EA200970307A1 - Способ получения галогенидов n-алкилнальтрексона - Google Patents
Способ получения галогенидов n-алкилнальтрексонаInfo
- Publication number
- EA200970307A1 EA200970307A1 EA200970307A EA200970307A EA200970307A1 EA 200970307 A1 EA200970307 A1 EA 200970307A1 EA 200970307 A EA200970307 A EA 200970307A EA 200970307 A EA200970307 A EA 200970307A EA 200970307 A1 EA200970307 A1 EA 200970307A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl
- carbonate
- producing
- trexone
- halogenides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
Abstract
Изобретение касается нового способа получения бромида N-метилнальтрексона, включающего, по меньшей мере, стадии, заключающиеся в: (i) осуществлении взаимодействия метилсульфата N-метилнальтрексона в водном растворе со щелочным агентом, выбранным в группе, включающей карбонат натрия, карбонат калия, карбонат кальция, карбонат магния, карбонат цезия, карбонат стронция и их смеси, так, чтобы величина рН водной реакционной среды находилась в диапазоне от 7 до 10, затем в (ii) осуществлении взаимодействия продукта, полученного таким образом, с бромисто-водородной кислотой, которую добавляют так, чтобы величина рН водной реакционной среды находилась в диапазоне от 0,5 до 5, с получением, таким образом, бромида N-метилнальтрексона.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0608286A FR2906252B1 (fr) | 2006-09-21 | 2006-09-21 | Procede de preparation d'halogenures de n-aklyl naltrexone |
PCT/FR2007/001516 WO2008034973A1 (fr) | 2006-09-21 | 2007-09-19 | Procede de preparation d'halogenures de n-alkyl naltrexone |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200970307A1 true EA200970307A1 (ru) | 2009-12-30 |
EA015426B1 EA015426B1 (ru) | 2011-08-30 |
Family
ID=38016779
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200970307A EA015426B1 (ru) | 2006-09-21 | 2007-09-19 | Способ получения галогенидов n-алкилнальтрексона |
Country Status (36)
Country | Link |
---|---|
US (2) | US7645880B2 (ru) |
EP (1) | EP2069362B1 (ru) |
JP (1) | JP5214615B2 (ru) |
KR (1) | KR101434693B1 (ru) |
CN (2) | CN101516892B (ru) |
AR (1) | AR062918A1 (ru) |
AU (1) | AU2007298855B2 (ru) |
BR (1) | BRPI0718440A2 (ru) |
CA (1) | CA2663509C (ru) |
CL (1) | CL2007002711A1 (ru) |
CO (1) | CO6170362A2 (ru) |
CR (1) | CR10660A (ru) |
DO (1) | DOP2011000307A (ru) |
EA (1) | EA015426B1 (ru) |
ES (1) | ES2531093T3 (ru) |
FR (1) | FR2906252B1 (ru) |
GT (1) | GT200900060A (ru) |
HK (1) | HK1135389A1 (ru) |
HN (1) | HN2009000503A (ru) |
IL (1) | IL197402A (ru) |
JO (1) | JO3023B1 (ru) |
MA (1) | MA30793B1 (ru) |
ME (1) | MEP10509A (ru) |
MX (1) | MX2009003084A (ru) |
MY (1) | MY148094A (ru) |
NI (1) | NI200900035A (ru) |
NO (1) | NO20091561L (ru) |
NZ (1) | NZ575417A (ru) |
PE (1) | PE20080867A1 (ru) |
SV (1) | SV2009003192A (ru) |
TN (1) | TN2009000080A1 (ru) |
TW (1) | TWI465451B (ru) |
UA (1) | UA96957C2 (ru) |
UY (1) | UY30599A1 (ru) |
WO (1) | WO2008034973A1 (ru) |
ZA (1) | ZA200901846B (ru) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010522756A (ja) | 2007-03-29 | 2010-07-08 | プロジェニックス ファーマシューティカルズ,インコーポレーテッド | 結晶形およびその使用 |
