CL2013001251A1 - Proceso para preparar naltrexona que comprende hacer reaccionar noroximorfona con ciclopropilmetil haluro en presencia de n-etil-2-pirrolidona; proceso para preparar nalmafeno que comprende fabricar naltrexona y procesarla de manera adicional a partir de para nalmafeno mediante la reaccion de wittig; naltrexona; y nalmafeno. - Google Patents

Proceso para preparar naltrexona que comprende hacer reaccionar noroximorfona con ciclopropilmetil haluro en presencia de n-etil-2-pirrolidona; proceso para preparar nalmafeno que comprende fabricar naltrexona y procesarla de manera adicional a partir de para nalmafeno mediante la reaccion de wittig; naltrexona; y nalmafeno.

Info

Publication number
CL2013001251A1
CL2013001251A1 CL2013001251A CL2013001251A CL2013001251A1 CL 2013001251 A1 CL2013001251 A1 CL 2013001251A1 CL 2013001251 A CL2013001251 A CL 2013001251A CL 2013001251 A CL2013001251 A CL 2013001251A CL 2013001251 A1 CL2013001251 A1 CL 2013001251A1
Authority
CL
Chile
Prior art keywords
naltrexone
nalmaphene
preparing
nalmafen
pyrrolidone
Prior art date
Application number
CL2013001251A
Other languages
English (en)
Inventor
Faveri Carla De
Florian Anton Martin Huber
Mariano Stivanello
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of CL2013001251A1 publication Critical patent/CL2013001251A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
CL2013001251A 2010-11-05 2013-05-06 Proceso para preparar naltrexona que comprende hacer reaccionar noroximorfona con ciclopropilmetil haluro en presencia de n-etil-2-pirrolidona; proceso para preparar nalmafeno que comprende fabricar naltrexona y procesarla de manera adicional a partir de para nalmafeno mediante la reaccion de wittig; naltrexona; y nalmafeno. CL2013001251A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201001007 2010-11-05
DKPA201100396 2011-05-25

Publications (1)

Publication Number Publication Date
CL2013001251A1 true CL2013001251A1 (es) 2013-08-30

Family

ID=46552826

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2013001251A CL2013001251A1 (es) 2010-11-05 2013-05-06 Proceso para preparar naltrexona que comprende hacer reaccionar noroximorfona con ciclopropilmetil haluro en presencia de n-etil-2-pirrolidona; proceso para preparar nalmafeno que comprende fabricar naltrexona y procesarla de manera adicional a partir de para nalmafeno mediante la reaccion de wittig; naltrexona; y nalmafeno.

Country Status (12)

Country Link
KR (1) KR101837795B1 (es)
CN (1) CN103237804B (es)
AR (1) AR087142A1 (es)
BR (1) BR112013009407B8 (es)
CL (1) CL2013001251A1 (es)
CO (1) CO6700868A2 (es)
IL (1) IL225790A (es)
JO (1) JO3209B1 (es)
PE (2) PE20140357A1 (es)
SG (1) SG189369A1 (es)
TW (1) TWI516491B (es)
ZA (1) ZA201303224B (es)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991005768A1 (en) * 1989-10-16 1991-05-02 The United States Of America, Represented By The Secretary, United States Department Of Commerce Total synthesis of northebaine, normorphine, noroxymorphone enantiomers and derivatives via n-nor intermediates
UA87884C2 (uk) * 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Безводна кристалічна калієва сіль інгібітора віл-інтегрази
FR2906252B1 (fr) * 2006-09-21 2008-11-28 Sanofi Aventis Sa Procede de preparation d'halogenures de n-aklyl naltrexone
WO2008138383A1 (de) * 2007-05-16 2008-11-20 Cilag Ag Verfahren zur herstellung von n-methylnaltrexonbromid
WO2010039209A2 (en) * 2008-09-30 2010-04-08 Mallinckrodt Inc. Processes for the synthesis of tertiary amines

Also Published As

Publication number Publication date
ZA201303224B (en) 2014-07-30
TW201219396A (en) 2012-05-16
KR20130129928A (ko) 2013-11-29
CO6700868A2 (es) 2013-06-28
BR112013009407B1 (pt) 2021-07-20
BR112013009407B8 (pt) 2022-11-22
CN103237804A (zh) 2013-08-07
IL225790A0 (en) 2013-06-27
IL225790A (en) 2016-07-31
JO3209B1 (ar) 2018-03-08
AR087142A1 (es) 2014-02-26
TWI516491B (zh) 2016-01-11
PE20171309A1 (es) 2017-09-05
CN103237804B (zh) 2016-06-08
BR112013009407A2 (pt) 2016-07-19
SG189369A1 (en) 2013-05-31
KR101837795B1 (ko) 2018-03-12
PE20140357A1 (es) 2014-03-29

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