DOP2011000307A - Procedimiento de preparacion de halogenuros de n-alquil-naltrexona - Google Patents

Procedimiento de preparacion de halogenuros de n-alquil-naltrexona

Info

Publication number
DOP2011000307A
DOP2011000307A DO2011000307A DO2011000307A DOP2011000307A DO P2011000307 A DOP2011000307 A DO P2011000307A DO 2011000307 A DO2011000307 A DO 2011000307A DO 2011000307 A DO2011000307 A DO 2011000307A DO P2011000307 A DOP2011000307 A DO P2011000307A
Authority
DO
Dominican Republic
Prior art keywords
carbonate
methyl
naltrexone
naltrexona
halogenure
Prior art date
Application number
DO2011000307A
Other languages
English (en)
Inventor
Alan Dlubala
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of DOP2011000307A publication Critical patent/DOP2011000307A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La invención se refiere a un nuevo procedimiento de preparación del bromuro de N-metil-naltrexona, que comprende al menos las etapas que consisten en: (i) hacer reaccionar el metilsulfato de N-metil-naltrexona en solución acuosa con un agente alcalino elegido del grupo constituido por carbonato de sodio, carbonato de potasio, carbonato de calcio, carbonato de magnesio, carbonato de cesio, carbonato de estroncio y las mezclas de estos, para un pH del medio de reacción acuoso comprendido entre 7 y 10, Y después (ii) hacer reaccionar el producto así obtenido con el ácido bromhídrico que se añade, para un pH del medio de reacción acuoso comprendido entre 0,5 y 5 Y obtener así el bromuro de N-metil-naltrexona.
DO2011000307A 2006-09-21 2011-10-07 Procedimiento de preparacion de halogenuros de n-alquil-naltrexona DOP2011000307A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0608286A FR2906252B1 (fr) 2006-09-21 2006-09-21 Procede de preparation d'halogenures de n-aklyl naltrexone

Publications (1)

Publication Number Publication Date
DOP2011000307A true DOP2011000307A (es) 2011-10-31

Family

ID=38016779

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2011000307A DOP2011000307A (es) 2006-09-21 2011-10-07 Procedimiento de preparacion de halogenuros de n-alquil-naltrexona

Country Status (36)

Country Link
US (2) US7645880B2 (es)
EP (1) EP2069362B1 (es)
JP (1) JP5214615B2 (es)
KR (1) KR101434693B1 (es)
CN (2) CN101516892B (es)
AR (1) AR062918A1 (es)
AU (1) AU2007298855B2 (es)
BR (1) BRPI0718440A2 (es)
CA (1) CA2663509C (es)
CL (1) CL2007002711A1 (es)
CO (1) CO6170362A2 (es)
CR (1) CR10660A (es)
DO (1) DOP2011000307A (es)
EA (1) EA015426B1 (es)
ES (1) ES2531093T3 (es)
FR (1) FR2906252B1 (es)
GT (1) GT200900060A (es)
HK (1) HK1135389A1 (es)
HN (1) HN2009000503A (es)
IL (1) IL197402A (es)
JO (1) JO3023B1 (es)
MA (1) MA30793B1 (es)
ME (1) MEP10509A (es)
MX (1) MX2009003084A (es)
MY (1) MY148094A (es)
NI (1) NI200900035A (es)
NO (1) NO20091561L (es)
NZ (1) NZ575417A (es)
PE (1) PE20080867A1 (es)
SV (1) SV2009003192A (es)
TN (1) TN2009000080A1 (es)
TW (1) TWI465451B (es)
UA (1) UA96957C2 (es)
UY (1) UY30599A1 (es)
WO (1) WO2008034973A1 (es)
ZA (1) ZA200901846B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2134718A2 (en) 2007-03-29 2009-12-23 Progenics Pharmaceuticals, Inc. Crystal forms of (r)-n-methylnaltrexone bromide and uses thereof
WO2008138383A1 (de) * 2007-05-16 2008-11-20 Cilag Ag Verfahren zur herstellung von n-methylnaltrexonbromid
WO2009009292A2 (en) * 2007-07-11 2009-01-15 Mallinckrodt Inc. Crystalline forms of naltrexone methobromide
EP2019105A1 (en) * 2007-07-19 2009-01-28 Siegfried Ltd. Process for the preparation of quaternary n-alkyl morphine or morphinane alkaloid derivatives
CA2738246C (en) * 2008-09-30 2017-09-05 Mallinckrodt Inc. Processes for the alkylation of secondary amine groups of morphinan derivatives
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US8563724B2 (en) * 2009-02-23 2013-10-22 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US8436174B2 (en) * 2009-02-23 2013-05-07 Mallinckrodt Llc (+)-morphinanium quaternary salts and processes for their production
CN102325777B (zh) * 2009-02-23 2015-08-12 马林克罗特公司 (+)-吗啡喃*n-氧化物及其制备方法
US8853401B2 (en) 2009-04-24 2014-10-07 Brock University Processes for the preparation of morphinane and morphinone compounds
WO2011009020A2 (en) 2009-07-16 2011-01-20 Mallinckrodt Inc. Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
CN101845047B (zh) * 2009-12-31 2011-12-07 南京臣功制药有限公司 一种溴甲基纳曲酮的制备方法
EP2635586B1 (en) * 2010-11-05 2017-02-08 H. Lundbeck A/S Method for the manufacturing of naltrexone
JO3209B1 (ar) * 2010-11-05 2018-03-08 H Lundbeck As طريقة لتصنيع نالتريكسون
US8580963B2 (en) 2010-11-05 2013-11-12 H. Lundbeck A/S Method for the manufacturing of naltrexone
US9029543B2 (en) 2011-04-05 2015-05-12 Alkermes, Inc. Process for the synthesis of quaternary amine compounds
AU2012304484B2 (en) 2011-09-08 2016-07-28 SpecGx LLC Production of alkaloids without the isolation of intermediates
CN103172640A (zh) * 2011-12-22 2013-06-26 天津康鸿医药科技发展有限公司 一种(r)-n-溴甲基纳曲酮的制备方法以及纳曲酮衍生物
WO2013164383A1 (en) 2012-05-03 2013-11-07 H. Lundbeck A/S Method for the manufacturing of naltrexone
CN105985348B (zh) * 2015-02-12 2019-02-01 正大天晴药业集团股份有限公司 一种溴甲基纳曲酮的制备方法
CN106317064B (zh) * 2015-06-30 2018-06-19 北大方正集团有限公司 溴甲纳曲酮的制备方法
KR102201609B1 (ko) * 2019-04-19 2021-01-12 연성정밀화학(주) 날데메딘의 제조방법
CN111777617A (zh) * 2020-07-10 2020-10-16 华润三九医药股份有限公司 一种溴甲纳曲酮的精制方法
WO2022076470A1 (en) 2020-10-06 2022-04-14 Sorrento Therapeutics, Inc. Oral delayed burst formulation of low-dose naltrexone or naloxone used for|treating fibromyalgia and long covid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4176186A (en) * 1978-07-28 1979-11-27 Boehringer Ingelheim Gmbh Quaternary derivatives of noroxymorphone which relieve intestinal immobility
JP2006509745A (ja) * 2002-11-08 2006-03-23 マリンクロッド・インコーポレイテッド 第四級ｎ−アルキルモルフィナンアルカロイド塩の製造方法
AR057325A1 (es) * 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos

Also Published As

Publication number Publication date
IL197402A (en) 2012-12-31
AU2007298855B2 (en) 2012-09-13
ES2531093T3 (es) 2015-03-10
IL197402A0 (en) 2009-12-24
NO20091561L (no) 2009-06-16
EA200970307A1 (ru) 2009-12-30
JP5214615B2 (ja) 2013-06-19
TW200821314A (en) 2008-05-16
FR2906252B1 (fr) 2008-11-28
EA015426B1 (ru) 2011-08-30
MX2009003084A (es) 2009-04-02
CO6170362A2 (es) 2010-06-18
EP2069362B1 (fr) 2014-07-09
CR10660A (es) 2009-06-24
AU2007298855A1 (en) 2008-03-27
AR062918A1 (es) 2008-12-17
KR20090057031A (ko) 2009-06-03
HN2009000503A (es) 2011-03-02
UY30599A1 (es) 2008-05-02
CA2663509C (fr) 2014-03-18
WO2008034973A1 (fr) 2008-03-27
NZ575417A (en) 2011-09-30
MA30793B1 (fr) 2009-10-01
UA96957C2 (ru) 2011-12-26
US8288547B2 (en) 2012-10-16
GT200900060A (es) 2011-01-04
JP2010504308A (ja) 2010-02-12
PE20080867A1 (es) 2008-08-22
CN101516892A (zh) 2009-08-26
TWI465451B (zh) 2014-12-21
TN2009000080A1 (en) 2010-08-19
HK1135389A1 (en) 2010-06-04
CN101516892B (zh) 2012-06-20
US20080214817A1 (en) 2008-09-04
FR2906252A1 (fr) 2008-03-28
US20100145051A1 (en) 2010-06-10
ME00613B (me) 2011-12-20
ZA200901846B (en) 2010-07-28
CL2007002711A1 (es) 2008-04-18
JO3023B1 (ar) 2016-09-05
US7645880B2 (en) 2010-01-12
KR101434693B1 (ko) 2014-08-27
CN102225939A (zh) 2011-10-26
EP2069362A1 (fr) 2009-06-17
MY148094A (en) 2013-02-28
CA2663509A1 (fr) 2008-03-27
SV2009003192A (es) 2009-10-27
BRPI0718440A2 (pt) 2013-11-19
MEP10509A (en) 2011-12-20
NI200900035A (es) 2010-01-26

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