WO2008138383A1 (de) * | 2007-05-16 | 2008-11-20 | Cilag Ag | Verfahren zur herstellung von n-methylnaltrexonbromid |
WO2009009292A2 (en) * | 2007-07-11 | 2009-01-15 | Mallinckrodt Inc. | Crystalline forms of naltrexone methobromide |
EP2019105A1 (en) * | 2007-07-19 | 2009-01-28 | Siegfried Ltd. | Process for the preparation of quaternary n-alkyl morphine or morphinane alkaloid derivatives |
PL2344506T3 (pl) * | 2008-09-30 | 2016-08-31 | SpecGx LLC | Sposoby alkilowania grup aminy drugorzędowej pochodnych morfinanowych |
EP2398807A1 (en) * | 2009-02-23 | 2011-12-28 | Mallinckrodt LLC | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
US8946419B2 (en) | 2009-02-23 | 2015-02-03 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
JP5784507B2 (ja) * | 2009-02-23 | 2015-09-24 | マリンクロッド エルエルシー | (+)−モルフィナニウム第四級塩およびその生成方法 |
WO2010096790A1 (en) * | 2009-02-23 | 2010-08-26 | Mallinckrodt Inc. | (+)-morphinananium n-oxides and processes for their production |
US8853401B2 (en) | 2009-04-24 | 2014-10-07 | Brock University | Processes for the preparation of morphinane and morphinone compounds |
US8829020B2 (en) | 2009-07-16 | 2014-09-09 | Mallinckrodt Llc | Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
CN101845047B (zh) * | 2009-12-31 | 2011-12-07 | 南京臣功制药有限公司 | 一种溴甲基纳曲酮的制备方法 |
JO3209B1 (ar) * | 2010-11-05 | 2018-03-08 | H Lundbeck As | طريقة لتصنيع نالتريكسون |
RS55777B1 (sr) | 2010-11-05 | 2017-07-31 | H Lundbeck As | Postupak za proizvodnju naltreksona |
US8580963B2 (en) | 2010-11-05 | 2013-11-12 | H. Lundbeck A/S | Method for the manufacturing of naltrexone |
WO2012138888A1 (en) | 2011-04-05 | 2012-10-11 | Alkermes, Inc. | Process for the synthesis of quaternary amine compounds |
RU2014112493A (ru) | 2011-09-08 | 2015-10-20 | МАЛЛИНКРОДТ Эл-Эл-Си | Получения алкалоидов без выделения промежуточных продуктов |
CN103172640A (zh) * | 2011-12-22 | 2013-06-26 | 天津康鸿医药科技发展有限公司 | 一种(r)-n-溴甲基纳曲酮的制备方法以及纳曲酮衍生物 |
US20140155608A1 (en) | 2012-05-03 | 2014-06-05 | H. Lundbeck A/S | Method for the manufacturing of naltrexone |
CN105985348B (zh) * | 2015-02-12 | 2019-02-01 | 正大天晴药业集团股份有限公司 | 一种溴甲基纳曲酮的制备方法 |
CN106317064B (zh) * | 2015-06-30 | 2018-06-19 | 北大方正集团有限公司 | 溴甲纳曲酮的制备方法 |
KR102201609B1 (ko) * | 2019-04-19 | 2021-01-12 | 연성정밀화학(주) | 날데메딘의 제조방법 |
CN111777617A (zh) * | 2020-07-10 | 2020-10-16 | 华润三九医药股份有限公司 | 一种溴甲纳曲酮的精制方法 |
EP4225312A1 (en) | 2020-10-06 | 2023-08-16 | Scilex Holding Company | Oral delayed burst formulation of low-dose naltrexone or naloxone used for treating fibromyalgia and long covid |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4176186A (en) * | 1978-07-28 | 1979-11-27 | Boehringer Ingelheim Gmbh | Quaternary derivatives of noroxymorphone which relieve intestinal immobility |
CA2504262C (en) * | 2002-11-08 | 2012-01-10 | Mallinckrodt, Inc. | Process for the preparation of quaternary n-alkyl morphinan alkaloid salts |
AR057325A1 (es) * | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
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2006
- 2006-09-21 FR FR0608286A patent/FR2906252B1/fr not_active Expired - Fee Related
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2007
