IL225790A - Process for the manufacture of naltrexone by reacting noroxymorphone with cyclopropylmethyl halide in the presence of n-ethyl-2-pyrrolidone - Google Patents

Process for the manufacture of naltrexone by reacting noroxymorphone with cyclopropylmethyl halide in the presence of n-ethyl-2-pyrrolidone

Info

Publication number
IL225790A
IL225790A IL225790A IL22579013A IL225790A IL 225790 A IL225790 A IL 225790A IL 225790 A IL225790 A IL 225790A IL 22579013 A IL22579013 A IL 22579013A IL 225790 A IL225790 A IL 225790A
Authority
IL
Israel
Prior art keywords
naltrexone
pyrrolidone
ethyl
manufacture
cyclopropylmethyl halide
Prior art date
Application number
IL225790A
Other languages
Hebrew (he)
Other versions
IL225790A0 (en
Original Assignee
H Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/DK2011/000128 external-priority patent/WO2012059103A1/en
Application filed by H Lundbeck A/S filed Critical H Lundbeck A/S
Publication of IL225790A0 publication Critical patent/IL225790A0/en
Publication of IL225790A publication Critical patent/IL225790A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D489/00Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08Oxygen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL225790A 2010-11-05 2013-04-17 Process for the manufacture of naltrexone by reacting noroxymorphone with cyclopropylmethyl halide in the presence of n-ethyl-2-pyrrolidone IL225790A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201001007 2010-11-05
DKPA201100396 2011-05-25
PCT/DK2011/000128 WO2012059103A1 (en) 2010-11-05 2011-11-04 Method for the manufacturing of naltrexone

Publications (2)

Publication Number Publication Date
IL225790A0 IL225790A0 (en) 2013-06-27
IL225790A true IL225790A (en) 2016-07-31

Family

ID=46552826

Family Applications (1)

Application Number Title Priority Date Filing Date
IL225790A IL225790A (en) 2010-11-05 2013-04-17 Process for the manufacture of naltrexone by reacting noroxymorphone with cyclopropylmethyl halide in the presence of n-ethyl-2-pyrrolidone

Country Status (12)

Country Link
KR (1) KR101837795B1 (en)
CN (1) CN103237804B (en)
AR (1) AR087142A1 (en)
BR (1) BR112013009407B8 (en)
CL (1) CL2013001251A1 (en)
CO (1) CO6700868A2 (en)
IL (1) IL225790A (en)
JO (1) JO3209B1 (en)
PE (2) PE20171309A1 (en)
SG (1) SG189369A1 (en)
TW (1) TWI516491B (en)
ZA (1) ZA201303224B (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69033035T2 (en) * 1989-10-16 1999-08-05 Us Health TOTAL SYNTHESIS OF NORTHEBAIN, NORMORPHIN, NOROXYMORPHONE ENANTIOMERS AND DERIVATIVES VIA N-NOR INTERMEDIATE COMPOUNDS
UA87884C2 (en) * 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Potassium salt of an hiv integrase inhibitor
FR2906252B1 (en) * 2006-09-21 2008-11-28 Sanofi Aventis Sa PROCESS FOR THE PREPARATION OF NALTREXONE N-AKLYL HALIDES
WO2008138383A1 (en) * 2007-05-16 2008-11-20 Cilag Ag Method for the production of n-methyl naltrexone bromide
CA2738246C (en) * 2008-09-30 2017-09-05 Mallinckrodt Inc. Processes for the alkylation of secondary amine groups of morphinan derivatives

Also Published As

Publication number Publication date
PE20140357A1 (en) 2014-03-29
AR087142A1 (en) 2014-02-26
CL2013001251A1 (en) 2013-08-30
ZA201303224B (en) 2014-07-30
TWI516491B (en) 2016-01-11
IL225790A0 (en) 2013-06-27
CN103237804B (en) 2016-06-08
BR112013009407B1 (en) 2021-07-20
KR101837795B1 (en) 2018-03-12
JO3209B1 (en) 2018-03-08
PE20171309A1 (en) 2017-09-05
SG189369A1 (en) 2013-05-31
TW201219396A (en) 2012-05-16
BR112013009407A2 (en) 2016-07-19
CO6700868A2 (en) 2013-06-28
KR20130129928A (en) 2013-11-29
BR112013009407B8 (en) 2022-11-22
CN103237804A (en) 2013-08-07

Similar Documents

Publication Publication Date Title
EP2653458A4 (en) Process for producing acetic acid
ZA201108659B (en) Preparation of nalmefene hydrochloride from naltrexone
PT2853609T (en) Method of manufacture of a structural component of a vehicle
HK1210170A1 (en) Process for improved opioid synthesis
IL236711A0 (en) Process for improved opioid synthesis
IL215553A0 (en) Processes for the preparation of morphinane and morphinone compounds
EP2558441A4 (en) Process for producing isocyanates
GB2509659B (en) Process for the 3-O-demethylation of morphinan compounds
ZA201304489B (en) Process for producing ammonium nitrate
AP3415A (en) Method for manufacturing of naltrexone
EP2641889A4 (en) Methanol production process
HK1202874A1 (en) Process for recovery of nalmefene hydrochloride
EP2522648A4 (en) Process for producing difluorocyclopropane compound
GB201006589D0 (en) Manufacturing process for glazing with integral wiring
IL225790A (en) Process for the manufacture of naltrexone by reacting noroxymorphone with cyclopropylmethyl halide in the presence of n-ethyl-2-pyrrolidone
GB201021753D0 (en) Process for producing 2-alkyl-cyclopent-2-enone compounds
IL226097A0 (en) Process for producing 4-carbonyloxyquinoline derivatives
HU0900003D0 (en) Process for producing alginit with silver- gold- and coppercolloid
HUP0900077A2 (en) Process for producing alginit with silver- gold- and coppercolloid

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed