IL225790A - Process for the manufacture of naltrexone by reacting noroxymorphone with cyclopropylmethyl halide in the presence of n-ethyl-2-pyrrolidone - Google Patents

Process for the manufacture of naltrexone by reacting noroxymorphone with cyclopropylmethyl halide in the presence of n-ethyl-2-pyrrolidone

Info

Publication number
IL225790A
IL225790A IL225790A IL22579013A IL225790A IL 225790 A IL225790 A IL 225790A IL 225790 A IL225790 A IL 225790A IL 22579013 A IL22579013 A IL 22579013A IL 225790 A IL225790 A IL 225790A
Authority
IL
Israel
Prior art keywords
naltrexone
pyrrolidone
ethyl
manufacture
cyclopropylmethyl halide
Prior art date
Application number
IL225790A
Other languages
Hebrew (he)
Other versions
IL225790A0 (en
Original Assignee
H Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/DK2011/000128 external-priority patent/WO2012059103A1/en
Application filed by H Lundbeck A/S filed Critical H Lundbeck A/S
Publication of IL225790A0 publication Critical patent/IL225790A0/en
Publication of IL225790A publication Critical patent/IL225790A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D489/00Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08Oxygen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL225790A 2010-11-05 2013-04-17 Process for the manufacture of naltrexone by reacting noroxymorphone with cyclopropylmethyl halide in the presence of n-ethyl-2-pyrrolidone IL225790A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201001007 2010-11-05
DKPA201100396 2011-05-25
PCT/DK2011/000128 WO2012059103A1 (en) 2010-11-05 2011-11-04 Method for the manufacturing of naltrexone

Publications (2)

Publication Number Publication Date
IL225790A0 IL225790A0 (en) 2013-06-27
IL225790A true IL225790A (en) 2016-07-31

Family

ID=46552826

Family Applications (1)

Application Number Title Priority Date Filing Date
IL225790A IL225790A (en) 2010-11-05 2013-04-17 Process for the manufacture of naltrexone by reacting noroxymorphone with cyclopropylmethyl halide in the presence of n-ethyl-2-pyrrolidone

Country Status (12)

Country Link
KR (1) KR101837795B1 (en)
CN (1) CN103237804B (en)
AR (1) AR087142A1 (en)
BR (1) BR112013009407B8 (en)
CL (1) CL2013001251A1 (en)
CO (1) CO6700868A2 (en)
IL (1) IL225790A (en)
JO (1) JO3209B1 (en)
PE (2) PE20171309A1 (en)
SG (1) SG189369A1 (en)
TW (1) TWI516491B (en)
ZA (1) ZA201303224B (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2129395T3 (en) * 1989-10-16 1999-06-16 Us Health TOTAL SYNTHESIS OF NORTEBAINE, NORMORPHINE, NOROXYMORPHONE ENANTIOMERS AND THEIR DERIVATIVES THROUGH N-NOR INTERMEDIATE PRODUCTS.
UA87884C2 (en) * 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Potassium salt of an hiv integrase inhibitor
FR2906252B1 (en) * 2006-09-21 2008-11-28 Sanofi Aventis Sa PROCESS FOR THE PREPARATION OF NALTREXONE N-AKLYL HALIDES
WO2008138383A1 (en) * 2007-05-16 2008-11-20 Cilag Ag Method for the production of n-methyl naltrexone bromide
US8080661B2 (en) * 2008-09-30 2011-12-20 Mallinckrodt Llc Processes for the synthesis of tertiary amines

Also Published As

Publication number Publication date
TW201219396A (en) 2012-05-16
PE20171309A1 (en) 2017-09-05
KR20130129928A (en) 2013-11-29
BR112013009407A2 (en) 2016-07-19
BR112013009407B1 (en) 2021-07-20
AR087142A1 (en) 2014-02-26
JO3209B1 (en) 2018-03-08
CL2013001251A1 (en) 2013-08-30
KR101837795B1 (en) 2018-03-12
ZA201303224B (en) 2014-07-30
TWI516491B (en) 2016-01-11
BR112013009407B8 (en) 2022-11-22
CN103237804A (en) 2013-08-07
IL225790A0 (en) 2013-06-27
PE20140357A1 (en) 2014-03-29
SG189369A1 (en) 2013-05-31
CO6700868A2 (en) 2013-06-28
CN103237804B (en) 2016-06-08

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Legal Events

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