- 2007-09-19 AU AU2007298855A patent/AU2007298855B2/en not_active Ceased
- 2007-09-19 TW TW096134967A patent/TWI465451B/zh not_active IP Right Cessation
- 2007-09-19 MY MYPI20091158A patent/MY148094A/en unknown
- 2007-09-19 UA UAA200903924A patent/UA96957C2/ru unknown
- 2007-09-19 BR BRPI0718440-9A2A patent/BRPI0718440A2/pt not_active IP Right Cessation
- 2007-09-19 ME MEP-105/09A patent/MEP10509A/xx unknown
- 2007-09-19 NZ NZ575417A patent/NZ575417A/en not_active IP Right Cessation
- 2007-09-19 EP EP07848250.2A patent/EP2069362B1/fr active Active
- 2007-09-19 WO PCT/FR2007/001516 patent/WO2008034973A1/fr active Application Filing
- 2007-09-19 CN CN2007800350747A patent/CN101516892B/zh not_active Expired - Fee Related
- 2007-09-19 ZA ZA200901846A patent/ZA200901846B/xx unknown
- 2007-09-19 KR KR1020097005731A patent/KR101434693B1/ko not_active IP Right Cessation
- 2007-09-19 CA CA2663509A patent/CA2663509C/fr not_active Expired - Fee Related
- 2007-09-19 JP JP2009528751A patent/JP5214615B2/ja not_active Expired - Fee Related
- 2007-09-19 EA EA200970307A patent/EA015426B1/ru not_active IP Right Cessation
- 2007-09-19 MX MX2009003084A patent/MX2009003084A/es active IP Right Grant
- 2007-09-19 ES ES07848250T patent/ES2531093T3/es active Active
- 2007-09-19 CN CN2011101080743A patent/CN102225939A/zh active Pending
- 2007-09-20 UY UY30599A patent/UY30599A1/es not_active Application Discontinuation
- 2007-09-20 PE PE2007001269A patent/PE20080867A1/es not_active Application Discontinuation
- 2007-09-20 CL CL200702711A patent/CL2007002711A1/es unknown
- 2007-09-20 JO JOP/2007/0399A patent/JO3023B1/ar active
- 2007-09-20 AR ARP070104157A patent/AR062918A1/es unknown
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2008
- 2008-03-17 US US12/049,607 patent/US7645880B2/en not_active Expired - Fee Related
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2009
- 2009-03-04 IL IL197402A patent/IL197402A/en not_active IP Right Cessation
- 2009-03-10 TN TN2009000080A patent/TN2009000080A1/fr unknown
- 2009-03-11 CR CR10660A patent/CR10660A/es unknown
- 2009-03-12 GT GT200900060A patent/GT200900060A/es unknown
- 2009-03-18 HN HN2009000503A patent/HN2009000503A/es unknown
- 2009-03-19 CO CO09028774A patent/CO6170362A2/es active IP Right Grant
- 2009-03-19 NI NI200900035A patent/NI200900035A/es unknown
- 2009-03-19 SV SV2009003192A patent/SV2009003192A/es active IP Right Grant
- 2009-04-16 MA MA31789A patent/MA30793B1/fr unknown
- 2009-04-20 NO NO20091561A patent/NO20091561L/no not_active Application Discontinuation
- 2009-11-25 US US12/625,649 patent/US8288547B2/en not_active Expired - Fee Related
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2010
- 2010-02-22 HK HK10101845.3A patent/HK1135389A1/xx not_active IP Right Cessation
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2011
- 2011-10-07 DO DO2011000307A patent/DOP2011000307A/es unknown
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Legal Events
Date | Code | Title | Description |
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MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ KZ KG MD TJ TM |
|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): BY RU |