UY30599A1 - Procedimiento de preparacion de halogenuros de n-alquil-naltrexona - Google Patents

Procedimiento de preparacion de halogenuros de n-alquil-naltrexona

Info

Publication number
UY30599A1
UY30599A1 UY30599A UY30599A UY30599A1 UY 30599 A1 UY30599 A1 UY 30599A1 UY 30599 A UY30599 A UY 30599A UY 30599 A UY30599 A UY 30599A UY 30599 A1 UY30599 A1 UY 30599A1
Authority
UY
Uruguay
Prior art keywords
carbonate
methyl
naltrexona
halogenure
alquil
Prior art date
Application number
UY30599A
Other languages
English (en)
Inventor
Alain Dlubala
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of UY30599A1 publication Critical patent/UY30599A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

Abstract

La invencion se refiere a un nuevo procedimiento de preparacion del bromuro de N-metil-naltrexona, que comprende al menos las etapas que consisten en: (i) hacer reaccionar el metilsulfato de N-metil-naltrexona en solucion acuosa con un agente alcalino elegido del grupo constituido por carbonato de sodio, carbonato de potasio, carbonato de calcio, carbonato de magnesio, carbonato de cesio, carbonato de estroncio y las mezclas de estos, para un pH del medio de reaccion acuoso comprendido entre 7 y 10, y después (ii) hacer reaccionar el producto así obtenido con el ácido bromhídrico que se anade, para un pH del medio de reaccion acuoso comprendido entre 0,5 y 5 y obtener así el bromuro de N-metil-naltrexona.
UY30599A 2006-09-21 2007-09-20 Procedimiento de preparacion de halogenuros de n-alquil-naltrexona UY30599A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0608286A FR2906252B1 (fr) 2006-09-21 2006-09-21 Procede de preparation d'halogenures de n-aklyl naltrexone

Publications (1)

Publication Number Publication Date
UY30599A1 true UY30599A1 (es) 2008-05-02

Family

ID=38016779

Family Applications (1)

Application Number Title Priority Date Filing Date
UY30599A UY30599A1 (es) 2006-09-21 2007-09-20 Procedimiento de preparacion de halogenuros de n-alquil-naltrexona

Country Status (36)

Country Link
US (2) US7645880B2 (es)
EP (1) EP2069362B1 (es)
JP (1) JP5214615B2 (es)
KR (1) KR101434693B1 (es)
CN (2) CN101516892B (es)
AR (1) AR062918A1 (es)
AU (1) AU2007298855B2 (es)
BR (1) BRPI0718440A2 (es)
CA (1) CA2663509C (es)
CL (1) CL2007002711A1 (es)
CO (1) CO6170362A2 (es)
CR (1) CR10660A (es)
DO (1) DOP2011000307A (es)
EA (1) EA015426B1 (es)
ES (1) ES2531093T3 (es)
FR (1) FR2906252B1 (es)
GT (1) GT200900060A (es)
HK (1) HK1135389A1 (es)
HN (1) HN2009000503A (es)
IL (1) IL197402A (es)
JO (1) JO3023B1 (es)
MA (1) MA30793B1 (es)
ME (1) MEP10509A (es)
MX (1) MX2009003084A (es)
MY (1) MY148094A (es)
NI (1) NI200900035A (es)
NO (1) NO20091561L (es)
NZ (1) NZ575417A (es)
PE (1) PE20080867A1 (es)
SV (1) SV2009003192A (es)
TN (1) TN2009000080A1 (es)
TW (1) TWI465451B (es)
UA (1) UA96957C2 (es)
UY (1) UY30599A1 (es)
WO (1) WO2008034973A1 (es)
ZA (1) ZA200901846B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010522756A (ja) 2007-03-29 2010-07-08 プロジェニックス ファーマシューティカルズ，インコーポレーテッド 結晶形およびその使用
WO2008138383A1 (de) * 2007-05-16 2008-11-20 Cilag Ag Verfahren zur herstellung von n-methylnaltrexonbromid
WO2009009292A2 (en) * 2007-07-11 2009-01-15 Mallinckrodt Inc. Crystalline forms of naltrexone methobromide
EP2019105A1 (en) * 2007-07-19 2009-01-28 Siegfried Ltd. Process for the preparation of quaternary n-alkyl morphine or morphinane alkaloid derivatives
PL2344506T3 (pl) * 2008-09-30 2016-08-31 SpecGx LLC Sposoby alkilowania grup aminy drugorzędowej pochodnych morfinanowych
EP2398807A1 (en) * 2009-02-23 2011-12-28 Mallinckrodt LLC (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
JP5784507B2 (ja) * 2009-02-23 2015-09-24 マリンクロッド エルエルシー （＋）−モルフィナニウム第四級塩およびその生成方法
WO2010096790A1 (en) * 2009-02-23 2010-08-26 Mallinckrodt Inc. (+)-morphinananium n-oxides and processes for their production
US8853401B2 (en) 2009-04-24 2014-10-07 Brock University Processes for the preparation of morphinane and morphinone compounds
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
CN101845047B (zh) * 2009-12-31 2011-12-07 南京臣功制药有限公司 一种溴甲基纳曲酮的制备方法
JO3209B1 (ar) * 2010-11-05 2018-03-08 H Lundbeck As طريقة لتصنيع نالتريكسون
RS55777B1 (sr) 2010-11-05 2017-07-31 H Lundbeck As Postupak za proizvodnju naltreksona
US8580963B2 (en) 2010-11-05 2013-11-12 H. Lundbeck A/S Method for the manufacturing of naltrexone
WO2012138888A1 (en) 2011-04-05 2012-10-11 Alkermes, Inc. Process for the synthesis of quaternary amine compounds
RU2014112493A (ru) 2011-09-08 2015-10-20 МАЛЛИНКРОДТ Эл-Эл-Си Получения алкалоидов без выделения промежуточных продуктов
CN103172640A (zh) * 2011-12-22 2013-06-26 天津康鸿医药科技发展有限公司 一种(r)-n-溴甲基纳曲酮的制备方法以及纳曲酮衍生物
US20140155608A1 (en) 2012-05-03 2014-06-05 H. Lundbeck A/S Method for the manufacturing of naltrexone
CN105985348B (zh) * 2015-02-12 2019-02-01 正大天晴药业集团股份有限公司 一种溴甲基纳曲酮的制备方法
CN106317064B (zh) * 2015-06-30 2018-06-19 北大方正集团有限公司 溴甲纳曲酮的制备方法
KR102201609B1 (ko) * 2019-04-19 2021-01-12 연성정밀화학(주) 날데메딘의 제조방법
CN111777617A (zh) * 2020-07-10 2020-10-16 华润三九医药股份有限公司 一种溴甲纳曲酮的精制方法
EP4225312A1 (en) 2020-10-06 2023-08-16 Scilex Holding Company Oral delayed burst formulation of low-dose naltrexone or naloxone used for treating fibromyalgia and long covid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4176186A (en) * 1978-07-28 1979-11-27 Boehringer Ingelheim Gmbh Quaternary derivatives of noroxymorphone which relieve intestinal immobility
CA2504262C (en) * 2002-11-08 2012-01-10 Mallinckrodt, Inc. Process for the preparation of quaternary n-alkyl morphinan alkaloid salts
AR057325A1 (es) * 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos

