PE20140357A1 - METHOD FOR THE PREPARATION OF NALTREXONE - Google Patents

METHOD FOR THE PREPARATION OF NALTREXONE

Info

Publication number
PE20140357A1
PE20140357A1 PE2013000948A PE2013000948A PE20140357A1 PE 20140357 A1 PE20140357 A1 PE 20140357A1 PE 2013000948 A PE2013000948 A PE 2013000948A PE 2013000948 A PE2013000948 A PE 2013000948A PE 20140357 A1 PE20140357 A1 PE 20140357A1
Authority
PE
Peru
Prior art keywords
pyrrolidone
ethyl
noroxymorphone
naltrexone
purifying agent
Prior art date
Application number
PE2013000948A
Other languages
Spanish (es)
Inventor
Faveri Carla De
Florian Anton Martin Huber
Mariano Stivanello
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of PE20140357A1 publication Critical patent/PE20140357A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)

Abstract

REFERIDA A UN PROCESO DE ELABORACION DE NALTREXONA QUE COMPRENDE HACER REACCIONAR NOROXIMORFONA CON CICLOPROPILMETIL HALURO TAL COMO CICLOPROPILMETIL BROMURO EN PRESENCIA DE N-ETIL-2-PIRROLIDONA Y UN DEPURADOR ACIDO TAL COMO UNA BASE ORGANICA O INORGANICA, DONDE LA RELACION PESO POR PESO DE N-ETIL-2-PIRROLIDONA Y NOROXIMORFONA ES DE 0,5:1 A 10:1 Y LA RELACION MOLAR ENTRE NOROXIMORFONA Y EL DEPURADOR ACIDO ES DE 1:0,5 A 1:2. LA TEMPERATURA DE REACCION SE ENCUENTRA EN UN RANGO DE 30�C A 100�CREFERRING TO A NALTREXONE MANUFACTURING PROCESS THAT INCLUDES REACTING NOROXYMORPHONE WITH CYCLOPROPYLMETHYL HALIDE SUCH AS CYCLOPROPYLMETHYL BROMIDE IN THE PRESENCE OF N-ETHYL-2-PYRROLIDONE AND A PURIFYING AGENT FOR N-ETHYL-2-PYRROLIDONE, OR A PURIFYING AGENT FOR ACID ORGALIZED NOROXIMORPHONE, OR ACIDAL DIMORPHONE PURIFYOR -ETHYL-2-PYRROLIDONE AND NOROXYMORPHONE IS FROM 0.5: 1 TO 10: 1 AND THE MOLAR RATIO BETWEEN NOROXYMORPHONE AND THE ACID CLEANER IS FROM 1: 0.5 TO 1: 2. THE REACTION TEMPERATURE IS IN A RANGE OF 30�C TO 100�C

PE2013000948A 2010-11-05 2011-11-04 METHOD FOR THE PREPARATION OF NALTREXONE PE20140357A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201001007 2010-11-05
DKPA201100396 2011-05-25

Publications (1)

Publication Number Publication Date
PE20140357A1 true PE20140357A1 (en) 2014-03-29

Family

ID=46552826

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2013000948A PE20140357A1 (en) 2010-11-05 2011-11-04 METHOD FOR THE PREPARATION OF NALTREXONE
PE2017001285A PE20171309A1 (en) 2010-11-05 2011-11-04 METHOD FOR THE PREPARATION OF NALTREXONE

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2017001285A PE20171309A1 (en) 2010-11-05 2011-11-04 METHOD FOR THE PREPARATION OF NALTREXONE

Country Status (12)

Country Link
KR (1) KR101837795B1 (en)
CN (1) CN103237804B (en)
AR (1) AR087142A1 (en)
BR (1) BR112013009407B8 (en)
CL (1) CL2013001251A1 (en)
CO (1) CO6700868A2 (en)
IL (1) IL225790A (en)
JO (1) JO3209B1 (en)
PE (2) PE20140357A1 (en)
SG (1) SG189369A1 (en)
TW (1) TWI516491B (en)
ZA (1) ZA201303224B (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991005768A1 (en) * 1989-10-16 1991-05-02 The United States Of America, Represented By The Secretary, United States Department Of Commerce Total synthesis of northebaine, normorphine, noroxymorphone enantiomers and derivatives via n-nor intermediates
UA87884C2 (en) * 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Potassium salt of an hiv integrase inhibitor
FR2906252B1 (en) * 2006-09-21 2008-11-28 Sanofi Aventis Sa PROCESS FOR THE PREPARATION OF NALTREXONE N-AKLYL HALIDES
WO2008138383A1 (en) * 2007-05-16 2008-11-20 Cilag Ag Method for the production of n-methyl naltrexone bromide
WO2010039209A2 (en) * 2008-09-30 2010-04-08 Mallinckrodt Inc. Processes for the synthesis of tertiary amines

Also Published As

Publication number Publication date
ZA201303224B (en) 2014-07-30
TW201219396A (en) 2012-05-16
KR20130129928A (en) 2013-11-29
CO6700868A2 (en) 2013-06-28
BR112013009407B1 (en) 2021-07-20
BR112013009407B8 (en) 2022-11-22
CN103237804A (en) 2013-08-07
IL225790A0 (en) 2013-06-27
IL225790A (en) 2016-07-31
JO3209B1 (en) 2018-03-08
AR087142A1 (en) 2014-02-26
TWI516491B (en) 2016-01-11
PE20171309A1 (en) 2017-09-05
CN103237804B (en) 2016-06-08
BR112013009407A2 (en) 2016-07-19
SG189369A1 (en) 2013-05-31
KR101837795B1 (en) 2018-03-12
CL2013001251A1 (en) 2013-08-30

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Legal Events

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FG Grant, registration
FD Application declared void or lapsed