IL225790A - Process for preparation of naltrexone by reaction of noroxymorphone with cyclopropyl-methyl-halide in the presence of n-ethyl-2-pyrolidone - Google Patents

Process for preparation of naltrexone by reaction of noroxymorphone with cyclopropyl-methyl-halide in the presence of n-ethyl-2-pyrolidone

Info

Publication number
IL225790A
IL225790A IL225790A IL22579013A IL225790A IL 225790 A IL225790 A IL 225790A IL 225790 A IL225790 A IL 225790A IL 22579013 A IL22579013 A IL 22579013A IL 225790 A IL225790 A IL 225790A
Authority
IL
Israel
Prior art keywords
naltrexone
pyrrolidone
ethyl
manufacture
cyclopropylmethyl halide
Prior art date
Application number
IL225790A
Other languages
English (en)
Hebrew (he)
Other versions
IL225790A0 (en
Original Assignee
H Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/DK2011/000128 external-priority patent/WO2012059103A1/en
Application filed by H Lundbeck A/S filed Critical H Lundbeck A/S
Publication of IL225790A0 publication Critical patent/IL225790A0/en
Publication of IL225790A publication Critical patent/IL225790A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
IL225790A 2010-11-05 2013-04-17 Process for preparation of naltrexone by reaction of noroxymorphone with cyclopropyl-methyl-halide in the presence of n-ethyl-2-pyrolidone IL225790A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201001007 2010-11-05
DKPA201100396 2011-05-25
PCT/DK2011/000128 WO2012059103A1 (en) 2010-11-05 2011-11-04 Method for the manufacturing of naltrexone

Publications (2)

Publication Number Publication Date
IL225790A0 IL225790A0 (en) 2013-06-27
IL225790A true IL225790A (en) 2016-07-31

Family

ID=46552826

Family Applications (1)

Application Number Title Priority Date Filing Date
IL225790A IL225790A (en) 2010-11-05 2013-04-17 Process for preparation of naltrexone by reaction of noroxymorphone with cyclopropyl-methyl-halide in the presence of n-ethyl-2-pyrolidone

Country Status (12)

Country Link
KR (1) KR101837795B1 (es)
CN (1) CN103237804B (es)
AR (1) AR087142A1 (es)
BR (1) BR112013009407B8 (es)
CL (1) CL2013001251A1 (es)
CO (1) CO6700868A2 (es)
IL (1) IL225790A (es)
JO (1) JO3209B1 (es)
PE (2) PE20140357A1 (es)
SG (1) SG189369A1 (es)
TW (1) TWI516491B (es)
ZA (1) ZA201303224B (es)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991005768A1 (en) * 1989-10-16 1991-05-02 The United States Of America, Represented By The Secretary, United States Department Of Commerce Total synthesis of northebaine, normorphine, noroxymorphone enantiomers and derivatives via n-nor intermediates
UA87884C2 (uk) * 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Безводна кристалічна калієва сіль інгібітора віл-інтегрази
FR2906252B1 (fr) * 2006-09-21 2008-11-28 Sanofi Aventis Sa Procede de preparation d'halogenures de n-aklyl naltrexone
WO2008138383A1 (de) * 2007-05-16 2008-11-20 Cilag Ag Verfahren zur herstellung von n-methylnaltrexonbromid
WO2010039209A2 (en) * 2008-09-30 2010-04-08 Mallinckrodt Inc. Processes for the synthesis of tertiary amines

Also Published As

Publication number Publication date
ZA201303224B (en) 2014-07-30
TW201219396A (en) 2012-05-16
KR20130129928A (ko) 2013-11-29
CO6700868A2 (es) 2013-06-28
BR112013009407B1 (pt) 2021-07-20
BR112013009407B8 (pt) 2022-11-22
CN103237804A (zh) 2013-08-07
IL225790A0 (en) 2013-06-27
JO3209B1 (ar) 2018-03-08
AR087142A1 (es) 2014-02-26
TWI516491B (zh) 2016-01-11
PE20171309A1 (es) 2017-09-05
CN103237804B (zh) 2016-06-08
BR112013009407A2 (pt) 2016-07-19
SG189369A1 (en) 2013-05-31
KR101837795B1 (ko) 2018-03-12
PE20140357A1 (es) 2014-03-29
CL2013001251A1 (es) 2013-08-30

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Legal Events

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