Also Published As

Publication number Publication date
AU2007298855A1 (en) 2008-03-27
CL2007002711A1 (es) 2008-04-18
MA30793B1 (fr) 2009-10-01
JP2010504308A (ja) 2010-02-12
EA200970307A1 (ru) 2009-12-30
GT200900060A (es) 2011-01-04
US8288547B2 (en) 2012-10-16
PE20080867A1 (es) 2008-08-22
IL197402A (en) 2012-12-31
EA015426B1 (ru) 2011-08-30
US7645880B2 (en) 2010-01-12
FR2906252A1 (fr) 2008-03-28
BRPI0718440A2 (pt) 2013-11-19
ZA200901846B (en) 2010-07-28
ME00613B (me) 2011-12-20
TN2009000080A1 (en) 2010-08-19
CA2663509A1 (fr) 2008-03-27
US20100145051A1 (en) 2010-06-10
UA96957C2 (ru) 2011-12-26
JP5214615B2 (ja) 2013-06-19
CN101516892B (zh) 2012-06-20
DOP2011000307A (es) 2011-10-31
NZ575417A (en) 2011-09-30
JO3023B1 (ar) 2016-09-05
TWI465451B (zh) 2014-12-21
HK1135389A1 (en) 2010-06-04
HN2009000503A (es) 2011-03-02
MX2009003084A (es) 2009-04-02
CN101516892A (zh) 2009-08-26
EP2069362B1 (fr) 2014-07-09
AU2007298855B2 (en) 2012-09-13
MY148094A (en) 2013-02-28
NO20091561L (no) 2009-06-16
US20080214817A1 (en) 2008-09-04
CO6170362A2 (es) 2010-06-18
KR20090057031A (ko) 2009-06-03
WO2008034973A1 (fr) 2008-03-27
NI200900035A (es) 2010-01-26
FR2906252B1 (fr) 2008-11-28
IL197402A0 (en) 2009-12-24
SV2009003192A (es) 2009-10-27
EP2069362A1 (fr) 2009-06-17
CN102225939A (zh) 2011-10-26
MEP10509A (en) 2011-12-20
CA2663509C (fr) 2014-03-18
TW200821314A (en) 2008-05-16
KR101434693B1 (ko) 2014-08-27
ES2531093T3 (es) 2015-03-10
CR10660A (es) 2009-06-24
AR062918A1 (es) 2008-12-17

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Effective date: 20170725