxy-9a-methyl-9a-homoerythromycin a 11,12-hydrogenorthoborat- dihydrat - Google Patents

Synthese von 9-deoxo-9a-aza 11,12-deoxy-9a-methyl-9a-homoerythromycin a 11,12-hydrogenorthoborat- dihydrat

Info

Publication number
ATE326477T1
ATE326477T1 AT97500120T AT97500120T ATE326477T1 AT E326477 T1 ATE326477 T1 AT E326477T1 AT 97500120 T AT97500120 T AT 97500120T AT 97500120 T AT97500120 T AT 97500120T AT E326477 T1 ATE326477 T1 AT E326477T1
Authority
AT
Austria
Prior art keywords
deoxo
deoxy
hydrogenorthoborate
homoerythromycin
aza
Prior art date
Application number
AT97500120T
Other languages
English (en)
Inventor
Jasanada Miguel Santos Bayod
Gonzalez Jose Ramon Fernandez
Original Assignee
Astur Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astur Pharma Sa filed Critical Astur Pharma Sa
Application granted granted Critical
Publication of ATE326477T1 publication Critical patent/ATE326477T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT97500120T 1996-07-11 1997-07-07 Synthese von 9-deoxo-9a-aza 11,12-deoxy-9a-methyl-9a-homoerythromycin a 11,12-hydrogenorthoborat- dihydrat ATE326477T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009601561A ES2122905B1 (es) 1996-07-11 1996-07-11 Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).

Publications (1)

Publication Number Publication Date
ATE326477T1 true ATE326477T1 (de) 2006-06-15

Family

ID=8295476

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97500120T ATE326477T1 (de) 1996-07-11 1997-07-07 Synthese von 9-deoxo-9a-aza 11,12-deoxy-9a-methyl-9a-homoerythromycin a 11,12-hydrogenorthoborat- dihydrat

Country Status (6)

Country Link
US (1) US5869629A (de)
EP (1) EP0827965B1 (de)
JP (1) JP3101590B2 (de)
AT (1) ATE326477T1 (de)
DE (1) DE69735871D1 (de)
ES (1) ES2122905B1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020231A2 (en) * 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
ES2122905B1 (es) * 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
PT102130A (pt) * 1998-03-13 1999-09-30 Hovione Sociedade Quimica S A Processo de preparacao de dihidrato de azitromicina
TW546302B (en) 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
DE20023815U1 (de) 1999-06-29 2006-06-08 Sandoz Ag Azithromycin enthaltende Zusammensetzungen
ES2177373B1 (es) 1999-11-26 2003-11-01 Astur Pharma Sa Preparacion de azitromicina en su forma no cristalina
US6787342B2 (en) * 2000-02-16 2004-09-07 Merial Limited Paste formulations
ES2162764B1 (es) * 2000-05-17 2003-04-01 Ercros Ind Sa Forma polimorfica del dihidrato de azitromicina, y su procedimiento deobtencion.
WO2002010144A1 (es) * 2000-07-25 2002-02-07 Laboratorio Silanes, S.A. De C.V. PROCESO PARA LA PREPARACION EN UN SOLO PASO DE 7,16-DIOXA-2-AZA-10-O-CLADINOSIL-12-O-DESOSAMINIL-4,5-DIHIDROXI-6-ETIL-3,5,9,11,13,15-HEXAMETILBICICLO[11.2.1]HEXADECA-1(2)-EN-8-ONA Y OBTENCION DE UNA FORMA NUEVA DE 9-DESOXO-9a-AZA-9a-METIL-9a-HOMOERITROMICINA A
AU2001280000A1 (en) * 2000-08-23 2002-03-04 Jaweed Mukarram, Siddiqui Mohammed Process for preparation of anhydrous azithromycin
EP1383780A1 (de) * 2001-04-27 2004-01-28 Pfizer Products Inc. Verfahren zur herstellung von 4"-substituierte-9-deoxo-9a-homoerythromycin a derivate
EP1490382A4 (de) * 2002-04-03 2007-09-12 Hanmi Pharm Ind Co Ltd Verfahren zur herstellung von azithromycin und dabei verwendetes kristallines 9-desoxo-9a-aza-9a-homoerythromycin-a-hydrat
ITMI20021209A1 (it) * 2002-06-04 2003-12-04 Chemi Spa Processo di preparazione di azitromicina ad elevata purezza
HRP20020614A2 (en) 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
GB2395482A (en) * 2003-07-03 2004-05-26 Jubilant Organosys Ltd Process for preparing non-hygroscopic azithromycin dihydrate
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US7683162B2 (en) * 2004-08-30 2010-03-23 Taro Pharmaceutical Industries Limited Process of preparing a crystalline azithromycin monohydrate
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
CN103214531B (zh) * 2013-04-24 2017-12-01 菏泽市方明制药有限公司 一种阿奇霉素前体氮红霉素的制备方法
EP2868652A1 (de) * 2013-11-05 2015-05-06 Evonik Industries AG Katalytische Hydrierung zur Herstellung von Aminen aus Amidacetalen, Keten-N,O-acetalen oder Esterimiden

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4153788A (en) * 1974-04-09 1979-05-08 Zyma S.A. Process of preparing mono-O-β-hydroxyethyl-7 rutoside
NL7806452A (nl) * 1978-06-14 1979-12-18 Tno Werkwijze voor de behandeling van aromatische polya- midevezels, die geschikt zijn voor gebruik in construc- tiematerialen en rubbers, alsmede aldus behandelde vezels en met deze vezels gewapende gevormde voort- brengsels.
YU43116B (en) * 1979-04-02 1989-04-30 Pliva Pharm & Chem Works Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox
YU43006B (en) * 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
RU2066324C1 (ru) * 1987-07-09 1996-09-10 Пфайзер Инк. Кристаллический дигидрат азитромицина и способ его получения
US5300634A (en) * 1991-05-07 1994-04-05 Wako Pure Chemical Industries, Ltd. Process for producing maltooligosaccharide derivative
WO1994026758A1 (en) * 1993-05-19 1994-11-24 Pfizer Inc. Intermediate for azithromycin
ECSP951389A (es) * 1995-02-21 1996-05-10 Un procedimiento de obtencion de hidrato de azitromicina
ES2122905B1 (es) * 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).

Also Published As

Publication number Publication date
DE69735871D1 (de) 2006-06-22
EP0827965A3 (de) 1998-06-03
EP0827965B1 (de) 2006-05-17
JPH1072482A (ja) 1998-03-17
US5869629A (en) 1999-02-09
JP3101590B2 (ja) 2000-10-23
EP0827965A2 (de) 1998-03-11
ES2122905B1 (es) 1999-11-16
ES2122905A1 (es) 1998-12-16

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