JO3209B1 - طريقة لتصنيع نالتريكسون - Google Patents

طريقة لتصنيع نالتريكسون

Info

Publication number
JO3209B1
JO3209B1 JOP/2011/0328A JOP20110328A JO3209B1 JO 3209 B1 JO3209 B1 JO 3209B1 JO P20110328 A JOP20110328 A JO P20110328A JO 3209 B1 JO3209 B1 JO 3209B1
Authority
JO
Jordan
Prior art keywords
naltrexone
manufacturing
morphinan
dihydroxy
epoxy
Prior art date
Application number
JOP/2011/0328A
Other languages
English (en)
Inventor
Anton Martin Huber Florian
De Faveri Carla
Stivanello Mariano
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Application granted granted Critical
Publication of JO3209B1 publication Critical patent/JO3209B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

يتعلق الاختراع الحالي بعملية محسـنة لإنتاج نالتريكسـون [17 - (سـيكلو بروبيل ميثيل) - 4، 5? - إيبوكسي - 3، 14 - داي هيدروكسي - مورفينان - 6 - أون] من نوروكسي مورفون [4، 5 - ? - إيبوكسي - 3، 14 - داي هيدروكسي - مورفينان - 6 - أون] عن طريق الألكلة باستخدام هاليد سيكلو بروبيل ميثيل.
JOP/2011/0328A 2010-11-05 2011-10-31 طريقة لتصنيع نالتريكسون JO3209B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201001007 2010-11-05
DKPA201100396 2011-05-25

Publications (1)

Publication Number Publication Date
JO3209B1 true JO3209B1 (ar) 2018-03-08

Family

ID=46552826

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2011/0328A JO3209B1 (ar) 2010-11-05 2011-10-31 طريقة لتصنيع نالتريكسون

Country Status (12)

Country Link
KR (1) KR101837795B1 (ar)
CN (1) CN103237804B (ar)
AR (1) AR087142A1 (ar)
BR (1) BR112013009407B8 (ar)
CL (1) CL2013001251A1 (ar)
CO (1) CO6700868A2 (ar)
IL (1) IL225790A (ar)
JO (1) JO3209B1 (ar)
PE (2) PE20140357A1 (ar)
SG (1) SG189369A1 (ar)
TW (1) TWI516491B (ar)
ZA (1) ZA201303224B (ar)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE178329T1 (de) * 1989-10-16 1999-04-15 Us Health Totale synthese von northebain-, normorphin-, noroxymorphon-enantiomeren und -derivaten via n- nor-zwischenverbindungen
UA87884C2 (uk) * 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Безводна кристалічна калієва сіль інгібітора віл-інтегрази
FR2906252B1 (fr) * 2006-09-21 2008-11-28 Sanofi Aventis Sa Procede de preparation d'halogenures de n-aklyl naltrexone
WO2008138383A1 (de) * 2007-05-16 2008-11-20 Cilag Ag Verfahren zur herstellung von n-methylnaltrexonbromid
CN102227433B (zh) * 2008-09-30 2015-01-07 马林克罗特有限公司 烷基化吗啡喃衍生物的仲胺基团的方法

Also Published As

Publication number Publication date
TW201219396A (en) 2012-05-16
CN103237804A (zh) 2013-08-07
PE20140357A1 (es) 2014-03-29
AR087142A1 (es) 2014-02-26
SG189369A1 (en) 2013-05-31
ZA201303224B (en) 2014-07-30
CO6700868A2 (es) 2013-06-28
BR112013009407B8 (pt) 2022-11-22
CL2013001251A1 (es) 2013-08-30
KR20130129928A (ko) 2013-11-29
BR112013009407A2 (pt) 2016-07-19
IL225790A0 (en) 2013-06-27
TWI516491B (zh) 2016-01-11
PE20171309A1 (es) 2017-09-05
BR112013009407B1 (pt) 2021-07-20
KR101837795B1 (ko) 2018-03-12
CN103237804B (zh) 2016-06-08
IL225790A (en) 2016-07-31

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