ATE388159T1 - Verfahren zur herstellung von azithromycin- dihydrat - Google Patents
Verfahren zur herstellung von azithromycin- dihydratInfo
- Publication number
- ATE388159T1 ATE388159T1 AT01939983T AT01939983T ATE388159T1 AT E388159 T1 ATE388159 T1 AT E388159T1 AT 01939983 T AT01939983 T AT 01939983T AT 01939983 T AT01939983 T AT 01939983T AT E388159 T1 ATE388159 T1 AT E388159T1
- Authority
- AT
- Austria
- Prior art keywords
- azithromycin
- desmethyl
- dihydrate
- acetone
- azithromycine
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- -1 AZITHROMYCINE DIHYDRATE Chemical class 0.000 title 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 6
- 229960004099 azithromycin Drugs 0.000 abstract 5
- MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 abstract 5
- HRKNNHYKWGYTEN-HOQMJRDDSA-N (2r,3s,4r,5r,8r,10r,11r,12s,13s,14r)-11-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)NC[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 HRKNNHYKWGYTEN-HOQMJRDDSA-N 0.000 abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 1
- VQEMDSRIOVZAOM-UHFFFAOYSA-N 4-(4-methylsulfonylphenyl)-1,3-thiazol-2-amine Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=CSC(N)=N1 VQEMDSRIOVZAOM-UHFFFAOYSA-N 0.000 abstract 1
- 229960004924 azithromycin dihydrate Drugs 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 235000019253 formic acid Nutrition 0.000 abstract 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17433000P | 2000-01-04 | 2000-01-04 | |
| US22068100P | 2000-07-25 | 2000-07-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE388159T1 true ATE388159T1 (de) | 2008-03-15 |
Family
ID=26870122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01939983T ATE388159T1 (de) | 2000-01-04 | 2001-01-04 | Verfahren zur herstellung von azithromycin- dihydrat |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6586576B2 (de) |
| EP (1) | EP1246831B1 (de) |
| AT (1) | ATE388159T1 (de) |
| AU (1) | AU2928701A (de) |
| CA (1) | CA2396426A1 (de) |
| DE (1) | DE60133083D1 (de) |
| IL (1) | IL150564A0 (de) |
| PT (1) | PT1246831E (de) |
| WO (1) | WO2001049697A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20020231A2 (en) * | 2002-03-18 | 2003-12-31 | Pliva D D | ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A |
| ES2162764B1 (es) * | 2000-05-17 | 2003-04-01 | Ercros Ind Sa | Forma polimorfica del dihidrato de azitromicina, y su procedimiento deobtencion. |
| KR100431431B1 (ko) * | 2001-04-25 | 2004-05-14 | 한미약품 주식회사 | 아지트로마이신 수화물의 1,2-프로필렌글리콜 내포화합물,그의 제조방법 및 그의 약학적 조성물 |
| US6861413B2 (en) | 2001-05-22 | 2005-03-01 | Pfizer Inc. | Stable non-dihydrate azithromycin oral suspensions |
| BR0209918A (pt) | 2001-05-22 | 2004-03-30 | Pfizer Prod Inc | Formas cristalinas da azitromicina |
| ITMI20021209A1 (it) * | 2002-06-04 | 2003-12-04 | Chemi Spa | Processo di preparazione di azitromicina ad elevata purezza |
| HRP20020614A2 (en) * | 2002-07-22 | 2004-06-30 | PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. | Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a |
| GB2395482A (en) * | 2003-07-03 | 2004-05-26 | Jubilant Organosys Ltd | Process for preparing non-hygroscopic azithromycin dihydrate |
| AU2004294813A1 (en) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Spray-congeal process using an extruder for preparing multiparticulate azithromycin compositions containing preferably a poloxamer and a glyceride |
| RU2258070C1 (ru) * | 2004-01-29 | 2005-08-10 | Открытое акционерное общество "Акционерное курганское общество медицинских препаратов и изделий "Синтез" | Способ получения азитромицина |
