BR112013009407A2 - method for the manufacture of naltrexone - Google Patents

method for the manufacture of naltrexone

Info

Publication number
BR112013009407A2
BR112013009407A2 BR112013009407A BR112013009407A BR112013009407A2 BR 112013009407 A2 BR112013009407 A2 BR 112013009407A2 BR 112013009407 A BR112013009407 A BR 112013009407A BR 112013009407 A BR112013009407 A BR 112013009407A BR 112013009407 A2 BR112013009407 A2 BR 112013009407A2
Authority
BR
Brazil
Prior art keywords
naltrexone
manufacture
dihydroxy
epoxy
cyclopropylmethyl
Prior art date
Application number
BR112013009407A
Other languages
Portuguese (pt)
Other versions
BR112013009407B1 (en
BR112013009407B8 (en
Inventor
Carla De Faveri
Florian Anton Martin Huber
Mariano Stivanello
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Priority claimed from PCT/DK2011/000128 external-priority patent/WO2012059103A1/en
Publication of BR112013009407A2 publication Critical patent/BR112013009407A2/en
Publication of BR112013009407B1 publication Critical patent/BR112013009407B1/en
Publication of BR112013009407B8 publication Critical patent/BR112013009407B8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

método para a fabricação de naltrexona. a presente invenção refere-se a um processo melhorado para produzir naltrexona [17-(ciclopropilmetil)-4,5<244>-epóxi-3,14-diidróxi-morinan-6-ona] a partir de noroximorfona [4,5-<244>-epóxi-3,14-diidróxi-morfinan-6-ona] pela alquilação com um haleto de ciclopropilmetila.method for the manufacture of naltrexone. The present invention relates to an improved process for producing naltrexone [17- (cyclopropylmethyl) -4,5β-epoxy-3,14-dihydroxy-morinan-6-one] from noroxymorphone [4,5- β-epoxy-3,14-dihydroxy-morfinan-6-one] by alkylation with a cyclopropylmethyl halide.

BR112013009407A 2010-11-05 2011-11-04 METHOD FOR MANUFACTURING NALTREXONE BR112013009407B8 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA201001007 2010-11-05
DKPA201001007 2010-11-05
DKPA201100396 2011-05-25
DKPA201100396 2011-05-25
PCT/DK2011/000128 WO2012059103A1 (en) 2010-11-05 2011-11-04 Method for the manufacturing of naltrexone

Publications (3)

Publication Number Publication Date
BR112013009407A2 true BR112013009407A2 (en) 2016-07-19
BR112013009407B1 BR112013009407B1 (en) 2021-07-20
BR112013009407B8 BR112013009407B8 (en) 2022-11-22

Family

ID=46552826

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013009407A BR112013009407B8 (en) 2010-11-05 2011-11-04 METHOD FOR MANUFACTURING NALTREXONE

Country Status (12)

Country Link
KR (1) KR101837795B1 (en)
CN (1) CN103237804B (en)
AR (1) AR087142A1 (en)
BR (1) BR112013009407B8 (en)
CL (1) CL2013001251A1 (en)
CO (1) CO6700868A2 (en)
IL (1) IL225790A (en)
JO (1) JO3209B1 (en)
PE (2) PE20171309A1 (en)
SG (1) SG189369A1 (en)
TW (1) TWI516491B (en)
ZA (1) ZA201303224B (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2129395T3 (en) * 1989-10-16 1999-06-16 Us Health TOTAL SYNTHESIS OF NORTEBAINE, NORMORPHINE, NOROXYMORPHONE ENANTIOMERS AND THEIR DERIVATIVES THROUGH N-NOR INTERMEDIATE PRODUCTS.
UA87884C2 (en) * 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Potassium salt of an hiv integrase inhibitor
FR2906252B1 (en) * 2006-09-21 2008-11-28 Sanofi Aventis Sa PROCESS FOR THE PREPARATION OF NALTREXONE N-AKLYL HALIDES
WO2008138383A1 (en) * 2007-05-16 2008-11-20 Cilag Ag Method for the production of n-methyl naltrexone bromide
US8080661B2 (en) * 2008-09-30 2011-12-20 Mallinckrodt Llc Processes for the synthesis of tertiary amines

Also Published As

Publication number Publication date
TW201219396A (en) 2012-05-16
PE20171309A1 (en) 2017-09-05
KR20130129928A (en) 2013-11-29
BR112013009407B1 (en) 2021-07-20
AR087142A1 (en) 2014-02-26
JO3209B1 (en) 2018-03-08
CL2013001251A1 (en) 2013-08-30
KR101837795B1 (en) 2018-03-12
ZA201303224B (en) 2014-07-30
TWI516491B (en) 2016-01-11
BR112013009407B8 (en) 2022-11-22
CN103237804A (en) 2013-08-07
IL225790A0 (en) 2013-06-27
PE20140357A1 (en) 2014-03-29
SG189369A1 (en) 2013-05-31
IL225790A (en) 2016-07-31
CO6700868A2 (en) 2013-06-28
CN103237804B (en) 2016-06-08

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Legal Events

Date Code Title Description
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 04/11/2011, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: REF. RPI 2637 DE 20/07/2021 QUANTO A QUALIFICACAO DO TITULAR.