ATE320441T1 - Einstufiges verfahren zur herstellung von 7,16- - Google Patents
Einstufiges verfahren zur herstellung von 7,16-Info
- Publication number
- ATE320441T1 ATE320441T1 AT00959035T AT00959035T ATE320441T1 AT E320441 T1 ATE320441 T1 AT E320441T1 AT 00959035 T AT00959035 T AT 00959035T AT 00959035 T AT00959035 T AT 00959035T AT E320441 T1 ATE320441 T1 AT E320441T1
- Authority
- AT
- Austria
- Prior art keywords
- erythromycin
- iminoether
- aza
- step process
- mesitylenesulfonyloxime
- Prior art date
Links
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 4
- 229960003276 erythromycin Drugs 0.000 abstract 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 229930006677 Erythromycin A Natural products 0.000 abstract 2
- ODUCDPQEXGNKDN-UHFFFAOYSA-N nitroxyl Chemical compound O=N ODUCDPQEXGNKDN-UHFFFAOYSA-N 0.000 abstract 2
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
- 239000003120 macrolide antibiotic agent Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
- 230000017105 transposition Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/MX2000/000030 WO2002010144A1 (es) | 2000-07-25 | 2000-07-25 | PROCESO PARA LA PREPARACION EN UN SOLO PASO DE 7,16-DIOXA-2-AZA-10-O-CLADINOSIL-12-O-DESOSAMINIL-4,5-DIHIDROXI-6-ETIL-3,5,9,11,13,15-HEXAMETILBICICLO[11.2.1]HEXADECA-1(2)-EN-8-ONA Y OBTENCION DE UNA FORMA NUEVA DE 9-DESOXO-9a-AZA-9a-METIL-9a-HOMOERITROMICINA A |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE320441T1 true ATE320441T1 (de) | 2006-04-15 |
Family
ID=19741683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00959035T ATE320441T1 (de) | 2000-07-25 | 2000-07-25 | Einstufiges verfahren zur herstellung von 7,16- |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6528492B1 (de) |
| EP (1) | EP1304326B1 (de) |
| AT (1) | ATE320441T1 (de) |
| AU (1) | AU2000270425A1 (de) |
| CA (1) | CA2417353C (de) |
| DE (1) | DE60026718T2 (de) |
| ES (1) | ES2260047T3 (de) |
| WO (1) | WO2002010144A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20020231A2 (en) * | 2002-03-18 | 2003-12-31 | Pliva D D | ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A |
| BR0209918A (pt) * | 2001-05-22 | 2004-03-30 | Pfizer Prod Inc | Formas cristalinas da azitromicina |
| US6861413B2 (en) | 2001-05-22 | 2005-03-01 | Pfizer Inc. | Stable non-dihydrate azithromycin oral suspensions |
| HRP20020614A2 (en) | 2002-07-22 | 2004-06-30 | PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. | Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a |
| US7468428B2 (en) * | 2004-03-17 | 2008-12-23 | App Pharmaceuticals, Llc | Lyophilized azithromycin formulation |
| US20060116336A1 (en) * | 2004-03-17 | 2006-06-01 | American Pharmaceutical Partners, Inc. | Lyophilized azithromycin formulation |
| WO2007080507A2 (en) * | 2006-01-12 | 2007-07-19 | Wockhardt Ltd | Processes for the preparation of azithromycin |
| JP2012520268A (ja) | 2009-03-13 | 2012-09-06 | ダ・ボルテラ | グラム陰性細菌の除去のための組成物及び方法 |
| CN103087125B (zh) * | 2013-02-06 | 2015-12-02 | 浙江国邦药业有限公司 | 制备阿奇霉素一锅煮的工艺方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1100504A (en) | 1967-08-16 | 1968-01-24 | Pliva Pharm & Chem Works | Erythromycin oxime and 9-amino-3-o-cladinosyl-5-o-desosaminyl-6,11,12-trihydroxy-2,4,6,8,10,12-hexamethylpentadecane-13-olide |
| YU43116B (en) | 1979-04-02 | 1989-04-30 | Pliva Pharm & Chem Works | Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox |
| YU43006B (en) | 1981-03-06 | 1989-02-28 | Pliva Pharm & Chem Works | Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof |
| US4474768A (en) | 1982-07-19 | 1984-10-02 | Pfizer Inc. | N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor |
| RU2066324C1 (ru) | 1987-07-09 | 1996-09-10 | Пфайзер Инк. | Кристаллический дигидрат азитромицина и способ его получения |
| WO1989002271A1 (en) | 1987-09-10 | 1989-03-23 | Pfizer | Azithromycin and derivatives as antiprotozoal agents |
| EP0699207B1 (de) | 1993-05-19 | 1997-06-25 | Pfizer Inc. | Zwischenprodukt für azithromycin |
| US5605889A (en) * | 1994-04-29 | 1997-02-25 | Pfizer Inc. | Method of administering azithromycin |
| ES2122905B1 (es) * | 1996-07-11 | 1999-11-16 | Astur Pharma Sa | Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato). |
| PT102006B (pt) | 1997-05-19 | 2000-06-30 | Hovione Sociedade Quimica S A | Novo processo de preparacao de azitromicina |
| TW546302B (en) | 1998-05-08 | 2003-08-11 | Biochemie Sa | Improvements in macrolide production |
| CA2245398C (en) | 1998-08-21 | 2002-01-29 | Apotex Inc. | Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof |
| GB9824580D0 (en) * | 1998-11-10 | 1999-01-06 | Biochemie Sa | Organic compounds |
| DE20023815U1 (de) | 1999-06-29 | 2006-06-08 | Sandoz Ag | Azithromycin enthaltende Zusammensetzungen |
| WO2002009640A2 (en) | 2000-08-01 | 2002-02-07 | Shiva Prasad Singh | Process for the preparation of anhydrous azithromycin |
| DE60114028T2 (de) | 2000-08-23 | 2006-07-13 | Wockhardt Ltd. | Verfahren zur herstellung von wasserfreiem azithromycin |
-
2000
- 2000-07-25 AT AT00959035T patent/ATE320441T1/de active
- 2000-07-25 ES ES00959035T patent/ES2260047T3/es not_active Expired - Lifetime
- 2000-07-25 DE DE60026718T patent/DE60026718T2/de not_active Expired - Lifetime
- 2000-07-25 EP EP00959035A patent/EP1304326B1/de not_active Expired - Lifetime
- 2000-07-25 AU AU2000270425A patent/AU2000270425A1/en not_active Abandoned
- 2000-07-25 CA CA002417353A patent/CA2417353C/en not_active Expired - Fee Related
- 2000-07-25 US US09/673,021 patent/US6528492B1/en not_active Expired - Lifetime
- 2000-07-25 WO PCT/MX2000/000030 patent/WO2002010144A1/es not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1304326A1 (de) | 2003-04-23 |
| AU2000270425A1 (en) | 2002-02-13 |
| EP1304326B1 (de) | 2006-03-15 |
| EP1304326A4 (de) | 2004-06-16 |
| WO2002010144A1 (es) | 2002-02-07 |
| DE60026718T2 (de) | 2006-11-16 |
| CA2417353A1 (en) | 2003-01-27 |
| DE60026718D1 (de) | 2006-05-11 |
| CA2417353C (en) | 2009-09-01 |
| US6528492B1 (en) | 2003-03-04 |
| ES2260047T3 (es) | 2006-11-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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