IL225790A0 - Method for the manufacturing of naltrexone - Google Patents

Method for the manufacturing of naltrexone

Info

Publication number
IL225790A0
IL225790A0 IL225790A IL22579013A IL225790A0 IL 225790 A0 IL225790 A0 IL 225790A0 IL 225790 A IL225790 A IL 225790A IL 22579013 A IL22579013 A IL 22579013A IL 225790 A0 IL225790 A0 IL 225790A0
Authority
IL
Israel
Prior art keywords
naltrexone
manufacturing
Prior art date
Application number
IL225790A
Other languages
Hebrew (he)
Other versions
IL225790A (en
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/DK2011/000128 external-priority patent/WO2012059103A1/en
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of IL225790A0 publication Critical patent/IL225790A0/en
Publication of IL225790A publication Critical patent/IL225790A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
IL225790A 2010-11-05 2013-04-17 Process for the manufacture of naltrexone by reacting noroxymorphone with cyclopropylmethyl halide in the presence of n-ethyl-2-pyrrolidone IL225790A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201001007 2010-11-05
DKPA201100396 2011-05-25
PCT/DK2011/000128 WO2012059103A1 (en) 2010-11-05 2011-11-04 Method for the manufacturing of naltrexone

Publications (2)

Publication Number Publication Date
IL225790A0 true IL225790A0 (en) 2013-06-27
IL225790A IL225790A (en) 2016-07-31

Family

ID=46552826

Family Applications (1)

Application Number Title Priority Date Filing Date
IL225790A IL225790A (en) 2010-11-05 2013-04-17 Process for the manufacture of naltrexone by reacting noroxymorphone with cyclopropylmethyl halide in the presence of n-ethyl-2-pyrrolidone

Country Status (12)

Country Link
KR (1) KR101837795B1 (en)
CN (1) CN103237804B (en)
AR (1) AR087142A1 (en)
BR (1) BR112013009407B8 (en)
CL (1) CL2013001251A1 (en)
CO (1) CO6700868A2 (en)
IL (1) IL225790A (en)
JO (1) JO3209B1 (en)
PE (2) PE20171309A1 (en)
SG (1) SG189369A1 (en)
TW (1) TWI516491B (en)
ZA (1) ZA201303224B (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69033035T2 (en) * 1989-10-16 1999-08-05 Us Health TOTAL SYNTHESIS OF NORTHEBAIN, NORMORPHIN, NOROXYMORPHONE ENANTIOMERS AND DERIVATIVES VIA N-NOR INTERMEDIATE COMPOUNDS
UA87884C2 (en) * 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Potassium salt of an hiv integrase inhibitor
FR2906252B1 (en) * 2006-09-21 2008-11-28 Sanofi Aventis Sa PROCESS FOR THE PREPARATION OF NALTREXONE N-AKLYL HALIDES
WO2008138383A1 (en) * 2007-05-16 2008-11-20 Cilag Ag Method for the production of n-methyl naltrexone bromide
CA2738246C (en) * 2008-09-30 2017-09-05 Mallinckrodt Inc. Processes for the alkylation of secondary amine groups of morphinan derivatives

Also Published As

Publication number Publication date
PE20140357A1 (en) 2014-03-29
AR087142A1 (en) 2014-02-26
CL2013001251A1 (en) 2013-08-30
ZA201303224B (en) 2014-07-30
TWI516491B (en) 2016-01-11
CN103237804B (en) 2016-06-08
BR112013009407B1 (en) 2021-07-20
IL225790A (en) 2016-07-31
KR101837795B1 (en) 2018-03-12
JO3209B1 (en) 2018-03-08
PE20171309A1 (en) 2017-09-05
SG189369A1 (en) 2013-05-31
TW201219396A (en) 2012-05-16
BR112013009407A2 (en) 2016-07-19
CO6700868A2 (en) 2013-06-28
KR20130129928A (en) 2013-11-29
BR112013009407B8 (en) 2022-11-22
CN103237804A (en) 2013-08-07

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