NI200900035A - Procedimiento de preparación de halogenuros de n-alquil-naltrexona. - Google Patents

Procedimiento de preparación de halogenuros de n-alquil-naltrexona.

Info

Publication number
NI200900035A
NI200900035A NI200900035A NI200900035A NI200900035A NI 200900035 A NI200900035 A NI 200900035A NI 200900035 A NI200900035 A NI 200900035A NI 200900035 A NI200900035 A NI 200900035A NI 200900035 A NI200900035 A NI 200900035A
Authority
NI
Nicaragua
Prior art keywords
naltrexone
carbonate
preparation
methyl
halogenides
Prior art date
Application number
NI200900035A
Other languages
English (en)
Inventor
Dlubala Alain
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of NI200900035A publication Critical patent/NI200900035A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La invención se refiere a un nuevo procedimiento de preparación del bromuro de N-metil-naltrexona, que comprende al menos las etapas que consisten en: (i) hacer reaccionar el metilsulfato de N-metil-naltrexona en solución acuosa con un agente alcalino elegido del grupo constituido por carbonato de sodio, carbonato de potasio, carbonato de calcio, carbonato de magnesio, carbonato de cesio, carbonato de estroncio y las mezclas de estos, para un pH del medio de reacción acuoso comprendido entre 7 y 10, y después (ii) hacer reaccionar el producto así obtenido con el ácido bromhídrico que se añade, para un pH del medio de reacción acuoso comprendiendo entre 0,5 y 5 y obtener así el bromuro de N-metil-naltrexona.
NI200900035A 2006-09-21 2009-03-19 Procedimiento de preparación de halogenuros de n-alquil-naltrexona. NI200900035A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0608286A FR2906252B1 (fr) 2006-09-21 2006-09-21 Procede de preparation d'halogenures de n-aklyl naltrexone

Publications (1)

Publication Number Publication Date
NI200900035A true NI200900035A (es) 2010-01-26

Family

ID=38016779

Family Applications (1)

Application Number Title Priority Date Filing Date
NI200900035A NI200900035A (es) 2006-09-21 2009-03-19 Procedimiento de preparación de halogenuros de n-alquil-naltrexona.

Country Status (36)

