PE20080867A1 - Procedimiento de preparacion de halogenuros de n-alquil-naltrexona - Google Patents

Procedimiento de preparacion de halogenuros de n-alquil-naltrexona

Info

Publication number
PE20080867A1
PE20080867A1 PE2007001269A PE2007001269A PE20080867A1 PE 20080867 A1 PE20080867 A1 PE 20080867A1 PE 2007001269 A PE2007001269 A PE 2007001269A PE 2007001269 A PE2007001269 A PE 2007001269A PE 20080867 A1 PE20080867 A1 PE 20080867A1
Authority
PE
Peru
Prior art keywords
naltrexone
procedure
preparation
halogenide
alkyl
Prior art date
Application number
PE2007001269A
Other languages
English (en)
Inventor
Alain Dlubala
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PE20080867A1 publication Critical patent/PE20080867A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

REFERIDA A UN COMPUESTO DE ION DOBLE DE N-METIL-NALTREXONA, DE FORMULA I, DONDE DICHO ION SE ENCUENTRA BAJO LA CONFIGURACION (R) O (S) CON RESPECTO AL ATOMO DE NITROGENO Y EN EL ESTADO DE HIDRATO TAL COMO HEMIHIDRATO, DIHIDRATO Y TRIHIDRATO. TAMBIEN ESTA REFERIDA A UN PROCEDIMIENTO DE PREPARACION, EN EL QUE REACCIONA METILSULFATO DE N-METIL-NALTREXONA EN SOLUCION ACUOSA CON UN AGENTE ALCALINO TAL COMO CARBONATO DE POTASIO, CALCIO, MAGNESIO, ENTRE OTROS, EN UN MEDIO DE pH ENTRE 7 Y 10, Y LUEGO SE HACE REACCIONAR EL PRODUCTO OBTENIDO CON ACIDO BROMHIDRICO EN MEDIO ACUOSO DE pH ENTRE 0.5 Y 5. DICHO COMPUESTO ES UTIL EN LA REDUCCION DE LOS EFECTOS SECUNDARIOS EN EL TRATAMIENTO MORFINICO
PE2007001269A 2006-09-21 2007-09-20 Procedimiento de preparacion de halogenuros de n-alquil-naltrexona PE20080867A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0608286A FR2906252B1 (fr) 2006-09-21 2006-09-21 Procede de preparation d'halogenures de n-aklyl naltrexone

Publications (1)

Publication Number Publication Date
PE20080867A1 true PE20080867A1 (es) 2008-08-22

Family

ID=38016779

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001269A PE20080867A1 (es) 2006-09-21 2007-09-20 Procedimiento de preparacion de halogenuros de n-alquil-naltrexona

Country Status (36)

Country Link
US (2) US7645880B2 (es)
EP (1) EP2069362B1 (es)
JP (1) JP5214615B2 (es)
KR (1) KR101434693B1 (es)
CN (2) CN101516892B (es)
AR (1) AR062918A1 (es)
AU (1) AU2007298855B2 (es)
BR (1) BRPI0718440A2 (es)
CA (1) CA2663509C (es)
CL (1) CL2007002711A1 (es)
CO (1) CO6170362A2 (es)
CR (1) CR10660A (es)
DO (1) DOP2011000307A (es)
EA (1) EA015426B1 (es)
ES (1) ES2531093T3 (es)
FR (1) FR2906252B1 (es)
GT (1) GT200900060A (es)
HK (1) HK1135389A1 (es)
HN (1) HN2009000503A (es)
IL (1) IL197402A (es)
JO (1) JO3023B1 (es)
MA (1) MA30793B1 (es)
ME (1) MEP10509A (es)
MX (1) MX2009003084A (es)
MY (1) MY148094A (es)
NI (1) NI200900035A (es)
NO (1) NO20091561L (es)
NZ (1) NZ575417A (es)
PE (1) PE20080867A1 (es)
SV (1) SV2009003192A (es)
TN (1) TN2009000080A1 (es)
TW (1) TWI465451B (es)
UA (1) UA96957C2 (es)
UY (1) UY30599A1 (es)
WO (1) WO2008034973A1 (es)
ZA (1) ZA200901846B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2765811T5 (es) 2007-03-29 2024-02-27 Progenics Pharm Inc Forma cristalina de bromuro de (R)-n-metilnaltrexona y sus usos
WO2008138383A1 (de) 2007-05-16 2008-11-20 Cilag Ag Verfahren zur herstellung von n-methylnaltrexonbromid
US8383649B2 (en) * 2007-07-11 2013-02-26 Mallinckrodt Llc Crystalline forms of naltrexone methobromide
EP2019105A1 (en) * 2007-07-19 2009-01-28 Siegfried Ltd. Process for the preparation of quaternary n-alkyl morphine or morphinane alkaloid derivatives
NZ592006A (en) * 2008-09-30 2013-03-28 Mallinckrodt Llc Processes for the alkylation of secondary amine groups of morphinan derivatives
CN102325777B (zh) * 2009-02-23 2015-08-12 马林克罗特公司 (+)-吗啡喃*n-氧化物及其制备方法
CN102325775A (zh) * 2009-02-23 2012-01-18 马林克罗特公司 (+)-6-羟基-吗啡喃或(+)-6-氨基-吗啡喃衍生物
CN102325776A (zh) * 2009-02-23 2012-01-18 马林克罗特公司 (+)-吗啡喃*季盐及其制备方法
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
JP5824448B2 (ja) 2009-04-24 2015-11-25 ブロック ユニバーシティ モルフィナンおよびモルフィノン化合物の調製法
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
CN101845047B (zh) * 2009-12-31 2011-12-07 南京臣功制药有限公司 一种溴甲基纳曲酮的制备方法
US8580963B2 (en) 2010-11-05 2013-11-12 H. Lundbeck A/S Method for the manufacturing of naltrexone
MX2013005009A (es) 2010-11-05 2013-08-01 Lundbeck & Co As H Metodo para la elaboracion de naltrexona.
JO3209B1 (ar) * 2010-11-05 2018-03-08 H Lundbeck As طريقة لتصنيع نالتريكسون
US9029543B2 (en) 2011-04-05 2015-05-12 Alkermes, Inc. Process for the synthesis of quaternary amine compounds
KR20140063763A (ko) 2011-09-08 2014-05-27 말린크로트 엘엘씨 중간체를 단리하지 않는 알칼로이드의 제조 방법
CN103172640A (zh) * 2011-12-22 2013-06-26 天津康鸿医药科技发展有限公司 一种(r)-n-溴甲基纳曲酮的制备方法以及纳曲酮衍生物
WO2013164383A1 (en) 2012-05-03 2013-11-07 H. Lundbeck A/S Method for the manufacturing of naltrexone
CN105985348B (zh) * 2015-02-12 2019-02-01 正大天晴药业集团股份有限公司 一种溴甲基纳曲酮的制备方法
CN106317064B (zh) * 2015-06-30 2018-06-19 北大方正集团有限公司 溴甲纳曲酮的制备方法
KR102201609B1 (ko) * 2019-04-19 2021-01-12 연성정밀화학(주) 날데메딘의 제조방법
CN111777617A (zh) * 2020-07-10 2020-10-16 华润三九医药股份有限公司 一种溴甲纳曲酮的精制方法
EP4225312A1 (en) 2020-10-06 2023-08-16 Scilex Holding Company Oral delayed burst formulation of low-dose naltrexone or naloxone used for treating fibromyalgia and long covid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4176186A (en) * 1978-07-28 1979-11-27 Boehringer Ingelheim Gmbh Quaternary derivatives of noroxymorphone which relieve intestinal immobility
PT1562953E (pt) * 2002-11-08 2009-11-19 Mallinckrodt Inc Processo para a preparação de sais quaternários de n -alquilmorfinano
AR057325A1 (es) * 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos

Also Published As

Publication number Publication date
BRPI0718440A2 (pt) 2013-11-19
JP5214615B2 (ja) 2013-06-19
CN101516892A (zh) 2009-08-26
SV2009003192A (es) 2009-10-27
TW200821314A (en) 2008-05-16
FR2906252B1 (fr) 2008-11-28
NZ575417A (en) 2011-09-30
EP2069362B1 (fr) 2014-07-09
TWI465451B (zh) 2014-12-21
TN2009000080A1 (en) 2010-08-19
EA015426B1 (ru) 2011-08-30
DOP2011000307A (es) 2011-10-31
MA30793B1 (fr) 2009-10-01
UA96957C2 (ru) 2011-12-26
US8288547B2 (en) 2012-10-16
NI200900035A (es) 2010-01-26
GT200900060A (es) 2011-01-04
JO3023B1 (ar) 2016-09-05
MX2009003084A (es) 2009-04-02
EA200970307A1 (ru) 2009-12-30
NO20091561L (no) 2009-06-16
AU2007298855A1 (en) 2008-03-27
HK1135389A1 (en) 2010-06-04
UY30599A1 (es) 2008-05-02
FR2906252A1 (fr) 2008-03-28
US20100145051A1 (en) 2010-06-10
JP2010504308A (ja) 2010-02-12
KR20090057031A (ko) 2009-06-03
CL2007002711A1 (es) 2008-04-18
US7645880B2 (en) 2010-01-12
CN101516892B (zh) 2012-06-20
CR10660A (es) 2009-06-24
CA2663509C (fr) 2014-03-18
ZA200901846B (en) 2010-07-28
HN2009000503A (es) 2011-03-02
CO6170362A2 (es) 2010-06-18
EP2069362A1 (fr) 2009-06-17
MY148094A (en) 2013-02-28
WO2008034973A1 (fr) 2008-03-27
US20080214817A1 (en) 2008-09-04
CA2663509A1 (fr) 2008-03-27
IL197402A0 (en) 2009-12-24
ME00613B (me) 2011-12-20
KR101434693B1 (ko) 2014-08-27
IL197402A (en) 2012-12-31
CN102225939A (zh) 2011-10-26
AR062918A1 (es) 2008-12-17
AU2007298855B2 (en) 2012-09-13
MEP10509A (en) 2011-12-20
ES2531093T3 (es) 2015-03-10

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