AR087142A1 - METHOD FOR THE ELABORATION OF NALTREXONE - Google Patents

METHOD FOR THE ELABORATION OF NALTREXONE

Info

Publication number
AR087142A1
AR087142A1 ARP110104090A ARP110104090A AR087142A1 AR 087142 A1 AR087142 A1 AR 087142A1 AR P110104090 A ARP110104090 A AR P110104090A AR P110104090 A ARP110104090 A AR P110104090A AR 087142 A1 AR087142 A1 AR 087142A1
Authority
AR
Argentina
Prior art keywords
naltrexone
elaboration
morphinan
dihydroxy
epoxy
Prior art date
Application number
ARP110104090A
Other languages
Spanish (es)
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of AR087142A1 publication Critical patent/AR087142A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)

Abstract

La presente hace referencia a un proceso mejorado para la producción de [17-(ciclopropilmetil)-4,5a-epoxi-3,14-dihidroxi-morfinan-6-ona] naltrexona a partir de [4,5-a-epoxi-3,14-dihidroxi-morfinan-6-ona] noroximorfona mediante alquilación con un ciclopropilmetil haluro.This refers to an improved process for the production of [17- (cyclopropylmethyl) -4,5a-epoxy-3,14-dihydroxy-morphinan-6-one] naltrexone from [4,5-a-epoxy- 3,14-dihydroxy-morphinan-6-one] noroxymorphone by alkylation with a cyclopropylmethyl halide.

ARP110104090A 2010-11-05 2011-11-03 METHOD FOR THE ELABORATION OF NALTREXONE AR087142A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201001007 2010-11-05
DKPA201100396 2011-05-25

Publications (1)

Publication Number Publication Date
AR087142A1 true AR087142A1 (en) 2014-02-26

Family

ID=46552826

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110104090A AR087142A1 (en) 2010-11-05 2011-11-03 METHOD FOR THE ELABORATION OF NALTREXONE

Country Status (12)

Country Link
KR (1) KR101837795B1 (en)
CN (1) CN103237804B (en)
AR (1) AR087142A1 (en)
BR (1) BR112013009407B8 (en)
CL (1) CL2013001251A1 (en)
CO (1) CO6700868A2 (en)
IL (1) IL225790A (en)
JO (1) JO3209B1 (en)
PE (2) PE20140357A1 (en)
SG (1) SG189369A1 (en)
TW (1) TWI516491B (en)
ZA (1) ZA201303224B (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0496830B1 (en) * 1989-10-16 1999-03-31 THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE Total synthesis of northebaine, normorphine, noroxymorphone enantiomers and derivatives via n-nor intermediates
UA87884C2 (en) * 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Potassium salt of an hiv integrase inhibitor
FR2906252B1 (en) * 2006-09-21 2008-11-28 Sanofi Aventis Sa PROCESS FOR THE PREPARATION OF NALTREXONE N-AKLYL HALIDES
WO2008138383A1 (en) * 2007-05-16 2008-11-20 Cilag Ag Method for the production of n-methyl naltrexone bromide
WO2010039209A2 (en) * 2008-09-30 2010-04-08 Mallinckrodt Inc. Processes for the synthesis of tertiary amines

Also Published As

Publication number Publication date
BR112013009407A2 (en) 2016-07-19
JO3209B1 (en) 2018-03-08
KR101837795B1 (en) 2018-03-12
PE20140357A1 (en) 2014-03-29
CO6700868A2 (en) 2013-06-28
IL225790A (en) 2016-07-31
PE20171309A1 (en) 2017-09-05
BR112013009407B8 (en) 2022-11-22
CN103237804B (en) 2016-06-08
IL225790A0 (en) 2013-06-27
TW201219396A (en) 2012-05-16
CN103237804A (en) 2013-08-07
SG189369A1 (en) 2013-05-31
CL2013001251A1 (en) 2013-08-30
BR112013009407B1 (en) 2021-07-20
TWI516491B (en) 2016-01-11
ZA201303224B (en) 2014-07-30
KR20130129928A (en) 2013-11-29

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