EA201101319A1 - Композиции и способы элиминации грамотрицательных бактерий - Google Patents
Композиции и способы элиминации грамотрицательных бактерийInfo
- Publication number
- EA201101319A1 EA201101319A1 EA201101319A EA201101319A EA201101319A1 EA 201101319 A1 EA201101319 A1 EA 201101319A1 EA 201101319 A EA201101319 A EA 201101319A EA 201101319 A EA201101319 A EA 201101319A EA 201101319 A1 EA201101319 A1 EA 201101319A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compositions
- colon
- bacteria
- gramorable
- elimination
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 241000894006 Bacteria Species 0.000 title abstract 2
- 230000008030 elimination Effects 0.000 title 1
- 238000003379 elimination reaction Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 4
- 210000001072 colon Anatomy 0.000 abstract 3
- 108010028921 Lipopeptides Proteins 0.000 abstract 1
- 108010040201 Polymyxins Proteins 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 229940126575 aminoglycoside Drugs 0.000 abstract 1
- 244000052616 bacterial pathogen Species 0.000 abstract 1
- 210000004534 cecum Anatomy 0.000 abstract 1
- 238000005202 decontamination Methods 0.000 abstract 1
- 230000003588 decontaminative effect Effects 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 210000003405 ileum Anatomy 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000003120 macrolide antibiotic agent Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 229940072132 quinolone antibacterials Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Раскрыты пероральные композиции для доставки лекарственного средства со специфическим введением антибактериальных агентов в подвздошной кишке, слепой кишке и/или толстой кишке, без существенного введения где-либо в другом участке желудочно-кишечного тракта. Композиции включают в качестве активных средств комбинацию макролидного, или аминогликозидного, или хинолонового антибактериального средства и антиграмотрицательного липопептидного (полимиксинового) антибактериального агента или других пептидных антибактериальных средств, эффективных против грамотрицательных бактерий. Композиции можно применять для лечения инфекций или нежелательной колонизации в толстой кишке и для обеспечения эффективной деконтаминации флоры толстой кишки от нежелательных или потенциально патогенных бактерий.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16016209P | 2009-03-13 | 2009-03-13 | |
PCT/EP2010/053231 WO2010103119A1 (en) | 2009-03-13 | 2010-03-12 | Compositions and methods for elimination of gram-negative bacteria |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201101319A1 true EA201101319A1 (ru) | 2012-04-30 |
Family
ID=42153903
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201101319A EA201101319A1 (ru) | 2009-03-13 | 2010-03-12 | Композиции и способы элиминации грамотрицательных бактерий |
Country Status (12)
Country | Link |
---|---|
US (1) | US20120058936A1 (ru) |
EP (1) | EP2405909A1 (ru) |
JP (1) | JP2012520268A (ru) |
KR (1) | KR20120004448A (ru) |
CN (1) | CN102413826A (ru) |
AU (1) | AU2010223233A1 (ru) |
BR (1) | BRPI1009823A2 (ru) |
CA (1) | CA2754604A1 (ru) |
EA (1) | EA201101319A1 (ru) |
IL (1) | IL214979A0 (ru) |
MX (1) | MX2011009548A (ru) |
WO (1) | WO2010103119A1 (ru) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012061902A1 (en) * | 2010-11-12 | 2012-05-18 | Monash University | Micronised spray-dried particles comprising polymyxin |
WO2012085241A1 (en) | 2010-12-22 | 2012-06-28 | Da Volterra | Compositions and methods for the controlled repopulation of gram-negative bacteria in the colon |
CN103130881B (zh) * | 2013-02-06 | 2014-09-10 | 王冬国 | 一种肺炎克雷伯菌的耐药新基因 |
US10682360B2 (en) | 2014-01-27 | 2020-06-16 | Susanne GARDNER | Antimicrobial formulations and applications thereof |
CA2936741C (en) | 2014-10-31 | 2018-11-06 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
WO2016159741A1 (ko) * | 2015-04-03 | 2016-10-06 | 건국대학교 글로컬산학협력단 | Adk 단백질을 유효성분으로 포함하는 카바페넴 내성 그람음성균에 대한 항균용 조성물 |
US11174288B2 (en) | 2016-12-06 | 2021-11-16 | Northeastern University | Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria |
CN107184953A (zh) * | 2017-05-22 | 2017-09-22 | 山东省科学院生物研究所 | 一种抗菌脂肽皮脂膜修复组合物及其应用 |
US10722473B2 (en) | 2018-11-19 | 2020-07-28 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
CN110179967A (zh) * | 2019-05-28 | 2019-08-30 | 中国医药集团总公司四川抗菌素工业研究所 | 多粘菌素母核和一种抗生素的组合物及其应用 |
CN112316112A (zh) * | 2020-11-30 | 2021-02-05 | 河南农业大学 | 阿奇霉素在逆转食品动物源致病菌抗生素耐药性的用途 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3494308A (en) | 1967-11-14 | 1970-02-10 | George S Perrin | Composite article having portions simulating wood |
US4474768A (en) | 1982-07-19 | 1984-10-02 | Pfizer Inc. | N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor |
UA27040C2 (ru) | 1987-07-09 | 2000-02-28 | Пфайзер Інк. | Кристаллический дигидрат азитромицина и способ получения кристаллического дигидрата азитромицина |
US6235313B1 (en) | 1992-04-24 | 2001-05-22 | Brown University Research Foundation | Bioadhesive microspheres and their use as drug delivery and imaging systems |
US5840332A (en) * | 1996-01-18 | 1998-11-24 | Perio Products Ltd. | Gastrointestinal drug delivery system |
CA2245398C (en) | 1998-08-21 | 2002-01-29 | Apotex Inc. | Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof |
CN1273142C (zh) | 1998-11-30 | 2006-09-06 | 特瓦制药工业有限公司 | 阿齐霉素的乙醇化物,制备方法以及医药组合物 |
AU5820400A (en) | 1999-06-29 | 2001-01-31 | Biochemie S.A. | Macrolides |
PT1246831E (pt) | 2000-01-04 | 2008-03-28 | Teva Pharma | Método de preparação de di-hidrato de azitromicina |
ATE320441T1 (de) | 2000-07-25 | 2006-04-15 | Silanes Sa De Cv Lab | Einstufiges verfahren zur herstellung von 7,16- |
ES2172417B1 (es) | 2000-07-31 | 2003-09-16 | Sint Quimica Sa | Nueva forma mejorada de azitromicina monohidrato de menor higroscopicidad, procedimiento de preparacion y composiciones farmaceuticas que la comprenden. |
DE60114028T2 (de) | 2000-08-23 | 2006-07-13 | Wockhardt Ltd. | Verfahren zur herstellung von wasserfreiem azithromycin |
US6949519B2 (en) | 2000-11-27 | 2005-09-27 | Sandoz Ag | Macrolide solvates |
NZ529118A (en) | 2001-05-22 | 2005-10-28 | Pfizer Prod Inc | Crystal forms of azithromycin |
WO2006045156A1 (en) * | 2004-10-29 | 2006-05-04 | Monash University | Therapy for multi-drug resistant microorganisms |
US9149439B2 (en) * | 2005-03-21 | 2015-10-06 | Sandoz Ag | Multi-particulate, modified-release composition |
WO2008076806A2 (en) * | 2006-12-15 | 2008-06-26 | Trustees Of Boston University | Compositions and methods to potentiate colistin activity |
DE102007009242A1 (de) | 2007-02-22 | 2008-09-18 | Evonik Röhm Gmbh | Pellets mit magensaftresistenter Wirkstoff-Matix |
WO2009037264A2 (en) * | 2007-09-17 | 2009-03-26 | Da Volterra | Colonic delivery of antimicrobial agents |
-
2010
- 2010-03-12 BR BRPI1009823A patent/BRPI1009823A2/pt not_active IP Right Cessation
- 2010-03-12 WO PCT/EP2010/053231 patent/WO2010103119A1/en active Application Filing
- 2010-03-12 CA CA2754604A patent/CA2754604A1/en not_active Abandoned
- 2010-03-12 MX MX2011009548A patent/MX2011009548A/es not_active Application Discontinuation
- 2010-03-12 US US13/256,220 patent/US20120058936A1/en not_active Abandoned
- 2010-03-12 JP JP2011553474A patent/JP2012520268A/ja not_active Withdrawn
- 2010-03-12 KR KR1020117024134A patent/KR20120004448A/ko not_active Application Discontinuation
- 2010-03-12 AU AU2010223233A patent/AU2010223233A1/en not_active Abandoned
- 2010-03-12 EP EP10708768A patent/EP2405909A1/en not_active Withdrawn
- 2010-03-12 EA EA201101319A patent/EA201101319A1/ru unknown
- 2010-03-12 CN CN2010800194632A patent/CN102413826A/zh active Pending
-
2011
- 2011-09-05 IL IL214979A patent/IL214979A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2012520268A (ja) | 2012-09-06 |
CA2754604A1 (en) | 2010-09-16 |
US20120058936A1 (en) | 2012-03-08 |
KR20120004448A (ko) | 2012-01-12 |
EP2405909A1 (en) | 2012-01-18 |
CN102413826A (zh) | 2012-04-11 |
WO2010103119A1 (en) | 2010-09-16 |
AU2010223233A1 (en) | 2011-10-06 |
IL214979A0 (en) | 2011-11-30 |
BRPI1009823A2 (pt) | 2019-09-24 |
MX2011009548A (es) | 2011-12-14 |
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