ME00613B - POSTUPAK ZA DOBIJANJE N-ALKILNALTREKSON HALlDA - Google Patents

POSTUPAK ZA DOBIJANJE N-ALKILNALTREKSON HALlDA

Info

Publication number
ME00613B
ME00613B MEP-2009-105A MEP10509A ME00613B ME 00613 B ME00613 B ME 00613B ME P10509 A MEP10509 A ME P10509A ME 00613 B ME00613 B ME 00613B
Authority
ME
Montenegro
Prior art keywords
carbonate
halides
preparing
methylnaltrexone
reaction
Prior art date
Application number
MEP-2009-105A
Other languages
English (en)
French (fr)
Inventor
Alain Dlubala
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of ME00613B publication Critical patent/ME00613B/me
Publication of MEP10509A publication Critical patent/MEP10509A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

Abstract

Ovaj pronalazak se odnosi na novi postupak za dobijanje N-metilnaltrekson bromida, koji sadrži najmanje korake koji se sastoje od: (i) reakcije N-metilnaltrekson metil sulfata u vodenom rastvoru sa nekim alkalnim reagensom koje se bira iz grupe koju čine  natrijum karbonat, kalijum karbonat, kalcijum karbonat, magnezijum karbonat, cezijum karbonat, i stroncijum  karbonat i njihove smeše, pri pH vodene reakcione sredine između  7 i 10, i zatim od (ii) reakcije tako dobijenog proizvoda sa bromovodoničnom kiselinom pri pH vodene reakcione sredine između 0,5 i 5, i pri tome se dobija N-metilnaltrekson bromid.  
MEP-105/09A 2006-09-21 2007-09-19 Process for preparing n-alkyl naltrexone halides MEP10509A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0608286A FR2906252B1 (fr) 2006-09-21 2006-09-21 Procede de preparation d'halogenures de n-aklyl naltrexone
PCT/FR2007/001516 WO2008034973A1 (fr) 2006-09-21 2007-09-19 Procede de preparation d'halogenures de n-alkyl naltrexone

Publications (2)

Publication Number Publication Date
ME00613B true ME00613B (me) 2011-12-20
MEP10509A MEP10509A (en) 2011-12-20

Family

ID=38016779

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-105/09A MEP10509A (en) 2006-09-21 2007-09-19 Process for preparing n-alkyl naltrexone halides

Country Status (36)

Country Link
US (2) US7645880B2 (me)
EP (1) EP2069362B1 (me)
JP (1) JP5214615B2 (me)
KR (1) KR101434693B1 (me)
CN (2) CN101516892B (me)
AR (1) AR062918A1 (me)
AU (1) AU2007298855B2 (me)
BR (1) BRPI0718440A2 (me)
CA (1) CA2663509C (me)
CL (1) CL2007002711A1 (me)
CO (1) CO6170362A2 (me)
CR (1) CR10660A (me)
DO (1) DOP2011000307A (me)
EA (1) EA015426B1 (me)
ES (1) ES2531093T3 (me)
FR (1) FR2906252B1 (me)
GT (1) GT200900060A (me)
HK (1) HK1135389A1 (me)
HN (1) HN2009000503A (me)
IL (1) IL197402A (me)
JO (1) JO3023B1 (me)
MA (1) MA30793B1 (me)
ME (1) MEP10509A (me)
MX (1) MX2009003084A (me)
MY (1) MY148094A (me)
NI (1) NI200900035A (me)
NO (1) NO20091561L (me)
NZ (1) NZ575417A (me)
PE (1) PE20080867A1 (me)
SV (1) SV2009003192A (me)
TN (1) TN2009000080A1 (me)
TW (1) TWI465451B (me)
UA (1) UA96957C2 (me)
UY (1) UY30599A1 (me)
WO (1) WO2008034973A1 (me)
ZA (1) ZA200901846B (me)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010522756A (ja) 2007-03-29 2010-07-08 プロジェニックス ファーマシューティカルズ，インコーポレーテッド 結晶形およびその使用
WO2008138383A1 (de) * 2007-05-16 2008-11-20 Cilag Ag Verfahren zur herstellung von n-methylnaltrexonbromid
WO2009009292A2 (en) * 2007-07-11 2009-01-15 Mallinckrodt Inc. Crystalline forms of naltrexone methobromide
EP2019105A1 (en) * 2007-07-19 2009-01-28 Siegfried Ltd. Process for the preparation of quaternary n-alkyl morphine or morphinane alkaloid derivatives
PL2344506T3 (pl) * 2008-09-30 2016-08-31 SpecGx LLC Sposoby alkilowania grup aminy drugorzędowej pochodnych morfinanowych
EP2398807A1 (en) * 2009-02-23 2011-12-28 Mallinckrodt LLC (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
JP5784507B2 (ja) * 2009-02-23 2015-09-24 マリンクロッド エルエルシー （＋）−モルフィナニウム第四級塩およびその生成方法
WO2010096790A1 (en) * 2009-02-23 2010-08-26 Mallinckrodt Inc. (+)-morphinananium n-oxides and processes for their production
US8853401B2 (en) 2009-04-24 2014-10-07 Brock University Processes for the preparation of morphinane and morphinone compounds
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
CN101845047B (zh) * 2009-12-31 2011-12-07 南京臣功制药有限公司 一种溴甲基纳曲酮的制备方法
JO3209B1 (ar) * 2010-11-05 2018-03-08 H Lundbeck As طريقة لتصنيع نالتريكسون
RS55777B1 (sr) 2010-11-05 2017-07-31 H Lundbeck As Postupak za proizvodnju naltreksona
US8580963B2 (en) 2010-11-05 2013-11-12 H. Lundbeck A/S Method for the manufacturing of naltrexone
WO2012138888A1 (en) 2011-04-05 2012-10-11 Alkermes, Inc. Process for the synthesis of quaternary amine compounds
RU2014112493A (ru) 2011-09-08 2015-10-20 МАЛЛИНКРОДТ Эл-Эл-Си Получения алкалоидов без выделения промежуточных продуктов
CN103172640A (zh) * 2011-12-22 2013-06-26 天津康鸿医药科技发展有限公司 一种(r)-n-溴甲基纳曲酮的制备方法以及纳曲酮衍生物
US20140155608A1 (en) 2012-05-03 2014-06-05 H. Lundbeck A/S Method for the manufacturing of naltrexone
CN105985348B (zh) * 2015-02-12 2019-02-01 正大天晴药业集团股份有限公司 一种溴甲基纳曲酮的制备方法
CN106317064B (zh) * 2015-06-30 2018-06-19 北大方正集团有限公司 溴甲纳曲酮的制备方法
KR102201609B1 (ko) * 2019-04-19 2021-01-12 연성정밀화학(주) 날데메딘의 제조방법
CN111777617A (zh) * 2020-07-10 2020-10-16 华润三九医药股份有限公司 一种溴甲纳曲酮的精制方法
EP4225312A1 (en) 2020-10-06 2023-08-16 Scilex Holding Company Oral delayed burst formulation of low-dose naltrexone or naloxone used for treating fibromyalgia and long covid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4176186A (en) * 1978-07-28 1979-11-27 Boehringer Ingelheim Gmbh Quaternary derivatives of noroxymorphone which relieve intestinal immobility
CA2504262C (en) * 2002-11-08 2012-01-10 Mallinckrodt, Inc. Process for the preparation of quaternary n-alkyl morphinan alkaloid salts
AR057325A1 (es) * 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos

Also Published As

Publication number Publication date
AU2007298855A1 (en) 2008-03-27
CL2007002711A1 (es) 2008-04-18
MA30793B1 (fr) 2009-10-01
JP2010504308A (ja) 2010-02-12
EA200970307A1 (ru) 2009-12-30
GT200900060A (es) 2011-01-04
US8288547B2 (en) 2012-10-16
PE20080867A1 (es) 2008-08-22
IL197402A (en) 2012-12-31
EA015426B1 (ru) 2011-08-30
US7645880B2 (en) 2010-01-12
FR2906252A1 (fr) 2008-03-28
BRPI0718440A2 (pt) 2013-11-19
ZA200901846B (en) 2010-07-28
TN2009000080A1 (en) 2010-08-19
CA2663509A1 (fr) 2008-03-27
US20100145051A1 (en) 2010-06-10
UA96957C2 (ru) 2011-12-26
JP5214615B2 (ja) 2013-06-19
CN101516892B (zh) 2012-06-20
DOP2011000307A (es) 2011-10-31
NZ575417A (en) 2011-09-30
JO3023B1 (ar) 2016-09-05
TWI465451B (zh) 2014-12-21
HK1135389A1 (en) 2010-06-04
HN2009000503A (es) 2011-03-02
MX2009003084A (es) 2009-04-02
CN101516892A (zh) 2009-08-26
EP2069362B1 (fr) 2014-07-09
AU2007298855B2 (en) 2012-09-13
MY148094A (en) 2013-02-28
NO20091561L (no) 2009-06-16
US20080214817A1 (en) 2008-09-04
CO6170362A2 (es) 2010-06-18
KR20090057031A (ko) 2009-06-03
WO2008034973A1 (fr) 2008-03-27
NI200900035A (es) 2010-01-26
FR2906252B1 (fr) 2008-11-28
IL197402A0 (en) 2009-12-24
SV2009003192A (es) 2009-10-27
EP2069362A1 (fr) 2009-06-17
UY30599A1 (es) 2008-05-02
CN102225939A (zh) 2011-10-26
MEP10509A (en) 2011-12-20
CA2663509C (fr) 2014-03-18
TW200821314A (en) 2008-05-16
KR101434693B1 (ko) 2014-08-27
ES2531093T3 (es) 2015-03-10
CR10660A (es) 2009-06-24
AR062918A1 (es) 2008-12-17

Similar Documents

Publication Publication Date Title
ME00613B (me) POSTUPAK ZA DOBIJANJE N-ALKILNALTREKSON HALlDA
JP2013516388A5 (me)
EA201070700A1 (ru) Способы получения циклоалкилкарбоксамидопиридинбензойных кислот
DE602007004134D1 (de) Ionisiertes Wasser und Verfahren zu dessen Herstellung
UA87389C2 (ru) Способ получения тризамещенных солей метилглицин-n,n-диуксусной кислоты и катионов щелочных металлов
MY156416A (en) Alkali-type nonionic surfactant composition
NO20085164L (no) Blyfri primaersprengstoffblanding og fremgangsmate for fremstilling derav
BR0215555A (pt) Preparação de reagentes de bromação não perigosos
RS54909B1 (sr) Postupak za dobijanje vodenog rastvora koji sadrži najmanje jedan hidrokarbonat zemnoalkalnog metala i njegova upotreba
DE602005024824D1 (de) Verfahren zur herstellung von substituierten tetrazolen aus aminotetrazolen
JP2008043836A5 (me)
NO20091206L (no) Belagte detergenssammensetninger og fremstillingsmate
HRP20180454T1 (hr) Postupak za proizvodnju 3-okso-pregn-4-en-21,17-karbolaktona pomoću bezmetalne oksidacije 17-(3-hidroksipropil)-3,17-dihidroksiandrostana
UA109269C2 (uk) Незлежувана композиція хлориду калію, спосіб її отримання і застосування
DE60237921D1 (de) Reinigung von oniumhydroxiden durch elektrodialyse
ZA200709019B (en) Fast-dissolving bentonite granulate
EA201171467A1 (ru) Способ получения композиции, содержащей антивинную кислоту
RS53093B (en) PROCEDURE FOR IMPROVING OPACITY
TH135001A (th) กรรมวิธีสำหรับการเตรียม n-แอลคิลแนลเทรกโซนเฮไลด์
WO2007129184A3 (en) An improved process for the preparation of phenytoin sodium
TH135001B (th) กรรมวิธีสำหรับการเตรียม n-แอลคิลแนลเทรกโซนเฮไลด์
JP2009280532A5 (me)
HUP0500184A2 (hu) Eljárás D-glükuronsav előállítására
RU2009132767A (ru) Способ производства водки
RU99126214A (ru) Способ очистки раствора хлорида натрия