Country Link
US (2) US7645880B2 (es)
EP (1) EP2069362B1 (es)
JP (1) JP5214615B2 (es)
KR (1) KR101434693B1 (es)
CN (2) CN102225939A (es)
AR (1) AR062918A1 (es)
AU (1) AU2007298855B2 (es)
BR (1) BRPI0718440A2 (es)
CA (1) CA2663509C (es)
CL (1) CL2007002711A1 (es)
CO (1) CO6170362A2 (es)
CR (1) CR10660A (es)
DO (1) DOP2011000307A (es)
EA (1) EA015426B1 (es)
ES (1) ES2531093T3 (es)
FR (1) FR2906252B1 (es)
GT (1) GT200900060A (es)
HK (1) HK1135389A1 (es)
HN (1) HN2009000503A (es)
IL (1) IL197402A (es)
JO (1) JO3023B1 (es)
MA (1) MA30793B1 (es)
ME (1) ME00613B (es)
MX (1) MX2009003084A (es)
MY (1) MY148094A (es)
NI (1) NI200900035A (es)
NO (1) NO20091561L (es)
NZ (1) NZ575417A (es)
PE (1) PE20080867A1 (es)
SV (1) SV2009003192A (es)
TN (1) TN2009000080A1 (es)
TW (1) TWI465451B (es)
UA (1) UA96957C2 (es)
UY (1) UY30599A1 (es)
WO (1) WO2008034973A1 (es)
ZA (1) ZA200901846B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101801979A (zh) 2007-03-29 2010-08-11 普罗热尼奇制药公司 (r)-n-溴化甲基纳曲酮的晶体形式及其用途
WO2008138383A1 (de) * 2007-05-16 2008-11-20 Cilag Ag Verfahren zur herstellung von n-methylnaltrexonbromid
US8383649B2 (en) * 2007-07-11 2013-02-26 Mallinckrodt Llc Crystalline forms of naltrexone methobromide
EP2019105A1 (en) * 2007-07-19 2009-01-28 Siegfried Ltd. Process for the preparation of quaternary n-alkyl morphine or morphinane alkaloid derivatives
EP2344506B1 (en) * 2008-09-30 2016-02-10 Mallinckrodt LLC Processes for the alkylation of secondary amine groups of morphinan derivatives
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
CN102325776A (zh) * 2009-02-23 2012-01-18 马林克罗特公司 (+)-吗啡喃*季盐及其制备方法
EP2398807A1 (en) * 2009-02-23 2011-12-28 Mallinckrodt LLC (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
WO2010096790A1 (en) * 2009-02-23 2010-08-26 Mallinckrodt Inc. (+)-morphinananium n-oxides and processes for their production
WO2010121369A1 (en) 2009-04-24 2010-10-28 Brock University Processes for the preparation of morphinane and morphinone compounds
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
CN101845047B (zh) * 2009-12-31 2011-12-07 南京臣功制药有限公司 一种溴甲基纳曲酮的制备方法
US8580963B2 (en) 2010-11-05 2013-11-12 H. Lundbeck A/S Method for the manufacturing of naltrexone
DK2635586T3 (en) 2010-11-05 2017-03-27 H Lundbeck As PROCEDURE FOR THE PREPARATION OF NALTREXON
JO3209B1 (ar) * 2010-11-05 2018-03-08 H Lundbeck As طريقة لتصنيع نالتريكسون
WO2012138888A1 (en) 2011-04-05 2012-10-11 Alkermes, Inc. Process for the synthesis of quaternary amine compounds
EP2753622B1 (en) 2011-09-08 2016-01-20 Mallinckrodt LLC Production of alkaloids without the isolation of intermediates
CN103172640A (zh) * 2011-12-22 2013-06-26 天津康鸿医药科技发展有限公司 一种(r)-n-溴甲基纳曲酮的制备方法以及纳曲酮衍生物
US20140155608A1 (en) 2012-05-03 2014-06-05 H. Lundbeck A/S Method for the manufacturing of naltrexone
CN105985348B (zh) * 2015-02-12 2019-02-01 正大天晴药业集团股份有限公司 一种溴甲基纳曲酮的制备方法
CN106317064B (zh) * 2015-06-30 2018-06-19 北大方正集团有限公司 溴甲纳曲酮的制备方法
KR102201609B1 (ko) * 2019-04-19 2021-01-12 연성정밀화학(주) 날데메딘의 제조방법
CN111777617A (zh) * 2020-07-10 2020-10-16 华润三九医药股份有限公司 一种溴甲纳曲酮的精制方法
WO2022076470A1 (en) 2020-10-06 2022-04-14 Sorrento Therapeutics, Inc. Oral delayed burst formulation of low-dose naltrexone or naloxone used for|treating fibromyalgia and long covid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4176186A (en) * 1978-07-28 1979-11-27 Boehringer Ingelheim Gmbh Quaternary derivatives of noroxymorphone which relieve intestinal immobility
PT1562953E (pt) * 2002-11-08 2009-11-19 Mallinckrodt Inc Processo para a preparação de sais quaternários de n -alquilmorfinano
AR057325A1 (es) * 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos

Also Published As

Publication number Publication date
AU2007298855A1 (en) 2008-03-27
CA2663509C (fr) 2014-03-18
TW200821314A (en) 2008-05-16
JP5214615B2 (ja) 2013-06-19
DOP2011000307A (es) 2011-10-31
BRPI0718440A2 (pt) 2013-11-19
AU2007298855B2 (en) 2012-09-13
ES2531093T3 (es) 2015-03-10
UA96957C2 (ru) 2011-12-26
EA015426B1 (ru) 2011-08-30
EP2069362A1 (fr) 2009-06-17
MEP10509A (en) 2011-12-20
CN102225939A (zh) 2011-10-26
CA2663509A1 (fr) 2008-03-27
WO2008034973A1 (fr) 2008-03-27
US20080214817A1 (en) 2008-09-04
NO20091561L (no) 2009-06-16
UY30599A1 (es) 2008-05-02
HN2009000503A (es) 2011-03-02
US8288547B2 (en) 2012-10-16
JP2010504308A (ja) 2010-02-12
FR2906252B1 (fr) 2008-11-28
ME00613B (me) 2011-12-20
MY148094A (en) 2013-02-28
FR2906252A1 (fr) 2008-03-28
TWI465451B (zh) 2014-12-21
CL2007002711A1 (es) 2008-04-18
US7645880B2 (en) 2010-01-12
CN101516892B (zh) 2012-06-20
CN101516892A (zh) 2009-08-26
CR10660A (es) 2009-06-24
AR062918A1 (es) 2008-12-17
MA30793B1 (fr) 2009-10-01
NZ575417A (en) 2011-09-30
TN2009000080A1 (en) 2010-08-19
US20100145051A1 (en) 2010-06-10
ZA200901846B (en) 2010-07-28
MX2009003084A (es) 2009-04-02
KR20090057031A (ko) 2009-06-03
CO6170362A2 (es) 2010-06-18
GT200900060A (es) 2011-01-04
PE20080867A1 (es) 2008-08-22
IL197402A0 (en) 2009-12-24
HK1135389A1 (en) 2010-06-04
IL197402A (en) 2012-12-31
EA200970307A1 (ru) 2009-12-30
JO3023B1 (ar) 2016-09-05
EP2069362B1 (fr) 2014-07-09
SV2009003192A (es) 2009-10-27
KR101434693B1 (ko) 2014-08-27

Similar Documents

Publication Publication Date Title
NI200900035A (es) Procedimiento de preparación de halogenuros de n-alquil-naltrexona.
ES2555989T3 (es) Procedimiento para la síntesis del ácido 2,5-furanodicarboxílico
BR112012027444A2 (pt) bloco cáustico altamente concentrado para lavagem de louças
MY156416A (en) Alkali-type nonionic surfactant composition
WO2010035199A3 (en) Granular cleaning and disinfecting composition
ES2720874T3 (es) Limpiador de tuberías alcalino clorado con ácido metanosulfónico
JP2013538269A5 (es)
CO6341493A2 (es) Destintado de un sustrato celulosico utilizando hidroxido de magnesio
FR2836681B1 (fr) Compose phosphocalcique modifie, composition injectable le contenant
BRPI0516335A (pt) composição de limpeza lìquida/gel e processo para a preparação de uma composição de limpeza lìquida/gel
DOP2009000041A (es) Procedimiento de preparacion de halogenuros de n-alquil-naltrexona
CR9424A (es) Ibuprofeno solubilizado
ITMO20040200A1 (it) Processo per la produzione di complessi ferro succinilcaseina e ferro casein acetil aspartilato e loro utilizzato nelle relative composizioni farmaceutiche.
AR071540A1 (es) Proceso para la produccion de un compuesto de toluidina
GB2400108A (en) Effervescent tablets
TH135001B (th) กรรมวิธีสำหรับการเตรียม n-แอลคิลแนลเทรกโซนเฮไลด์
CO6341494A2 (es) Destintado de un sustrato celulosico utilizando silicato de magnesio
EA200500747A1 (ru) Средство для дезинфекции
AR057310A1 (es) Proceso de elaboracion de un epoxido a partir de un hidrocarburo alifatico polihidroxilado y de un agente de cloracion
TH135001A (th) กรรมวิธีสำหรับการเตรียม n-แอลคิลแนลเทรกโซนเฮไลด์
RU2011151667A (ru) Способ стабилизации щелочного раствора пероксида водорода
UY30891A1 (es) Nueva composicion y proceso para el tratamiento de material de fibra
BRMU8403319U (pt) fabricação de hipoclorito de cálcio a partir de óxido de cálcio sem purificação
TH90691B (th) สารผสมสารซักฟอกเหลว
TH128437A (th) กระบวนการสำหรับการเตรียมเกลือโมโนเวเลนต์ซักซิเนต