| US7468428B2 (en) | 2004-03-17 | 2008-12-23 | App Pharmaceuticals, Llc | Lyophilized azithromycin formulation |
| US20060116336A1 (en) * | 2004-03-17 | 2006-06-01 | American Pharmaceutical Partners, Inc. | Lyophilized azithromycin formulation |
| US7683162B2 (en) * | 2004-08-30 | 2010-03-23 | Taro Pharmaceutical Industries Limited | Process of preparing a crystalline azithromycin monohydrate |
| WO2007029266A2 (en) * | 2005-05-24 | 2007-03-15 | Kopran Research Laboratories Ltd | A process for preparing 9-deoxo-9a-aza-9a-homoerythromycin a |
| WO2007015265A2 (en) * | 2005-05-24 | 2007-02-08 | Kopran Research Laboratories Ltd | A process for preparing 6,9-imino ether |
| US20090318375A1 (en) * | 2005-06-08 | 2009-12-24 | Hanmi Pharm Co., Ltd | Crystalline Azithromycin L-Malate Monohydrate and Pharmaceutical Composition Containing Same |
| AU2009313325B2 (en) * | 2008-11-07 | 2014-05-01 | Takeda Pharmaceutical Company Limited | Factor VIII formulations |
| JP2012520268A (ja) | 2009-03-13 | 2012-09-06 | ダ・ボルテラ | グラム陰性細菌の除去のための組成物及び方法 |
| US8106111B2 (en) | 2009-05-15 | 2012-01-31 | Eastman Chemical Company | Antimicrobial effect of cycloaliphatic diol antimicrobial agents in coating compositions |
| WO2011015219A1 (en) * | 2009-08-06 | 2011-02-10 | Shifa Pharmed Industrial Group Co. | Process for the purification of azithromycin by separation from its thermal degradation products and/or isomers |
| CN104004037B (zh) * | 2014-06-12 | 2016-10-19 | 宜春学院 | 黄芩苷及其酯的8-位甲胺类衍生物及其制备方法 |
| CN104910222B (zh) * | 2015-06-29 | 2018-02-13 | 石药集团欧意药业有限公司 | 阿奇霉素新晶型化合物及其制备方法 |
| CN105030704B (zh) * | 2015-06-29 | 2018-09-07 | 石药集团欧意药业有限公司 | 阿奇霉素片剂及其制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU43006B (en) * | 1981-03-06 | 1989-02-28 | Pliva Pharm & Chem Works | Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof |
| US4474768A (en) | 1982-07-19 | 1984-10-02 | Pfizer Inc. | N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor |
| PH19293A (en) * | 1982-11-15 | 1986-03-04 | Pfizer | Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof |
| RU2066324C1 (ru) * | 1987-07-09 | 1996-09-10 | Пфайзер Инк. | Кристаллический дигидрат азитромицина и способ его получения |
| WO1989002271A1 (en) | 1987-09-10 | 1989-03-23 | Pfizer | Azithromycin and derivatives as antiprotozoal agents |
| PT102130A (pt) * | 1998-03-13 | 1999-09-30 | Hovione Sociedade Quimica S A | Processo de preparacao de dihidrato de azitromicina |
-
2001
- 2001-01-04 AT AT01939983T patent/ATE388159T1/de not_active IP Right Cessation
- 2001-01-04 DE DE60133083T patent/DE60133083D1/de not_active Expired - Lifetime
- 2001-01-04 WO PCT/US2001/000364 patent/WO2001049697A1/en not_active Ceased
- 2001-01-04 IL IL15056401A patent/IL150564A0/xx unknown
- 2001-01-04 PT PT01939983T patent/PT1246831E/pt unknown
- 2001-01-04 US US09/755,829 patent/US6586576B2/en not_active Expired - Fee Related
- 2001-01-04 AU AU29287/01A patent/AU2928701A/en not_active Abandoned
- 2001-01-04 CA CA002396426A patent/CA2396426A1/en not_active Abandoned
- 2001-01-04 EP EP01939983A patent/EP1246831B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU2928701A (en) | 2001-07-16 |
| IL150564A0 (en) | 2003-02-12 |
| US6586576B2 (en) | 2003-07-01 |
| WO2001049697A1 (en) | 2001-07-12 |
| DE60133083D1 (de) | 2008-04-17 |
| PT1246831E (pt) | 2008-03-28 |
| EP1246831B1 (de) | 2008-03-05 |
| CA2396426A1 (en) | 2001-07-12 |
| EP1246831A4 (de) | 2003-04-23 |
| US20010047089A1 (en) | 2001-11-29 |
| EP1246831A1 (de) | 2002-10-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |