PL2344506T3 - Sposoby alkilowania grup aminy drugorzędowej pochodnych morfinanowych - Google Patents
Sposoby alkilowania grup aminy drugorzędowej pochodnych morfinanowychInfo
- Publication number
- PL2344506T3 PL2344506T3 PL09789376T PL09789376T PL2344506T3 PL 2344506 T3 PL2344506 T3 PL 2344506T3 PL 09789376 T PL09789376 T PL 09789376T PL 09789376 T PL09789376 T PL 09789376T PL 2344506 T3 PL2344506 T3 PL 2344506T3
- Authority
- PL
- Poland
- Prior art keywords
- alkylation
- processes
- secondary amine
- amine groups
- morphinan derivatives
- Prior art date
Links
- 230000029936 alkylation Effects 0.000 title 1
- 238000005804 alkylation reaction Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- INAXVFBXDYWQFN-XHSDSOJGSA-N morphinan Chemical class C1C2=CC=CC=C2[C@]23CCCC[C@H]3[C@@H]1NCC2 INAXVFBXDYWQFN-XHSDSOJGSA-N 0.000 title 1
- 229940051807 opiod analgesics morphinan derivative Drugs 0.000 title 1
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
- C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19469808P | 2008-09-30 | 2008-09-30 | |
| EP09789376.2A EP2344506B1 (en) | 2008-09-30 | 2009-09-29 | Processes for the alkylation of secondary amine groups of morphinan derivatives |
| PCT/US2009/005356 WO2010039209A2 (en) | 2008-09-30 | 2009-09-29 | Processes for the synthesis of tertiary amines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2344506T3 true PL2344506T3 (pl) | 2016-08-31 |
Family
ID=41396271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09789376T PL2344506T3 (pl) | 2008-09-30 | 2009-09-29 | Sposoby alkilowania grup aminy drugorzędowej pochodnych morfinanowych |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8080661B2 (pl) |
| EP (1) | EP2344506B1 (pl) |
| CN (1) | CN102227433B (pl) |
| AU (1) | AU2009300379B2 (pl) |
| CA (1) | CA2738246C (pl) |
| ES (1) | ES2566559T3 (pl) |
| NZ (1) | NZ592006A (pl) |
| PL (1) | PL2344506T3 (pl) |
| WO (1) | WO2010039209A2 (pl) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8829020B2 (en) | 2009-07-16 | 2014-09-09 | Mallinckrodt Llc | Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
| US20110015219A1 (en) * | 2009-07-16 | 2011-01-20 | Mallinckrodt Inc. | (+)-Morphinans as Antagonists of Toll-Like Receptor 9 and Therapeutic Uses Thereof |
| US10363251B2 (en) | 2009-07-16 | 2019-07-30 | Mallinckrodt Llc | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
| PL2593095T3 (pl) | 2010-07-16 | 2019-12-31 | Mallinckrodt Llc | (+)-morfinany jako antagoniści receptora toll-podobnego 9 i ich terapeutyczne zastosowania |
| JO3209B1 (ar) * | 2010-11-05 | 2018-03-08 | H Lundbeck As | طريقة لتصنيع نالتريكسون |
| DK2635586T3 (en) * | 2010-11-05 | 2017-03-27 | H Lundbeck As | PROCEDURE FOR THE PREPARATION OF NALTREXON |
| US8580963B2 (en) | 2010-11-05 | 2013-11-12 | H. Lundbeck A/S | Method for the manufacturing of naltrexone |
| US8987293B2 (en) * | 2010-12-23 | 2015-03-24 | Phoenix Pharmalabs, Inc. | Morphinans useful as analgesics |
| CN103596962B (zh) * | 2011-05-02 | 2017-02-15 | 布鲁克大学 | 通过使用环化脱水试剂的n‑氧化物的n‑脱甲基化制备吗啡类似物的方法和中间体 |
| EP2809674A4 (en) * | 2012-02-03 | 2015-09-02 | Univ Brock | METHOD FOR THE PRODUCTION OF MORPHINE ANALOGUE BY REACTION OF ORGANOMETALLIC REAGENTS WITH AN OXAZOLIDINE DERIVED FROM MORPHINANESE |
| WO2013164383A1 (en) | 2012-05-03 | 2013-11-07 | H. Lundbeck A/S | Method for the manufacturing of naltrexone |
| US9701687B2 (en) * | 2014-05-05 | 2017-07-11 | Noramco, Inc. | Process for the preparation of opioid compounds |
| US9701688B2 (en) * | 2014-05-05 | 2017-07-11 | Noramco, Inc. | Process for the preparation of opioid compounds |
| EP4225312A1 (en) | 2020-10-06 | 2023-08-16 | Scilex Holding Company | Oral delayed burst formulation of low-dose naltrexone or naloxone used for treating fibromyalgia and long covid |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE638369A (pl) * | 1962-10-10 | |||
| US4017497A (en) * | 1975-11-18 | 1977-04-12 | Bristol-Myers Company | Process for the preparation of 14-hydroxymorphinan derivatives |
| US4141897A (en) * | 1976-12-20 | 1979-02-27 | Research Corporation | N-dealkylation of N-alkyl-14-hydroxymorphinans and derivatives thereof |
| US4176186A (en) | 1978-07-28 | 1979-11-27 | Boehringer Ingelheim Gmbh | Quaternary derivatives of noroxymorphone which relieve intestinal immobility |
| US4272540A (en) * | 1979-04-24 | 1981-06-09 | Sisa, Incorporated | 14-Methoxymorphinan-6-one compounds and therapeutic methods of treating pain and drug dependence with them |
| US4277605A (en) * | 1980-03-07 | 1981-07-07 | Bristol-Myers Company | Chemical compounds |
| US4322426A (en) | 1980-04-28 | 1982-03-30 | E. I. Du Pont De Nemours And Company | 17-Substituted-6-desoxy-7,8-dihydro-6α-methylnoroxymorphone narcotic antagonists |
| US5668285A (en) | 1986-10-31 | 1997-09-16 | The United States Of America As Represented By The Department Of Health And Human Services | Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates |
| US5869669A (en) * | 1996-07-26 | 1999-02-09 | Penick Corporation | Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates |
| JP2007504150A (ja) * | 2003-08-27 | 2007-03-01 | サザン・リサーチ・インスティテュート | ピリドモルヒナン（ｐｙｒｉｄｏｍｏｒｐｈｉｎａｎ）類及びピリダジノモルヒナン（ｐｙｒｉｄａｚｉｎｏｍｏｒｐｈｉｎａｎ）類、並びに、それらの使用 |
| AU2005232748A1 (en) * | 2004-04-13 | 2005-10-27 | The Mclean Hospital Corporation | R(-)-11-hydroxyaporphine derivatives and uses thereof |
| GB2471800B (en) | 2006-05-25 | 2011-03-09 | Alpharma | Preparation of N-alkylated morphinans by reduction of an iminium group |
| GB2471801B (en) | 2006-05-25 | 2011-02-16 | Alpharma | Process useful in the preparation of morphine antagonists |
| US20100022774A1 (en) | 2006-05-25 | 2010-01-28 | Ole Heine Kvernenes | Process useful in the preparation of morphinan antagonists |
| FR2906252B1 (fr) * | 2006-09-21 | 2008-11-28 | Sanofi Aventis Sa | Procede de preparation d'halogenures de n-aklyl naltrexone |
-
2009
- 2009-09-29 ES ES09789376.2T patent/ES2566559T3/es active Active
- 2009-09-29 AU AU2009300379A patent/AU2009300379B2/en active Active
- 2009-09-29 EP EP09789376.2A patent/EP2344506B1/en active Active
- 2009-09-29 NZ NZ592006A patent/NZ592006A/xx unknown
- 2009-09-29 PL PL09789376T patent/PL2344506T3/pl unknown
- 2009-09-29 CA CA2738246A patent/CA2738246C/en active Active
- 2009-09-29 US US12/586,843 patent/US8080661B2/en active Active
- 2009-09-29 CN CN200980147645.5A patent/CN102227433B/zh active Active
- 2009-09-29 WO PCT/US2009/005356 patent/WO2010039209A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US8080661B2 (en) | 2011-12-20 |
| AU2009300379B2 (en) | 2015-04-02 |
| CN102227433B (zh) | 2015-01-07 |
| EP2344506B1 (en) | 2016-02-10 |
| AU2009300379A1 (en) | 2010-04-08 |
| ES2566559T3 (es) | 2016-04-13 |
| EP2344506A2 (en) | 2011-07-20 |
| US20100081819A1 (en) | 2010-04-01 |
| CA2738246C (en) | 2017-09-05 |
| WO2010039209A2 (en) | 2010-04-08 |
| CA2738246A1 (en) | 2010-04-08 |
| CN102227433A (zh) | 2011-10-26 |
| WO2010039209A3 (en) | 2010-09-16 |
| NZ592006A (en) | 2013-03-28 |
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